Maternal exposure to traffic pollutant causes impairment of spermatogenesis and alterations of genome-wide mRNA and microRNA expression in F2 male mice
In this study, healthy C57BL/6 J mice were used to establish an animal model of maternal exposure to traffic pollutant during pregnancy, and the toxic effects on the reproductive system of F2 male mice were analysed using mRNA and miRNA microarray. Our results showed that 54 miRNAs and 1927 mRNAs were significantly altered in the exposed group. Gene Ontology (GO) analysis revealed that the most significant GO terms for biological process, molecular function and cellular component were myeloid cell differentiation, growth factor binding and main axon. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis de...
Source: Environmental Toxicology and Pharmacology - September 18, 2018 Category: Environmental Health Source Type: research

Dietary co-exposure to methylmercury and monosodium glutamate disrupts cellular and behavioral responses in the lobster cockroach, Nauphoeta cinerea model
Publication date: Available online 16 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Blessing A. Afolabi, Isaac A. Adedara, Diogo O. Souza, João B.T. RochaAbstractThe present study aims to investigate the effect of monosodium glutamate (MSG) both separately and combined with a low dose of methylmercury (MeHg) on behavioral and biochemical parameters in Nauphoeta cinerea (lobster cockroach). Cockroaches were fed with the basal diet alone, basal diet + 2% NaCl, basal diet + 2% MSG; basal diet + 0.125 mg/g MeHg, basal diet + 0.125 mg/g MeHg + 2% NaCl;...
Source: Environmental Toxicology and Pharmacology - September 17, 2018 Category: Environmental Health Source Type: research

Hazardous effects of chemical pesticides on human health–Cancer and other associated disorders
Publication date: October 2018Source: Environmental Toxicology and Pharmacology, Volume 63Author(s): Akash Sabarwal, Kunal Kumar, Rana P. SinghAbstractPoisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes through which humans get exposed to pesticides. The mode of exposure is an important factor as it also signifies the concentration of pesticides exposure. Pesticides are used extensively in agricultural and domestic settings. These chemicals are believed to cause many disorders in humans and w...
Source: Environmental Toxicology and Pharmacology - September 8, 2018 Category: Environmental Health Source Type: research

Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress
Publication date: Available online 6 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Hu Yimeng, Liu Jie, Yuan Yin, Chen Jing, Cheng Siyuan, Wang Huawei, Xu YanchengAbstractSodium butyrate (NaB), a histone deacetylase (HDAC) inhibitors, has been reported to attenuate hyperglycemia in rats. Our objective was to explore the effect and underlying mechanism of NaB on islet β-cell dysfunction and apoptosis in type 2 diabetic (T2DM) rats. T2DM models were induced by the combination of streptozotocin (STZ, 40 mg/kg) and high-fat-diet, while NaB (500 mg/kg/d) was intraperitoneally inject...
Source: Environmental Toxicology and Pharmacology - September 7, 2018 Category: Environmental Health Source Type: research

Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway
Publication date: Available online 6 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): E.O. Adegoke, Chen Wang, N.S Machebe, Xue Wang, Hao Wang, S.O Adeniran, Han Zhang, Peng Zheng, Guixue ZhangAbstractSertoli cells were treated with 0, 20, 40, 60 and 80 µg/L of MC-LR to investigate its toxic effects, mechanism of action and immune response of the cells. Our results revealed that treatment containing 20 µg/L of MC-LR was non-toxic to the cells. Treatments containing 40, 60 and 80 µg/L of MC-LR reduced the cell viability, induced nuclear morphological changes an...
Source: Environmental Toxicology and Pharmacology - September 7, 2018 Category: Environmental Health Source Type: research

Hazardous Effects of Chemical Pesticides on Human Health- Cancer and Other Associated Disorders
Publication date: Available online 1 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Akash Sabarwal, Kunal Kumar, Rana P. SinghAbstractPoisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes through which humans get exposed to pesticides. The mode of exposure is an important factor as it also signifies the concentration of pesticides exposure. Pesticides are used extensively in agricultural and domestic settings. These chemicals are believed to cause many disorders in hu...
Source: Environmental Toxicology and Pharmacology - September 2, 2018 Category: Environmental Health Source Type: research

