A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen
Publication date: Available online 29 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Hyun Jung Park, Wahn Soo Choi, Won Young Lee, Youngsok Choi, Chankyu Park, Jin Hoi Kim, Kwon Ho Hong, Hyuk Song The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensitized with one of four chemical allergens – toluene diisocyanate (TDI), hexamethy...
Source: Environmental Toxicology and Pharmacology - December 29, 2017 Category: Environmental Health Source Type: research

Impact of co-exposure of aldrin and titanium dioxide nanoparticles at biochemical and molecular levels in zebrafish
Publication date: Available online 27 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Reena C. Jhamtani, Saurabh Shukla, P. Sivaperumal, M.S. Dahiya, Rakhi Agarwal Aldrin (ALD), a persistent-organic-pollutant (POP), an organochlorine-cyclodiene-pesticide is highly toxic in nature. Titanium dioxide nanoparticles (TNP) are widely used for various industrial applications. Despite the remarkable research on pesticide toxicity, the work with impact of nanoparticles on POP has been dealt with marginally. Chemicals co-exist in the environment and exhibit interactive effects. An investigation was carried...
Source: Environmental Toxicology and Pharmacology - December 28, 2017 Category: Environmental Health Source Type: research

In situ assessment of Karaj River genotoxic impact with the alkaline comet assay and micronucleus test, on feral brown trout (Salmo trutta fario)
Publication date: Available online 28 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mehran Hariri, Alireza Mirvaghefi, Hamid Farahmand, Lobat Taghavi, Amir-Reza Shahabinia The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage significantly increased in sampled fish erythrocytes, liver and gill from low levels in the upstream river (Vara...
Source: Environmental Toxicology and Pharmacology - December 28, 2017 Category: Environmental Health Source Type: research

Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats
This study aimed to investigate the prophylactic impacts of venlafaxine against CP-induced lung toxicity in rats. Rats were assigned randomly into 3 groups; control, CP (150 mg/kg) and CP/venlafaxine (50 mg/kg). On the end day, rats were sacrificed then bronchoalveolar fluid (BALF) and lungs were harvested. CP produced significant decrease in animal body weights and significant increase in lung/body weight ratio; levels of LDH, total protein, total and differential cell counts in BALF in comparison with control group. Moreover, significant elevation in contents of MDA, NOx, TNF-α and IL-1β and significant de...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1
Publication date: Available online 27 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Anna Bizoń, Halina Milnerowicz Paraoxonase 1 (PON1) is calcium depend enzyme involved in many functions in human body. PON1 is synthesized in the liver and secreted to the bloodstream where bounds high-density lipoproteins (HDL). Association of PON1 with HDL increases the enzyme stability and biological activities. PON1 have three different activities: phosphotriesterase, lactonase and arylesterase. Until now there is now commercial available kits to determine these three PON1 activities. Also there is no date ...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Myricetin enhances on apoptosis induced by serum deprivation in PC12 cells mediated by mitochondrial signaling pathway
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Gongxun Tan, Rachael A. Uson-Lopez, Md. Mostafizur Rahman, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki Polyphenols have many beneficial effects and an effective disease therapeutic auxiliary drug. Previously, myricetin, a polyphenol, had been reported to possess various biological effects on human physiology. However, mechanism of myricetin on apoptosis induced in PC12 cells is still unclear. PC12 cells were treated with myricetin in two concentration levels comprising 0.1 and 1 μM under serum-free condition....
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Cancelling pesticide registrations and revoking tolerances: The case of chlorpyrifos
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Terence J. Centner Petitions submitted to the United States Environmental Protection Agency (EPA) have sought to cancel registrations of chlorpyrifos and to revoke chlorpyrifos tolerances in or on food due to adverse health effects on people. Under federal law, tolerances for pesticide chemical residues in or on food must provide with reasonable certainty that no harm will result from a person's aggregate exposure. Petitioners’ claims are analyzed under the legal requirements to discern whether the EPA had a rationa...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Denise C. Bailey, Callie E. Todt, Shelbie L. Burchfield, Aireal S. Pressley, Rachel D. Denney, Isaac B. Snapp, Rekek Negga, Wendy L. Traynor, Vanessa A. Fitsanakis Glyphosate-containing herbicides are among the most widely-used in the world. Although glyphosate itself is relatively non-toxic, growing evidence suggests that commercial herbicide formulations may lead to increased oxidative stress and mitochondrial inhibition. In order to assess these mechanisms in vivo, we chronically (24h) exposed Caenorhabditis elegans to...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Changes in first trimester fetal CYP1A1 and AHRR DNA methylation and mRNA expression in response to exposure to maternal cigarette smoking
This study assessed the impact of exposure to maternal smoking on first trimester fetal CYP1A1 and AHRR mRNA expression and DNA methylation for CpG-sites displaying maternal smoking during pregnancy-mediated methylation changes at birth. The analyses included first trimester (6–12 weeks) placentas (N=39) and livers (N=43). For AHRR, exposure to maternal smoking was associated with increased DNA methylation in the placentas of female fetuses; mRNA expression, however, was unchanged. While exposure to maternal smoking was not associated with AHRR DNA methylation changes in fetal livers; mRNA expression was increased. F...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Combined toxicity of triclosan, 2,4-dichlorophenol and 2,4,6-trichlorophenol to zebrafish (Danio rerio)
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Yuhuan Zhang, Mi Liu, Jinfeng Liu, Xuedong Wang, Caihong Wang, Weiming Ai, Shaobo Chen, Huili Wang Triclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol (2,4-DCP) are the most prevalent chlorinated phenolic pollutants in aquatic environments. Our results showed LC50 and EC50 values of 0.51, 1.11, 2.45mg/L, and 0.36, 0.74, 1.53mg/L for TCS, 2,4,6-TCP and 2,4-DCP, respectively, to 120hpf zebrafish. The highest TCSD (the mixture of TCS, 2,4,6-TCP and 2,4-DCP) toxicity was observed at a TCS:2,4,6-TCP:2,4-D...
Source: Environmental Toxicology and Pharmacology - December 27, 2017 Category: Environmental Health Source Type: research

