Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies
ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.PMID:33706863 | DOI:10.2807/1560-7917.ES.2021.26.10.2001134 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Kamelia R Stanoeva Annemiek A van der Eijk Adam Meijer Laetitia M Kortbeek Marion P G Koopmans Chantal B E M Reusken Source Type: research

Correction for Euro Surveill. 2020;24(13)
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.210311c2.NO ABSTRACTPMID:33706864 | DOI:10.2807/1560-7917.ES.2021.26.10.210311c2 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

COVID-19: cross-border contact tracing in Germany, February to April 2020
ConclusionIn the COVID-19 pandemic, cross-border contact tracing is considered a critical component of the outbreak response. While only a minority of international contact tracing activities were related to exposure events in transport, they contributed substantially to the workload. The numerous communications highlight the need for fast and efficient global outbreak communication channels between PHA.PMID:33706859 | DOI:10.2807/1560-7917.ES.2021.26.10.2001236 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Inessa Markus Gyde Steffen Raskit Lachmann Adine Marquis Timm Schneider Sara Tomczyk Uwe Koppe Anna M Rohde Susanne Barbara Schink Janna Seifried Teresa Domaszewska Ute Rexroth Maria An der Heiden Source Type: research

Correction for Euro Surveill. 2020;26(9)
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.210311c.NO ABSTRACTPMID:33706860 | DOI:10.2807/1560-7917.ES.2021.26.10.210311c (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique, Spain, January and February 2021
We describe 20 cases of acute onset of a single supraclavicular lymphadenopathy manifesting between 24 h and 9 days after ipsilateral intramuscular administration of an mRNA-based COVID-19 vaccine, referred to our WHO Collaborating Centre for Vaccine Safety. Our results indicate that the swelling of supraclavicular lymph nodes following immunisation may constitute a benign and self-limited condition, related to a higher than recommended injection site.PMID:33706861 | DOI:10.2807/1560-7917.ES.2021.26.10.2100193 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Mar ía Fernández-Prada Irene Rivero-Calle Ana Calvache-Gonz ález Federico Martin ón-Torres Source Type: research

Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.2100130.ABSTRACTWe show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.PMID:33706...
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: V ítor Borges Carlos Sousa Lu ís Menezes Ant ónio Maia Gonçalves Miguel Pic ão Jos é Pedro Almeida Margarida Vieita Rafael Santos Ana Rita Silva Mariana Costa Lu ís Carneiro Pedro Casaca Pedro Pinto-Leite Andr é Peralta-Santos Joana Isidro S ílvi Source Type: research

Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies
ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.PMID:33706863 | DOI:10.2807/1560-7917.ES.2021.26.10.2001134 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Kamelia R Stanoeva Annemiek A van der Eijk Adam Meijer Laetitia M Kortbeek Marion P G Koopmans Chantal B E M Reusken Source Type: research

Correction for Euro Surveill. 2020;24(13)
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.210311c2.NO ABSTRACTPMID:33706864 | DOI:10.2807/1560-7917.ES.2021.26.10.210311c2 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

COVID-19: cross-border contact tracing in Germany, February to April 2020
ConclusionIn the COVID-19 pandemic, cross-border contact tracing is considered a critical component of the outbreak response. While only a minority of international contact tracing activities were related to exposure events in transport, they contributed substantially to the workload. The numerous communications highlight the need for fast and efficient global outbreak communication channels between PHA.PMID:33706859 | DOI:10.2807/1560-7917.ES.2021.26.10.2001236 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Inessa Markus Gyde Steffen Raskit Lachmann Adine Marquis Timm Schneider Sara Tomczyk Uwe Koppe Anna M Rohde Susanne Barbara Schink Janna Seifried Teresa Domaszewska Ute Rexroth Maria An der Heiden Source Type: research

Correction for Euro Surveill. 2020;26(9)
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.210311c.NO ABSTRACTPMID:33706860 | DOI:10.2807/1560-7917.ES.2021.26.10.210311c (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique, Spain, January and February 2021
We describe 20 cases of acute onset of a single supraclavicular lymphadenopathy manifesting between 24 h and 9 days after ipsilateral intramuscular administration of an mRNA-based COVID-19 vaccine, referred to our WHO Collaborating Centre for Vaccine Safety. Our results indicate that the swelling of supraclavicular lymph nodes following immunisation may constitute a benign and self-limited condition, related to a higher than recommended injection site.PMID:33706861 | DOI:10.2807/1560-7917.ES.2021.26.10.2100193 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Mar ía Fernández-Prada Irene Rivero-Calle Ana Calvache-Gonz ález Federico Martin ón-Torres Source Type: research

Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.2100130.ABSTRACTWe show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.PMID:33706...
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: V ítor Borges Carlos Sousa Lu ís Menezes Ant ónio Maia Gonçalves Miguel Pic ão Jos é Pedro Almeida Margarida Vieita Rafael Santos Ana Rita Silva Mariana Costa Lu ís Carneiro Pedro Casaca Pedro Pinto-Leite Andr é Peralta-Santos Joana Isidro S ílvi Source Type: research

Towards a sensitive and accurate interpretation of molecular testing for SARS-CoV-2: a rapid review of 264 studies
ConclusionOptimal SARS-CoV-2 molecular testing relies on choosing the most appropriate sample type, collected with adequate sampling technique, and with the infection timeline in mind. We outlined knowledge gaps and directions for future well-documented systematic studies.PMID:33706863 | DOI:10.2807/1560-7917.ES.2021.26.10.2001134 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Kamelia R Stanoeva Annemiek A van der Eijk Adam Meijer Laetitia M Kortbeek Marion P G Koopmans Chantal B E M Reusken Source Type: research

Correction for Euro Surveill. 2020;24(13)
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.210311c2.NO ABSTRACTPMID:33706864 | DOI:10.2807/1560-7917.ES.2021.26.10.210311c2 (Source: Euro Surveill)
Source: Euro Surveill - March 12, 2021 Category: Infectious Diseases Authors: Eurosurveillance editorial team Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9):2100133. doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on mod...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | PMC:PMC7934221 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | PMC:PMC7934222 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | PMC:PMC7934224 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9):2100133. doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on mod...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | PMC:PMC7934221 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | PMC:PMC7934222 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | PMC:PMC7934224 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9):2100133. doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on mod...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | PMC:PMC7934221 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | PMC:PMC7934222 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | PMC:PMC7934224 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9). doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling a...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9). doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling a...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021
Euro Surveill. 2021 Mar;26(9). doi: 10.2807/1560-7917.ES.2021.26.9.2100133.ABSTRACTThe emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling a...
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Alexandre Gaymard Paolo Bosetti Adeline Feri Gregory Destras Vincent Enouf Alessio Andronico Sonia Burrel Sylvie Behillil Claire Sauvage Antonin Bal Florence Morfin Sylvie Van Der Werf Laurence Josset ANRS MIE AC43 COVID-19 French viro COVID group Fran ç Source Type: research

High impact of molecular surveillance on hepatitis A outbreak case detection in Sweden: a retrospective study, 2009 to 2018
ConclusionSequence-based typing contributed substantially to detecting clustering cases and identifying outbreaks in Sweden. The results show routine sequence-based typing detects outbreaks, promotes timely outbreak investigations and facilitates international collaboration.PMID:33663645 | DOI:10.2807/1560-7917.ES.2021.26.9.1900763 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Maximilian Riess Theresa Enkirch Lena Sundqvist Josefine Lundberg Ederth Source Type: research

Incidence of COVID-19 in patients exposed to chloroquine and hydroxychloroquine: results from a population-based prospective cohort in Catalonia, Spain, 2020
ConclusionsPatients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 nor hospitalisation, compared with controls. As controls were mainly female, findings might not be generalisable to a male population.PMID:33663646 | DOI:10.2807/1560-7917.ES.2021.26.9.2001202 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Rosa Maria Vivanco-Hidalgo Israel Molina Elisenda Martinez Ram ón Roman-Viñas Adri án Sánchez-Montalvá Joan Fibla Caridad Pontes C ésar Velasco Muñoz Real World Data Working Group Source Type: research

Economic evaluation of whole genome sequencing for pathogen identification and surveillance - results of case studies in Europe and the Americas 2016 to 2019
ConclusionsEven at cost levels documented here, WGS provides a level of additional information that more than balances the additional costs if used effectively. The substantial cost differences for WGS between reference laboratories were due to economies of scale, degree of automation, sequencing technology used and institutional discounts for equipment and consumables, as well as the extent to which sequencers are used at full capacity.PMID:33663647 | DOI:10.2807/1560-7917.ES.2021.26.9.1900606 (Source: Euro Surveill)
Source: Euro Surveill - March 5, 2021 Category: Infectious Diseases Authors: Frank Alleweldt Şenda Kara Kris Best Frank M Aarestrup Martin Beer Theo M Bestebroer Josefina Campos Gabriele Casadei Isabel Chinen Gary Van Domselaar Catherine Dominguez Helen E Everett Ron Am Fouchier Kathie Grant Jonathan Green Dirk H öper Jonathan J Source Type: research

