European Review for Medical and Pharmacological Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dyslipidemia and heart failure: current evidence and perspectives of use of statins
Eur Rev Med Pharmacol Sci. 2024 Apr;28(7):2860-2877. doi: 10.26355/eurrev_202404_35929.ABSTRACTHeart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the spectrum of CAD have not been replicated in HF. Multiple potential pleiotropic effects of statins include anti-inflammatory, antioxidant, endothelial stabilization, antiapoptotic, anti-thrombotic, and modulation of the autonomic system apart from lipid lowering. These benevolent actions need to be c...
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: A Pradhan M Bhandari P Vishwakarma P Gualtieri L Di Renzo F Iellamo R Sethi M A Perrone Source Type: research

High MCM6 expression promotes proliferation and correlates with poor prognosis in triple-negative breast cancer
CONCLUSIONS: MCM6 overexpression in TNBC links to a worse prognosis and reduced cell proliferation upon MCM6 knockdown. We developed a risk score model based on MCM6-related genes predicting TNBC patient prognosis, potentially assisting future treatment strategies.PMID:38639528 | DOI:10.26355/eurrev_202404_35921 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: H Zhang Y-D Lin M-X Zhuang L Zhu Y Yu X-G Chen Q-S Wang M-B Lin Source Type: research

Clinical determinants of clinical response to Sonidegib in advanced basal cell carcinoma: a monocenter experience
CONCLUSIONS: The associations between the clinical outcome of interest (objective response rate) and the clinicopathological and treatment characteristics were evaluated. No statistically significant association was observed. Our analysis confirms the observation that no statistically significant correlation exists between clinical response and Sonidegib alternate dose regimen.PMID:38639529 | DOI:10.26355/eurrev_202404_35923 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: G Spallone A Carbone F Sperati P Frascione L Eibenschutz Source Type: research

Proposal of model for personalized early adapted cancer screening in people living with HIV: experience of "Gaetano Martino" Hospital University of Messina
Eur Rev Med Pharmacol Sci. 2024 Apr;28(7):2929-2942. doi: 10.26355/eurrev_202404_35924.ABSTRACTHuman immunodeficiency virus (HIV) infection has historically been related to the development of specific cancers, some of which are so closely linked to the infection, such as Kaposi's Sarcoma (KS), that they have earned the name Acquired Immuno-Deficiency Syndrome (AIDS)-defining cancers (ADCs). While the development of antiretroviral therapy (ART) has decreased the incidence of AIDS-defining cancers, the resulting aging of people living with HIV (PLWH) highlighted an increased occurrence of other forms of cancer. At the "Gaeta...
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: G F Pellican ò A Squeri G Ciappina R Squeri V I Palmara S Parisi I Campo C Saitta M Rossanese E Di Trapani S Mancuso N Catalano A Allegra G Mancuso G Murolo A Bignucolo D A Restivo P Consolo M Berretta Source Type: research

The relationship between quality of sleep and physical activity with level of symptom severity post-COVID-19 among HIV/AIDS patients
CONCLUSIONS: Physical activity was associated with the severity of the COVID-19 symptoms (p = 0.007). However, sleep quality was not associated with the severity of COVID-19 (p = 0.409). Physical activity may be one of the factors that prevent further severe COVID-19 symptoms. Therefore, physical activity should be considered as an effective factor to reduce the impact of COVID-19 and should be included in health care and prevention strategies.PMID:38639531 | DOI:10.26355/eurrev_202404_35926 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: M Luthfi Adillah S Yona C Edison Source Type: research

Investigation on the relationship between serum periostin, MMP-7, TGF- β, and IL-18 levels and the clinical course and prognosis of COVID-19
CONCLUSIONS: It is still not possible to predict which patients with early COVID-19 pneumonia will go on to develop MAS despite receiving standard treatment. The results of our study suggest that elevation of periostin and MMP-7 levels in the early period may predict the development of macrophage activation syndrome.PMID:38639532 | DOI:10.26355/eurrev_202404_35927 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: M E Tuna B Kerget A Aksakal E E ğilmez Ö Araz E Y U çar L Sa ğlam Source Type: research

The global impact of SARS-CoV-2 variant BA.2.86: a comprehensive analysis with the latest developments and transmission trends - an epidemiological study
CONCLUSIONS: The SARS-CoV-2, novel variant BA.2.86, spread over six continents and 89 countries and affected 19,532 people worldwide. The disease is more prevalent in the United Kingdom, United States of America, and European countries. The detection of the disease in multiple continents and countries suggests some degree of transmissibility. Global health authorities need to rethink their policies and implement strict strategies to eradicate emerging variants and minimize the global disease burden.PMID:38639533 | DOI:10.26355/eurrev_202404_35928 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: S A Meo A S Meo D M Halepoto Source Type: research

