Clinical significance of IL-37 serum level and polymorphism in patients with endometrial cancer
Eur Cytokine Netw. 2023 Dec 1;34(4):63-69. doi: 10.1684/ecn.2023.0491.ABSTRACTEndometrial cancer (EC) is recognized as the second most common type of cancer among women. Interleukin-37 (IL-37) is a recently discovered member of the IL-1 cytokine family characterized by its anti-inflammatory properties, which are believed to have both anti-tumour and tumorigenic effects. However, the precise role of IL-37 in the development of EC remains largely unknown. In the current study, we aimed to explore genotype and allele frequencies of the IL-37 gene (rs4241122) and measure IL-37 protein levels in patients with EC, with a view to...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Mohammad Reza Haghshenas Zahra Shiravani Mohammad Samare-Najaf Soolmaz Khansalar Seyed Ali Razavinasab Abbas Ghaderi Navid Jamali Source Type: research
Growth factors and cytokines involved in liver regeneration
Eur Cytokine Netw. 2023 Dec 1;34(4):38-45. doi: 10.1684/ecn.2023.0483.ABSTRACTThe regenerative ability of the liver is essential for maintaining physiological functions and the injury repair process. The biological mechanisms that regulate liver regeneration remain poorly defined. These mechanisms are notable issues in clinical practice that affect the treatment of hepatic loss caused by hepatectomy, hepatic poisoning, or chronic viral infection. Increasing evidence shows that numerous growth factors, cytokines, and metabolic pathways influence the liver regenerative process. Of particular importance are cytokines and grow...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Chen Liu Xiaomeng Liu Hongyuan Zhou Wei Zhang Tianqiang Song Source Type: research
Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice
In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated inte...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Wei Zhuang Zhen Li Source Type: research
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced maturation of spermatogonial cells from prepubertal mice in vitro is enhanced by testosterone
In conclusion, our results indicate that testicular cells express GM-CSF/GM-CSFR, and that GM-CSF is involved in the development of different stages of spermatogenesis in vitro. Furthermore, testosterone enhances the development of spermatogenic cells and potentiates the effect of GMCSF on the development of post-meiotic cells. These findings provide evidence that GM-CSF and testosterone are involved in the development of spermatogenesis in vitro and in vivo. In brief: Testicular somatic and germ cells express GM-CSF and GM-CSFR. Our study suggests that testicular GM-CSF is involved in the development of spermatogenesis, w...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Areej Jorban Eitan Lunenfeld Mahmoud Huleihel Source Type: research
Clinical significance of IL-37 serum level and polymorphism in patients with endometrial cancer
Eur Cytokine Netw. 2023 Dec 1;34(4):63-69. doi: 10.1684/ecn.2023.0491.ABSTRACTEndometrial cancer (EC) is recognized as the second most common type of cancer among women. Interleukin-37 (IL-37) is a recently discovered member of the IL-1 cytokine family characterized by its anti-inflammatory properties, which are believed to have both anti-tumour and tumorigenic effects. However, the precise role of IL-37 in the development of EC remains largely unknown. In the current study, we aimed to explore genotype and allele frequencies of the IL-37 gene (rs4241122) and measure IL-37 protein levels in patients with EC, with a view to...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Mohammad Reza Haghshenas Zahra Shiravani Mohammad Samare-Najaf Soolmaz Khansalar Seyed Ali Razavinasab Abbas Ghaderi Navid Jamali Source Type: research
Growth factors and cytokines involved in liver regeneration
Eur Cytokine Netw. 2023 Dec 1;34(4):38-45. doi: 10.1684/ecn.2023.0483.ABSTRACTThe regenerative ability of the liver is essential for maintaining physiological functions and the injury repair process. The biological mechanisms that regulate liver regeneration remain poorly defined. These mechanisms are notable issues in clinical practice that affect the treatment of hepatic loss caused by hepatectomy, hepatic poisoning, or chronic viral infection. Increasing evidence shows that numerous growth factors, cytokines, and metabolic pathways influence the liver regenerative process. Of particular importance are cytokines and grow...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Chen Liu Xiaomeng Liu Hongyuan Zhou Wei Zhang Tianqiang Song Source Type: research
Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice
In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated inte...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Wei Zhuang Zhen Li Source Type: research
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced maturation of spermatogonial cells from prepubertal mice in vitro is enhanced by testosterone
In conclusion, our results indicate that testicular cells express GM-CSF/GM-CSFR, and that GM-CSF is involved in the development of different stages of spermatogenesis in vitro. Furthermore, testosterone enhances the development of spermatogenic cells and potentiates the effect of GMCSF on the development of post-meiotic cells. These findings provide evidence that GM-CSF and testosterone are involved in the development of spermatogenesis in vitro and in vivo. In brief: Testicular somatic and germ cells express GM-CSF and GM-CSFR. Our study suggests that testicular GM-CSF is involved in the development of spermatogenesis, w...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Areej Jorban Eitan Lunenfeld Mahmoud Huleihel Source Type: research