Impact of physical distancing measures against COVID-19 on contacts and mixing patterns: repeated cross-sectional surveys, the Netherlands, 2016-17, April 2020 and June 2020
ConclusionStrict physical distancing measures greatly reduced overall contact numbers, which likely contributed to curbing the first wave of the COVID-19 epidemic in the Netherlands. However, age groups reacted differently when measures were relaxed, with children reverting to normal contact numbers and elderly individuals maintaining restricted contact numbers. These findings offer guidance for age-targeted measures in future waves of the pandemic.PMID:33632374 | PMC:PMC7908067 | DOI:10.2807/1560-7917.ES.2021.26.8.2000994 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jantien A Backer Liesbeth Mollema Eric Ra Vos Don Klinkenberg Fiona Rm van der Klis Hester E de Melker Susan van den Hof Jacco Wallinga Source Type: research

Estimates of mortality attributable to COVID-19: a statistical model for monitoring COVID-19 and seasonal influenza, Denmark, spring 2020
ConclusionAttMOMO estimates mortality attributable to several pathogens simultaneously, providing a fuller picture of mortality by COVID-19 during the pandemic in the context of other seasonal diseases and mortality patterns. Using Danish data, we show that the model accurately estimates mortality attributable to COVID-19 and influenza, respectively. We propose using standardised indicators for pathogen circulation in the population, to make estimates comparable between countries and applicable for timely monitoring.PMID:33632375 | PMC:PMC7908066 | DOI:10.2807/1560-7917.ES.2021.26.8.2001646 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jens Nielsen Naja Hulvej Rod Lasse S Vestergaard Theis Lange Source Type: research

Screening for < em > Candida auris < /em > in patients admitted to eight intensive care units in England, 2017 to 2018
ConclusionThese findings imply that C. auris colonisation among patients admitted to ICUs in England is currently rare. We would not currently recommend widespread screening for C. auris in ICUs in England. Hospitals should continue to screen high-risk individuals based on local risk assessment.PMID:33632376 | PMC:PMC7908068 | DOI:10.2807/1560-7917.ES.2021.26.8.1900730 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Ashley Sharp Berit Muller-Pebody Andre Charlett Bharat Patel Rebecca Gorton Jonathan Lambourne Martina Cummins Adela Alcolea-Medina Mark Wilks Robin Smith Damien Mack Susan Hopkins Andrew Dodgson Phillipa Burns Nelun Perera Felicia Lim Gopal Rao Priya Kha Source Type: research

Impact of physical distancing measures against COVID-19 on contacts and mixing patterns: repeated cross-sectional surveys, the Netherlands, 2016-17, April 2020 and June 2020
ConclusionStrict physical distancing measures greatly reduced overall contact numbers, which likely contributed to curbing the first wave of the COVID-19 epidemic in the Netherlands. However, age groups reacted differently when measures were relaxed, with children reverting to normal contact numbers and elderly individuals maintaining restricted contact numbers. These findings offer guidance for age-targeted measures in future waves of the pandemic.PMID:33632374 | DOI:10.2807/1560-7917.ES.2021.26.8.2000994 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jantien A Backer Liesbeth Mollema Eric Ra Vos Don Klinkenberg Fiona Rm van der Klis Hester E de Melker Susan van den Hof Jacco Wallinga Source Type: research

Estimates of mortality attributable to COVID-19: a statistical model for monitoring COVID-19 and seasonal influenza, Denmark, spring 2020
ConclusionAttMOMO estimates mortality attributable to several pathogens simultaneously, providing a fuller picture of mortality by COVID-19 during the pandemic in the context of other seasonal diseases and mortality patterns. Using Danish data, we show that the model accurately estimates mortality attributable to COVID-19 and influenza, respectively. We propose using standardised indicators for pathogen circulation in the population, to make estimates comparable between countries and applicable for timely monitoring.PMID:33632375 | DOI:10.2807/1560-7917.ES.2021.26.8.2001646 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jens Nielsen Naja Hulvej Rod Lasse S Vestergaard Theis Lange Source Type: research

Screening for < em > Candida auris < /em > in patients admitted to eight intensive care units in England, 2017 to 2018
ConclusionThese findings imply that C. auris colonisation among patients admitted to ICUs in England is currently rare. We would not currently recommend widespread screening for C. auris in ICUs in England. Hospitals should continue to screen high-risk individuals based on local risk assessment.PMID:33632376 | DOI:10.2807/1560-7917.ES.2021.26.8.1900730 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Ashley Sharp Berit Muller-Pebody Andre Charlett Bharat Patel Rebecca Gorton Jonathan Lambourne Martina Cummins Adela Alcolea-Medina Mark Wilks Robin Smith Damien Mack Susan Hopkins Andrew Dodgson Phillipa Burns Nelun Perera Felicia Lim Gopal Rao Priya Kha Source Type: research

