Effects of the chronic exposure to cerium dioxide nanoparticles in Oncorhynchus mykiss: assessment of oxidative stress, neurotoxicity and histological alterations
Publication date: Available online 23 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): A.T. Correia, D. Rebelo, J Marques, B. NunesAbstractCerium dioxide nanoparticles (CeO2-NPs) have a variety of uses, especially in the production of solar panels, oxygen pumps, gas sensors, computer chips and catalytic converters. Despite their worldwide use, the few published studies demonstrate that metallic nanoparticles, in general, are still not properly characterized in terms of their potencial ecotoxicological effects. CeO2-NPs, in particular, have demonstrated extreme antioxidant activity, but their in vivo...
Source: Environmental Toxicology and Pharmacology - February 23, 2019 Category: Environmental Health Source Type: research

The neuroprotective effect of hyperoxygenate hydrogen-rich saline on CO-induced brain injury in rats
This study was designed to investigate the neuroprotective effect of hyperoxygenate hydrogen-rich saline (HOHS) against brain injury induced by carbon monoxide (CO) poisoning in rats. A rat model of CO poisoning was established by administering CO via intraperitoneal injection to male Sprague-Dawley rats. Forty-eight adult male rats were randomly divided into the following groups: normal control group (NG), CO poisoning group (CO), HOS treatment group (hyperoxygenated solution, HOS) and HOHS treatment group (HOHS). After CO poisoning, the carboxyhemoglobin (COHb) contents in the blood of rats in all the CO poisoning groups...
Source: Environmental Toxicology and Pharmacology - February 20, 2019 Category: Environmental Health Source Type: research

Identification and characterization of novel bacterial polyaromatic hydrocarbon-degrading enzymes as potential tools for cleaning up hydrocarbon pollutants from different environmental sources
Publication date: Available online 20 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Heba A.R. Abdelhaleem, Haggag S. Zein, Ahmed Z. Abdel Azeiz, Ahmed N. Sharaf, Abdelhadi A. AbdelhadiAbstractPolycyclic aromatic hydrocarbons (PAHs) are recalcitrant hazardous environmental contaminants. Various strategies, including chemical and physical like oxidation, fixation, leaching, and electrokinetic or biological-based techniques are used for remediation of polluted sites. Bioremediation of PAHs, via PAH-degrading endophytic and rhizospheric microbes, represent a time-/cost-effective way for ecorestoratio...
Source: Environmental Toxicology and Pharmacology - February 20, 2019 Category: Environmental Health Source Type: research

Differential toxicity of water versus gavage exposure to trichloroethylene in rats
Publication date: Available online 16 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Angela R Stermer, David Klein, Shelby K. Wilson, Chimeddulam Dalaijamts, Cathy Yue Bai, Susan J. Hall, Samantha Madnick, Enrica Bianchi, Weihsueh A. Chiu, Kim BoekelheideAbstractTrichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. T...
Source: Environmental Toxicology and Pharmacology - February 17, 2019 Category: Environmental Health Source Type: research

Cadmium: toxic effects on placental and embryonic development
In this report, we review published data linking pregnancy exposure to cadmium to placenta and fetal growth and development toxicity and summarize the related mechanisms. An understanding of how cadmium exposure contributes to placental and fetal development is necessary for the development of prevention and control strategies for fetal development defects caused by cadmium exposure during pregnancy. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 16, 2019 Category: Environmental Health Source Type: research

Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice
This study, for the first time, obtained and reports three novel forms (I-III) of cedrol polymorphs. The three forms of cedrol were recrystallized from seven organic solvents by slow cooling or volatilization and identified by thermal analysis, fourier transform infrared spectroscopy, scanning electron microscopy and powder X-ray diffraction analysis. Form I originated from acetone and cyclohexane. Form II was obtained from ethanol, ethyl acetate, acetonitrile and n-hexane. Form III was recrystallized from methanol. The anti-inflammatory and analgesic activities of the three crystalline forms were evaluated by acetic acid ...
Source: Environmental Toxicology and Pharmacology - February 14, 2019 Category: Environmental Health Source Type: research