Sensitivity of medaka (Oryzias latipes) to 4-nonylphenol subacute exposure; erythrocyte alterations and apoptosis
Publication date: Available online 26 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alaa El-Din H. Sayed, Chisato Kataoka, Shoji Oda, Shosaku Kashiwada, Hiroshi Mitani The present study was undertaken to assess the effects of the endocrine-disrupting compound; 4-nonylphenol (4-NP) in medaka (Oryzias latipes). The frequencies of erythrocyte alterations, apoptosis, and micronuclei were used as biological indicators of damage. Medaka were exposed 15 days to 4-NP at three sublethal concentrations (50, 80, and 100 100 μg/l 4-NP) and results compared with those of a previous study using catfis...
Source: Environmental Toxicology and Pharmacology - December 26, 2017 Category: Environmental Health Source Type: research

Paraquat treatment modulates integrin associated protein (CD47) and basigin (CD147) expression and mitochondrial potential on erythroid cells in mice
Publication date: Available online 23 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nitin Bhardwaj, Ashutosh Singh The present study is focused on the interaction of paraquat with the erythroid system in bone marrow and spleen of mice. Administration of paraquat (10 mg/kg of body weight i.p. on alternate days in C57Bl/6 mice) induced the level of reactive oxygen species in bone marrow (BM) on 7, 14, and 21 day time points but it was unchanged in spleen erythroid cell. A marked induction of CD147 expression in BM and spleen erythroid cells was observed in the paraquat treated mice. Paraquat ...
Source: Environmental Toxicology and Pharmacology - December 24, 2017 Category: Environmental Health Source Type: research

Acute toxicity, uptake, and elimination of zinc oxide nanoparticles (ZnO NPs) using saltwater microcrustacean, Artemia franciscana
This study aims to evaluate the potential toxic effects of ZnO nanoparticles on Artemia franciscana nauplii. The ZnO NPs suspension was characterized by TEM, EDS and DLS techniques. Acute toxicity was investigated by exposure of nauplii to concentrations of 1, 5, 7.5, 10, 15, 20, 25 and 30 mg/L of ZnO NPs for 48 h and 96 h. The 96-h EC10 and EC50 values of ZnO NPs were found to be 1.39 mg/L and 4.86 mg/L respectively. The ZnO NPs suspensions did not cause any significant acute toxicity after 48 h of exposure, but the immobilization rate increase significantly compare to control group after 96 h (P < ...
Source: Environmental Toxicology and Pharmacology - December 21, 2017 Category: Environmental Health Source Type: research

