Delayed respiratory syncytial virus epidemic in children after relaxation of COVID-19 physical distancing measures, Ashdod, Israel, 2021
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100706.ABSTRACTFollowing low incidence of respiratory syncytial virus (RSV) infections in 2020 during the COVID-19 pandemic, we noted a resurgence in hospitalised children in spring/summer 2021 following relaxation of public health measures. We compared this outbreak to previous autumn/winter seasons. We found higher weekly case numbers and incidence rates, more cases from urban neighbourhoods with lower socioeconomic status, and similar clinical presentation and severity. Public health implications include the re-evaluation of palivizumab administration...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Moran Weinberger Opek Yonatan Yeshayahu Aharona Glatman-Freedman Zalman Kaufman Nadav Sorek Tal Brosh-Nissimov Source Type: research

Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter?
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100639.ABSTRACTSince the introduction of non-pharmacological interventions to control COVID-19, respiratory syncytial virus (RSV) activity in Europe has been limited. Surveillance data for 17 countries showed delayed RSV epidemics in France (≥ 12 w) and Iceland (≥ 4 w) during the 2020/21 season. RSV cases (predominantly small children) in France and Iceland were older compared with previous seasons. We hypothesise that future RSV epidemic(s) could start outside the usual autumn/winter season and be larger than expected. Year-round surveillance of R...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Jojanneke van Summeren Adam Meijer Gu ðrún Aspelund Jean Sebastien Casalegno Gu ðrún Erna Uy Hoang Bruno Lina VRS study group in Lyon Simon de Lusignan Anne C Teirlinck Valt ýr Thors John Paget Source Type: research

Transmission of paediatric respiratory syncytial virus and influenza in the wake of the COVID-19 pandemic
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100186.ABSTRACTThe non-pharmaceutical interventions implemented to slow the spread of SARS-CoV-2 have had consequences on the transmission of other respiratory viruses, most notably paediatric respiratory syncytial virus (RSV) and influenza. At the beginning of 2020, lockdown measures in the southern hemisphere led to a winter season with a marked reduction in both infections. Intermittent lockdowns in the northern hemisphere also appeared to interrupt transmission during winter 2020/21. However, a number of southern and northern hemisphere countries hav...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Thomas C Williams Ian Sinha Ian G Barr Maria Zambon Source Type: research

Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rh ône Loire, France
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100630.ABSTRACTThe Rhône-Loire metropolitan areas' 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower respiratory tract infection incidence among infants ≤ 3 months decreased twofold, the proportion of cases among children aged> 3 months to 5 years increased, and cases among adults> 65 years were markedly reduced. NPI appeared to reduce the RSV burden among at-risk groups, and should be promoted to minimise ...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Jean-Sebastien Casalegno Dominique Ploin Aymeric Cantais Elsa Masson Emilie Bard Martine Valette Remi Fanget Sandrine Couray Targe Anne-Florence Myar-Dury Muriel Doret-Dion Mona Massoud Gregory Queromes Philippe Vanhems Olivier Claris Marine Butin Sylvie Source Type: research

Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020
ConclusionCOVID-19 non-pharmaceutical interventions led to reduced circulation of influenza and RSV in South Africa. This has limited the country's ability to provide influenza virus strains for the selection of the annual influenza vaccine. Delayed increases in RSV case numbers may reflect the easing of COVID-19 control measures. An increase in influenza virus detection was not observed, suggesting that the measures may have impacted the two pathogens differently. The impact that lowered and/or delayed influenza and RSV circulation in 2020 will have on the intensity and severity of subsequent annual epidemics is unknown a...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Stefano Tempia Sibongile Walaza Jinal N Bhiman Meredith L McMorrow Jocelyn Moyes Thulisa Mkhencele Susan Meiring Vanessa Quan Kate Bishop Johanna M McAnerney Anne von Gottberg Nicole Wolter Mignon Du Plessis Florette K Treurnicht Orienka Hellferscee Halim Source Type: research

Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care: I-MOVE-COVID-19 project, Europe, December 2020 to May 2021
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100670.ABSTRACTWe measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults ≥ 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vacc...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Esther Kissling Mariette Hooiveld Virginia Sandonis Mart ín Iv án Martínez-Baz Naoma William Ana-Maria Vilcu Clara Mazagatos Lisa Domegan Simon de Lusignan Adam Meijer Ausenda Machado Mia Brytting Itziar Casado Josephine-L K Murray Sylvie Belhillil Amp Source Type: research

Job vacancies at the European Centre for Disease Prevention and Control (ECDC)
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2107221.NO ABSTRACTPMID:34296677 | DOI:10.2807/1560-7917.ES.2021.26.29.2107221 (Source: Euro Surveill)
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

Delayed respiratory syncytial virus epidemic in children after relaxation of COVID-19 physical distancing measures, Ashdod, Israel, 2021
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100706.ABSTRACTFollowing low incidence of respiratory syncytial virus (RSV) infections in 2020 during the COVID-19 pandemic, we noted a resurgence in hospitalised children in spring/summer 2021 following relaxation of public health measures. We compared this outbreak to previous autumn/winter seasons. We found higher weekly case numbers and incidence rates, more cases from urban neighbourhoods with lower socioeconomic status, and similar clinical presentation and severity. Public health implications include the re-evaluation of palivizumab administration...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Moran Weinberger Opek Yonatan Yeshayahu Aharona Glatman-Freedman Zalman Kaufman Nadav Sorek Tal Brosh-Nissimov Source Type: research

Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter?
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100639.ABSTRACTSince the introduction of non-pharmacological interventions to control COVID-19, respiratory syncytial virus (RSV) activity in Europe has been limited. Surveillance data for 17 countries showed delayed RSV epidemics in France (≥ 12 w) and Iceland (≥ 4 w) during the 2020/21 season. RSV cases (predominantly small children) in France and Iceland were older compared with previous seasons. We hypothesise that future RSV epidemic(s) could start outside the usual autumn/winter season and be larger than expected. Year-round surveillance of R...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Jojanneke van Summeren Adam Meijer Gu ðrún Aspelund Jean Sebastien Casalegno Gu ðrún Erna Uy Hoang Bruno Lina VRS study group in Lyon Simon de Lusignan Anne C Teirlinck Valt ýr Thors John Paget Source Type: research

Transmission of paediatric respiratory syncytial virus and influenza in the wake of the COVID-19 pandemic
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100186.ABSTRACTThe non-pharmaceutical interventions implemented to slow the spread of SARS-CoV-2 have had consequences on the transmission of other respiratory viruses, most notably paediatric respiratory syncytial virus (RSV) and influenza. At the beginning of 2020, lockdown measures in the southern hemisphere led to a winter season with a marked reduction in both infections. Intermittent lockdowns in the northern hemisphere also appeared to interrupt transmission during winter 2020/21. However, a number of southern and northern hemisphere countries hav...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Thomas C Williams Ian Sinha Ian G Barr Maria Zambon Source Type: research

Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rh ône Loire, France
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100630.ABSTRACTThe Rhône-Loire metropolitan areas' 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower respiratory tract infection incidence among infants ≤ 3 months decreased twofold, the proportion of cases among children aged> 3 months to 5 years increased, and cases among adults> 65 years were markedly reduced. NPI appeared to reduce the RSV burden among at-risk groups, and should be promoted to minimise ...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Jean-Sebastien Casalegno Dominique Ploin Aymeric Cantais Elsa Masson Emilie Bard Martine Valette Remi Fanget Sandrine Couray Targe Anne-Florence Myar-Dury Muriel Doret-Dion Mona Massoud Gregory Queromes Philippe Vanhems Olivier Claris Marine Butin Sylvie Source Type: research

Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020
ConclusionCOVID-19 non-pharmaceutical interventions led to reduced circulation of influenza and RSV in South Africa. This has limited the country's ability to provide influenza virus strains for the selection of the annual influenza vaccine. Delayed increases in RSV case numbers may reflect the easing of COVID-19 control measures. An increase in influenza virus detection was not observed, suggesting that the measures may have impacted the two pathogens differently. The impact that lowered and/or delayed influenza and RSV circulation in 2020 will have on the intensity and severity of subsequent annual epidemics is unknown a...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Stefano Tempia Sibongile Walaza Jinal N Bhiman Meredith L McMorrow Jocelyn Moyes Thulisa Mkhencele Susan Meiring Vanessa Quan Kate Bishop Johanna M McAnerney Anne von Gottberg Nicole Wolter Mignon Du Plessis Florette K Treurnicht Orienka Hellferscee Halim Source Type: research

