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Editorial board
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Biosimilars: Extrapolating the evidence. A roundtable discussion
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): Bradley J. Monk, Morton Coleman, Philip Lammers, George Somlo (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Urothelial carcinoma management in elderly or unfit patients
Publication date: March 2016Source: European Journal of Cancer Supplements, Volume 14, Issue 1Author(s): Joaquim Bellmunt, Nicolas Mottet, Maria De Santis (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Urothelial carcinoma management in elderly or unfit patients
Publication date: March 2016 Source:European Journal of Cancer Supplements, Volume 14, Issue 1 Author(s): Joaquim Bellmunt, Nicolas Mottet, Maria De Santis (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - March 22, 2016 Category: Cancer & Oncology Source Type: research

Biosimilars: Extrapolating the evidence. A roundtable discussion
Publication date: December 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 2 Author(s): Bradley J. Monk, Morton Coleman, Philip Lammers, George Somlo (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - January 22, 2016 Category: Cancer & Oncology Source Type: research

A75
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): D. Korobkov, N. Plotnikova, G. Meltsaev, S. Kemaykin, A. Almyashev, S. Haritonov Breast cancer is one of the most common cancers in women. The incidence of breast cancer in 2014 in the Republic of Mordovia was 69.9 per 100,000 female populations. Breast cancer occurs when excessive expression of oncoproteins switches in the case of transformation of proto-oncogene in PRADI. In primary breast tumors, mutations and the expression of the three oncogenes Her2/neu, C-mys, Int-2, as well as in supressonyh ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A122
Conclusion Expression of CD79b, CD22, CD38 is the main feature of cells with recurrent genetic injuries. Immunophenotype without expression of CD79b, CD22, CD38 in most cases differentiates CLL patients with del(13)(q14.3), del (13)(q34), (13q)(34) trisomy and with normal karyotype. Coexpression in the most of the cells of the three antigens CD79b, CD22, CD38 and more bright expression of CD20 proposes trisomy 12 or del(6q). Partial expression of CD79b and CD38 may correlate with del(11)(q23). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P17
Conclusion Allogeneic transplantation of bone marrow cells on porous incubator was shown to prolong and enhance antitumor and antimetastatic action compared to injecting the cells. This effect is directly due to the stimulation of antitumor immunity, that is described by the study of immunity factors. The results show perspectives of porous TiNi-based scaffolds in complex treatment of neoplastic diseases. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T35
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): F. Kisseljov, S. Vinokurova, N. Kisseljova, L. Pavlova, M. Fedorova, A. Katargin, A. Petrenko, L. Korolenkova Epigenetics investigates mechanisms that control inheritance of gene expression program during somatic cell divisions. These mechanisms include regulation by DNA methylation, histone post-translational modifications and nucleosome positioning, functioning of regulatory non-coding RNAs, control of alternative splicing of mRNA precursors and high-order chromatin organization. Genome-wide lo...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A112
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): E. Kisseleva, A. Krylov, K. Rutto, V. Lioudyno Recruitment of mononuclear phagocytes from the blood into tissues is considered to be a crucial process during inflammatory reactions, wound healing and tumor growth. Macrophages are known to reveal high plasticity and may change under the influence of microenvironment. The aim of the study was to evaluate the changes of macrophage functional activity under the influence of Vascular endothelial growth factor (VEGF) in vitro. This factor is known to be the ma...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P88
Conclusion Taking together, findings of the study will lay the fundamental groundwork for the development of novel anticancer strategies and new chemotherapy effects of small molecules. The mechanism of PARP-1 inhibition by MGBLs and its epigenetic influence on silent genes, via DNA methylation and histone modifications make reasonable further study of these compounds in three prospective directions: (1) as self-acting cytotoxic agents; (2) as a component of combined chemotherapy targeting DNA repair by PARP-1, thereby facilitating DNA damage caused by other anticancer drugs; (3) as an agents reactivating epigenetically re...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A144
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): T. Khramova, V. Varaksin, L. Beduleva, I. Menshikov Existing methods for the preoperative detection of metastases in thyroid cancer have low efficiency and highly invasive. Therefore, the searches for laboratory markers that will indicate the presence of metastases including hidden with high reliability in cancer of the thyroid gland are relevant. Immune system is one of the key mechanisms for regulation of tissue proliferation. Autoreactive lymphocytes restrict the growth and proliferation of tissues. I...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P69
Conclusion Exposure to TCDD induces a mechanism of two-stage regulation of the expression of some IL-12 family subunits through primary activation of the aryl hydrocarbon receptor by the TCDD-containing complex followed by ATF3-dependent suppression of their expression. This may result in an abrupt reduction of the anti-tumor response mediated by O and NK cells. The observed increase in ATF3 and decrease in IL-12 following exposure to TCDD are consistent with data on the expression of these genes in tumor-associated macrophages (TAMs). Reliance upon available data that demonstrate a decrease in IL-12 alongside an increase ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T15
Conclusion Neoadjuvant chemotherapy increases blood levels of circulating tumor cells, endothelial progenitor cells and mesenchymal stem cells progenitor fibroblasts, thus promoting the formation of premetastatic niche. The study was conducted with financial support from the Council for Grants of the President of the Russian Federation (Russia) for the state support of young philosophy doctors, agreements of SC 114.120.14.168-MD Russian Scientific Foundation (Russia), Grant No. 14-15-00318 (sample collection) and Russian Foundation for Basic Research (Russia), Grant No. 15-34-20864. We acknowledge support of this work by t...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P121
Conclusion Thus, if the amount of radiation exposure of BAL cells was significantly reduced by the 1st and 7th days, and after inhalation of sulfur dioxide – tended to increase, then the combined action on the 7th day it was almost half the theoretical (hypothetical) the sum of the separate effects of the studied factors. Exposure to sulfur dioxide significantly slowed the activation of cell count. It was found, that after combined action of the investigated factors the morphological characteristics of macrophages (reducing the square of cells and their nuclei) have changed (7th and 15th day). The absorption activity of ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research