Histological and ultrastructural alterations of the Italian newt (Lissotriton italicus) skin after exposure to ecologically relevant concentrations of nonylphenol ethoxylates
Publication date: Available online 7 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Elvira Brunelli Nonylphenol ethoxylates (NPEs) are well known endocrine disruptors. Widespread environmental contamination from NPEs is an issue of great concern. Despite amphibians are often exposed to such contaminants, very little attention has been dedicated to this vertebrate group. No information is available on the effects of NPEs onto the amphibian skin and only few reports have been conducted on fish. Here, histological and ultrastructural modifications of the skin have been evaluated in the Italian newt Li...
Source: Environmental Toxicology and Pharmacology - April 8, 2018 Category: Environmental Health Source Type: research

CInP/ZnS QD exposure induces developmental toxicity in rare minnow (Gobiocypris rarus) embryos
Publication date: Available online 5 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Yao Chen, Yang Yang, Fang Ou, Li Liu, Xiao-hong Liu, Zhi-Jian Wang, Li Jin We investigated the in vivo toxicity of InP/ZnS quantum dots (QDs) in Chinese rare minnow (Gobiocypris rarus) embryos. The 72 h post-fertilization (hpf) LC50 (median lethal concentration) was 1678.007 nmol/L. Rare minnows exposed to InP/ZnS QDs exhibited decreased spontaneous movement, decreased survival and hatchability rates, and an increased malformation rate. Pericardial edema, spinal curvature, bent tails and vitelline cysts were obs...
Source: Environmental Toxicology and Pharmacology - April 6, 2018 Category: Environmental Health Source Type: research

Aflatoxin B1-contaminated diet disrupts the blood –brain barrier and affects fish behavior: Involvement of neurotransmitters in brain synaptosomes
Publication date: Available online 4 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Matheus D. Baldissera, Carine F. Souza, Carla Cristina Zeppenfeld, Sharine N. Descovi, Karen Luise S. Moreira, Maria Izabel U.M. da Rocha, Marcelo L. da Veiga, Aleksandro S. da Silva, Bernardo Baldisserotto It is known that the cytotoxic effects of aflatoxin B1 (AFB1) in endothelial cells of the blood–brain barrier (BBB) are associated with behavioral dysfunction. However, the effects of a diet contaminated with AFB1 on the behavior of silver catfish remain unknown. Thus, the aim of this study was to evaluate ...
Source: Environmental Toxicology and Pharmacology - April 5, 2018 Category: Environmental Health Source Type: research

Thiamethoxam induced hepatic energy changes in silver catfish via impairment of the phosphoryl transfer network pathway: Toxicological effects on energetics homeostasis
Publication date: Available online 3 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Matheus D. Baldissera, Carine F. Souza, Jaqueline I. Golombieski, Débora Seben, Letícia R. Sippert, Joseânia Salbego, Renato Zanella, Bernardo Baldisserotto Precise coupling of spatially separated intracellular adenosine triphosphate (ATP)-producing and ATP-consuming processes exerts a pivotal role in bioenergetic homeostasis of living organisms, and the phosphotransfer network pathway, catalyzed by adenylate kinase (AK) and pyruvate kinase (PK), is fundamental in cellular and tissue energetic ho...
Source: Environmental Toxicology and Pharmacology - April 3, 2018 Category: Environmental Health Source Type: research

Acute toxicity and associated mechanisms of four strobilurins in algae
This study investigated the acute toxicity of Kresoxim-methy (KRE), Pyraclostrobin (PYR), Trifloxystrobin (TRI) and Picoxystrobin (PIC) on two algae and their toxicity mechanisms. Four strobilurins showed lower toxic effects on Chlorella pyrenoidsa but higher on Chlorella vulgaris. bc1 complex activities in C. vulgaris were significantly inhibited by all strobilurins, suggesting bc 1 complex might be the target of strobilurin toxicity in algae. Moreover, SOD, CAT and POD activities were significantly up-regulated by all doses of KRE, PYR and PIC. In contrast, low concentrations of TRI stimulated SOD and POD activities but ...
Source: Environmental Toxicology and Pharmacology - April 3, 2018 Category: Environmental Health Source Type: research

Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP)
Publication date: Available online 30 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Elvira Mennillo, Åse Krøkje, Carlo Pretti, Valentina Meucci, Augustine Arukwe Pharmaceuticals such as racemate ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are highly detectable non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment and therefore are designated as one of the most emerging groups of pollutants that can affect environmental and human health. The potential impact of these pharmaceuticals was assessed for the first time in vitro using a rat hepatocellul...
Source: Environmental Toxicology and Pharmacology - March 31, 2018 Category: Environmental Health Source Type: research

High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38/JNK-mediated epithelial apoptosis
Publication date: Available online 30 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Chenming Xu, Qiwen Shi, Leifang Zhang, Hang Zhao Inhalation of fine particulate matter (PM2.5) is asscoiated with lung injury. High molecular weight hyaluronan (HMW-HA) is an essential constituent of extracellular matrix (ECM), exhibiting anti-oxidative and anti-inflammatory properties when administered by injection, inhalation, nebulization or gene delivery of HA synthases. The aim of the present study is to determine whether HMW-HA alleviates PM2.5-induced acute lung injury (ALI) and investigate the underlying me...
Source: Environmental Toxicology and Pharmacology - March 31, 2018 Category: Environmental Health Source Type: research

Regional variation in percutaneous absorption in the tree frog Litoria caerulea
This study investigated the in vitro percutaneous absorption of three model chemicals - benzoic acid, caffeine, and ibuprofen - through dorsal and ventral skin of the tree frog Litoria caerulea. Flux was significantly higher through the ventral skin for all chemicals. Relative lipophilicity affected flux differently in different skin regions. These differences are likely due to significantly thicker dorsal skin increasing absorption path length, and also possibly owing to lipoid secretions on the dorsum providing an additional diffusional barrier. This knowledge can advise risk mitigation of xenobiotics in agricultural and...
Source: Environmental Toxicology and Pharmacology - March 29, 2018 Category: Environmental Health Source Type: research

Crocin Reverses Unilateral Renal Ischemia Reperfusion Injury-Induced Augmentation of Oxidative Stress and Toll like receptor-4 Activity
In conclusion, crocin induced restoration of normal kidney functions is mediated through multiple mechanisms including mainly attenuation of oxidative stress and inflammation via down-regulation of renal TLR4 and IL6 expression. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 28, 2018 Category: Environmental Health Source Type: research

Genotoxic effect of Lippia alba (Mill.) N. E. Brown essential oil on fish (Oreochromis niloticus) and mammal (Mus musculus)
The objective of this study was to evaluate the genotoxic effect of Lippia alba essential oil in fish and mammals. The oil was extracted by hydrodistillation with a Clevenger apparatus and analyzed by gas chromatography coupled to mass spectrometry (GC-MS), where the compounds linalool, eucalyptol, γ-muurolene, and caryophyllene were identified as the most abundant compounds. Lippia alba essential oil showed inhibitory activity on LPS-stimulated Nitric Oxide (NO) production (77% at 20 µg.mL-1) in RAW 264.7 macrophages without influence cellular viability. Genotoxic action was observed by micronucleus and come...
Source: Environmental Toxicology and Pharmacology - March 26, 2018 Category: Environmental Health Source Type: research

IGFBP-3 plays an important role in senescence as an aging marker
In conclusion, IGFBP-3 up-regulates PI3K/Akt/mTOR signaling pathway and down-regulates autophagy during cell aging. These results suggest that IGFBP-3 could play a key role in aging study as an important aging marker. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Urine Cotinine Level with Smoking History Predicts a Risk of Coronary Artery Calcification
Publication date: Available online 21 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Hui-Jin Yu, Sangeun Lim, Min-Kyeong Kim, Seungjun Lee, Min-Jung Kwon, Hyosoon Park, Hee-Yeon Woo We investigated whether urine cotinine level, alone or combined with smoking status and cumulative smoking amount, could predict coronary calcium (CAC) score increase over time. The study population included 10,980 subjects. We analysed an association between CAC score increase over time and single or combined smoking-related factors. Urine cotinine level of ≥100 ng/mL, current or ex-smokers, and cumulative smoking...
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Toxicological effects of cadmium and lead on two freshwater diatoms
In this study, the cell growth, chlorophyll a content and superoxide dismutase activity in Halamphora veneta (Kützing) Levkov and Surirella crumena Brébisson exposed to cadmium and lead, were investigated. Furthermore, in order to explore the potential function of H. veneta on environmental monitoring and environmental remediation, expression of two genes (psbA, psaB) and morphological analysis of H. veneta were carried out. The cells growth of H. veneta and S. crumena were generally inhibited with cadmium and lead exposure during 96 h, while cells density of H. veneta was significantly increased under the lo...
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Nicorandil alleviates ovalbumin-induced airway inflammation in a mouse model of asthma
In conclusion, our results proposed that nicorandil is equipotent to dexamethasone in ameliorating allergic asthma by restoring oxidant/antioxidant balance and reducing inflammation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 20, 2018 Category: Environmental Health Source Type: research

