European Journal of Applied Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Microdamage study of granite under thermomechanical coupling based on the particle flow code
In this study, an improved temperature-dependent linear parallel bond model is introduced under the framework of a particle flow simulation. A series of numerical thermomechanical coupling tests are then conducted to calibrate the micro-parameters of the proposed model by considering the mechanical behavior of the rock under different thermomechanical loadings. Good agreement between the numerical results and experimental data are obtained, particularly in terms of the compression, tension, and elastic responses of granite. With this improved model, the thermodynamic response and underlying cracking behavior of a deep-buri...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Thermo-mechanical simulation of frost heave in saturated soils
AbstractRoads are exposed to various degradation mechanisms during their lifetime. The pavement deterioration caused by the surrounding environment is particularly severe in winter when the humidity and subfreezing temperatures prevail. Frost heave-induced damage is one of the winter-related pavement deterioration. It occurs when the porewater in the soil is exposed to freezing temperatures. The study of frost heave requires conducting a multiphysics analysis, considering the thermal, mechanical, and hydraulic fields. This paper presents the use of a coupled thermo-mechanical approach to simulate frost heave in saturated s...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Effects of time-varying liquid bridge forces on rheological properties, and resulting extrudability and constructability of three-dimensional printing mortar
This study proposes a particle-based method to simulate 3D printing mortar extrusion and construction as an overall planning tool for building design. First, a discrete element model with time-varying liquid bridge forces is developed to investigate the microscopic effects of these forces on global rheological properties. Next, a series of numerical simulations relevant to 3D printable mortar extrudability and constructability are carried out. The study demonstrates that the effects of time-varying liquid bridge forces on rheological properties and the resulting extrudability and constructability of 3D printing mortar are ...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Optimization of the mechanical performance and damage failure characteristics of laminated composites based on fiber orientation
In this study, the effect of fiber angle on the tensile load-bearing performance and damage failure characteristics of glass composite laminates was investigated experimentally, analytically, and numerically. The glass fabric in the laminate was perfectly aligned along the load direction (i.e., at 0 °), offset at angles of 30° and 45°, or mixed in different directions (i.e., 0°/30° or 0°/45°). The composite laminates were fabricated using vacuum-assisted resin molding. The influence of fiber orientation angle on the mechanical properties and stiffness degradation of the laminates was stu died via cyclic tensile stre...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Optimization design of anti-seismic engineering measures for intake tower based on non-dominated sorting genetic algorithm-II
AbstractHigh-rise intake towers in high-intensity seismic areas are prone to structural safety problems under vibration. Therefore, effective and low-cost anti-seismic engineering measures must be designed for protection. An intake tower in northwest China was considered the research object, and its natural vibration characteristics and dynamic response were first analyzed using the mode decomposition response spectrum method based on a three-dimensional finite element model. The non-dominated sorting genetic algorithm-II (NSGA-II) was adopted to optimize the anti-seismic scheme combination by comprehensively considering t...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Performance analysis of a novel medium temperature compressed air energy storage system based on inverter-driven compressor pressure regulation
AbstractIn compressed air energy storage systems, throttle valves that are used to stabilize the air storage equipment pressure can cause significant exergy losses, which can be effectively improved by adopting inverter-driven technology. In this paper, a novel scheme for a compressed air energy storage system is proposed to realize pressure regulation by adopting an inverter-driven compressor. The system proposed and a reference system are evaluated through exergy analysis, dynamic characteristics analysis, and various other assessments. A comprehensive performance analysis is conducted based on key parameters such as the...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Analysis of substrate specificity of cytochrome P450 monooxygenases involved in trichothecene toxin biosynthesis
AbstractTrichothecenes are a structurally diverse family of toxic secondary metabolites produced by certain species of multiple fungal genera. All trichothecene analogs share a core 12,13-epoxytrichothec-9-ene (EPT) structure but differ in presence, absence and types of substituents attached to various positions of EPT. Formation of some of the structural diversity begins early in the biosynthetic pathway such that some producing species have few trichothecene biosynthetic intermediates in common. Cytochrome P450 monooxygenases (P450s) play critical roles in formation of trichothecene structural diversity. Within some spec...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Four-week experimental plus 1-week taper period using live high train low does not alter muscle glycogen content
This study aimed to investigate the effects of a 4-week live high train low (LHTL; FiO2 ~ 13.5%), intervention, followed by a tapering phase, on muscle glycogen concentration. Fourteen physically active males (28 ± 6 years, 81.6 ± 15.4 kg, 179 ± 5.2 cm) were divided into a control group (CON;n = 5), and the group that performed the LHTL, which was exposed to hypoxia (LHTL;n = 9). The subjects trained using a one-legged knee extension exercise, which enabled four experimental conditions: leg training in hypoxia (TLHYP); leg control in hypoxia (CLHYP,n = 9); leg trained in normoxia (TLNOR,nâ...
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Postural adjustments and perceptual responses of Nordic running: concurrent effects of poles and irregular terrain
ConclusionBesides the invariability of usage poles on bilateral coordination and lower-limb kinematics, the runners seem to prioritize postural stability over lower limb stiffness when running in medium-length grass given the larger range of ankle and knee motion observed in irregular terrain. Further investigations at rougher/hilly terrains will likely provide additional insights into the neuromotor control strategies used to maintain the stability and on perceptual responses using poles during running. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