The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill
Publication date: Available online 11 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Grzegorz PrzydatekAbstractOne of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must be controlled regularly. One of the methods of determining the toxicity of substances contained in landfill leachate is the use of biological tests, based −&thin...
Source: Environmental Toxicology and Pharmacology - February 12, 2019 Category: Environmental Health Source Type: research

CIRCULATING miRNA-126, -145 AND -155 LEVELS IN MEXICAN WOMEN EXPOSED TO INORGANIC ARSENIC VIA DRINKING WATER
Publication date: Available online 7 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Sergio Zarazúa, Leticia Carrizales-Yáñez, Iván N. Pérez-MaldonadoAbstractThe aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 µg/g creatinine was found after urine samples wer...
Source: Environmental Toxicology and Pharmacology - February 8, 2019 Category: Environmental Health Source Type: research

Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure
Publication date: Available online 6 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Pavla Sehonova, Nina Tokanova, Nikola Hodkovicova, Hana Kocour Kroupova, Jitka Tumova, Jana Blahova, Petr Marsalek, Lucie Plhalova, Veronika Doubkova, Radka Dobsikova, Petr Chloupek, Dolezelova Petra, Faldyna Martin, Zdenka Svobodova, Faggio CaterinaAbstractThe purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrat...
Source: Environmental Toxicology and Pharmacology - February 7, 2019 Category: Environmental Health Source Type: research

Toxic effects of nitrogenous compounds (ammonia, nitrite, and nitrate) on acute toxicity and antioxidant responses of juvenile olive flounder, Paralichthys olivaceus
Publication date: Available online 2 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Jun-Hwan Kim, Yue Jai Kang, Kwang Il Kim, Jong-Hyun KimAbstractJuvenile Paralichthys olivaceus (mean length 7.29 ± 0.59 cm, mean weight 2.41 ± 0.35 g) were exposed to several concentrations of ammonia (0, 6.25, 12.5, 25, 50, and 100 mg/L), nitrite (0, 50, 100, 200, 400, and 800 mg/L), and nitrate (0, 250, 500, 1000, 2000, and 4000 mg/L) for 96 h in 20-L glass tanks. Lethal concentration 50% (LC50) was determined after removing and c...
Source: Environmental Toxicology and Pharmacology - February 3, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: February 2019Source: Environmental Toxicology and Pharmacology, Volume 66Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 1, 2019 Category: Environmental Health Source Type: research

Cypermethrin-based formulation Barrage® induces histological changes in gills of the Pantanal endemic shrimp Macrobrachium pantanalense
This study shows the high sensitivity of the shrimp M. pantanalense to the pesticide Barrage® highlighting the importance of monitoring agrochemicals residues in the Pantanal region (Brazil) and conduct risk evaluation studies to prevent deleterious effects on the aquatic communities of Pantanal. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 31, 2019 Category: Environmental Health Source Type: research

Antioxidant imbalance and genotoxicity detected in fish induced by titanium dioxide nanoparticles (NpTiO2) and inorganic lead (PbII)
This study evaluated the effects of the associated exposure to both types of contaminant, i.e., lead (a known genotoxic metal) and NpTiO2, in a freshwater fish (Astyanax serratus) through intraperitoneal injection for an acute assay of 96 h. The effects of this exposure were evaluated using the comet assay, DNA diffusion assay and piscine micronucleus test, as well as the quantification of antioxidant enzymes (SOD, CAT, and GST) and metallothioneins. Our findings indicate that co-exposure of PbII with NpTiO2 can provoke ROS imbalances, leading to DNA damage in the blood and liver tissue of A. serratus, as well as mo...
Source: Environmental Toxicology and Pharmacology - January 29, 2019 Category: Environmental Health Source Type: research