SET Promotes H2AK9 Acetylation by Suppressing HDAC1 in Trichloroethylene-induced Hepatic Cytotoxicity
In this study, we found a total of 136 histone acetylation sites involved in TCE-induced hepatic cytotoxicity with the technique of Triton-acid-urea polyacrylamide gel electrophoresis (TAU-PAGE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Importantly, 17 histone acetylation sites were revealed to be mediated by SET in TCE-induced cytotoxicity. The acetylation of histone H2AK9 (H2AK9ac) was further validated by Western-blot analysis. The data showed that TCE treatment increased the acetylation of H2AK9 in hepatic L-02 cell and decreased the one in SET-knockdown L-02 cells. Besides, levels of the ...
Source: Environmental Toxicology and Pharmacology - March 19, 2018 Category: Environmental Health Source Type: research

Urinary phthalate metabolite concentrations in girls with premature thelarche
Publication date: Available online 17 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Erdem Durmaz, Pinar Erkekoglu, Ali Asci, Sema Akçurin, İffet Bircan, Belma Kocer-Gumusel In girls, breast development before eight years of age is called “premature thelarche (PT)”. There are few studies in literature that show the interaction between PT and phthalate exposure. The aim of this study was to determine the urinary levels of di-(2-ethylhexyl) phthalate (DEHP) metabolites and other phthalate metabolites in girls with PT. PT group consisted of 29 newly diagnosed subjects. Control grou...
Source: Environmental Toxicology and Pharmacology - March 19, 2018 Category: Environmental Health Source Type: research

Effects of mancozeb, metalaxyl and tebuconazole on steroid production by bovine luteal cells in vitro
Publication date: Available online 13 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Nurgul Atmaca, Sevket Arikan, Dinc Essiz, Hakan Kalender, Ozkan Simsek, Fatih Sultan Bilmen, Ruhi Kabakci Mancozeb, metalaxyl and tebucanazole are widely used pesticides in agriculture and industry to treat plant pathogenic fungi. Livestock may be exposed to such substances by consuming contaminated plants. The present study was designed to evaluate the effects of these three fungicides on bovine luteal cell steroidogenesis. Luteal slices from mid-cycle corpus luteum were dissociated into single cell suspension in ...
Source: Environmental Toxicology and Pharmacology - March 14, 2018 Category: Environmental Health Source Type: research

Sensitivity of Arbor Acres broilers and Chemoprevention of Aflatoxin B1-induced liver injury by Curcumin, a natural potent inducer of Phase-II enzymes and Nrf2
In this study, we scrutinized the effects of curcumin and AFB1 supplemented diet alone or in combination on phase-ӀӀ enzymes. Histopathological examination showed that after 28 days, AFB1 (5.0 mg/kg diet) induced liver injury in broilers, but curcumin supplementation partially ameliorated liver injury in a dose-dependent manner. RT-PCR data revealed that AFB1 significantly (p < 0.01) down-regulated Nrf2 and its downstream genes mRNA expression level. Moreover, Western blot analysis showed that Nrf2, GSTM2, and GSTA3 protein expression level was markedly (p < 0.01) reduced in AFB1-fed group. However,...
Source: Environmental Toxicology and Pharmacology - March 12, 2018 Category: Environmental Health Source Type: research

