Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress
This study aimed to evaluate the therapeutic benefits of VC on inhibiting PFOS-induced liver steatosis in mice, followed by representative biochemical analysis and immunoassay. As results, VC was beneficial for reduced PFOS-induced liver damages, as showed in reductions of serological levels of transaminases (ALT and AST), lipids (TG and TC), fasting glucose and insulin, inflammatory cytokines (TNF-α and IL6), while content of fibroblast growth factor 21 (FGF21) in serum was increased. In addition, VC reduced histiocytic changes of PFOS-lesioned livers, as revealed in reduced TNF-α-labeled cells and increased F...
Source: Environmental Toxicology and Pharmacology - December 6, 2018 Category: Environmental Health Source Type: research

Differential biological effects in two pedigrees of clam Ruditapes philippinarum exposed to cadmium using iTRAQ-based proteomics
Publication date: Available online 4 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Zhen Lu, Shuang Wang, Xiujuan Shan, Chenglong Ji, Huifeng WuAbstractDue to the industrial discharges, cadmium (Cd) has been one of typical heavy metal pollutants in the Bohai Sea. Manila clam Ruditapes philippinarum is frequently used for pollution biomonitoring and consists of several pedigrees, of which White and Zebra clams are the dominant pedigrees along the Bohai Sea coast. However, limited attention has been paid on the differential biological effects in different pedigrees of clam to heavy metals. In this w...
Source: Environmental Toxicology and Pharmacology - December 5, 2018 Category: Environmental Health Source Type: research

Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes
In conclusion, this study provides mechanistic insight into cadmium-induced cytotoxicity of astrocytes and highlights potential targets for prevention of cadmium-induced apoptosis and cell cycle arrest. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 4, 2018 Category: Environmental Health Source Type: research

Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum
Publication date: Available online 3 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ming Cong, Huifeng Wu, Tengfei Cao, Chenglong Ji, Jiasen LvAbstractAmmonia nitrogen exposure has been found to significantly increase the early apoptosis rates of gill cells, affect the contents of ATP and disturb expressions of calcium-related genes in clam Ruditapes philippinarum. Mitochondria are the centers for energy production, initiation of apoptosis and calcium signal regulation. It is hypothesized that gill mitochondrion is a target organelle for the ammonia nitrogen. Thus, ATP metabolism together with ATP...
Source: Environmental Toxicology and Pharmacology - December 4, 2018 Category: Environmental Health Source Type: research

Pharmacokinetics and brain distribution of amitraz and its metabolites in rats
This study evaluated the systemic and brain exposure of amitraz and its major metabolites, BTS27271, 2’,4’-formoxylidide, and 2,4-dimethylaniline following administration of amitraz in male Sprague-Dawley rats. Significant metabolism of amitraz was observed following the intravenous and oral administration. Amitraz related metabolites were majority of the total exposure observed, especially following oral administration. BTS27271 had higher brain exposure than amitraz and its other metabolites, which was due to low plasma protein binding but high brain tissue binding of BTS27271. Since BTS27271 has similar or h...
Source: Environmental Toxicology and Pharmacology - November 24, 2018 Category: Environmental Health Source Type: research

Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: contribution to mode of action research
Publication date: Available online 23 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Sonja Kaisarevic, Dina Tenji, Varja Mihajlovic, Bojana Micic, Ester Francija, Jelena Periz-Stanacev, Bojana Krnic Skiljo, Dragica Brkic, Ivana TeodorovicAbstractPhysiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A an...
Source: Environmental Toxicology and Pharmacology - November 24, 2018 Category: Environmental Health Source Type: research

Carbon nanotubes and central nervous system: environmental risks, toxicological aspects and future perspectives
Publication date: Available online 22 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Alessio Facciolà, Giuseppa Visalli, Sebastiano La Maestra, Manuela Ceccarelli, Francesco D’Aleo, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Angela Di PietroAbstractDue to their morphological and physicochemical properties, carbon nanotubes (CNTs) enhance the structural properties of several materials and are produced in great volumes. The production and the manufacturing of CNTs-incorporated products can lead to the potential environmental release of CNTs. For these reasons, CNTs can repre...
Source: Environmental Toxicology and Pharmacology - November 23, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: December 2018Source: Environmental Toxicology and Pharmacology, Volume 64Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 22, 2018 Category: Environmental Health Source Type: research