Study of the spread of antimicrobial-resistant Enterobacteriaceae from wild mammals in the National Park of Aspromonte (Calabria, Italy)
Publication date: Available online 28 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Foti Maria, Siclari Antonino, Mascetti Antonietta, Fisichella VittorioAbstractAntimicrobial-resistant (AMR) bacteria are a threat to global health. Epidemiological studies are necessary to gain a more detailed understanding of the transmission modality of resistant bacteria to wild animals and their diffusion into the environment to ensure a broader evaluation of the epidemiological role of wildlife. The study aimed to identify little-known epidemiological aspects by focusing on the isolation of Enterobacteriaceae i...
Source: Environmental Toxicology and Pharmacology - August 29, 2018 Category: Environmental Health Source Type: research

Captan-induced increase in the concentrations of intracellular Ca2+ and Zn2+ and its correlation with oxidative stress in rat thymic lymphocytes
Publication date: Available online 27 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tomomi Inoue, Maika Kinoshita, Keisuke Oyama, Norio Kamemura, Yasuo OyamaAbstractCaptan, a phthalimide fungicide, is considered to be relatively nontoxic to mammals. There is a possibility that captan affects membrane and cellular parameters of mammalian cells, resulting in adverse effects, because of high residue levels. To test the possibility, we examined the effects of captan on rat thymic lymphocytes using flow-cytometry with appropriate fluorescent probes. Treatment with 10 and 30 µM captan induced apopt...
Source: Environmental Toxicology and Pharmacology - August 28, 2018 Category: Environmental Health Source Type: research

Cellular uptake and apoptotic potential of rhenium labeled magnetic protein cages in MDA-MB-231 cells
Publication date: Available online 25 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Elif Aşık, Tuğba Nur Aslan, N. Tülin Güray, Mürvet VolkanGraphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 26, 2018 Category: Environmental Health Source Type: research

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals
Publication date: Available online 25 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Gunnar Carlsson, Maria Blomberg, Johannes Pohl, Stefan ÖrnAbstractVeterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects also might be of concern in non-target animals such as fish. We tested if exposure to antiparasitic pharmaceuticals affect swimming activity in 6 days old zebrafish larvae. The results revealed that most pharmaceuticals did not cause any effects in s...
Source: Environmental Toxicology and Pharmacology - August 26, 2018 Category: Environmental Health Source Type: research

Exposure of cadmium via smoking and drinking water on zinc levels of biological samples of malnutrition pregnant women: A Prospective cohort study
Publication date: Available online 19 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Faiza Ali, Tasneem Gul Kazi, Hassan Imran Afridi, Jameel Ahmed BaigAbstractIn present study, the interaction of a toxic (cadmium) and essential element (zinc) was determined in scalp hair of pregnant and non-pregnant women resident in a rural area of Thraparkar, Pakistan, where malnutrition is prevalent. In the malnourished group (pregnant and nonpregnant women), deficiency of the essential element (zinc) due to malnutrition and exposure of toxic metal (cadmium) via non-branded cigarette smoking and drinking groundw...
Source: Environmental Toxicology and Pharmacology - August 20, 2018 Category: Environmental Health Source Type: research

MiR-132, miR-204 and BDNF-TrkB signaling pathway may be involved in spatial learning and memory impairment of the offspring rats caused by fluorine and aluminum exposure during the embryonic stage and into adulthood
This study showed that exposure to fluorine and aluminium, either alone or combined, during the embryonic stage and into adulthood caused spatial learning and memory impairment in offspring rats; its mechanism may be associated with increases in miR-132 and miR-204 expression and downregulation of the BDNF-TrkB pathway in the hippocampus. The effects of F were obvious, but the effects of Al were slight. There were antagonistic effects between F and Al, with Al reducing the toxicity of F. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Reduced testosterone and Ddx3y expression caused by long-term exposure to arsenic and its effect on spermatogenesis in mice
The objective of this investigation was to explore these effects and the underlying mechanisms. Male mice were treated with 5 and 50 ppm arsenic for 6 months via drinking water. The results showed that arsenic reduced sperm count and sperm motility and enhanced the abnormal sperm percentage. The decrease in the number of spermatogenic cells and sperm in seminiferous tubules and the decline in the Johnsen score were observed in both arsenic-treated groups, suggesting spermatogenesis disorders. Moreover, arsenic diminished serum testosterone, along with the reduced expression of luteinizing hormone receptor (LHR), ste...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

