Cichoric acid attenuates the toxicity of mesotrione. Effect on in vitro skin cell model
Publication date: Available online 24 March 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Agata Jabłońska-Trypuć, Rafał Krętowski, Grzegorz Świderski, Marzanna Cechowska-Pasko, Włodzimierz Lewandowski (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 25, 2020 Category: Environmental Health Source Type: research

A descriptive bibliometric study on bioavailability of pesticides in vegetables, food or wine research (1976-2018)
Publication date: Available online 20 March 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Pedro Andreo-Martínez, Víctor Manuel Ortiz-Martínez, Nuria García-Martínez, Pablo Pagán López, Joaquín Quesada-Medina, Miguel Ángel Cámara, José Oliva (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 21, 2020 Category: Environmental Health Source Type: research

Metabolomic perturbation precedes glycolytic dysfunction and procreates hyperglycemia in a rat model due to bisphenol S exposure
Publication date: July 2020Source: Environmental Toxicology and Pharmacology, Volume 77Author(s): Kapil Mandrah, Veena Jain, Jamal Ahmad Ansari, Somendu Kumar Roy (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 21, 2020 Category: Environmental Health Source Type: research

Bisphenol A-induced metabolic disorders: From exposure to mechanism of action
Publication date: July 2020Source: Environmental Toxicology and Pharmacology, Volume 77Author(s): Muhammad Sajid Hamid Akash, Shakila Sabir, Kanwal Rehman (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 20, 2020 Category: Environmental Health Source Type: research

Anorexic responses to trichothecene deoxynivalenol and its congeners correspond to secretion of tumor necrosis factor-α and interleukin-1β
Publication date: Available online 5 March 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Qinghua Wu, Jianming Yue, Haibin Zhang, Kamil Kuca, Wenda Wu (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 7, 2020 Category: Environmental Health Source Type: research

Embryotoxicity of atrazine and its degradation products to early life stages of zebrafish (Danio rerio)
Publication date: Available online 3 March 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Jana Blahova, Claudia Cocilovo, Lucie Plhalova, Zdenka Svobodova, Caterina Faggio (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 4, 2020 Category: Environmental Health Source Type: research

Effect of Pterois volitans (lionfish) venom on cholinergic and dopaminergic systems
Publication date: Available online 2 March 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Mayra P. Becerra-Amezcua, Arisaí C. Hernández-Sámano, Carlos Puch-Hau, Manuel B. Aguilar, Reyna C. Collí-Dulá (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 3, 2020 Category: Environmental Health Source Type: research

Editorial Board
Publication date: April 2020Source: Environmental Toxicology and Pharmacology, Volume 75Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 3, 2020 Category: Environmental Health Source Type: research

The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: a review of in vivo and in vitro studies
Publication date: Available online 27 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Jian Zhang (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 28, 2020 Category: Environmental Health Source Type: research

Relationship of chronic kidney disease with major air pollutants - a systematic review and meta-analysis of observational studies
ConclusionsChronic subjection to major air contaminants (PM10 and PM2.5) is more likely to cause CKD. Thus, developing global approaches of air pollution elimination to prevent CKD is urgent. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 23, 2020 Category: Environmental Health Source Type: research

Using zebrafish to assess the effect of chronic, early developmental exposure to environmentally relevant concentrations of 5-fluorouracil and leucovorin
Publication date: Available online 22 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): M. Ng, K. DeCicco-Skinner, V.P. ConnaughtonAbstractEnvironmental contaminants can deleteriously affect aquatic animals. One such contaminant is 5-fluorouracil (5-FU), a long-prescribed chemotherapeutic drug. Leucovorin (LV) is co-administered with 5-FU, potentiating its effects. Zebrafish (Danio rerio) larvae were reared in ng/L treatments of either 5-FU, LV, or a combined 5-FU/LV mixture for 8 dy. Survival was measured daily and swimming behavior assessed every other day. After 8 dy, larval length w...
Source: Environmental Toxicology and Pharmacology - February 23, 2020 Category: Environmental Health Source Type: research