Vaccine effectiveness against symptomatic SARS-CoV-2 infection in adults aged 65 years and older in primary care: I-MOVE-COVID-19 project, Europe, December 2020 to May 2021
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100670.ABSTRACTWe measured COVID-19 vaccine effectiveness (VE) against symptomatic SARS-CoV-2 infection at primary care/outpatient level among adults ≥ 65 years old using a multicentre test-negative design in eight European countries. We included 592 SARS-CoV-2 cases and 4,372 test-negative controls in the main analysis. The VE was 62% (95% CI: 45-74) for one dose only and 89% (95% CI: 79-94) for complete vaccination. COVID-19 vaccines provide good protection against COVID-19 presentation at primary care/outpatient level, particularly among fully vacc...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Esther Kissling Mariette Hooiveld Virginia Sandonis Mart ín Iv án Martínez-Baz Naoma William Ana-Maria Vilcu Clara Mazagatos Lisa Domegan Simon de Lusignan Adam Meijer Ausenda Machado Mia Brytting Itziar Casado Josephine-L K Murray Sylvie Belhillil Amp Source Type: research

Job vacancies at the European Centre for Disease Prevention and Control (ECDC)
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2107221.NO ABSTRACTPMID:34296677 | DOI:10.2807/1560-7917.ES.2021.26.29.2107221 (Source: Euro Surveill)
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

Delayed respiratory syncytial virus epidemic in children after relaxation of COVID-19 physical distancing measures, Ashdod, Israel, 2021
Euro Surveill. 2021 Jul;26(29). doi: 10.2807/1560-7917.ES.2021.26.29.2100706.ABSTRACTFollowing low incidence of respiratory syncytial virus (RSV) infections in 2020 during the COVID-19 pandemic, we noted a resurgence in hospitalised children in spring/summer 2021 following relaxation of public health measures. We compared this outbreak to previous autumn/winter seasons. We found higher weekly case numbers and incidence rates, more cases from urban neighbourhoods with lower socioeconomic status, and similar clinical presentation and severity. Public health implications include the re-evaluation of palivizumab administration...
Source: Euro Surveill - July 23, 2021 Category: Infectious Diseases Authors: Moran Weinberger Opek Yonatan Yeshayahu Aharona Glatman-Freedman Zalman Kaufman Nadav Sorek Tal Brosh-Nissimov Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March-June 2021, England
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100634.ABSTRACTAdults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than> 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Annabel A Powell Linda Power Samantha Westrop Kelsey McOwat Helen Campbell Ruth Simmons Mary E Ramsay Kevin Brown Shamez N Ladhani Gayatri Amirthalingam Source Type: research

Impact of non-pharmaceutical interventions against COVID-19 in Europe in 2020: a quasi-experimental non-equivalent group and time series design study
ConclusionsOur findings are that schools and some non-essential businesses operating 'as normal' as well as allowing mass gatherings were incompatible with suppressing disease spread. Closure of all businesses and stay at home orders are less likely to be required to keep disease incidence low. Our results help identify what were the most effective non-pharmaceutical interventions in this period.PMID:34269173 | DOI:10.2807/1560-7917.ES.2021.26.28.2001401 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Paul R Hunter Felipe J Col ón-González Julii Brainard Steven Rushton Source Type: research

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Euro Surveill. 2021 Jul;26(28). doi: 10.2807/1560-7917.ES.2021.26.28.2100573.ABSTRACTWe analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52-110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.PMID:342...
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Samuel Alizon St éphanie Haim-Boukobza Vincent Foulongne Laura Verdurme Sabine Trombert-Paolantoni Emmanuel Lecorche B énédicte Roquebert Mircea T Sofonea Source Type: research