iTRAQ-based secretome reveals that SiO2 induces the polarization of RAW264.7 macrophages by activation of the NOD-RIP2-NF-κB signaling pathway
Publication date: Available online 17 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Rong Fu, Qian Li, Rong Fan, Qinye Zhou, Xiaohan Jin, Jin Cao, Jiabao Wang, Yongqiang Ma, Tailong Yi, Maobin Zhou, Sanqiao Yao, Hongsheng Gao, Zhongwei Xu, Zhen YangAbstractSilicosis is characterized by inflammation and pulmonary fibrosis due to long-term inhalation of crystalline silica (SiO2). To clarify the role of macrophage polarization in the inflammatory response of silicosis, we used iTRAQ-coupled 2D LC-MS/MS to study the change in the secretome in RAW264.7 macrophages. We successfully screened 330 differenti...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population
Publication date: Available online 17 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Haoran Guo, Enmin Ding, Rongjian Sheng, Jian Cheng, Wenyan Cai, Jiadi Guo, Ning Wang, Hengdong Zhang, Baoli ZhuAbstractNoise-induced hearing loss (NIHL), one of the most widespread occupational health risks worldwide, is a kind of complex disorder resulting from both genetic and environmental factors. KCNQ4 channels are crucial to the internal ear potassium recycling. To explore whether KCNQ4 polymorphism is associated with individual susceptibility to NIHL, we performed this genetic association study on 571 NIHL ca...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Evidence of risks of renal function reduction due to occupational exposure to agrochemicals: a systematic review
Publication date: Available online 15 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ivângela Raphaela Gouveia Prudente, Candice Lima Cruz, Laranda de Carvalho Nascimento, Claúdia Cristina Kaiser, Adriana Gibara GuimarãesABSTRACTAgriculture accounts for an important economic activity worldwide and the search for the increased productivity incorporated the use of pesticides in this practice. Such compounds have significant environmental and human health effects, especially for workers exposed to them. Among the main health problems caused by pesticides are the renal alterations, w...
Source: Environmental Toxicology and Pharmacology - August 15, 2018 Category: Environmental Health Source Type: research

Different radiation dose rate as radioprotection and the cross effect with chromium using in vivo somatic cells of Drosophila
Publication date: Available online 13 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): L.M. Vidal, E. Pimentel, M.P. Cruces, J.C. Sánchez-MezaAbstractIonizing radiation plays a key role in the adaptation of an individual organism to environmental pollution, at the same time, it has biological effects that depend on radiation intensity or dose rate (DR). Although the effect of DR has been studied in vitro, the phenomenon known as the inverse effect of DR, which indicates as it decreases that the induction of damage is greater, has not been widely studied in vivo. The present study is aimed to te...
Source: Environmental Toxicology and Pharmacology - August 14, 2018 Category: Environmental Health Source Type: research

Phthalates Promote Prostate Cancer Cell Proliferation through Activation of ERK5 and p38
In this report we found that three typical phthalates, diethylhexyl phthalate (DEHP), Butyl benzyl phthalate (BBP) and Dibutyl phthalate (DBP), up-regulated cyclinD1 and PCNA, down-regulated P21, inducing proliferation of prostate cancer cells. Furthermore, we found that phthalates increased the expression of p-ERK5 and p-p38, along with upregulation of AP-1 (p-c-fos and p-c-jun). In studies with ERK5 and a p38 inhibitor, our data showed that downregulation of p-ERK5 or p38 inhibited phthalate-triggered cell proliferation. Taken together, findings from this study suggest that phthalates activate MAPK/AP-1 pathway and may p...
Source: Environmental Toxicology and Pharmacology - August 14, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 11, 2018 Category: Environmental Health Source Type: research

