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T32
We examined racial disparities among 102 oropharyngeal carcinoma (OPC) patients (30 African Americans, 72 Whites) comparing the present of HPV16/18 E6 and E7 oncoproteins, and p16Ink4A overexpression, with times to disease progression (DP) and disease specific survival (DSS). Expression of HPV16/18 transcripts was assessed by reverse transcription and polymerase chain reaction using type-specific E6/E7 primers; p16Ink4A was evaluated by immunohistochemistry. African Americans were significantly more likely to present with high T stage disease and receive nonsurgical treatment. HPV16/18 was present in 63% of patients; no ra...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P152
In this study, we asked by using gastrointestinal stromal tumours as a model if an epigenetic related HOX Antisense Intergenic RNA, or HOTAIR, is involved in establishment of DNA methylation patterns. To this end, we first showed high up-regulation of HOTAIR in patient samples of high risk compared to low and intermediate risk groups (n =66, p =6.7×10−6), what is supported by the earlier reports on common carcinomas. Highest levels of HOTAIR endogenous expression were next detected also in cell lines GIST T1, GIST48b and GIST882. Stable knockdown of HOTAIR was achieved in GIST T1 and GIST48b cells by RNAi using lentivir...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P74
In this study we show that intracellular cycling of exo- and endogenous Hsp70s increases the sensitivity of cancer cells to cytotoxic lymphocytes. Moreover, the results of in vivo studies employing B16 mouse melanoma and C6 rat glioblastoma as targets proved the therapeutic relevance of exogenous Hsp70 in intra-tumoral application. To uncover the mechanisms of the anticancer effect we used inhibitors and markers of intra- and extracellular protein transport. The data of these studies showed multiplicity of pathways using which exo-Hsp70 reaches cytosol and more usable ones was endocytosis. To be exported intracellular Hsp7...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P20
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): V. Gurtsevitch, L. Yakovleva, L. Scherback, E. Goncharova, K. Smirnova, N. Senyuta The Epstein–Barr virus (EBV) represents an etiological agent for a number of human benign and malignant tumors. One of the EBV encoded proteins, the latent membrane protein 1 (LMP1), is involved in activation of many signaling pathways and transcription factors leading EBV infected cells to immortalization and transformation. It’s well known that almost all worlds’ population is infected with EBV. As usually, inf...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P68
Conclusion Apparently, the TMEPAI may be a potential biomarker of malignant transformation risk of the stomach epithelium. The presented study was financially supported by Grants from the Russian Fund for Basic Research (14-04-31500) and Tomsk State University Competitiveness Improvement Program. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P114
Conclusion The data obtained show that further studies are required to improve personalized therapy for NSCLC patients. The frequency and type of KRAS and EGFR mutations were first assessed in NSCLC patients from West Siberia. This work was supported by a Grant from the OPTEK Company (No 122/2014/51/Nvs ). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A18
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): T. Gening, T. Abakumova, D. Dolgova, S. Gening, I. Antoneeva Tumor-associated neutrophils (TANs) are the cell population that differs in morphofunctional characteristics from peripheral blood cells (Gregory and Houghton, 2011). The first study to identify the presence of TANs as an independent poor prognostic factor and to include TANs into a prognostic risk model was published in 2006 (Donskov , 2006). Specific signals during cancer progression have been shown to induce the emergence of a pro-tumor ph...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A91
Conclusion One can conclude that serum procathepsin B and endogenous inhibitors of cysteine proteases cystatin B are prospective tumor biomarkers in reproductive system tumors. Procathepsin B and cystatin B seem to be important in differential diagnosis of ovarian cancer and benign ovarian tumors. Procathepsin B and cystatin B are involved in breast and endometrial cancer that warrants further investigation of their role in cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T33
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): M. Freidin Blood-derived biomarkers, such as circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA), are a valuable source of molecular genetic data for tumours they spring from. In translational cancer research, the “liquid biopsy” concept has been put forward to denote the detection and molecular characterization of these biomarkers. The idea of liquid biopsy is based on a hypothesis that profiles of somatic mutations in CTCs and ctDNA are identical to those in the original tumour. Therefore,...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P119
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): R. Fadeev, M. Solovieva, S. Zakharov, I. Fadeeva, A. Senotov, A. Golenkov, V. Akatov Acute myelomonocytic leukemia (FAB M4) is one of the most common forms of acute myeloid leukemia (AML). This AML form is characterized by rapid accumulation transformed myeloblasts and monoblasts in bone marrow, with the rapid suppression of normal hematopoiesis. Bone marrow microenvironment is one of the main factors determining drug resistance of leukemic cells. It is known that the adhesion of leukemic cells to ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P83
Conclusion The combination of nonspecific clinical signs (pain, dyspepsia) with biochemical markers of biliary pathology and endocrine pancreatic insufficiency – of PCa patients demonstrates the obligatoriness of differential diagnostic pancreatic and biliary pathology in their earlier stages. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A115
Conclusion Head and neck tumors are a rare group of clinically and biologically diverse neoplastic diseases. Among the residents of the Chelyabinsk region, men are 2–3 times more susceptible to cancer of the oral cavity and pharynx than women. High mortality rate is due to late referral of patients to specialized clinics; most head and neck cancer patients are diagnosed at advanced stages. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P127
Conclusion Genetic tests show that DNA methylation in patients with chronic atrophic gastritis has high diagnostic importance. Anti-H. pylori therapy at the different stages of “Correa” cascade has high level of induction in transforming into non invase gastric cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P43
Conclusion In serum of control (healthy) group, cystatin C concentration is significantly higher than cystatin SN level in serum, tears and intraocular fluid. The reverse correlation was revealed between the level of these inhibitors in serum, that is suggested their possible interaction. In melanoma patients the reciprocal changes in cystatin C and cystatin SN were shown: increased cystatin C and decreased cystatin SN level in all biological fluids studied. On the basis of cystatins distribution in biological fluids of patients one can suggest their involvement in pathological process as system reaction of organism on tum...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P78
Conclusion Intratumor morphological heterogeneity of IC NST contributes to distant metastasis probably by variations in expression of genes involved in cell motility and pre-metastatic niche formation between different morphological structures. The study was supported by the Russian Scientific Foundation (Grant #14-15-00318 ). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research