A single all-out bout of 30-s sprint-cycle performed on 5 consecutive days per week over 6  weeks does not enhance cardiovascular fitness, maximal strength, and clinical health markers in physically active young adults
ConclusionSix weeks of one all-out bout of 30-s sprint-cycle per day, for 5 consecutive days per week, was ineffective in improving cardiovascular fitness, maximal strength, and most health markers in physically active young adults. The present results when combined with the previous literature suggest that there is a possibility of a minimum threshold for a number of sprint-cycle bouts needed to be performed before any form of cardio-metabolic-health benefit is accrued. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - January 17, 2024 Category: Physiology Source Type: research

Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis
In this study, we combined one of the lead amino acids, L-tyrosine, which is known for its poor solubility in water due to its aromatic ring and hydroxyl group, with glycine as the partner, thus forming glycyl-L-tyrosine (GY) dipeptide. Subsequently, we investigated the utilization of GY dipeptide during fed-batch cultures of IgG-producing CHO cells, by changing its concentrations (0.125  × , 0.25 × , 0.5 × , 1.0 × , and 2.0 ×). Multivariate statistical analysis of culture profiles was then conducted to identify and correlate the most significant nutrients with the production, followed by in silico m...
Source: European Journal of Applied Physiology - January 16, 2024 Category: Physiology Source Type: research

Integrated omics analysis reveals the alteration of gut microbiota and fecal metabolites in Cervus elaphus kansuensis
In this study, the composition and diversity of the gut microbiome and fecal metabolomics ofC. elaphus kansuensis were identified and compared for the first time by using 16S rDNA sequencing, metagenomic sequencing, and LC-MS/MS. There were significant differences in gut microbiota structure and diversity between wild and farmedC. elaphus kansuensis. The 16S rDNA sequencing results showed that the genusUCRD-005 was dominant in both captive red deer (CRD) and wild red deer (WRD). Metagenomic sequencing showed similar results to those of 16S rDNA sequencing for gut microbiota in CRD and WRD at the phylum and genus levels. 16...
Source: European Journal of Applied Physiology - January 15, 2024 Category: Physiology Source Type: research

IS6 family insertion sequences promote optrA dissemination between plasmids varying in transfer abilities
AbstractPlasmids are the primary vectors for intercellular transfer of the oxazolidinone and phenicol cross-resistance geneoptrA, while insertion sequences (ISs) are mobile genetic elements that can mobilize plasmid-borneoptrA intracellularly. However, little is known about how the IS-mediated intracellular mobility facilitates the dissemination of theoptrA gene between plasmid categories that vary in transfer abilities, including non-mobilizable, mobilizable, and conjugative plasmids. Here, we performed a holistic genomic study of 52optrA-carrying plasmids obtained from searches guided by the Comprehensive Antibiotic Resi...
Source: European Journal of Applied Physiology - January 15, 2024 Category: Physiology Source Type: research

Heterologous biosynthesis of myxobacterial lanthipeptides melittapeptins
AbstractThe myxobacteria are an attractive bioresource for bioactive compounds since the large size genome contains many biosynthetic gene clusters of secondary metabolites. The genome of the myxobacteriumMelittangium boletus contains three biosynthetic gene clusters for lanthipeptide production. One of the gene clusters includes genes coding lanthipeptide precursor (melA), class II lanthipeptide synthetase (melM), and transporter (melT). The amino acid sequence ofmelA indicated similarity with that of known lanthipeptides mersacidin and lichenicidin A1 by the alignment. To perform heterologous production of new lanthipept...
Source: European Journal of Applied Physiology - January 15, 2024 Category: Physiology Source Type: research

The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults
ConclusionThese findings demonstrate the superiority of acute trunk stretching over passive sitting of equated duration for BP in middle-aged to older adults, with an appreciable effect in males compared to females. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - January 13, 2024 Category: Physiology Source Type: research