Titanium dioxide nanoparticles induce mouse hippocampal neuron apoptosis via oxidative stress- and calcium imbalance-mediated endoplasmic reticulum stress
Publication date: Available online 10 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Qiong He, Xuejiao Zhou, Yang Liu, Wenfeng Gou, Jiahui Cui, Zengqiang Li, Yingliang Wu, Daiying ZuoAbstractThe purpose of this study was to explore the potential neurotoxicity and the underlying mechanism of titanium dioxide nanoparticles (TiO2-NPs) to mouse hippocampal neuron HT22 cells. We found that TiO2-NPs had concentration-dependent and time-dependent cytotoxicities to HT22 cells by the MTT assay. Propidium iodide (PI) staining with FACScan flow cytometry proved that TiO2-NPs dose-dependently increased the apop...
Source: Environmental Toxicology and Pharmacology - August 10, 2018 Category: Environmental Health Source Type: research

Cytotoxic and genotoxic effects of antihypertensives distributed in brazil by social programs: are they safe?
Publication date: Available online 9 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, E. Michel Mansur MachadoAbstractHypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. I...
Source: Environmental Toxicology and Pharmacology - August 10, 2018 Category: Environmental Health Source Type: research

MicroRNA-375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression
In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells. To investigate the role therapeutic potential of miR-375, one kidney cancer cell line (A-498) was selected for further experimentation. It was observed that overexpression of miR-375 inhibits A-498 kidney cancer proliferation by induction of apoptosis. In addition, overexpression of miR-375 causes suppression of migration and invasion of the A-498 kidney cancers cells. Bioinformatic analysis revealed PDK1 to be putat...
Source: Environmental Toxicology and Pharmacology - August 8, 2018 Category: Environmental Health Source Type: research

Effects and mechanisms of sub-chronic exposure to Copper nanoparticles on renal cytochrome P450 enzymes in rats
In this study, we investigated the effects of Cu NPs on renal oxidative stress, cytokines and histopathology of rats. We found that Cu NPs (200 mg/kg) significantly disordered the function and structure of the kidney and caused a dose-dependent increase in oxidative stress and cytokines, which significantly decreased the levels of mRNA, protein, and activity of CYP450 s. Micro-coppers (Cu MPs) and Cu ions have similar effects, but their effects on CYP450 s were weaker than Cu NPs. The expression of nuclear receptors were inhibited and the expression of Akt, STAT3/5, CREB, p70S6K, NF-κB, P38 and E...
Source: Environmental Toxicology and Pharmacology - August 8, 2018 Category: Environmental Health Source Type: research

4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals
Publication date: Available online 3 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Shaoping Huang, Senyang Cao, Tao Zhou, Lu Kong, Geyu LiangABSTRACT4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We applied comparative proteomics to explore the molecular targets affected by 4t-OP. 81 differentially expressed (DE) proteins...
Source: Environmental Toxicology and Pharmacology - August 4, 2018 Category: Environmental Health Source Type: research

MicroRNA -375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression
In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells. To investigate the role therapeutic potential of miR-375, one kidney cancer cell line (A-498) was selected for further experimentation. It was observed that overexpression of miR-375 inhibits A-498 kidney cancer proliferation by induction of apoptosis. In addition, overexpression of miR-375 causes suppression of migration and invasion of the A-498 kidney cancers cells. Bioinformatic analysis revealed PDK1 to be putat...
Source: Environmental Toxicology and Pharmacology - August 3, 2018 Category: Environmental Health Source Type: research