Effects of low concentrations of ibuprofen on freshwater fish Rhamdia quelen
This study evaluated the effects of ibuprofen in environmental concentrations (0, 0.1, 1 and 10 μg/L) on the freshwaterspecies Rhamdia quelen exposed for 14 days. In the posterior kidney, ibuprofen increased glutathione-S-transferase activity in all groups exposed. Furthermore, increased glutathione peroxidase activity and the levels of reduced glutathione in the group exposed to 10 μg/L. Ibuprofen decreased the carbonic anhydrase activity in the posterior kidney in all exposed groups, and increased the activity in the gills in group exposed to 0.1 μg/L. The levels of plasma magnesium increased in groups exp...
Source: Environmental Toxicology and Pharmacology - March 11, 2018 Category: Environmental Health Source Type: research

Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn2+
In conclusion, chlorothalonil at low (sublethal) micromolar concentrations is cytotoxic to mammalian cells under oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

Are we closer to the vision? A proposed framework for incorporating omics into environmental assessments
Publication date: Available online 8 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Christopher J. Martyniuk Environmental science has benefited a great deal from omics-based technologies. High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals. While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in “real-world” exposure scenarios. Clarity in the interpretation of these data limits their...
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury
Publication date: Available online 8 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sh Mohammadi, M Gholamin, M. Mohammadi, A. Mansouri, R. Mahmoodian, S. Attari, S.M. Kebriaei, B. Zibaei, M. Roshanaei, F. Daneshvar, M. Khandehro, M.A. Khodadadegan, A. Delshad, F. Mohammadzadeh, Mostafa Peyvandi, Majid Ghayour-Mobarhan, Shima Tavallaie, Samaneh Boroumand-Noughabi, Gordon A.A. Ferns In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expr...
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

TOXICOLOGICAL EFFECT OF Al2O3 NANOPARTICLES ON HISTOARCHITECTURE OF THE FRESHWATER FISH OREOCHROMIS MOSSAMBICUS
Publication date: Available online 5 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Murali M., Athif P., Suganthi P., Sadiq Bukhari A., Syed Mohamed H.E., Basu H., Singhal R.K. In the present study, freshwater fish Oreochromis mossambicus were exposed to sub lethal concentrations (120, 150 and 180ppm) of Aluminium oxide nanoparticles (Al2O3 NPs) for 96 hours. Histological abnormalities were not observed in the organs of control fishes whereas severe damages and extensive architectural loss was found in the brain, gill, intestine, kidney and muscle tissues of treated fishes with more pronounced effe...
Source: Environmental Toxicology and Pharmacology - March 6, 2018 Category: Environmental Health Source Type: research

Non-metric multidimensional scaling and human risks of heavy metal concentrations in wild marine organisms from the Maowei Sea, the Beibu Gulf, South China Sea
Publication date: Available online 5 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Gu Yang-Guang, Huang Hong-Hui, Liu Yong, Gong Xiu-Yu, Liao Xiu-Li We investigated heavy metal concentrations in wild marine organisms from Maowei Sea, a significant gulf of low-latitude developing regions of the Beibu Gulf, South China Sea. Twenty species, comprising fish, cephalopods, and crustaceans were collected and analyzed for heavy metals. Heavy metal levels (mg/kg, wet weight) in the aquatic organism samples were: 0.003–1.800 for Cd, 0.02–0.14 for Pb, 0.10–0.63 for Cr, 0.20–77.50 for ...
Source: Environmental Toxicology and Pharmacology - March 6, 2018 Category: Environmental Health Source Type: research

Effects of topical exposure to a mixture of chlorpyrifos, cypermethrin and captan on the hematological and immunological systems in male Wistar rats
Publication date: Available online 2 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Soraya Aroonvilairat, Chanthana Tangjarukij, Thiwaree Sornprachum, Papada Chaisuriya, Taweeratana Siwadune, Kavi Ratanabanangkoon Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three groups of 10 rats were dermally exposed to three different doses (high,...
Source: Environmental Toxicology and Pharmacology - March 3, 2018 Category: Environmental Health Source Type: research

