Alternate day dosing of posaconazole tablets in children leads to efficient plasma levels
This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 16, 2018 Category: Hematology Authors: Alessio Mesini, Maura Faraci, Stefano Giardino, Erica Ricci, Sebastiano Barco, Giuliana Cangemi, Edoardo Lanino, Elio Castagnola Tags: Letter to the Editor Source Type: research
PlGF and sFlt ‐1 Levels in Patients with Non‐Transfusion‐Dependent Thalassemia: Correlations with Markers of Iron Burden and Endothelial Dysfunction
ConclusionsIn this study, we demonstrated an association between increased PlGF and iron overload and the degree of tissue hypoxia in patients with NTDT. High vWF:antigen expressing endothelial damage may be associated with specific NTDT comorbidities.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 15, 2018 Category: Hematology Authors: Charikleia Kelaidi, Antonis Kattamis, Filia Apostolakou, Christos Poziopoulos, Christina Lazaropoulou, Polyxeni Delaporta, Ino Kanavaki, Ioannis Papassotiriou Tags: Original Article Source Type: research
Hepcidin regulation in a mouse model of acute hypoxia
ConclusionSpleen and liver are not involved in the early stages of hypoxia‐induced hepcidin down‐regulation. Our data support the role of PDGF‐BB and probably also of erythroferrone in the recruitment of iron for erythropoiesis in the hypoxia setting. The rapid normalization of all the erythroid factors against persistent hepcidin suppression suggests that other signals are involved that should be clarified in future studies.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 15, 2018 Category: Hematology Authors: Giulia Ravasi, Sara Pelucchi, Gaia Buoli Comani, Federico Greni, Raffaella Mariani, Irene Pelloni, Silvia Bombelli, Roberto Perego, Donatella Barisani, Alberto Piperno Tags: Original Article Source Type: research
Co ‐transplantation of haploidentical hematopoietic stem cell and allogeneic bone‐marrow‐derived mesenchymal stromal cells as a first‐line treatment in very severe aplastic anemia patients with refractory infections
ConclusionsUpfront HRD‐ HSCT may be a safe and promising choice for VSAA patients in critical situations without suitably matched donors.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 13, 2018 Category: Hematology Authors: Chunyan Yue, Yingying Ding, Yang Gao, Li Li, Yan Pang, Zenghui Liu, Hang Zhang, Yang Xiao, Zujun Jiang, Haowen Xiao Tags: Original Article Source Type: research
Safety of direct oral anticoagulants vs warfarin in patients with chronic liver disease and atrial fibrillation
European Journal of Haematology, EarlyView. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 13, 2018 Category: Hematology Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 13, 2018 Category: Hematology Source Type: research
Safety of direct oral anticoagulants vs warfarin in patients with chronic liver disease and atrial fibrillation
ConclusionNo significant differences in bleeding rates were noted in patients treated with warfarin and DOAC agents. Further studies evaluating DOAC agents are needed to better understand the optimal anticoagulation strategy in setting of CLD. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 13, 2018 Category: Hematology Authors: Pavel Goriacko, Keith T. Veltri Tags: ORIGINAL ARTICLE Source Type: research
Pretreatment with standard ‐dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (ITP)
European Journal of Haematology, EarlyView. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Source Type: research
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European Journal of Haematology, Ahead of Print. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Source Type: research
Clinicopathological characteristics of de novo and secondary myeloid sarcoma: a monocentric retrospective study
ConclusionDe novo myeloid sarcoma mostly presented isolated. Lesions were often localized at skin and lymph nodes. Genetic aberrations frequently involved core‐binding factor rearrangements in de novo cases and a complex karyotype in secondary cases.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Authors: Helena Claerhout, Sophie Van Aelst, Celine Melis, Thomas Tousseyn, Olivier Gheysens, Peter Vandenberghe, Daan Dierickx, Nancy Boeckx Tags: Original Article Source Type: research
Screening and Diagnostic Clinical Algorithm for Paroxysmal Nocturnal Hemoglobinuria: Expert Consensus
ConclusionThese results facilitated development of a consensus‐based, clinically relevant algorithm, providing non‐specialist clinicians with actionable guidance on PNH screening and diagnosis.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Authors: Alexander R öth, Jaroslaw Maciejewski, Jun‐Ichi Nishimura, Deepak Jain, Jeffrey I. Weitz Tags: Original Article Source Type: research
Low response rate to ATG ‐based immunosuppressive therapy in very severe aplastic anaemia – a Swedish nationwide cohort study
ConclusionsReal‐world VSAA patients respond poorly to ATG which indicates the need for a different treatment approach. Our findings suggest that age alone should not be a discriminating factor for administering ATG treatment.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Authors: Krista Vaht, Magnus G öransson, Kristina Carlson, Cecilia Isaksson, Stig Lenhoff, Anna Sandstedt, Bertil Uggla, Jacek Winiarski, Per Ljungman, Mats Brune, Per‐Ola Andersson Tags: Original Article Source Type: research
Pretreatment with standard ‐dose intravenous methylprednisolone does not improve outcomes in newly diagnosed immune thrombocytopenia (ITP)
ConclusionsInitiating methylprednisolone at a conventional dose provided no significant benefit compared to giving oral prednisone only to adults with ITP. (Source: European Journal of Haematology)
Source: European Journal of Haematology - March 12, 2018 Category: Hematology Authors: Ana ïs Essilini, Thibault Comont, Johanne Germain, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Serge Madaule, Laurent Sailler, Maryse Lapeyre‐Mestre, Odile Beyne‐Rauzy, Bertrand Godeau, Daniel Adoue, Guillaume Moulis, Tags: ORIGINAL ARTICLE Source Type: research
