Worsening heart failure comes into focus, chronic heart failure takes a backseat
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: Maribel Gonz ález‐Del‐Hoyo, Xavier Rossello Tags: Invited Editorial Source Type: research

Breaking down peripartum cardiomyopathy: A learning adventure. Letter regarding the article ‘Outcomes at 1 year in women with peripartum cardiomyopathy: Findings from the ESC EORP PPCM Registry’
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: Andreas S. Papazoglou, Ana Rita Leite Tags: Letter to the Editor Source Type: research

Myocardial perfusion in cardiac amyloidosis
ConclusionCardiac amyloidosis is associated with severe inducible myocardial ischaemia demonstrable by histology and CMR stress perfusion mapping. Histological evaluation indicates a complex pathophysiology, where in addition to systolic and diastolic dysfunction, amyloid infiltration of the epicardial arteries and disruption and rarefaction of the capillaries play a role in contributing to myocardial ischaemia. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: Liza Chacko, Tushar Kotecha, Adam Ioannou, Niket Patel, Ana Martinez ‐Naharro, Yousuf Razvi, Rishi Patel, Paolo Massa, Lucia Venneri, James Brown, Aldostefano Porcari, Kristopher Knott, Charlotte Manisty, Daniel Knight, Tim Lockie, Roby R Tags: Research Article Source Type: research

Early changes in estimated glomerular filtration rate post ‐initiation of empagliflozin in EMPEROR‐Preserved
ConclusionAn initial relatively small eGFR decrease may be expected after empagliflozin initiation. Such small eGFR decrease was not associated with adverse cardiovascular outcomes with empagliflozin. In contrast, eGFR decrease was associated with poor cardiovascular outcomes with placebo. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: Tripti Rastogi, Jo ão Pedro Ferreira, Javed Butler, Bettina Johanna Kraus, Michaela Mattheus, Martina Brueckmann, Gerasimos Filippatos, Christoph Wanner, Stuart J. Pocock, Milton Packer, Stefan D. Anker, Faiez Zannad Tags: Research Article Source Type: research

Anaemia in patients with cardiogenic shock complicating acute myocardial infarction: Surrogate marker of poor outcome or therapeutic target?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: J J Coughlan, Xavier Rossello Tags: Invited Editorial Source Type: research

Sodium loading in ambulatory patients with heart failure with reduced ejection fraction: Mechanistic insights into sodium handling
ConclusionsSelected HFrEF patients can tolerate sodium loading, with increased renal sodium excretion and decreased neurohormonal activation. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 22, 2024 Category: Cardiology Authors: Jeroen Dauw, Evelyne Meekers, Pieter Martens, S ébastien Deferm, Sebastiaan Dhont, Wouter Marchal, Liesbeth Mesotten, Matthias Dupont, Petra Nijst, W.H. Wilson Tang, Stefan P. Janssens, Wilfried Mullens Tags: Research Article Source Type: research

The blood urea nitrogen to creatinine ratio in chronic heart failure: ‘When the past is prologue’
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 19, 2024 Category: Cardiology Authors: Rafael de la Espriella, Alberto Ortiz, Julio N úñez Tags: Invited Editorial Source Type: research

Clinical phenogroup diversity and multiplicity: impact on mechanisms of exercise intolerance in heart failure with preserved ejection fraction
ConclusionsThough cardiac output response to exercise is limited in patients with HFpEF compared to those with non-cardiac dyspnoea, the relative contributions of cardiac and peripheral limitations vary with differing numbers and types of clinical phenotypic traits present. Patients fulfilling criteria for greater multiplicity and diversity of HFpEF phenogroup traits have poorer exercise capacity, worsening haemodynamic perturbations, and greater risk for adverse outcome. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 19, 2024 Category: Cardiology Authors: Kathryn Larson, Massar Omar, Hidemi Sorimachi, Kazunori Omote, Alessio Alogna, Dejana Popovic, Atsushi Tada, Shunichi Doi, Jwan Naser, Yogesh N.V. Reddy, Margaret M. Redfield, Barry A. Borlaug Tags: Research Article Source Type: research

Why do clinicians not prescribe quadruple medical therapy for heart failure with reduced ejection fraction?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 18, 2024 Category: Cardiology Authors: Stephen J. Greene, Muhammad Shahzeb Khan, Javed Butler Tags: Invited Editorial Source Type: research

De novo versus upgrade cardiac resynchronization therapy: A different patient population and outcome?
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 18, 2024 Category: Cardiology Authors: B éla Merkely, Annamária Kosztin Tags: Invited Editorial Source Type: research

The effect of sodium –glucose cotransporter 2 inhibitors on left cardiac remodelling in heart failure with reduced ejection fraction: Systematic review and meta‐analysis
ConclusionsSodium –glucose cotransporter 2 inhibitors improve cardiac structure and function in patients with HFrEF. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 18, 2024 Category: Cardiology Authors: Muhammad Shariq Usman, James L. Januzzi, Stefan D. Anker, Ali Salman, Puja B. Parikh, Marianno Adamo, Gerasimos Filippatos, Muhammad Shahzeb Khan, Anuradha Lala, Subodh Verma, Marco Metra, Javed Butler Tags: Research Article Source Type: research

Reassessing the management of hypertension: Time to prevent aldosterone ‐mediated heart failure
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 18, 2024 Category: Cardiology Authors: Bertram Pitt, Jenifer M. Brown, Anand Vaidya, Javier Diez Tags: Viewpoint Source Type: research

Reply to the letter regarding the article ‘Head‐to‐head comparison between recommendations by the ESC and ACC/AHA/HFSA heart failure guidelines’
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 17, 2024 Category: Cardiology Authors: Antoni Bayes ‐Genis, Alberto Aimo Tags: Letter to the Editor Source Type: research

Independent prognostic importance of blood urea nitrogen to creatinine ratio in heart failure
ConclusionHigher BUN/creatinine ratio was associated with worse outcomes in patients with chronic HF across the spectrum of left ventricular ejection fraction, independently of eGFR and NT-proBNP. BUN/creatinine ratio may reflect neurohumoral activation (especially increased arginine vasopressin), altered renal blood flow or other pathophysiologic mechanisms not incorporated in conventional prognostic variables. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 16, 2024 Category: Cardiology Authors: Paolo Tolomeo, Jawad H. Butt, Toru Kondo, Gianluca Campo, Akshay S. Desai, Pardeep S. Jhund, Lars K øber, Martin P. Lefkowitz, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Muthiah Vaduganathan, Michael R. Zile, Milton Packer, John J.V. Tags: Research Article Source Type: research

Blood pressure levels and adverse cardiovascular outcomes in heart failure: A systematic review and meta ‐analysis
ConclusionsThe findings suggest that lower and normal baseline SBP levels (<130,<120, and  <  110 mmHg) may be associated with future risk of worse outcomes in patients with HF. Optimal baseline blood pressure levels for these patients may lie within the range of ≥140 mmHg for SBP. In the absence of observational studies with repeated blood pressure measurements or definitive trials evaluating optimal blood pressure targets, individualized blood pressure targets based on patients' unique circumstances are warranted in HF management. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - January 13, 2024 Category: Cardiology Authors: Samuel Seidu, Claire A Lawson, Setor K Kunutsor, Kamlesh Khunti, Giuseppe M C Rosano Tags: Research Article Source Type: research