Effect of air pre-exposure on Tetrabromobisphenol A resistance in the clam Ruditapes philippinarum
Publication date: Available online 22 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Fengxiao Hu, Yuan Yuan, Ruo Yang, Weini Zhang, Xinhua ChenAbstractThe present study was conducted to evaluate how air pre-exposure influences the responses in gills and digestive gland of Ruditapes philippinarum on subsequent Tetrabromobisphenol A (TBBPA) exposure. Firstly, clams were maintained in seawater or pre-exposed to air for 24 h, and then exposed to 0 or 100 μg/L TBBPA. Clam tissues were sampled after 1 day (T1) and 7 days (T7) of exposure to TBBPA. The results showed that in comparison w...
Source: Environmental Toxicology and Pharmacology - February 23, 2020 Category: Environmental Health Source Type: research

Optimised method for determination hypoglycine A in maple plant material by multidimensional gas chromatography/mass spectrometry
Publication date: Available online 21 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Petr Doležal, Jana Doležalová, Tereza Morávková, Roman StupkaAbstractIn 2018, more than 50 cases of horse death by equine atypical myopathy (AM) were reported in the Czech Republic. This disease is often associated with the toxin hypoglycine A (HGA), which is found in several maple plant materials. To monitor this toxin in products of these trees that grow in or around horse pastures, a rapid and inexpensive analytical method that can provide the required accuracy is needed.Until now, maple ...
Source: Environmental Toxicology and Pharmacology - February 21, 2020 Category: Environmental Health Source Type: research

Ecotoxicological effects of alpha-cypermethrin on freshwater alga Chlorella sp.: Growth inhibition and oxidative stress studies
Publication date: May 2020Source: Environmental Toxicology and Pharmacology, Volume 76Author(s): Prithu Baruah, Neha ChaurasiaAbstractAlpha-cypermethrin (ACy) is a synthetic pyrethroid insecticide commonly used in agricultural practices for controlling a broad range of insect pests particularly belonging to the order Lepidoptera and Coleoptera. The present study aims to evaluate the toxic effect of ACy on microalgae by studying its influence on Chlorella sp. According to our knowledge, this is the first detailed study of ACy toxicity on microalgae. Significant growth inhibition of Chlorella sp. was observed at high ACy con...
Source: Environmental Toxicology and Pharmacology - February 12, 2020 Category: Environmental Health Source Type: research

Pulmonary protective efficacy of S-2[2-aminoethylamino] ethyl phenyl sulphide (DRDE-07) and its analogues against sulfur mustard induced toxicity in mice
Publication date: Available online 8 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): A.K. Soni, A.S.B. Bhaskar, U. Pathak, D.P. Nagar, A.K. Gupta, G.M. KannanAbstractOur previous study showed that percutaneous sulfur mustard (SM) exposure induced pulmonary toxicity, which was attenuated by DRDE-07 (S-2[2-aminoethylamino] ethyl phenyl sulphide) pretreatment. The present study aimed to evaluate the protective efficacy of DRDE-07 and its analogues viz., DRDE-30 (S-2(2-aminoethyl amino)ethyl propyl sulphide) and DRDE-35 (S-2(2-aminoethyl amino)ethyl butyl sulphide) against SM. Thirty minutes before per...
Source: Environmental Toxicology and Pharmacology - February 9, 2020 Category: Environmental Health Source Type: research

Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants
Publication date: Available online 7 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Indra Hering, Elke Eilebrecht, Michael J. Parnham, Nazende Günday-Türeli, Akif Emre Türeli, Marc Weiler, Christoph Schäfers, Martina Fenske, Matthias G. WackerAbstractNanomaterials have gained huge importance in various fields including nanomedicine. Nanoformulations of drugs and nanocarriers are used to increase pharmaceutical potency. However, it was seen that polymeric nanomaterials can cause negative effects. Thus, it is essential to identify nanomaterials with the least adverse effects on a...
Source: Environmental Toxicology and Pharmacology - February 9, 2020 Category: Environmental Health Source Type: research