Clinical significance of IL-37 serum level and polymorphism in patients with endometrial cancer
Eur Cytokine Netw. 2023 Dec 1;34(4):63-69. doi: 10.1684/ecn.2023.0491.ABSTRACTEndometrial cancer (EC) is recognized as the second most common type of cancer among women. Interleukin-37 (IL-37) is a recently discovered member of the IL-1 cytokine family characterized by its anti-inflammatory properties, which are believed to have both anti-tumour and tumorigenic effects. However, the precise role of IL-37 in the development of EC remains largely unknown. In the current study, we aimed to explore genotype and allele frequencies of the IL-37 gene (rs4241122) and measure IL-37 protein levels in patients with EC, with a view to...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Mohammad Reza Haghshenas Zahra Shiravani Mohammad Samare-Najaf Soolmaz Khansalar Seyed Ali Razavinasab Abbas Ghaderi Navid Jamali Source Type: research
Growth factors and cytokines involved in liver regeneration
Eur Cytokine Netw. 2023 Dec 1;34(4):38-45. doi: 10.1684/ecn.2023.0483.ABSTRACTThe regenerative ability of the liver is essential for maintaining physiological functions and the injury repair process. The biological mechanisms that regulate liver regeneration remain poorly defined. These mechanisms are notable issues in clinical practice that affect the treatment of hepatic loss caused by hepatectomy, hepatic poisoning, or chronic viral infection. Increasing evidence shows that numerous growth factors, cytokines, and metabolic pathways influence the liver regenerative process. Of particular importance are cytokines and grow...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Chen Liu Xiaomeng Liu Hongyuan Zhou Wei Zhang Tianqiang Song Source Type: research
Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice
In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated inte...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Wei Zhuang Zhen Li Source Type: research
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced maturation of spermatogonial cells from prepubertal mice in vitro is enhanced by testosterone
In conclusion, our results indicate that testicular cells express GM-CSF/GM-CSFR, and that GM-CSF is involved in the development of different stages of spermatogenesis in vitro. Furthermore, testosterone enhances the development of spermatogenic cells and potentiates the effect of GMCSF on the development of post-meiotic cells. These findings provide evidence that GM-CSF and testosterone are involved in the development of spermatogenesis in vitro and in vivo. In brief: Testicular somatic and germ cells express GM-CSF and GM-CSFR. Our study suggests that testicular GM-CSF is involved in the development of spermatogenesis, w...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Areej Jorban Eitan Lunenfeld Mahmoud Huleihel Source Type: research
Clinical significance of IL-37 serum level and polymorphism in patients with endometrial cancer
Eur Cytokine Netw. 2023 Dec 1;34(4):63-69. doi: 10.1684/ecn.2023.0491.ABSTRACTEndometrial cancer (EC) is recognized as the second most common type of cancer among women. Interleukin-37 (IL-37) is a recently discovered member of the IL-1 cytokine family characterized by its anti-inflammatory properties, which are believed to have both anti-tumour and tumorigenic effects. However, the precise role of IL-37 in the development of EC remains largely unknown. In the current study, we aimed to explore genotype and allele frequencies of the IL-37 gene (rs4241122) and measure IL-37 protein levels in patients with EC, with a view to...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Mohammad Reza Haghshenas Zahra Shiravani Mohammad Samare-Najaf Soolmaz Khansalar Seyed Ali Razavinasab Abbas Ghaderi Navid Jamali Source Type: research
Growth factors and cytokines involved in liver regeneration
Eur Cytokine Netw. 2023 Dec 1;34(4):38-45. doi: 10.1684/ecn.2023.0483.ABSTRACTThe regenerative ability of the liver is essential for maintaining physiological functions and the injury repair process. The biological mechanisms that regulate liver regeneration remain poorly defined. These mechanisms are notable issues in clinical practice that affect the treatment of hepatic loss caused by hepatectomy, hepatic poisoning, or chronic viral infection. Increasing evidence shows that numerous growth factors, cytokines, and metabolic pathways influence the liver regenerative process. Of particular importance are cytokines and grow...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Chen Liu Xiaomeng Liu Hongyuan Zhou Wei Zhang Tianqiang Song Source Type: research
Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice
In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier. In addition, the effect of DSS and/or tezepelumab on the phosphorylation of the JAK/STAT pathway was investigated. TSLP expression levels were elevated in DSS-induced IBD mice, whereas TSLP antibody treatment suppressed the pathological features associated with IBD and alleviated inte...
Source: European Cytokine Network - March 25, 2024 Category: Molecular Biology Authors: Wei Zhuang Zhen Li Source Type: research