Simultaneous Effects of Endocrine Disruptor Bisphenol A and Flavonoid Fisetin on Progesterone Production by Granulosa Cells
Publication date: Available online 2 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Alzbeta Bujnakova Mlynarcikova, Sona Scsukova In the present study, we aimed to examine effects of different concentrations of the endocrine disruptor Bisphenol A (BPA; 1 nM, 1 µM, 100 µM) and the flavonoid fisetin (1, 10, 25, 50 µM), individually and in combinations, on steroidogenic function of porcine ovarian granulosa cells (GCs) represented by progesterone production. We confirmed that BPA inhibited progesterone production by GCs at the highest concentration. Fisetin reduced gonadotropin-stimu...
Source: Environmental Toxicology and Pharmacology - March 3, 2018 Category: Environmental Health Source Type: research

Cadmium treatment induces echinocytosis, DNA damage, inflammation, and apoptosis in cardiac tissue of albino Wistar rats
This study was designed to investigate the effects of Cd intake on erythrocytes and cardiac tissue in male albino Wistar rats. We treated male albino Wistar rats with cadmium chloride (CdCl2) by intra-gastric administration for 30 days and examined Cd burden and changes in blood constituents and antioxidant status of blood and cardiac tissue. We also studied the structural alterations in the erthrocytes, elemental changes and Cd burden in cardiac tissue using scanning electron microscope (SEM/EDX). Inflammation and apoptosis were analysed in the cardiac tissue by polymerase chain reaction (PCR), western blotting, and DNA f...
Source: Environmental Toxicology and Pharmacology - February 28, 2018 Category: Environmental Health Source Type: research

Toxicity assessment of sediments from the Liaohe River Protected Area (China) under the influence of ammonia nitrogen, heavy metals and organic contaminants
Publication date: Available online 27 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Xin Ke, Qinghua Bao, Yifang Qi, Xiaoyan Huang, Haijun Zhang The aim of this study was to evaluate the toxicity of ammonia nitrogen, metals and organic contaminants in sediment collected from the Liaohe River Protected Areas. The TIE was applied to 16 samples. The zeolite, resin, and coconut charcoal were used to mask toxicity of the three kinds of pollutants, respectively. Then quantitative analyses together with a battery of bioassays were performed to evaluate toxic effects. At last, the spiking tests were use...
Source: Environmental Toxicology and Pharmacology - February 28, 2018 Category: Environmental Health Source Type: research

Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway
In conclusion, ALA possess protective effects against CPF-induced liver injury through attenuation of apoptosis and oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 24, 2018 Category: Environmental Health Source Type: research

Cytotoxic activity of fucoxanthin, alone and in combination with the cancer drugs imatinib and doxorubicin, in CML cell lines
This study unveiled in vitro cytotoxicity of Fx by inhibition of cell proliferation in both cell lines. Further studies are needed to elucidate the signal transduction pathways and molecular targets involved in that effect. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 17, 2018 Category: Environmental Health Source Type: research

Role of voltage-gated calcium channels on striatal dopamine release induced by inorganic mercury in freely moving rats
Publication date: Available online 12 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Lilian R. Ferreira Faro, Miguel Alfonso, Vania Moraes Ferreira, Rafael Durán The possible role of voltage-sensitive calcium channels (VSCC) activation on the HgCl2-induced dopamine release was investigated using selective VSCC blockers and the dopamine levels were measured by HPLC from samples obtained by in vivo brain microdialysis. Infusion of HgCl2 in nicardipine (10 or 100 μM) or flunaricine (10 μM) pretreated animals had no significant effect on dopamine release induced by HgCl2. Pretreatme...
Source: Environmental Toxicology and Pharmacology - February 13, 2018 Category: Environmental Health Source Type: research

Sperm DNA fragmentation: An early and reliable marker of air pollution
This study compared the seminal parameters and sperm DFI in men living in areas with different levels of air pollution. Results demonstrate that both steel plants workers and patients living in a high polluted area show a mean percentage of sperm DNA fragmentation above 30%, highlighting a clear sperm damage. In this work, two different techniques were used to measure sperm DNA damage in patients’ groups, finding in both cases a high sperm DFI in patients living in polluted areas. We candidate sperm DNA fragmentation as a valuable early marker of the presence and harmful effects of pollution. We suggest that sperm DN...
Source: Environmental Toxicology and Pharmacology - February 13, 2018 Category: Environmental Health Source Type: research