Effects of pH and nitrites on the toxicity of a cypermethrin-based pesticide to zebrafish embryos
The objective of this study was to evaluate the effects of pH and nitrite variation on the toxicity of the cypermethrin based pesticide Barrage®. Zebrafish embryos (Danio rerio) were exposed to a combination of pH or nitrite and cypermethrin through the Barrage® formulation for 96 hours and lethal and developmental endpoints assessed. Concerning mortality, pH seemed to increase Barrage® toxicity, while nitrite concentrations tested did not seem to change Barrage® lethality. At sublethal level, either for combinations involving pH or nitrites, results suggest some interactive effects of environmental ...
Source: Environmental Toxicology and Pharmacology - February 9, 2020 Category: Environmental Health Source Type: research

Immune status of Oreochromis niloticus subjected to long-term lead nitrate exposure and a Arthrospira platensis treatment trial
In this study, the impacts of lead toxicity on Oreochromisniloticus were investigated. Additionally, the potential ameliorative effects of the Spirulina algae Arthrospira platensis were evaluated. The median lethal concentration (LC50) of PbNO3 was determined to be 143.3 mg/l for O. niloticus weighing 42 ± 2.5 g. O. niloticus were exposed to 10% of the estimated PbNO3 LC50 for 12 weeks. The cumulative mortality rate (CMR) increased with exposure time. The results of assays for red blood cells (RBCs), haemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscul...
Source: Environmental Toxicology and Pharmacology - February 5, 2020 Category: Environmental Health Source Type: research

Disruption of Synaptic Expression Pattern and Age-related DNA oxidation in a Neuronal Model of Lead-induced Toxicity
Publication date: Available online 3 February 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Zuntao Wu, Lin Bai, Yunqi Tu, Lijie Zhang, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui HuangAbstractLead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, attention concerning long-term consequences of pubertal chronic Pb exposure on neurona...
Source: Environmental Toxicology and Pharmacology - February 4, 2020 Category: Environmental Health Source Type: research

Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: role of JNK/caspase-3 signaling inhibition
In conclusion, nilotinib refinement of cisplatin induced testicular toxicity is attributed to enhancing antioxidant capabilities, decreasing apoptotic signals and restoring regenerative capacity of testes suggesting nilotinib to be used in conjunction with cisplatin in treatment protocols to avoid cisplatin induced long term testicular toxicity. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 4, 2020 Category: Environmental Health Source Type: research

Effects of tetracycline on the relationship between the microbial community and oxidative stress in earthworms based on canonical correlation analysis
In this study, Eisenia fetida was taken as the test organism and tetracycline was taken as the stress compound. The artificial soil test was conducted to study the utilization intensity of different carbon sources (the Biolog-microplate supplied) by microorganisms under different stress times and stress concentrations. The changes in the in vivo key enzymes activities of earthworms and oxidative stress indicators, such as malondialdehyde (MDA), were explored. The canonical correlation analysis method was the first used to establish a analysis-model to explore the relationship between the functional diversity of microbial c...
Source: Environmental Toxicology and Pharmacology - February 2, 2020 Category: Environmental Health Source Type: research

Beauvericin: the beauty and the beast
Publication date: Available online 31 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Caloni Francesca, Fossati Paola, Anadón Arturo, Bertero AlessiaAbstractBeauvericin (BEA) is a natural bioactive compound, with a dual nature. On the one hand, the peculiar characteristics of its molecule confer to BEA interesting properties, such as antibacterial, antiviral, antifungal, antiparasitic, insecticidal and anticarcinogenic activities. On the other hand, it is a natural contaminant of food and feed commodities, and an emerging mycotoxin, but lacks a toxicological risk assessment evaluation for lon...
Source: Environmental Toxicology and Pharmacology - February 2, 2020 Category: Environmental Health Source Type: research