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021
We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80-90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.PMID:34269175 | DOI:10.2807/1560-7917.ES.2021.26.28.2100563 (Source: Euro Surveill)
Source: Euro Surveill - July 16, 2021 Category: Infectious Diseases Authors: Thomas Harder Judith Koch Sabine Vygen-Bonnet Wiebe K ülper-Schiek Antonia Pilic Sarah Reda Stefan Scholz Ole Wichmann Source Type: research

Predicted dominance of variant Delta of SARS-CoV-2 before Tokyo Olympic Games, Japan, July 2021
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100570.ABSTRACTUsing numbers of SARS-CoV-2 variants detected in Japan as at 13 June 2021, relative instantaneous reproduction numbers (RRI) of the R.1, Alpha, and Delta variants with respect to other strains circulating in Japan were estimated at 1.25, 1.44, and 1.95. Depending on the assumed serial interval distributions, RRI varies from 1.20-1.32 for R.1, 1.34-1.58 for Alpha, and 1.70-2.30 for Delta. The frequency of Delta is expected to take over Alpha in Japan before 23 July 2021.PMID:34240695 | DOI:10.2807/1560-7917.ES.2021.26.27.2100570 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Kimihito Ito Chayada Piantham Hiroshi Nishiura Source Type: research

Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission, United Kingdom, 2018/19 influenza season
ConclusionNanopore metagenomic sequencing can detect the emergence of novel variants and drug resistance, providing timely insights into antimicrobial stewardship and vaccine design. Full genome generation can help investigate and manage nosocomial outbreaks.PMID:34240696 | DOI:10.2807/1560-7917.ES.2021.26.27.2000004 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Yifei Xu Kuiama Lewandowski Louise O Downs James Kavanagh Thomas Hender Sheila Lumley Katie Jeffery Dona Foster Nicholas D Sanderson Ali Vaughan Marcus Morgan Richard Vipond Miles Carroll Timothy Peto Derrick Crook A Sarah Walker Philippa C Matthews Steve Source Type: research

SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100568.ABSTRACTWe compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic...
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Dung Nguyen Peter Simmonds Maurice Steenhuis Elise Wouters Daniel Desmecht Mutien Garigliany Marta Romano Cyril Barbezange Piet Maes Bram Van Holm Joaqu ín Mendoza Salvador Oyonarte Anders Fomsgaard Ria Lassauni ère Eva Zusinaite Katarina Resman Rus Tat Source Type: research

Job vacancy at the European Centre for Disease Prevention and Control (ECDC)
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2107081.NO ABSTRACTPMID:34240698 | DOI:10.2807/1560-7917.ES.2021.26.27.2107081 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

An outbreak caused by the SARS-CoV-2 Delta (B.1.617.2) variant in a care home after partial vaccination with a single dose of the COVID-19 vaccine Vaxzevria, London, England, April 2021
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100626.ABSTRACTWe investigated a COVID-19 outbreak of the SARS-CoV-2 Delta variant of concern in a London care home, where 8/21 residents and 14/21 staff had received a single dose of Vaxzevria (ChAdOx1-S; AstraZeneca) vaccine. We identified 24 SARS-CoV-2 infections (16 residents, 8 staff) among 40 individuals (19 residents, 21 staff); four (3 residents, 1 staff) were hospitalised, and none died. The attack rate after one vaccine dose was 35.7% (5/14) for staff and 81.3% (13/16) for residents.PMID:34240699 | DOI:10.2807/1560-7917.ES.2021.26.27.2100626 (S...
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Sarah V Williams Amoolya Vusirikala Shamez N Ladhani Elena Fernandez Ruiz De Olano Nalini Iyanger Felicity Aiano Kelly Stoker Guduru Gopal Rao Laurence John Bharat Patel Nick Andrews Gavin Dabrera Mary Ramsay Kevin E Brown Jamie Lopez Bernal Vanessa Salib Source Type: research