The effects of 1st and 2nd generation biodiesel exhaust exposure on hematological and biochemical blood indices of Fisher344 male rats – the FuelHealth project
In conclusion, exposure to DEE from B7, which was associated with higher exposure to polycyclic aromatic hydrocarbons, resulted in decreased number of T and NK lymphocytes, while DEE from SHB20 induced a higher level of DNA single-strand breaks, oxidative stress and increased red blood cells parameters. Additionally, DPF technology generated increased number of smaller PM and made the DEE more reactive and more harmful, manifested as deregulation of redox balance. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 3, 2018 Category: Environmental Health Source Type: research

Evidence that the radioprotector effect of ascorbic acid depends on the radiation dose rate
Publication date: Available online 1 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Elena González, Martha P. Cruces, Emilio Pimentel, Petra SánchezAbstractMany studies have revealed that ascorbic acid (Aa) acts as a powerful inhibitor of genetic damage. The objetive of the present study was to evaluate the radioprotector effect of Aa at two diferent radiation dose rates. The somatic mutation and recombination test in Drosophila melanogaster was used. 48 h larvae were treated for 24 h with 25, 50 and 100 mM of Aa. After pretreatment, larvae were irradiated with 20&...
Source: Environmental Toxicology and Pharmacology - August 2, 2018 Category: Environmental Health Source Type: research

Altered Formation of the Iron Oxide Nanoparticle-Biocorona due to Individual Variability and Exercise
Publication date: Available online 29 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Lisa M. Kobos, Sherleen Xue-Fu Adamson, Sheelagh Evans, Timothy Gavin, Jonathan H. ShannahanAbstractNanoparticles (NPs), introduced into a biological environment, accumulate a coating of biomolecules or biocorona (BC). Although the BC has toxicological and pharmacological consequences, the effects of inter-individual variability and exercise on NP-BC formation are unknown. We hypothesized that NPs incubated in plasma form distinct BCs between individuals, and exercise causes additional intra-individual alterations. 20...
Source: Environmental Toxicology and Pharmacology - July 29, 2018 Category: Environmental Health Source Type: research

CYP1A1 activity in rainbow trout is inhibited by the environmental pollutant p-cresol
In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected. These results indicate that p-cresol might affect the ability of fish to metabolize numerous aromat...
Source: Environmental Toxicology and Pharmacology - July 27, 2018 Category: Environmental Health Source Type: research

Ecotoxicological effect of fipronil and its metabolites on Folsomia candida in tropical soils
Publication date: Available online 26 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Talyta Zortéa, Tamires Rodrigues dos Reis, Suélen Serafini, José Paulo de Sousa, Aleksandro Schafer da Silva, Dilmar BarettaAbstractThe aim of this study is to evaluate the toxicity of the fipronil and its metabolites, fipronil sulfone and fipronil desulfinyl on Folsomia candida. Three types of soils were used to perform the ecotoxicological tests, two natural soils (Oxisol and Entisol), and an artificial substrate (Tropical Artificial Soil). The treatments consisted of increasing doses of a veter...
Source: Environmental Toxicology and Pharmacology - July 27, 2018 Category: Environmental Health Source Type: research

Postnatal low-concentration arsenic exposure induces autism-like behavior and affects frontal cortex neurogenesis in rats
This study aimed to explore the effects of postnatal low-concentration arsenic exposure on learning, social skills and frontal cortex neurogenesis in rats. Water-based arsenic exposure rat models were established on postnatal days 4-10 (P4-P10). The experimental animals were divided into four groups: the control group, a 15 µg/L As2O3 water group, a 30 µg/L As2O3 water group, and a 45 µg/L As2O3 water group. Cognitive function was examined with the Morris water maze, anxiety-like behavior with the open field test and light-dark box test, and social skills with a social interaction test. The frontal ...
Source: Environmental Toxicology and Pharmacology - July 25, 2018 Category: Environmental Health Source Type: research

Serum biomarker levels alter following nanoparticle (Al2O3, CuO, TiO2) exposures in freshwater fish (Oreochromis niloticus)
This study emphasized that NPs are not innocent compounds and can have hazardous effects when taken in substantial levels, suggesting there must be some criteria and limits in their usage and discharge to the environment. Nevertheless, more studies are needed to understand better their toxicities in different classes of animals. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 20, 2018 Category: Environmental Health Source Type: research

Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata
Publication date: Available online 18 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Messika Revel, Michel Fournier, Pierre Yves RobidouxAbstractPotential immunotoxicity and genotoxicity of as-produced and purified single walled carbon nanotubes (SWCNT, 500 µg Lˉ¹) with or without cadmium (20 µg Lˉ¹) was investigated in hemocytes of the freshwater mussel, Elliptio complanata. Our results showed a decrease in hemocyte viability after 3, and 8 days of exposure and an increase of hemocyte phagocytic efficiency for organisms exposed to Cd. No modification of the cyclo...
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Surachai Maijaroen, Nisachon Jangpromma, Jureerut Daduang, Sompong KlaynongsruangAbstractConventional colon cancer treatments have been associated with side effects. Consequently, the discovery of novel effective and safe therapies is urgently needed. Hence, cationic antimicrobial peptides KT2 and RT2 were evaluated towards human colon cancer HCT-116 cells. The MTT assay indicated that both KT2 and RT2 exhibited anticancer activity with good therapeutic indices, and were found to be non-toxic to non-cancerous Vero cells. ...
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

Electron shuttles enhance the degradation of sulfamethoxazole coupled with Fe(III) reduction by Shewanella oneidensis MR-1
This study indicates that the biochemical mechanisms play a vital role in SMX transformation and Fe(II) generation in this system.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

Anxiety-associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eigh...
Source: Environmental Toxicology and Pharmacology - July 13, 2018 Category: Environmental Health Source Type: research