Safety of emamectin benzoate administered in feed to Nile tilapia Oreochromis niloticus (L.)
This study evaluated the safety of EB-dosing in Nile tilapia Oreochromis niloticus at the recommended dose and dosage of 50 µg/kg biomass/day for 7 consecutive days (1X) and compared with control and 10 times the recommended dose (10X). Depletion of EB-residues in the edible muscle of 1X-dosed Nile tilapia was also studied. Mortality, behavioural changes, feed consumption, biomass, EB-residue depletion, and histopathological alterations in the kidney, liver and intestine were determined at slated intervals. Significant dose-dependent reduction in feed intake and biomass and insignificant mortalities were noted...
Source: Environmental Toxicology and Pharmacology - January 31, 2020 Category: Environmental Health Source Type: research

Ecotoxicological effects of alpha-cypermethrin on freshwater alga Chlorella sp: growth inhibition and oxidative stress studies
Publication date: Available online 30 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Prithu Baruah, Neha ChaurasiaAbstractAlpha-cypermethrin (ACy) is a synthetic pyrethroid insecticide commonly used in agricultural practices for controlling a broad range of insect pests particularly belonging to the order Lepidoptera and Coleoptera. The present study aims to evaluate the toxic effect of ACy on microalgae by studying its influence on Chlorella sp. According to our knowledge, this is the first detailed study of ACy toxicity on microalgae.Significant growth inhibition of Chlorella sp. was observed at ...
Source: Environmental Toxicology and Pharmacology - January 31, 2020 Category: Environmental Health Source Type: research

Editorial Board
Publication date: February 2020Source: Environmental Toxicology and Pharmacology, Volume 74Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 30, 2020 Category: Environmental Health Source Type: research

Total antioxidant status reduction conditioned by a serum selenium concentration decrease as a mechanism of the ultrasonographically measured brachial artery dilatation impairment in patients with arterial hypertension
The objective of the study was to determine the relationship between serum concentrations of selenium (SeS) and zinc (ZnS), total antioxidant status (TAS) and endothelial function assessed by ultrasonographic method of dilatation of the brachial artery in 141 hypertensive patients.Patients with SeS 
Source: Environmental Toxicology and Pharmacology - January 25, 2020 Category: Environmental Health Source Type: research

The dose-time effects of fluoride on the expression and DNA methylation level of the promoter region of BMP-2 and BMP-7 in rats
This study investigated the dose-time effects of fluoride on BMP-2 and BMP-7 levels and DNA methylation status of the promoter regions of these two genes in peripheral blood of rats. Eighty Wistar male rats were randomly divided into four groups and treated for 1 month and 3 months with distilled water (control), 25 mg/L, 50 mg/L or 100 mg/L of sodium fluoride (NaF). Rats exposed to fluoride had higher protein expression of BMP-2 and BMP-7 in plasma at 1 month and 3 months. An increase in BMP-2 expression was also observed with an increase of fluoride exposure time. Significant hypomethylation was obse...
Source: Environmental Toxicology and Pharmacology - January 24, 2020 Category: Environmental Health Source Type: research

hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: a case-control study
Publication date: Available online 21 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Lu Ma, Bing Liang, Yuan Yang, Liyuan Chen, Qizhan Liu, Aihua ZhangAbstractTo identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured by mehtylation-specific PCR and restriction fragment length polymorphism PCR in PBLCs, respectively. The results showed that the...
Source: Environmental Toxicology and Pharmacology - January 22, 2020 Category: Environmental Health Source Type: research