Microplastics occurrence in the tyrrhenian waters and in the gastrointestinal tract of two congener species of seabreams
Publication date: Available online 25 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): S. Savoca, G. Capillo, M. Mancuso, T. Bottari, R. Crupi, C. Branca, V. Romano, C. Faggio, G. D’Angelo, N SpanòAbstractIn this work it is reported for the first time the characterization of microplastics from sea water samples and in two congener species of seabreams: Pagellus erythrinus and P. bogaraveo, Mediterranean fish species of great commercial importance. An experimental survey was conducted on May-June 2017 in the southernmost part of the Tyrrhenian Sea. Microplastics found in the sea water and...
Source: Environmental Toxicology and Pharmacology - January 26, 2019 Category: Environmental Health Source Type: research

Effects of Perinatal Di (2-ethylhexyl) phthalate Exposure on Thyroid Function in Rat Offspring
Publication date: Available online 25 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Dong Jing, Cong Zhangzhao, You Mingdan, Fu Yuanyuan, Wang Yi, Wang Yuan, Fu Hui, Wei Lingling, Chen JieAbstractDi (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Pregnant female Wistar rats were randomly divided into f...
Source: Environmental Toxicology and Pharmacology - January 26, 2019 Category: Environmental Health Source Type: research

Ecotoxicological effects on Scenedesmus obliquus and Danio rerio Co-exposed to polystyrene nano-plastic particles and natural acidic organic polymer
Publication date: Available online 22 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yinghan Liu, Zhuang Wang, Se Wang, Hao Fang, Nan Ye, Degao WangAbstractThe importance of attention to unravel the interaction of nano-plastic particles (NPs) with natural acidic organic polymer (NAOP) in freshwater environment should not be neglected. However, toxicological data available for the interaction between NPs and NAOP remain limited. Here, we investigate the toxicological effects of three model polystyrene (PS) NPs with different functional groups (unmodified, amino- and carboxyl-modified PS NPs) on two ...
Source: Environmental Toxicology and Pharmacology - January 23, 2019 Category: Environmental Health Source Type: research

Nanoplastics and marine organisms: what has been studied?
Publication date: Available online 21 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Inês Ferreira, Cátia Venâncio, Isabel Lopes, Miguel OliveiraAbstractNowadays, there is an increased awareness on the threat that marine litter may pose to the marine environment. This review describes the major concerns related to plastic pollution, namely in terms of toxicity of different types and sizes of nanoplastics (particles smaller than 100 nm) to marine organisms, either producers or consumers. The available data show that nanoplastics may affect negatively organisms from differen...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Gills CYP1A of Oncorhynchus mykiss as a sensitive biomarker of crude oil pollution in freshwater environments
Publication date: Available online 21 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Leonardo Ramón Leggieri, Julieta S De Anna, Juan G. Cárcamo, Gerardo A. Cerón, Luis Arias Darraz, Antonella Panebianco, Carlos M. LuquetAbstractThe induction of CYP1 A activity (EROD) and protein expression was compared in liver and gills of rainbow trout from a stream polluted with crude oil, and through laboratory exposures to 1% and 5% of water accommodated fraction of the crude oil (WAF) for 1 and 4 days. Gills EROD increased 1.6-2.7-fold in fish from the polluted stream and during e...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Mechanisms of Engineered Nanoparticle induced Neurotoxicity in Caenorhabditis Elegans
Publication date: Available online 22 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sotirios I. Sinis, Konstantinos I. Gourgoulianis, Chrissi Hatzoglou, Sotirios G. ZarogiannisAbstractThe wide-spread implementation of nanoparticles poses a major health concern. Unique biokinetics allow them to transfer to neurons throughout the body and inflict neurotoxicity, which is challenging to evaluate solely in mammalian experimental models due to logistics, financial and ethical limitations. In recent years, the nematode Caenorhabditis elegans has emerged as a promising nanotoxicology experimental surrogat...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project
Publication date: Available online 18 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Pål Magnusson, Katarzyna Dziendzikowska, Michał Oczkowski, Johan Øvrevik, Dag M. Eide, Gunnar Brunborg, Kristine B. Gutzkow, Christine Instanes, Malgorzata Gajewska, Jacek Wilczak, Rafał Sapierzynski, Dariusz Kamola, Tomasz Królikowski, Marcin Kruszewski, Anna Lankoff, Remigiusz Mruk, Nur Duale, Joanna Gromadzka-Ostrowska, Oddvar MyhreAbstractIncreased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects i...
Source: Environmental Toxicology and Pharmacology - January 20, 2019 Category: Environmental Health Source Type: research