Effects of diesel exhaust particles on the expression of tau and autophagy proteins in human neuroblastoma cells
The objective of the present study was to evaluate the neurotoxic effects caused by diesel exhaust particles (DEPs). We determined the ability of DEPs and carbon black (CB) to induce neurotoxicity, oxidative stress and inflammation, and to disrupt the expression of tau and autophagy proteins in human neuroblastoma IMR-32 cells. Spherical CB (dominated by C, N, and S) and DEPs (dominated by C, N, and O) in aggregates were observed using a field emission-scanning electron microscope (FE-SEM) equipped with energy-dispersive x-ray (EDX) microanalysis. Cell viability was significantly decreased by CB and DEPs in IMR-32 cells, b...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “Effect of probiotic supplement on aflatoxicosis and gene expression in the liver of broiler chicken” [Environ. Toxicol. Pharmacol. 60 (2018) 118–127]
Publication date: Available online 29 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ramadan Salem, Nagwan El-Habashi, Sabreen E. Fadl, Osama A. Sakr, Zizy I. Elbialy (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Anxiety- associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: Available online 30 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “The research of genetic toxicity of β-phellandrene” [Environ. Toxicol. Pharmacol. 54 (2017) 28–33]
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Zhiyuan Cheng, Jianjun Jiang, Xiaohua Yang, Hongqian Chu, Ming Jin, Yuan Li, Tao Xi, Siqi Wang, Yao Huang, Lanqin Shang, Shuang Wu, Weidong Hao, Yueying Qian, Xuetao Wei (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism
In conclusion, diabetic-osteoarthritic state is characterised by more altered biochemical profile, relative to what is probable in either disease condition. Nevertheless, this situation remains subject to the influence of endogenous homeostatic mechanisms. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Ege Arzuk, Burak Turna, Murat Sözbilen, Hilmi OrhanAbstractParacetamol (PAR) overdose is associated with massive hepatic injury; it may induce kidney toxicity as well. It is essential to measure organ-specific activities of related CYPs for evaluating the overdose cases. Available HPLC-based methods require high amounts of tissue samples. In order to develop liquid chromatography mass spectrometry (LC–MS)-based methods to process small amounts of human tissues, liver and kidney samples were obtained. Individual micr...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: A combined kinetic and docking study
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Victor Markus, Kerem Teralı, Ozlem Dalmizrak, Nazmi OzerAbstractDeltamethrin (DEL), which is a synthetic pyrethroid insecticide, has been used successfully all over the world to treat mosquito nets for the control of malaria. Glutathione S-transferases (GSTs; EC 2.5.1.18) catalyze the conjugation of reduced glutathione (GSH) to a variety of xenobiotics and are normally recognized as detoxification enzymes. Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and th...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa
In conclusion, prenatal alcohol exposure causes a decrease in conversion of tryptophan to 5-HT in both muscle and mucosa although the effect is more pronounced in females. The observed sex difference may be related to changes associated with the estrous cycle. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Expression of cyp1a induced by benzo(A)pyrene and related biochemical and genotoxic biomarkers in the neotropical freshwater fish Prochilodus lineatus
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Caroline Santos, Marcelo Tempesta de Oliveira, Ilce Mara de Syllos Cólus, Silvia Helena Sofia, Claudia Bueno dos Reis MartinezAbstractThe goal of this work was to design specific cyp1a primers for the fish Prochilodus lineatus to study the expression of this gene and its relation to the activity of biotransformation phase I enzyme (ethoxyresorufin O-deethylase - EROD) and genotoxic damage after 6 and 24 h of benzo(a)pyrene (B(a)P) intraperitoneal injection. In comparison to fish injected only with canola oil (vehicle)...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Clinical and radiographic periodontal status and whole salivary cotinine, IL-1β and IL-6 levels in cigarette- and waterpipe-smokers and E-cig users
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Sameer A. Mokeem, Mohammed N. Alasqah, Dimitrios Michelogiannakis, Abdulaziz A. Al-Kheraif, Georgios E. Romanos, Fawad JavedAbstractThe aim was to compare the clinical (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PPD] and clinical attachment loss [CAL]) and radiographic (marginal bone loss [MBL]) periodontal parameters and whole salivary cotinine, interleukin (IL)-1β and IL-6 levels among cigarette-smokers, waterpipe-smokers, E-cig users and never-smokers. In total, 154 male individuals (39 cigaret...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Deciphering the toxic effects of iprodione, a fungicide and malathion, an insecticide on thiol protease inhibitor isolated from yellow Indian mustard seeds
This study was carried out to see the effect of commercially used pesticides on a specific plant protein viz. phytocystatin isolated from yellow mustard seeds (YMP). Phytocystatin is a thiol proteinase inhibitor, which regulates endogenous and exogenous cysteine proteinases and plays a vital physiological role in plants. Different classes of pesticides like fungicide (iprodione) of dicarboximide class and an insecticide (malathion) of class organophosphate are retorted for our study. In the presence of these pesticides, biophysical and biochemical changes were observed in phytocystatin. These changes were evaluated making ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio (Pistacia vera L.) cultivars collected from four geographical regions of Iran
In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five pistachio cultivars collected from four sites of Iran, were measured by HPLC. Based on the results, risk assessment for AFB1 and OTA residues was done. The highest mean concentrations of AFB1 and OTA were found in Ahmad-aghaei (4.33 and 2.19 ng/g, respectively) and Akbari (4.08 and 1.943 ng/g, respectively) cultivars from Rafsanjan, Iran. Even the highest concentrations of AFB1 and OTA in analyzed samples were lower than the corresponding maximum limits set by EU authorities. The hazard index (HI) value for consumers of Iranian pistachio is below ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Adapting and applying common methods used in pharmacovigilance to the environment: A possible starting point for the implementation  of eco-pharmacovigilance
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Jun Wang, Mengya Zhang, Shulan Li, Bingshu HeAbstractNow, the occurrence of pharmaceuticals in natural environment has been frequently reported around the world. As a kind of biologically active compounds specially designed to be effective even at very low concentration levels, pharmaceuticals in the environment could have adverse impacts to the health of human beings or other non-targeted organisms due to long-term exposures. To minimize the pharmaceutical pollution from the perspective of drug administration, a new concept c...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research