Up and down-regulation of mRNA in the cytotoxicity and genotoxicity of Plumbagin in HepG2/C3A
Publication date: Available online 10 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Giovanna Vaz Crippa, Thalita Alves Zanetti, Bruna Isabela Biazi, Adrivânio Baranoski, Lilian Areal Marques, Giuliana Castello Coatti, Sandra Regina Lepri, Mário Sérgio MantovaniAbstractStudies that evaluated the mechanisms of action of Plumbagin (PLB) and its toxicity may contribute to future therapeutic applications of this compound. We investigate biomarker important in the mechanisms of action correlate the expression of mRNA with the cytotoxic and genotoxic effects of PLB on HepG2/C3A. In th...
Source: Environmental Toxicology and Pharmacology - January 11, 2020 Category: Environmental Health Source Type: research

Analgesic and anti-inflammatory effects and mechanism of action of borneol on photodynamic therapy of acne
This study aims to explore the analgesic and anti-inflammatory effects of borneol, a traditional Chinese medicine, on photodynamic treatment of acne. Here, we found that borneol significantly decreased the auricular swelling rate and pain threshold of rats. We also showed that borneol noticeably reduced macrophage and lymphocyte infiltration. The number of Th cells was significantly higher in the control PDT group than in the PDT plus borneol treatment group (P 
Source: Environmental Toxicology and Pharmacology - January 9, 2020 Category: Environmental Health Source Type: research

Effect of α-Lipoic acid on spatial memory and structural integrity of developing hippocampal neurons in rats subjected to sodium arsenite exposure
ConclusionsThese observations are suggestive of beneficial effects of ALA on iAs induced effects on learning and memory as well as on hippocampal neuronal morphology. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 8, 2020 Category: Environmental Health Source Type: research

Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity
Publication date: Available online 3 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Dina Tucovic, Ivana Mirkov, Jelena Kulas, Milica Zeljkovic, Dusanka Popovic, Lidija Zolotarevski, Sladjana Djurdjic, Jelena Mutic, Milena Kataranovski, Aleksandra Popov AleksandrovAbstractAdverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in r...
Source: Environmental Toxicology and Pharmacology - January 5, 2020 Category: Environmental Health Source Type: research

Impacts of herbicide pendimethalin on sex steroid level, plasma vitellogenin concentration and aromatase activity in teleost Clarias batrachus (Linnaeus)
Publication date: Available online 3 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Priyanka Gupta, Sushant Kumar VermaAbstractPendimethalin (PM) is a selective herbicide, widely present in aquatic environment. It causes detrimental effects in fishes, but little is known regarding its reproductive toxicity. The present study was carried out in Clarias batrachus exposed to sub lethal concentrations of PM for 30, 45 and 60 days. Male fish showed a significant increase in plasma 17-βestradiol (E2) however plasma E2 in females was not affected. Plasma testosterone levels were significantly decreas...
Source: Environmental Toxicology and Pharmacology - January 5, 2020 Category: Environmental Health Source Type: research

Effects of prednisolone on behavior and hypothalamic–pituitary–interrenal axis activity in zebrafish
This study provides us with new insights into understanding the effects of glucocorticoids on the HPI axis. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 5, 2020 Category: Environmental Health Source Type: research

Evaluation of softwood and hardwood sawmill wastes impact on the common carp "Cyprinus carpio" and its aquatic environment: an oxidative stress study
This study provides a rational use of these enzymes as suitable biomarkers with different degrees of specificity and as important tool for environmental monitoring. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 5, 2020 Category: Environmental Health Source Type: research

Genes regulating wing patterning in Drosophila melanogaster show reduced expression under exposure of Daminozide, the fruit ripening retardant
Publication date: Available online 20 December 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sohini Singha Roy, Sujay GhoshAbstractIn our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed to explore the metabolic modification of Daminozide following ingestion, the effects of Daminozide on the expression of genes which are pivotal for wing developm...
Source: Environmental Toxicology and Pharmacology - December 21, 2019 Category: Environmental Health Source Type: research