Enhancement of myricetin on apoptosis induced by serum deprivation in PC-12 cells mediated by mitochondrial signaling pathway
Publication date: Available online 18 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Gongxun Tan, Rachael Uson Lopez, Md. Mostafizur Rahman, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki Polyphenols have many beneficial effects and an effective disease therapeutic auxiliary drug. Previously, myricetin, a polyphenol, had been reported to possess various biological effects on human physiology. However, mechanism of myricetin on apoptosis induced in PC12 cells is still unclear. PC12 cells were treated with myricetin in two concentration levels comprising 0.1 and 1 μM under serum-free con...
Source: Environmental Toxicology and Pharmacology - December 18, 2017 Category: Environmental Health Source Type: research

Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects
Publication date: Available online 16 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiang Yan, Fang Lei, Yajie Hu, Lihong Nie, Qingyi Jia, Hua Zhou, Fusheng Zhao, Yu Zheng We previously demonstrated that hydrogen sulfide (H2S) protected neonatal rat medulla oblongata from prenatal cigarette smoke exposure (CSE) via anti-apoptotic effect. The present work further investigated the involvement of anti-oxidative and anti-inflammatory effects of H2S in the protection. Pregnant Sprague-Dawley rats were randomly divided into NaCl, CSE, CSE + NaHS (a donor of H2S) and NaHS groups. All the tests wer...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

High Resolution Metabolomics to Determines the Risk Associated with bisphenol A Exposure in Humans
Publication date: Available online 16 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Seongha Cho, Adnan Khan, Sun Ha Jee, Hee-Seok Lee, Myung-Sil Hwang, Yong Eui Koo, Youngja H. Park Although high BPA exposure has been correlated with several metabolic diseases, the underlying mechanisms are unclear. In the present study, a metabolomics approach was used to explore the metabolic variations caused by low or high BPA exposure in female (n = 96) and male (n = 98) urine. Fatty acid elongation and sphingolipid metabolism were affected by high BPA exposure in males and females. Fatty acid elon...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

S-Allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: focus towards anti-oxidative efficiency
Publication date: Available online 16 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Palvannan Thayumanavan, Chitra Loganathan, Ancy Iruthayaraj, Kumaradhas Poomani, Selvan Nallaiyan A simple analogue of well known natural antioxidant glutathione (GSH) called S-Allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GGT, ALP and LDH) and bilirubin in the blood circulation. Such protective effect of SAG resulted in pr...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Regulation of ABCG2 by nuclear factor kappa B affects the sensitivity of human lung adenocarcinoma A549 cells to arsenic trioxide
In this study, using human lung adenocarcinoma A549 cells as a cell culture model, we demonstrated that an adenosine triphosphate binding cassette (ABC) transporter, ABCG2, was significantly increased by As2O3 treatment, while other ABC transporters, ABCB1 and ABCC1 showed no remarkable change in the response to As2O3. After inhibition of ABCG2 by its specific inhibitor, the drug sensitivity of As2O3 to A549 cells was significantly enhanced, manifested by decreased cell viability and colony formation as well as the increased ROS production and cell apoptosis. To further understand the molecular mechanism underlying the ele...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Eugenol enhances proliferation and migration of mouse bone marrow-derived mesenchymal stem cells in vitro
In conclusion, this study revealed that Eugenol enhances the proliferation and migration of MSCs, and thus this will be beneficial to the field of regenerative medicine. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Hepatoprotective effect of thymol against subchronic toxicity of titanium dioxide nanoparticles: Biochemical and histological evidences
In conclusion, thymol effectively protects against nano-TiO2-induced hepatotoxicity in rats by its antioxidant properties. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