The safety signal detection and analysis of monoclonal antibodies against SARS-CoV-2 based on real-world evidence - the suitable selectivity for different populations
CONCLUSIONS: In summary, SOT may be unsuitable for allergic patients and may lead to abnormal test results. BEB showed the highest correlations with gastrointestinal and neuropsychiatric events. In addition, its infusion reactions should also be noted. TIX/CIL can lead to a variety of cardiovascular events.PMID:38639534 | DOI:10.26355/eurrev_202404_35925 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: Y Wang X-W Xu S Zhou J-N Li Source Type: research

Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats
CONCLUSIONS: It may be possible to prevent nephrotoxicity by adding ATP + Benidipine or ATP to 5-FU treatment.PMID:38567613 | DOI:10.26355/eurrev_202403_35760 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: T Dagel D Altuner B Suleyman R Mammadov S Bulut T Bal Tastan M Gulaboglu H Suleyman Source Type: research

A comparative perspective on brucellar, pyogenic, and tuberculous spondylodiscitis
CONCLUSIONS: Weight loss, painless palpation, involved thoracic spine, psoas abscess, and neurologic deficit are symptoms favoring tuberculous spondylodiscitis. History of spine surgery, high fever, skin erythema, and paraspinal abscess are findings in favor of pyogenic spondylodiscitis. Rural living, sweating, and involved lumbar spine are symptoms that indicate brucellar spondylodiscitis. These symptoms can be used to distinguish the types of spondylodiscitis.PMID:38567614 | DOI:10.26355/eurrev_202403_35761 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: A I Baran M Celik Y Arslan S Incecik I Binici M Toprak M Sunnetcioglu Source Type: research

Analysis of candidemia cases in a city hospital during the COVID-19 pandemic
CONCLUSIONS: As our study observed, the COVID-19 pandemic brought increasing numbers of immunosuppressed patients, widespread use of antibacterials, and central venous catheters, increasing the frequency and mortality of candidemia cases. All health institutions should be prepared for the diagnosis and treatment of candidemia. In addition, C. auris, the frequency of which has increased in recent years, is a new factor that should be considered in candidemia cases.PMID:38567615 | DOI:10.26355/eurrev_202403_35762 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: O Ozalp S Komec M Unsel A Gunduz O Altuntas Aydin Source Type: research

Severity of COVID-19 manifestations in HIV patients: a systematic review and meta-analysis
CONCLUSIONS: PLWHs and HIV-negative individuals showed comparable rates and intensity of COVID-19. ART users exhibited immunological health comparable to immunocompetent people, demonstrating the essential role of ART in reducing the severity and mortality of PLWH with COVID-19.PMID:38567616 | DOI:10.26355/eurrev_202403_35763 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: A Alam A A Soeroto R A Susilohadi L A Chandra Source Type: research

Evaluation of vaccine effectiveness of mRNA COVID-19 vaccines in children: a systematic review and meta-analysis
CONCLUSIONS: Both partial and full immunization of the BNT162b2 mRNA vaccine provide benefits in reducing infection rates. VE varies over time and is closely associated with viral mutations and waning immunity. The specific mechanisms require further investigation.PMID:38567617 | DOI:10.26355/eurrev_202403_35764 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: Y-H Hu Y Ding L-W Li J Cheng Y-H Cai Source Type: research

Post-COVID syndrome: analysis of the prevalence of chemosensory dysfunction and predictive factors of recovery in COVID-19 long-haulers in Jordan
CONCLUSIONS: Chemosensory dysfunctions are largely subjective; therefore, more objective examinations are required to draw more definite conclusions.PMID:38567618 | DOI:10.26355/eurrev_202403_35765 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: H M Sawan A H Khalifeh M Ahmed M M Khalil S M Al Omari R Binsuwaidan Source Type: research

Evaluation of the hematological and immunological markers after the first and second doses of BNT162b2 mRNA vaccine
CONCLUSIONS: We can conclude that the Pfizer/BioNTech vaccine produced a more potent T-cell response than humoral ones.PMID:38567619 | DOI:10.26355/eurrev_202403_35766 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: M Rafeeq M S Jabir H M Al-Kuraishy Z M A Jeddoa S F Jawad M A A Najm A F Almulla E Elekhnawy J Z Tayyeb A Turkistani B A Alsfouk G E Batiha Source Type: research