Pesticide dermal absorption: Case study x In vitro study
Publication date: Available online 17 December 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Thalita Pedon de Araujo Cardoso, José Wellithom Viturino da Silva, Juliana Kishishita, Cheila Nataly Galindo Bedor, Danilo Cesar Galindo Bedor, Davi Pereira de Santana, Leila Bastos LealAbstractIn order to evaluate dermal absorption during typical working conditions in family farming, the amount of dimethoate on clothing and in the stratum corneum (SC) was measured in three rural workers. This was achieved by using cotton patches on the worker’s clothes and SC quantification by the tape stripping appr...
Source: Environmental Toxicology and Pharmacology - December 18, 2019 Category: Environmental Health Source Type: research

Ultrastructural alterations of whole blood by copper, manganese and mercury metal mixtures using a chronic in vivo model of coagulation
In conclusion, chronic or single high dosage exposure to these heavy metals can potentially induce or contribute to thrombosis. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 14, 2019 Category: Environmental Health Source Type: research

Examining the Evidence that Ethylmercury Crosses the Blood-Brain Barrier
Publication date: Available online 9 December 2019Source: Environmental Toxicology and PharmacologyAuthor(s): David A. Geier, Janet K. Kern, Kristin G. Homme, Mark R. GeierAbstractScientific research can provide us with factual, repeatable, measurable, and determinable results. As such, scientific research can provide information that can be used in the decision-making process in the care of patients and in public policy. Although it has been suggested that ethylmercury (C2H5Hg+)-containing compounds do not cross the blood-brain barrier (BBB), this review examines the literature that addresses the question as to whether et...
Source: Environmental Toxicology and Pharmacology - December 9, 2019 Category: Environmental Health Source Type: research

Triclosan alters adult zebrafish behavior and targets acetylcholinesterase activity and expression
Publication date: Available online 5 December 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Narasimha Pullaguri, Shubham Nema, Yogesh Bhargava, Anamika BhargavaAbstractTriclosan is widely used in consumer products as an antimicrobial agent. Epidemiological studies have reported the association of triclosan with adverse birth outcomes. The toxic effects of triclosan on the developing stages of zebrafish are reported, however, its role as behavioral modifier is limited. In the present study, adult zebrafish were exposed to triclosan (0.3 and 0.6 mg/L) for 48 hrs and the exploratory behavior wa...
Source: Environmental Toxicology and Pharmacology - December 5, 2019 Category: Environmental Health Source Type: research

Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
Publication date: Available online 3 December 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Radek Indra, Petr Pompach, Katarína Vavrová, Kateřina Jáklová, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt, Marie StiborováAbstractWe studied the in vitro metabolism of the anti-thyroid-cancer drug vandetanib in a rat animal model and demonstrated that N-desmethylvandetanib and vandetanib N-oxide are formed by NADPH- or NADH-mediated reactions catalyzed by rat hepatic microsomes and pure biotransformation enzymes...
Source: Environmental Toxicology and Pharmacology - December 4, 2019 Category: Environmental Health Source Type: research

Impact of cadmium toxicity on cartilage loss in a 3D in vitro model
In conclusion, our findings suggest a cytotoxic role of Cd in the articular cartilage, which could affect OA development. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 1, 2019 Category: Environmental Health Source Type: research

Potential risk of organophosphate exposure in male reproductive system of a non-target insect model Drosophila melanogaster
This study demonstrates altered testis structure, decreased germ cell viability and gross body weight, increased activities of oxidative stress markers lipid peroxidase (LPO), and the endogenous antioxidant enzyme catalase (CAT), and altered expression of reproductive marker proteins like vitellogenin and mitoferrin in acephate-exposed flies when compared to control counterparts. Altered reproductive behavior, indicated by a significant decline in the number of mating pairs, validates the adverse effect of chronic acephate exposure on male reproduction in the non-target insect model D. melanogaster.Graphical abstractThe pl...
Source: Environmental Toxicology and Pharmacology - November 27, 2019 Category: Environmental Health Source Type: research