Impact of physical distancing measures against COVID-19 on contacts and mixing patterns: repeated cross-sectional surveys, the Netherlands, 2016-17, April 2020 and June 2020
ConclusionStrict physical distancing measures greatly reduced overall contact numbers, which likely contributed to curbing the first wave of the COVID-19 epidemic in the Netherlands. However, age groups reacted differently when measures were relaxed, with children reverting to normal contact numbers and elderly individuals maintaining restricted contact numbers. These findings offer guidance for age-targeted measures in future waves of the pandemic.PMID:33632374 | DOI:10.2807/1560-7917.ES.2021.26.8.2000994 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jantien A Backer Liesbeth Mollema Eric Ra Vos Don Klinkenberg Fiona Rm van der Klis Hester E de Melker Susan van den Hof Jacco Wallinga Source Type: research

Estimates of mortality attributable to COVID-19: a statistical model for monitoring COVID-19 and seasonal influenza, Denmark, spring 2020
ConclusionAttMOMO estimates mortality attributable to several pathogens simultaneously, providing a fuller picture of mortality by COVID-19 during the pandemic in the context of other seasonal diseases and mortality patterns. Using Danish data, we show that the model accurately estimates mortality attributable to COVID-19 and influenza, respectively. We propose using standardised indicators for pathogen circulation in the population, to make estimates comparable between countries and applicable for timely monitoring.PMID:33632375 | DOI:10.2807/1560-7917.ES.2021.26.8.2001646 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jens Nielsen Naja Hulvej Rod Lasse S Vestergaard Theis Lange Source Type: research

Screening for < em > Candida auris < /em > in patients admitted to eight intensive care units in England, 2017 to 2018
ConclusionThese findings imply that C. auris colonisation among patients admitted to ICUs in England is currently rare. We would not currently recommend widespread screening for C. auris in ICUs in England. Hospitals should continue to screen high-risk individuals based on local risk assessment.PMID:33632376 | DOI:10.2807/1560-7917.ES.2021.26.8.1900730 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Ashley Sharp Berit Muller-Pebody Andre Charlett Bharat Patel Rebecca Gorton Jonathan Lambourne Martina Cummins Adela Alcolea-Medina Mark Wilks Robin Smith Damien Mack Susan Hopkins Andrew Dodgson Phillipa Burns Nelun Perera Felicia Lim Gopal Rao Priya Kha Source Type: research

Impact of physical distancing measures against COVID-19 on contacts and mixing patterns: repeated cross-sectional surveys, the Netherlands, 2016-17, April 2020 and June 2020
ConclusionStrict physical distancing measures greatly reduced overall contact numbers, which likely contributed to curbing the first wave of the COVID-19 epidemic in the Netherlands. However, age groups reacted differently when measures were relaxed, with children reverting to normal contact numbers and elderly individuals maintaining restricted contact numbers. These findings offer guidance for age-targeted measures in future waves of the pandemic.PMID:33632374 | DOI:10.2807/1560-7917.ES.2021.26.8.2000994 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jantien A Backer Liesbeth Mollema Eric Ra Vos Don Klinkenberg Fiona Rm van der Klis Hester E de Melker Susan van den Hof Jacco Wallinga Source Type: research

Estimates of mortality attributable to COVID-19: a statistical model for monitoring COVID-19 and seasonal influenza, Denmark, spring 2020
ConclusionAttMOMO estimates mortality attributable to several pathogens simultaneously, providing a fuller picture of mortality by COVID-19 during the pandemic in the context of other seasonal diseases and mortality patterns. Using Danish data, we show that the model accurately estimates mortality attributable to COVID-19 and influenza, respectively. We propose using standardised indicators for pathogen circulation in the population, to make estimates comparable between countries and applicable for timely monitoring.PMID:33632375 | DOI:10.2807/1560-7917.ES.2021.26.8.2001646 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Jens Nielsen Naja Hulvej Rod Lasse S Vestergaard Theis Lange Source Type: research

Screening for < em > Candida auris < /em > in patients admitted to eight intensive care units in England, 2017 to 2018
ConclusionThese findings imply that C. auris colonisation among patients admitted to ICUs in England is currently rare. We would not currently recommend widespread screening for C. auris in ICUs in England. Hospitals should continue to screen high-risk individuals based on local risk assessment.PMID:33632376 | DOI:10.2807/1560-7917.ES.2021.26.8.1900730 (Source: Euro Surveill)
Source: Euro Surveill - February 26, 2021 Category: Infectious Diseases Authors: Ashley Sharp Berit Muller-Pebody Andre Charlett Bharat Patel Rebecca Gorton Jonathan Lambourne Martina Cummins Adela Alcolea-Medina Mark Wilks Robin Smith Damien Mack Susan Hopkins Andrew Dodgson Phillipa Burns Nelun Perera Felicia Lim Gopal Rao Priya Kha Source Type: research