In-silico and in-vitro evaluation of Human Acetylcholinesterase Inhibition by Organophosphates
Publication date: Available online 17 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Anuj Ranjan, Abhishek Chauhan, Tanu Jindal Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Screening of OP was carried out by molecular docking with hAChE using Glide docking module of Schrodinger suite as the structural information of hAChE and OP together as co-crystal structure is rarely available. The docking was done at three different precision levels, high thro...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Role of fluoride induced histone trimethylation in development of skeletal fluorosis
In conclusion, present investigation is a first attempt to link fluoride induced hyper H3K9 tri-methylation mediated repression of TGFBR2 and SMAD3 with the development of skeletal fluorosis. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Enhanced visible light photodegradation of pharmaceutical pollutant, warfarin by nano-sized SnTe, effect of supporting, catalyst dose, and scavengers
Publication date: Available online 17 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): S. Vadaei, H. Faghihian Improvement of new nanophotocatalysts enable to decompose the pharmaceutical pollutants with the aid of solar energy is of particular importance. In this research, the ability of SnTe photocatalyst for degradation of warfarin was enhanced and the separation difficulties of the used photocatalyst, from solutions was removed by immobilization of the photocatalyst on a suitable porous support. A novel nano-sized photocatalyst was prepared by coupling of SnTe on the surface of SBA-15 support....
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

In vitro activity of Nigella sativa against antibiotic resistant Salmonella enterica
Publication date: Available online 17 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sadia Ashraf, Aftab Ahmad Anjum, Ali Ahmad, Sehrish Firyal, Saba Sana, Asma Abdul Latif Salmonellosis is a major food-borne disease worldwide and antimicrobial resistance in Salmonella is a public health problem. Phytochemicals are alternative therapeutics to treat antibiotic resistant Salmonella. Biochemically identified Salmonella enterica of human and poultry origin (n = 10) were confirmed by polymerase chain reaction. Susceptibility to antibiotics was determined by Kirby Bauer disc diffusion method. In-v...
Source: Environmental Toxicology and Pharmacology - December 17, 2017 Category: Environmental Health Source Type: research

Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats
Publication date: Available online 12 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Vida Bodaghi-Namileh, Mohammad Reza Sepand, Ameneh Omidi, Mehdi Aghsami, Seyed Afshin Seyednejad, Sara Kasirzadeh, Omid Sabzevari Industrial and agricultural developments in recent years have resulted in the excessive discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic toxicity. The main objective of this study was to evaluate acetyl-l-carnitine’s (ALC) protective ability against the arsenic-induced h...
Source: Environmental Toxicology and Pharmacology - December 13, 2017 Category: Environmental Health Source Type: research

Activation of human eosinophils with palladium nanoparticles (Pd NPs): importance of the actin cytoskeleton in Pd NPs-induced cellular adhesion
Publication date: Available online 11 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): P. Chhay, M. Murphy-Marion, Y. Samson, D. Girard Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it via different ways. Some studies reported an increased number of eosinophils into airways following NP exposure in vivo in rodent models of allergies...
Source: Environmental Toxicology and Pharmacology - December 12, 2017 Category: Environmental Health Source Type: research

Antifouling processes and toxicity effects of antifouling paints on marine environment. A review
Publication date: Available online 8 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Intissar Amara, Wafa Miled, Rihab Ben Slama, Neji Ladhari The production infrastructure in aquaculture invariably is a complex assortment of submerged components with cages, nets, floats and ropes. Cages are generally made from polyamide or high density polyethylene (PEHD). All of these structures serve as surfaces for biofouling. However, cage nets and supporting infrastructure offer fouling organisms thousands of square meters of multifilament netting. That's why, before immersing them in seawater, they should ...
Source: Environmental Toxicology and Pharmacology - December 9, 2017 Category: Environmental Health Source Type: research

The Selectivity of Artemisinin-Based Drugs on Human Lung Normal and Cancer Cells
Publication date: Available online 7 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xinyang Li, Shiyan Gu, Donglei Sun, Huangmei Dai, Hongyu Chen, Zunzhen Zhang Artemisinin-based drugs are documented to possess anticancer potential that is selectively effective to cancer cells. However, this selectivity is disputable in different studies and the mechanism is still unclear. To clarify this discrepancy, this study employed five assays to evaluate the cytotoxic effects of artemisinin and artesunate on normal human bronchial epithelial (HBE) cells and lung adenocarcinoma A549 cells. The results of f...
Source: Environmental Toxicology and Pharmacology - December 8, 2017 Category: Environmental Health Source Type: research

Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion
Publication date: Available online 7 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Eric Dede, Marcus J. Tindall, John W. Cherrie, Steve Hankin, Chris Collins Biological monitoring and physiologically-based pharmacokinetic (PBPK) modelling are useful complementary tools in quantifying human exposure to elements in the environment. In this work, we used PBPK models to determine the optimal time for collecting biological samples in a longitudinal study to determine if participants who consumed allotment produce had been exposed to arsenic, cadmium, chromium, nickel or lead. There are a number of P...
Source: Environmental Toxicology and Pharmacology - December 8, 2017 Category: Environmental Health Source Type: research

N-acetyl-l-cysteine ameliorates the PM2.5-induced oxidative stress by regulating SIRT-1 in rats
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Lu Yang, Zheng Duan, Xin Liu, Yadong Yuan Silent information regulator 1 (SIRT1), a class III histone deacetylase, plays a major role in combating cellular oxidative stress injury. However, the role of SIRT1 in oxidative stress induced by particulate matter remains unclear. A total of 32 healthy male Sprague–Dawley rats were divided into PM2.5, PM2.5 +NAC, filtered air (control), and filtered air+NAC (NAC control) groups. The expressions of MnSOD, SIRT1, and FOXO3a were examined at both transcriptional and protein l...
Source: Environmental Toxicology and Pharmacology - December 7, 2017 Category: Environmental Health Source Type: research

In vitro study on the joint hepatoxicity upon combined exposure of cadmium and BDE-209
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Lixin Wang, Miaomiao Zheng, Yu Gao, Jiansheng Cui Joint toxicity is an important issue during the risk assessment of environmental pollutants. Contamination of heavy metals and persistent organic pollutants (POPs) under the environmental and biological settings poses substantial health risk to humans. Although previous studies demonstrated the co-occurrence of cadmium and decabrominated diphenyl ether (BDE-209) in environmental mediums, food chains and even human body, their potentially joint toxicities remain elusive thu...
Source: Environmental Toxicology and Pharmacology - December 6, 2017 Category: Environmental Health Source Type: research

The Ascidian Embryo Teratogenicity assay in Ciona intestinalis as a new teratological screening to test the mixture effect of the co-exposure to ethanol and fluconazole.
Publication date: Available online 2 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Maria Battistoni, Silvia Mercurio, Gentile Francesco Ficetola, Francesca Cristiana Metruccio, Elena Menegola, Roberta Pennati The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8–250μM), to ethanol (Eth, 0.01–0.5%) and to their mixture (0.01% Eth+FLUCO 7.8–2...
Source: Environmental Toxicology and Pharmacology - December 3, 2017 Category: Environmental Health Source Type: research

Fabrication of capsaicin functionalized reduced graphene oxide and its effect on proliferation and differentiation of osteoblasts
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Liansuo Zhai, Lin Li, Qi Zhang Herein, we report a new simple and biological approach for the preparation of capsaicin adsorbed reduced graphene oxide (RGO), where capsaicin acts as a stabilizing and deoxygenating agent. The capsaicin that is decorated on graphene surface plays an important role as a capping agent to avoid the aggregation of graphene sheets. The capsaicin functionalized RGO stimulated the differentiation and proliferation of osteoblasts to a larger extent, which is a significant feature for the use of bio...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Evidence for estrogeno-mimetic effects of a mixture of low-dose pollutants in a model of ovariectomized mice
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Benoit Julien, Claudie Pinteur, Nathalie Vega, Emmanuel Labaronne, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni We recently hypothesized that a mixture of low-dosed dioxin, polychlorobiphenyl, phthalate and bisphenol may induce estrogeno-mimetic activities in a model of lifelong-exposed female mice. Herein, we evaluated the impact of this mixture in estrogen deficiency conditions. Based on the protective effects of estrogens against metabolic disorders, we reasoned that exposure to pollutants should a...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Antimutagenic action of the live yeast can be transmitted to the offspring of Drosophila melanogaster. A genetic study using the wing spot assay
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Emilio Pimentel, Martha P. Cruces The present study evaluates whether the protective effect of live yeast (LY) against direct and indirect mutagenic agents, persists in the offspring from individuals fed with LY. The wing-spot test in Drosophila was used; four different mates were performed: a) neither females nor males were fed with LY-enriched food (NLYxNLY); b) only females were fed (LYxNLY); c) males were fed (NLYxLY) or d) both progenitors were fed (LYxLY). Results confirm that LY strongly stimulates fecundity in fem...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prun ífera against Triton WR-1339 and hyperlipidemic diet in mice
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): A.C.V.A. Filho, P.A.S. Rodrigues, S.R. Benjamin, R.T.T. Paim, M.O. Holanda, J.Y.G. Silva, T.S. Milo, I.G.P. Vieira, M.G.R. Queiroz, M.I.F. Guedes Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and ...
Source: Environmental Toxicology and Pharmacology - November 17, 2017 Category: Environmental Health Source Type: research