The toxicology of indium oxide
Publication date: March 2018 Source:Environmental Toxicology and Pharmacology, Volume 58 Author(s): Ernst M. Bomhard Indium oxide (In2O3) is a technologically important semiconductor essentially used, doped with tin oxide, to form indium tin oxide (ITO). It is poorly soluble in all so far tested physiologic media. After repeated inhalation, In2O3 particles accumulate in the lungs. Their mobilization can cause significant systemic exposure over long periods of time. An increasing number of cases of severe lung effects (characterized by pulmonary alveolar proteinosis, emphysema and/or interstitial fibrosis) in workers of th...
Source: Environmental Toxicology and Pharmacology - February 13, 2018 Category: Environmental Health Source Type: research

Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: metabolomics and gene expression study
Publication date: Available online 10 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Rachid Jellali, Perrine Zeller, Françoise Gilard, Audrey Legendre, Marie José Fleury, Sébastien Jacques, Guillaume Tcherkez, Eric Leclerc Dichlorodiphenyl-trichloroethane (DDT) and permethrin (PMT) are amongst most prevalent pesticides in the environment. Although their toxicity has been extensively studied, molecular mechanisms and metabolic effects remain unclear, including in liver where their detoxification occurs. Here, we used metabolomics, coupled to RT-qPCR analysis, to examine effec...
Source: Environmental Toxicology and Pharmacology - February 11, 2018 Category: Environmental Health Source Type: research

Evaluation of caffeine effects on biochemical and genotoxic biomarkers in the neotropical freshwater teleost Prochilodus lineatus
Publication date: March 2018 Source:Environmental Toxicology and Pharmacology, Volume 58 Author(s): Thais G. Santos-Silva, Cassiana C. Montagner, Claudia B.R. Martinez Caffeine is often found in aquatic environments, leading to concerns regarding its adverse consequences for aquatic biota. Biochemical and genotoxic biomarkers were analysed in juveniles of Prochilodus lineatus to evaluate the effects of caffeine. Fish were exposed to caffeine (0.3, 3 and 30 μg L−1) for either 24 h or 168 h. Longer exposure to caffeine resulted in a significant reduction in the activity of the phase I biotransformation enzy...
Source: Environmental Toxicology and Pharmacology - February 11, 2018 Category: Environmental Health Source Type: research

Multiple pharmacological activities of Caesalpinia crista against aluminium-induced neurodegeneration in rats: Relevance for Alzheimer ’s disease
Publication date: March 2018 Source:Environmental Toxicology and Pharmacology, Volume 58 Author(s): Sunil K. Ravi, Balenahalli Narasingappa Ramesh, Ravi Mundugaru, Bruno Vincent Alzheimer’s disease (AD) is the most common form of dementia and mainly affects cognitive function of the aged populations. Aluminium, a neurotoxic metal, has been suggested as a contributing factor of AD. Caesalpinia crista is a medicinal plant known for its anti-microbial, anti-inflammatory and anti-oxidant properties. The present study was conducted in order to evaluate the neuroprotective effects of methanolic extracts of C. crista (MECC...
Source: Environmental Toxicology and Pharmacology - February 4, 2018 Category: Environmental Health Source Type: research

Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
Publication date: March 2018 Source:Environmental Toxicology and Pharmacology, Volume 58 Author(s): Victoria S. Parker, Edwin J. Squirewell, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. Duffel Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that are associated with varied adverse health effects. Lower chlorinated PCBs are prevalent in indoor and outdoor air and can be metabolized to their hydroxylated derivatives (OH-PCBs) followed by sulfation to form PCB sulfates. Sulfation is also a means of signal termination for steroid hormones. The human estrogen sulfotransferase (SULT1E1) and alc...
Source: Environmental Toxicology and Pharmacology - February 4, 2018 Category: Environmental Health Source Type: research

DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard
Publication date: Available online 2 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Yunes Panahi, Amir Fattahi, Hamid Reza Nejabati, Sina Abroon, Zeinab Latifi, Abolfazl Akbarzadeh, Tohid Ghasemnejad Sulfur mustard (SM) is an alkylating agent that causes severe damages to the skin, eyes, and the respiratory system. DNA alkylation is one of the most critical lesions that could lead to monoadducts and cross-links, as well as DNA strand breaks. In response to these adducts, cells initiate a series of reactions to recruit specific DNA repair pathways. The main DNA repair pathways in human cells, whi...
Source: Environmental Toxicology and Pharmacology - February 3, 2018 Category: Environmental Health Source Type: research

Methodology for Exposing Avian Embryos to Quantified Levels of Airborne Aromatic Compounds Associated with Crude Oil Spills
Publication date: Available online 10 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Benjamin Dubansky, Guido Verbeck, Phillip Mach, Warren Burggren Oil spills on birds and other organisms have focused primarily on direct effects of oil exposure through ingestion or direct body fouling. Little is known of indirect effects of airborne volatiles from spilled oil, especially on vulnerable developing embryos within the bird egg. Here a technique is described for exposing bird embryos in the egg to quantifiable amounts of airborne volatile toxicants from Deepwater Horizon crude oil. A novel membrane i...
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial
Conclusion Z. multiflora reduces inflammatory cells and oxidant biomarkers, while increase antioxidant biomarkers and improved PFT tests in SM exposed patients in a two moth treatment period. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

Radiofrequency electromagnetic radiation exposure effects on amygdala morphology, place preference behavior and brain caspase-3 activity in rats
Publication date: Available online 31 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sareesh Naduvil Narayanan, Nirupam Mohapatra, Pamala John, Nalini K., Raju Suresh Kumar, Satheesha B. Nayak, P. Gopalakrishna Bhat The purpose of the study was to evaluate the changes in amygdala morphology and emotional behaviors, upon exposure to chronic RFEMR in adolescent rats. Four weeks old male albino Wistar rats were exposed to 900 MHz (power density:146.60 μW/cm2) from a mobile phone in silent-mode for 28 days. Amygdala morphology was studied using cresyl violet, TUNEL and Golgi-Cox staining. Plac...
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

Multiple pharmacological activities of Caesalpinia crista against aluminium- induced neurodegeneration in rats: Relevance for Alzheimer ’s disease
Publication date: Available online 31 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sunil K. Ravi, Ramesh B. Narasingappa, Ravi Mundugaru, Bruno Vincent Alzheimer’s disease (AD) is the most common form of dementia and mainly affects cognitive function of the aged populations. Aluminium, a neurotoxic metal, has been suggested as a contributing factor of AD. Caesalpinia crista is a medicinal plant known for its anti-microbial, anti-inflammatory and anti-oxidant properties. The present study was conducted in order to evaluate the neuroprotective effects of methanolic extracts of C. crista (ME...
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

Hepatoprotective effects of capping protein gelsolin against hyperoxia-induced hepatotoxicity, oxidative stress and DNA damage in neonatal rats
Publication date: Available online 31 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sedat Per, Mehmet Kose, Ahmet Ozdemir, Dilek Pandir Tissues and organs get exposed to high oxygen (O2) supply in hyperoxia conditions. The goal of this research was to investigate the protective effect of actin binding protein gelsolin on hyperoxia-induced hepatotoxicity through histopathology and measurement of oxidative stress parameters and DNA damage in a neonatal Wistar albino rats. The pups were randomly separated to four equal groups such as: normoxia control group (NC), normoxia plus gelsolin group (NG, 1...
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways
Publication date: Available online 1 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Marwa M.M. Refaie, Maram El-Hussieny, Nagwa M. Zenhom Cadmium (Cd) intoxication in human occurs through inhalation of cigarette smoke and ingestion of contaminated water and food. We investigated the role of nebivolol (NEB) in Cd induced hepatotoxicity. In our study; NEB was given as (10mg/kg/d) orally to rats for 6 weeks, in the presence or absence of hepatotoxicity induced by oral administration of Cd (7mg/kg/d) for 6 weeks. Levels of serum liver enzyme biomarkers; alanine transaminase (ALT), aspartate transami...
Source: Environmental Toxicology and Pharmacology - February 2, 2018 Category: Environmental Health Source Type: research