Predicted dominance of variant Delta of SARS-CoV-2 before Tokyo Olympic Games, Japan, July 2021
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100570.ABSTRACTUsing numbers of SARS-CoV-2 variants detected in Japan as at 13 June 2021, relative instantaneous reproduction numbers (RRI) of the R.1, Alpha, and Delta variants with respect to other strains circulating in Japan were estimated at 1.25, 1.44, and 1.95. Depending on the assumed serial interval distributions, RRI varies from 1.20-1.32 for R.1, 1.34-1.58 for Alpha, and 1.70-2.30 for Delta. The frequency of Delta is expected to take over Alpha in Japan before 23 July 2021.PMID:34240695 | DOI:10.2807/1560-7917.ES.2021.26.27.2100570 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Kimihito Ito Chayada Piantham Hiroshi Nishiura Source Type: research

Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission, United Kingdom, 2018/19 influenza season
ConclusionNanopore metagenomic sequencing can detect the emergence of novel variants and drug resistance, providing timely insights into antimicrobial stewardship and vaccine design. Full genome generation can help investigate and manage nosocomial outbreaks.PMID:34240696 | DOI:10.2807/1560-7917.ES.2021.26.27.2000004 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Yifei Xu Kuiama Lewandowski Louise O Downs James Kavanagh Thomas Hender Sheila Lumley Katie Jeffery Dona Foster Nicholas D Sanderson Ali Vaughan Marcus Morgan Richard Vipond Miles Carroll Timothy Peto Derrick Crook A Sarah Walker Philippa C Matthews Steve Source Type: research

SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100568.ABSTRACTWe compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic...
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Dung Nguyen Peter Simmonds Maurice Steenhuis Elise Wouters Daniel Desmecht Mutien Garigliany Marta Romano Cyril Barbezange Piet Maes Bram Van Holm Joaqu ín Mendoza Salvador Oyonarte Anders Fomsgaard Ria Lassauni ère Eva Zusinaite Katarina Resman Rus Tat Source Type: research

Job vacancy at the European Centre for Disease Prevention and Control (ECDC)
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2107081.NO ABSTRACTPMID:34240698 | DOI:10.2807/1560-7917.ES.2021.26.27.2107081 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

An outbreak caused by the SARS-CoV-2 Delta (B.1.617.2) variant in a care home after partial vaccination with a single dose of the COVID-19 vaccine Vaxzevria, London, England, April 2021
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100626.ABSTRACTWe investigated a COVID-19 outbreak of the SARS-CoV-2 Delta variant of concern in a London care home, where 8/21 residents and 14/21 staff had received a single dose of Vaxzevria (ChAdOx1-S; AstraZeneca) vaccine. We identified 24 SARS-CoV-2 infections (16 residents, 8 staff) among 40 individuals (19 residents, 21 staff); four (3 residents, 1 staff) were hospitalised, and none died. The attack rate after one vaccine dose was 35.7% (5/14) for staff and 81.3% (13/16) for residents.PMID:34240699 | DOI:10.2807/1560-7917.ES.2021.26.27.2100626 (S...
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Sarah V Williams Amoolya Vusirikala Shamez N Ladhani Elena Fernandez Ruiz De Olano Nalini Iyanger Felicity Aiano Kelly Stoker Guduru Gopal Rao Laurence John Bharat Patel Nick Andrews Gavin Dabrera Mary Ramsay Kevin E Brown Jamie Lopez Bernal Vanessa Salib Source Type: research

Predicted dominance of variant Delta of SARS-CoV-2 before Tokyo Olympic Games, Japan, July 2021
Euro Surveill. 2021 Jul;26(27). doi: 10.2807/1560-7917.ES.2021.26.27.2100570.ABSTRACTUsing numbers of SARS-CoV-2 variants detected in Japan as at 13 June 2021, relative instantaneous reproduction numbers (RRI) of the R.1, Alpha, and Delta variants with respect to other strains circulating in Japan were estimated at 1.25, 1.44, and 1.95. Depending on the assumed serial interval distributions, RRI varies from 1.20-1.32 for R.1, 1.34-1.58 for Alpha, and 1.70-2.30 for Delta. The frequency of Delta is expected to take over Alpha in Japan before 23 July 2021.PMID:34240695 | DOI:10.2807/1560-7917.ES.2021.26.27.2100570 (Source: Euro Surveill)
Source: Euro Surveill - July 9, 2021 Category: Infectious Diseases Authors: Kimihito Ito Chayada Piantham Hiroshi Nishiura Source Type: research