Prenatal exposure to the pesticide metam sodium induces sensorimotor and neurobehavioral abnormalities in mice offspring
Publication date: Available online 27 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Nour-eddine Kaikai, Saadia Ba-M’hamed, Mohamed Bennis, Abderrazzak GhanimaAbstractThe present study has investigated developmental neurotoxicity of Metam sodium (MS), from gestational day 6 and throughout the gestation period until delivery. Therefore, mated female mice were orally exposed on a daily basis to 0 (control), 50, 100 or 150 mg of MS/kg of body weight and their standard fertility and reproductive parameters were assessed. The offspring were examined for their sensorimotor development, depr...
Source: Environmental Toxicology and Pharmacology - November 27, 2019 Category: Environmental Health Source Type: research

Allicin modulates diclofenac sodium induced hepatonephro toxicity in rats via reducing oxidative stress and caspase 3 protein expression
ConclusionThis study indicated that allicin had potential preventive effects against diclofenac sodium induced hepatonephro toxicity in rats. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 24, 2019 Category: Environmental Health Source Type: research

Biomarkers of occupational exposure to pesticides: Systematic review of insecticides
ConclusionVarious insecticide biomarkers were mentioned; nonetheless, only a few are specific and used to identify the wide range of insecticides to which farm workers are exposed. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 23, 2019 Category: Environmental Health Source Type: research

Identifying adverse outcome pathways (aop) for amsterdam city fish by integrated field monitoring
Publication date: Available online 21 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ron van der Oost, David J. McKenzie, Frank Verweij, Carl Satumalay, Natascha van der Molen, Matthew J. Winter, J. Kevin ChipmanAbstractThe European City Fish project aimed to develop a generic methodology for ecological risk assessment for urban rivers. Since traditional methods only consider a small fraction of substances present in the water cycle, biological effect monitoring is required for a more reliable assessment of the pollution status. A major challenge for environmental risk assessment (ERA) is the appl...
Source: Environmental Toxicology and Pharmacology - November 22, 2019 Category: Environmental Health Source Type: research

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: inflammation and DNA strand breaks
Publication date: Available online 21 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Niels Hadrup, Anne T. Saber, Zdenka O. Kyjovska, Nicklas R. Jacobsen, Minnamari Vippola, Essi Sarlin, Yaobo Ding, Otmar Schmid, Håkan Wallin, Keld A. Jensen, Ulla VogelAbstractExposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 µg by intratracheal instillation. Recovery periods were 1, 3, or ...
Source: Environmental Toxicology and Pharmacology - November 22, 2019 Category: Environmental Health Source Type: research

L-glutamine supplementation exerts cardio-renal protection in estrogen-progestin oral contraceptive-treated female rats
Publication date: Available online 22 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kehinde Samuel Olaniyi, Isaiah Woru Sabinari, Lawrence Aderemi OlatunjiAbstractGlycogen and lipid disruptions represent a spectrum of metabolic disorders that are crucial risk factors for cardiovascular disease in estrogen-progestin oral contraceptive (COC) users. L-glutamine (GLN) has been shown to exert a modulatory effect in metabolic disorders-related syndromes. We therefore hypothesized that GLN supplementation would protect against myocardial and renal glycogen-lipid mishandling in COC-treated animals by mod...
Source: Environmental Toxicology and Pharmacology - November 22, 2019 Category: Environmental Health Source Type: research

Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism
The objective of this study is to elucidate the protective actions of D-pinitol on arsenic-induced cytotoxicity and explore its controlling role in biomolecular mechanisms in PC12 cells. Obtained results demonstrated that co-exposure of D-pinitol with arsenic increases cell viability, decreases DNA damage and protects PC12 cells from arsenic-induced cytotoxicity by increasing glutathione (GSH) level and glutathione reductase (GR). Protein expression of western blot analysis showed that co-exposure of D-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regula...
Source: Environmental Toxicology and Pharmacology - November 21, 2019 Category: Environmental Health Source Type: research