Corrigendum to “Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China” [Environ. Toxicol. Pharmacol. 65 (January) 2019 82–89]
Publication date: Available online 18 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Mingxiao Di, Xiaoning Liu, Wenfeng Wang, Jun Wang (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 20, 2019 Category: Environmental Health Source Type: research

Modulation of homologous recombination repair gene polymorphisms on genetic damage in chromate exposed workers
Publication date: Available online 16 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Changmao Long, Jiaxing Liu, Guiping Hu, Huimin Feng, Di Zhou, Jing Wang, Xinxia Zhai, Zuchang Zhao, Shanfa Yu, Tiancheng Wang, Guang JiaAbstractHexavalent chromium [Cr(VI)] is one of the most common environmental carcinogens, which is associated with DNA damage, genetic instability and increase the risk of cancer development. However, the mechanisms of genetic damage induced by Cr(VI) remains to be thoroughly illustrated. A molecular epidemiological study was conducted on 120 chromate exposed workers and 97 control...
Source: Environmental Toxicology and Pharmacology - January 17, 2019 Category: Environmental Health Source Type: research

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 15, 2019 Category: Environmental Health Source Type: research

A comparative study on influences of static electric field and power frequency electric field on cognition in mice
This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFEF with the same strength (35 kV/m) for 49 days, respectively. Behaviors in Morris water maze test and amino acid neurotransmitter levels in hippocampus were examined during exposure. Results indicated that the exposure of 35 kV/m SEF would not cause significant influences on learning and memory ability in mice, while the exposure of 35 kV/m PFEF would cause significant positive effects on learning and memory ability in mice on day 33. This di...
Source: Environmental Toxicology and Pharmacology - January 5, 2019 Category: Environmental Health Source Type: research

Bioconcentration and ecotoxicity of sulfadiazine in the aquatic midge Chironomus riparius
Publication date: Available online 31 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Zhengxin Xie, Jun Tang, Xiangwei Wu, Shisuo Fan, Haomiao Cheng, Xuede Li, Rimao HuaAbstractAlthough sulfadiazine (SDZ) is widespread in aquatic environments, information regarding the effects of SDZ on aquatic insects is still limited. In the present study, the bioconcentration and the effects of SDZ on the antioxidant system and the expression of endocrine and stress-related genes in Chironomus riparius larvae were investigated. The larvae were exposed to SDZ at the nominal concentrations of 2, 20 and 200 μg/L...
Source: Environmental Toxicology and Pharmacology - December 31, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: January 2019Source: Environmental Toxicology and Pharmacology, Volume 65Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 30, 2018 Category: Environmental Health Source Type: research

Investigation of the differential transport mechanism of cinnabar and mercury containing compounds
ConclusionThis study demonstrates that differential transport and accumulation of mercury in 293 T cells exists among cinnabar and the three mercury-containing compounds HgCl2, MeHg and HgS, leading to distinct sensitivity to mercury induced cytotoxicity. The kidney organic anion transporters OAT1 and OAT3 are partially involved in the regulation of the transport of HgCl2 and MeHg, but not in the regulation of the transport of cinnabar. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 27, 2018 Category: Environmental Health Source Type: research

Acute Exposure to a Glyphosate-Containing Herbicide Formulation Inhibits Complex II and Increases Hydrogen Peroxide in the Model Organism Caenorhabditis elegans
Publication date: Available online 24 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Shelbie L. Burchfield, Denise C. Bailey, Callie E. Todt, Rachel D. Denney, Rekek Negga, Vanessa A. FitsanakisAbstractGlyphosate-based herbicides, such as Touchdown (TD) and Roundup, are among the most heavily-used herbicides in the world. While the active ingredient is generally considered non-toxic, the toxicity resulting from exposure to commercially-sold formulations is less clear. In many cases, cell cultures or various model organisms exposed to glyphosate formulations show toxicity and, in some cases, lethal...
Source: Environmental Toxicology and Pharmacology - December 25, 2018 Category: Environmental Health Source Type: research

Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up
ConclusionsPCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 24, 2018 Category: Environmental Health Source Type: research

Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)
Publication date: Available online 21 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Eloy Gasca-Pérez, Marcela Galar-Martínez, Sandra García-Medina, Isabel A. Pérez-Coyotl, Karina Ruiz-Lara, Selene Cano-Viveros, Ricardo Pérez-Pastén Borja, Leobardo M. Gómez-OlivánAbstractThe aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L-1) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxid...
Source: Environmental Toxicology and Pharmacology - December 22, 2018 Category: Environmental Health Source Type: research

Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis
This study evaluated if MMP2, MMP9 and MMP20 are expressed during enamel development and assessed the association between polymorphisms in these genes with DF. Mice susceptible and resistant to DF were used to evaluate if MMPs were candidate genes for DF. The animals received fluoride and their enamels were used for immunohistochemistry. Additionally, 481 subjects from a city with fluoridation of public water supplies were recruited. Genotyping was performed using real time PCR. Allele/genotype frequencies were compared between groups. MMP2, MMP9 and MMP20 immunostaining was detected in both animal groups. DF was observed ...
Source: Environmental Toxicology and Pharmacology - December 21, 2018 Category: Environmental Health Source Type: research

Evaluating the protective efficacy of Silybum marianum against deltamethrin induced hepatotoxicity in piscine model
Publication date: Available online 21 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Rajinder Jindal, Reshma Sinha, Prabhjeet BrarAbstractWith the known facts of deltamethrin toxicity in aquaculture, efforts have been made to ameliorate its toxicity with supplementation of Silybum marianum plant extract in Cyprinus carpio. For validating its efficacy, standard techniques of histopathology, anti-oxidant profile and RAPD-PCR were used. By performing acute toxicity bioassay, 96 h LC50 of the pesticide to C. carpio was determined and was found to be 2 µg/L. Histopathological alterations were com...
Source: Environmental Toxicology and Pharmacology - December 21, 2018 Category: Environmental Health Source Type: research

Temperature affects the toxicity of lead-contaminated food in Geophagus brasiliensis (QUOY & GAIMARD, 1824)
The objective of this work was to evaluate the effects of lead-contaminated feed in fish (Geophagus brasiliensis) exposed to different temperatures. A factorial experiment was performed with two temperatures (25 and 28°C), and two feeds (control and lead contaminated - 60 mg/kg) for a sum of four treatments (25°C, Control = 25/C; 25°C, 60 mg/kg = 25/60; 28°C, Control = 28/C and 28°C, 60 mg/kg = 28/60). Analyses of the lead accumulation, oxidative stress and genotoxic damage were performed. The gills and liver showed increased lead concentrations in fish receiving lead-contaminated food at both temperatu...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yuhang Hong, Yi Huang, Guangwen Yan, Zhiqiu HuangAbstractIn the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that activity of superoxide dismutase (SOD) and catalase (CAT) decreased remarkably in all treatments except t...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yawei Wang, Yazhen Hu, Zuntao Wu, Yanbin Su, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui HuangAbstractBoth β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results indicated that in SH-SY5Y cells exposed to Pb, the expression...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Haemato-immunological studies in ZnO and TiO2 nanoparticles exposed euryhaline fish, Oreochromis mossambicus
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): P. Suganthi, M. Murali, P. Athif, A. Sadiq Bukhari, H.E. Syed Mohamed, H. Basu, R.K. SinghalAbstractThe present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 hrs) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ppm) NPs were identified by using probit analysis. RBC, Hb and ...
Source: Environmental Toxicology and Pharmacology - December 19, 2018 Category: Environmental Health Source Type: research