Protective effects of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats
In conclusion, PAs exhibited a significant chemopreventive potential against Cd-induced testicular oxidative damage in rats, possibly through the modification of Nrf2-Keap1 signal path. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 15, 2017 Category: Environmental Health Source Type: research

Pesticides contaminated dust exposure, risk diagnosis and exposure markers in occupational and residential settings of Lahore, Pakistan
Publication date: Available online 7 November 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sidra Waheed, Crispin Halsall, Andrew J. Sweetman, Kevin C. Jones, Riffat Naseem Malik There are few studies documenting the dust loaded with pesticides as a potential non-dietary exposure source for occupational worker and populations living near agricultural farms and pesticides formulation plants. In present study we have evaluated the pesticide concentration in dust from potential sites and relevant health risk from dust ingestion. Furthermore, the effect of currently used pesticides was investigated on blood...
Source: Environmental Toxicology and Pharmacology - November 8, 2017 Category: Environmental Health Source Type: research

A Zinc Schiff base complex inhibits cancer progression both in vivo and in vitro by inducing apoptosis
In conclusion, the synthesized Zn-complex may be developed for efficacious, multidrug resistance reversal, non-toxic chemotherapeutic agents in future. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 7, 2017 Category: Environmental Health Source Type: research

Trans-generational transmission of altered phenotype resulting from flubendiamide-induced changes in apoptosis in larval imaginal discs of Drosophila melanogaster
This study further demonstrated trans-generational transmission of altered phenotype in three subsequent generations of a non-target insect model, D. melanogaster. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 7, 2017 Category: Environmental Health Source Type: research

The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning
This study can provide a scientific basis for a further understanding of the causes of health damage caused by fluoride and the improvement of targeted prevention strategies. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 6, 2017 Category: Environmental Health Source Type: research

Protective effect of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats
In conclusion, PAs exhibited a significant chemopreventive potential against Cd-induced testicular oxidative damage in rats, possibly through the modification of Nrf2-Keap1 signal path. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 4, 2017 Category: Environmental Health Source Type: research

Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos
Publication date: Available online 31 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jian Yin, Ai-Ping Wang, Wan-Fang Li, Rui Shi, Hong-Tao Jin, Jin-Feng Wei Cadmium (Cd) and lead (Pb) are naturally existing heavy metals that pose significant health risks. The present study aims to identify sensitive biomarkers for differentiating the toxicities induced by Cd and Pb and for providing clues for the early prediction of toxicity and environmental risk assessment. Indicators related to oxidative stress and inflammatory responses in zebrafish treated with Cd and Pb over time (from 24hpf to 96hpf) were...
Source: Environmental Toxicology and Pharmacology - November 1, 2017 Category: Environmental Health Source Type: research

Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators?
The objective of this study was to identify core groups of transcripts and molecular signaling pathways that respond to 17alpha-ethylinestadiol (EE2), a ubiquitous estrogenic contaminant, using transcriptome datasets generated from six independent laboratories. We sought to determine which biomarkers and gene networks were those most robust and reliably detected in multiple laboratories. Six laboratories conducted microarray analysis in pieces of the same liver from male fathead minnows exposed to ∼15ng/L EE2 for 96hours. There were common transcriptional networks identified in every dataset. These included a down-regu...
Source: Environmental Toxicology and Pharmacology - November 1, 2017 Category: Environmental Health Source Type: research

Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47
In this study, we used human neuroblastoma SH-SY5Y cells to explore the effects of PBDE-47 on autophagy and investigate the role of autophagy in PBDE-47-induced cell death. Results showed PBDE-47 could increase autophagic level (performation of cell ultrastructure with double membrane formation, MDC-positive cells raised, autophagy-related proteins LC3-II, Beclin1 and P62 increased) after cells exposed to PBDE-47. Then cells were exposed to PBDE-47 (1, 5, 10μmol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10μmol/L (9, 12, 18, 2...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

Fluoride: A Review of Pre-clinical and Clinical Studies
Publication date: Available online 24 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Divya Sharma, Aarti Singh, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma, Jaya Dwivedi Fluoride is ubiquitous in environment and profound in bones, teeth and calcified tissues of human body. Fluoride have been the topic of regular discussion and investigations. Besides its toxicity, fluoride have also been examined for its beneficial effects like prevention and treatment of tooth decay, microbial infection, inflammation, cancer, occurrence of renal stone and many more. Since last many decades, several efforts hav...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

A study of genotoxicity and oxidative stress induced by mercuric chloride in the marine polychaete Perinereis aibuhitensis
Publication date: Available online 28 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lai Jun Zhang, Yao Li, Pan Chen, Xiao Mei Li, Yong Gan Chen, Yu Yu Hang, Wei Jie Gong The marine polychaete worm Perinereis aibuhitensis was used to study the genotoxic effects of mercuric chloride by means of the comet assay and micronucleus (MN) test. P. aibuhitensis was subjected in vivo to two different concentrations of mercuric chloride (0.05mgL−1 and 0.5mgL−1) for 96h. The comet assay of coelomocytes demonstrated that TailDNA% values increased with extended exposure to or increased concentratio...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

Prediction of aquatic toxicity of benzene derivatives using molecular descriptor from atomic weighted vectors.
Publication date: Available online 13 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yoan Martínez-López, Stephen J. Barigye, Oscar Martínez-Santiago, Yovani Marrero-Ponce, James Green, Juan A. Castillo-Garit Several descriptors from atom weighted vectors are used in the prediction of aquatic toxicity of set of organic compounds of 392 benzene derivatives to the protozoo ciliate Tetrahymena pyriformis (log(IGC50)−1). These descriptors are calculated using the MD-LOVIs software and various Aggregation Operators are examined with the aim comparing their performances in pr...
Source: Environmental Toxicology and Pharmacology - October 14, 2017 Category: Environmental Health Source Type: research

T-2 toxin induces cytotoxicity and disrupts tight junction barrier in SerW3 cells
This study focused on revealing the cytotoxic effects of T-2 on Sertoli cells associated with cell junctional barriers. In the present study, SerW3 cells were exposed to T-2 toxin at 12, 120 and 1200ng/ml doses for 24 and 48hours. Cytotoxicity tests including cell viability (MTT), lactate dehydrogenase (LDH) cytotoxicity test and trypan blue exclusion assay were performed. Occludin, ZO-1, N-cadherin and β-catenin were immunolabelled, expressions of occludin and N-cadherin were determined by western blotting. SerW3 cell barrier integrity was measured by transepithelial electrical resistance (TEER). Cytotoxicity caused ...
Source: Environmental Toxicology and Pharmacology - October 13, 2017 Category: Environmental Health Source Type: research

Effects of glyphosate-based herbicide on pintado da Amaz ônia: Hematology, histological aspects, metabolic parameters and genotoxic potential
This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL−1 of Roundup Original® (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times. Elevated cholesterol and triglycerides revealed an adaptive response. Protein and lactate levels also increased during the experiment, however no changes were observed for muscle lactate. Increment of the transaminases suggests da...
Source: Environmental Toxicology and Pharmacology - October 12, 2017 Category: Environmental Health Source Type: research