Changes in intermediate metabolism and oxidative balance parameters in sexually matured three-barbeled catfishes exposed to herbicides from rice crops (Roundup ®, Primoleo® and Facet®)
This study analyzed the effect of different concentrations of herbicides (Facet®, Primoleo®, and Roundup®) on metabolism and oxidative balance (superoxide dismutase and catalase activity, lipid peroxidation) in the gills, liver, kidneys, and tail muscle of adult catfish. All herbicides caused protein depletion in gills, increased glycogen and triacylglycerol consumption in the liver, and changes in muscle glycogen. Roundup® and Primoleo® stimulated lipid deposition in the liver, while Roundup® and Facet® stimulated lipid consumption in gills. In kidneys, protein content increased after Roundup&r...
Source: Environmental Toxicology and Pharmacology - January 9, 2018 Category: Environmental Health Source Type: research

Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model
Publication date: Available online 5 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sen Zhang, Huan Chen, An Wang, Yong Liu, Hongwei Hou, Qingyuan Hu To investigate the genotoxic characteristics of typical toxicants in particle phase of cigarette smoke, including B[a]P, nicotine, tar, NNN and NNK. The in vitro γH2AX assay was used to detect the DNA double-strand breaks (DSBs) in A549 cells using high content screening (HCS). The results showed all toxicants had a dose/time-dependent effects on induction of γH2AX except for NNN and NNK. Based on dose-response of γH2AX and Hill mo...
Source: Environmental Toxicology and Pharmacology - January 6, 2018 Category: Environmental Health Source Type: research

Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach
Publication date: Available online 5 January 2018 Source:Environmental Toxicology and Pharmacology Author(s): Wenmin Xing, Wenyan Gao, Huili Su, Sanying Wang, Jing Zhang, Genxiang Mao, Jing Yan Senescence is a complex multiple factor proces, which is still poorly understood. The purpose of this study was to find the proteome of cultured human fetal lung diploid fibroblasts (2BS) of different population doubling (PD), as well as the altered proteome induced by salidroside (SAL) in 2BS cells. Proteins were identified by two-dimensional electrophoresis (2-DE) combining matrix-assisted laser desorption/ionization-time and fli...
Source: Environmental Toxicology and Pharmacology - January 6, 2018 Category: Environmental Health Source Type: research

Long-term high air pollution exposure induced metabolic adaptations in traffic policemen
Conclusion Long-term high air pollution exposure may lead to metabolism adaptation and it is likely involved in the development of cardiovascular disease and diabetes mellitus. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 6, 2018 Category: Environmental Health Source Type: research

Celecoxib, a Cyclooxygenase-2 Inhibitor, offers Chemoprevention against Reproductive and Neurobehavioural Abnormalities Induced by Atrazine in Male Wistar Rats
Publication date: Available online 30 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): O.E. Kale, T.O. Oyesola, F.S. Raji The cyclooxygenase-2/prostanoid pathway (COX-2) serves as a potential therapeutic target in various pathological conditions. Thus, the modulatory effect of celecoxib (CXB), a COX-2 inhibitor, in atrazine-induced toxicity was investigated. Five groups (n = 6 rats per group) of adult male Wistar rats received corn oil, (10 ml/kg), atrazine (ATZ, 300 mg/kg) and CXB (5.7 mg/kg) respectively and their combinations via the oral route. Results obtained showed reduced (p &a...
Source: Environmental Toxicology and Pharmacology - December 30, 2017 Category: Environmental Health Source Type: research

Inhibition of copper-zinc superoxide dismutase activity by selected environmental xenobiotics
Publication date: Available online 29 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Łukasz Lewandowski, Marta Kepinska, Halina Milnerowicz The function of Cu,Zn-SOD is to dismutate superoxide into hydrogen peroxide and oxygen. This task is fulfilled due to structural nuances of the enzyme. Many environmental xenobiotics have been proved to inhibit Cu,Zn-SOD. Those compounds could be found not only in industrial sewage, cigarettes and various chemical agents − some of them are used as drugs, drug production substrates, or are the product of drug biotransformation. Cu,Zn-SOD exposition to ...
Source: Environmental Toxicology and Pharmacology - December 29, 2017 Category: Environmental Health Source Type: research