Manuscript prepared for submission to Environmental Toxicology and Pharmacology Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China
Publication date: Available online 17 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Mingxiao Di, Xiaoning Liu, Wenfeng Wang, Jun WangAbstractAs the source of water for the South-to-North Water Diversion Project of China, the water quality of the Danjiangkou Reservoir (DJKR) is related to the safety of drinking water for billions of residents. Consequently, microplastics in surface water and sediment samples of the DJKR were investigated in this study. Microplastics were observed in all water and sediment samples with abundances varying from 467 to 15017 n/m3 and 15 to 40 n/kg wet weight, respecti...
Source: Environmental Toxicology and Pharmacology - December 18, 2018 Category: Environmental Health Source Type: research

Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model
Publication date: Available online 16 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Sumitra Suntararuks, Luksamee Worasuttayangkurn, Jaratluck Akanimanee, Tawit Suriyo, Sumontha Nookabkaew, Nujorn Srisamut, Daranee Visitnonthachai, Piyajit Watcharasit, Jutamaad SatayavivadABSTRACTArsenic exposure has been linked to an impaired immune response and inflammation. Our study investigated the effects of sodium arsenite on host immune response and vascular inflammation during malarial infection. Mice were divided into three groups: control (C), Plasmodium berghei infection (I) and sodium arsenite exposu...
Source: Environmental Toxicology and Pharmacology - December 16, 2018 Category: Environmental Health Source Type: research

Senkyunolide H protects against MPP+-induced apoptosis via the ROS-mediated mitogen-activated protein kinase pathway in PC12 cells
In this study, we investigated the neuroprotective effects and potential mechanisms of SNH against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress. We demonstrated that SNH pretreatment significantly attenuated MPP+-induced neurotoxicity and apoptosis in PC12 cells. In addition, SNH attenuated the effect of MPP+ on the expression of the pro-apoptotic factors Bax and caspase-3. Meanwhile, SNH prevented oxidative stress by reducing reactive oxygen species generation, mitochondrial membrane potential loss, cytochrome C release, and malondialdehyde levels while increasing antioxidant enzyme activity (e.g., superoxi...
Source: Environmental Toxicology and Pharmacology - December 14, 2018 Category: Environmental Health Source Type: research

Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats
Publication date: Available online 13 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Noha M. Shawky, George S.G. Shehatou, Ghada M. Suddek, Nariman M. GameilAbstractThe purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats.Male Sprague Dawley rats (150-200 g) were fed on a standard diet (control) or a high fructose diet (HFrD, 60% w/w fructose) for 60 days. From day 16, two subgroups of HFrD...
Source: Environmental Toxicology and Pharmacology - December 14, 2018 Category: Environmental Health Source Type: research

DNA damage checkpoint response to aflatoxin B1
Publication date: Available online 7 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ayse Basak Engin, Atilla EnginAbstractAlthough most countries regulate the aflatoxin levels in food by legislations, high amounts of aflatoxin B1 (AFB1)-DNA adducts can still be detected in normal and tumorous tissue obtained from cancer patients. AFB1 cannot directly interact with DNA unless it is biotransformed to AFB1-8, 9-epoxide via cytochrome p450 enzymes. This metabolite spontaneously and irreversibly attaches to guanine residues to generate highly mutagenic DNA adducts. AFB1-induced mutation of ATM kinase r...
Source: Environmental Toxicology and Pharmacology - December 8, 2018 Category: Environmental Health Source Type: research

Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol
In this study, daurinoline was firstly demonstrated that inhibited the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells. And these effects were associated with EMT and Notch-1 reversal. Moreover, daurinoline could significantly enhance the anti-tumor effect of Taxol rather than epirubicin, adriamycin and cisplatin. And the reverse fold (RF) value of daurinoline was greater than terfenadine reported before. There are little cytotoxic effects of daurinoline and its derivatives reported by L.W. Fu, et al. (2001). Therefore, daurinoline may be a potential anti-tumor agent or chemosensitizer f...
Source: Environmental Toxicology and Pharmacology - December 7, 2018 Category: Environmental Health Source Type: research

Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress
This study aimed to evaluate the therapeutic benefits of VC on inhibiting PFOS-induced liver steatosis in mice, followed by representative biochemical analysis and immunoassay. As results, VC was beneficial for reduced PFOS-induced liver damages, as showed in reductions of serological levels of transaminases (ALT and AST), lipids (TG and TC), fasting glucose and insulin, inflammatory cytokines (TNF-α and IL6), while content of fibroblast growth factor 21 (FGF21) in serum was increased. In addition, VC reduced histiocytic changes of PFOS-lesioned livers, as revealed in reduced TNF-α-labeled cells and increased F...
Source: Environmental Toxicology and Pharmacology - December 6, 2018 Category: Environmental Health Source Type: research

Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics
Publication date: Available online 4 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Zhen Lu, Shuang Wang, Xiujuan Shan, Chenglong Ji, Huifeng WuAbstractDue to the industrial discharges, cadmium (Cd) has been one of typical heavy metal pollutants in the Bohai Sea. Manila clam Ruditapes philippinarum is frequently used for pollution biomonitoring and consists of several pedigrees, of which White and Zebra clams are the dominant pedigrees along the Bohai Sea coast. However, limited attention has been paid on the differential biological effects in different pedigrees of clam to heavy metals. In this w...
Source: Environmental Toxicology and Pharmacology - December 5, 2018 Category: Environmental Health Source Type: research

Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes
In conclusion, this study provides mechanistic insight into cadmium-induced cytotoxicity of astrocytes and highlights potential targets for prevention of cadmium-induced apoptosis and cell cycle arrest. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 4, 2018 Category: Environmental Health Source Type: research

Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum
Publication date: Available online 3 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ming Cong, Huifeng Wu, Tengfei Cao, Chenglong Ji, Jiasen LvAbstractAmmonia nitrogen exposure has been found to significantly increase the early apoptosis rates of gill cells, affect the contents of ATP and disturb expressions of calcium-related genes in clam Ruditapes philippinarum. Mitochondria are the centers for energy production, initiation of apoptosis and calcium signal regulation. It is hypothesized that gill mitochondrion is a target organelle for the ammonia nitrogen. Thus, ATP metabolism together with ATP...
Source: Environmental Toxicology and Pharmacology - December 4, 2018 Category: Environmental Health Source Type: research

Pharmacokinetics and brain distribution of amitraz and its metabolites in rats
This study evaluated the systemic and brain exposure of amitraz and its major metabolites, BTS27271, 2’,4’-formoxylidide, and 2,4-dimethylaniline following administration of amitraz in male Sprague-Dawley rats. Significant metabolism of amitraz was observed following the intravenous and oral administration. Amitraz related metabolites were majority of the total exposure observed, especially following oral administration. BTS27271 had higher brain exposure than amitraz and its other metabolites, which was due to low plasma protein binding but high brain tissue binding of BTS27271. Since BTS27271 has similar or h...
Source: Environmental Toxicology and Pharmacology - November 24, 2018 Category: Environmental Health Source Type: research

Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: contribution to mode of action research
Publication date: Available online 23 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Sonja Kaisarevic, Dina Tenji, Varja Mihajlovic, Bojana Micic, Ester Francija, Jelena Periz-Stanacev, Bojana Krnic Skiljo, Dragica Brkic, Ivana TeodorovicAbstractPhysiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A an...
Source: Environmental Toxicology and Pharmacology - November 24, 2018 Category: Environmental Health Source Type: research

Carbon nanotubes and central nervous system: environmental risks, toxicological aspects and future perspectives
Publication date: Available online 22 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Alessio Facciolà, Giuseppa Visalli, Sebastiano La Maestra, Manuela Ceccarelli, Francesco D’Aleo, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Angela Di PietroAbstractDue to their morphological and physicochemical properties, carbon nanotubes (CNTs) enhance the structural properties of several materials and are produced in great volumes. The production and the manufacturing of CNTs-incorporated products can lead to the potential environmental release of CNTs. For these reasons, CNTs can repre...
Source: Environmental Toxicology and Pharmacology - November 23, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: December 2018Source: Environmental Toxicology and Pharmacology, Volume 64Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 22, 2018 Category: Environmental Health Source Type: research