Iranian experiences in terms of consumption of disposable single- use plastics: Introduction to theoretical variables for developing environmental health promotion efforts
Publication date: Available online 14 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Akram Jahani, Tahereh Dehdari, Mahdi Farzadkia, Morteza MansourianAbstractIn recent years, the consumption of disposable plastic items such as single-use plastic bags, plates, cutlery and so on has rapidly increased in Iran. Present study explored the Iranians' experiences in terms of the consumption of disposable single-use plastics. A qualitative content analysis study was conducted in Delfan, Lorestan, Iran in 2017. Thirty semi-structured in-depth interviews were done with citizens who resided in Delfan. Partic...
Source: Environmental Toxicology and Pharmacology - November 15, 2018 Category: Environmental Health Source Type: research

In vitro toxicological activity of particulate matter generated by coal combustion
Publication date: Available online 8 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Hyun-Ki Cho, Chang-Gyun Park, Han-Jae Shin, Ki-Hong Park, Heung-Bin LimAbstractHerein, the toxicity of particles generated from the complete combustion of 1 g coal at 500, 700, and 900 °C were compared, and combustion at 700 °C generated the most toxins. Chemical analyses revealed that all components except catechol, resorcinol, and aromatic amines were most abundant at 700 °C. Toxicity results confirmed that the relative mutagenicity, cytotoxicity, redox cycling, and product...
Source: Environmental Toxicology and Pharmacology - November 9, 2018 Category: Environmental Health Source Type: research

Toxic Effects and Possible Mechanisms following Malathion exposure in porcine granulosa cells
In conclusion, malathion is a reproductive toxicant by inhibiting granulosa cell proliferation by multiple pathways connected to oxidative stress, DNA damage, apoptosis and autophagy. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 8, 2018 Category: Environmental Health Source Type: research

Thymol exposure mediates pro-oxidant shift by regulating Nrf2 and apoptotic events in zebrafish (Danio rerio) embryos
In this study, we exposed the zebrafish embryos to 25, 50 and 100µM of THY for 96 hours post fertilization (hpf). Noticeable teratogenic effects were observed upon assessing the survival rate (LC50 = 42.35µM), hatching process, morphological exam and cardiac functions, thereby verifying the toxicity of THY on zebrafish embryos. Furthermore, we analyzed the effect of THY on the levels of ROS, mitochondrial membrane potential (ΔΨm) and immunofluorescence by DCFH-DA, JC-1, Casp-3-FITIC staining, respectively. Furthermore, we preformed the expressional analysis of Nrf2, superoxide dis...
Source: Environmental Toxicology and Pharmacology - November 8, 2018 Category: Environmental Health Source Type: research

Microplastic in Marine Organism: Environmental and Toxicological Effects
Publication date: Available online 2 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Eleonora Guzzetti, Antoni Sureda, Silvia Tejada, Caterina FaggioAbstractMicroplastics are tiny ubiquitous plastic particles present in marine environments. They are not an individual entity, but constitute a cocktail of polymers and additives that can absorb substances from the surrounding environment, including living substances, nutrients and marine pollutants. Given their small size (
Source: Environmental Toxicology and Pharmacology - November 3, 2018 Category: Environmental Health Source Type: research

Protective role of L-glutamic acid and L-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats
Publication date: Available online 2 November 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Nataliya Salyha, Yuriy SalyhaAbstractExposure to the organophosphorus insecticide chlorpyrifos (CPF) can lead to oxidative stress. The aim of this work was to investigate and compare the protective effects of amino acids (L-glutamic acid (L-Glu) and L-cysteine (L-Cys) alone or in combination) for the purpose of suppression and mitigation of CPF-induced oxidative stress in rats. Rats were divided into five groups: CPF, CPF/L-Glu, CPF/L-Glu and L-Cys, CPF/L-Cys, control. The level of GSH and the activities of glutath...
Source: Environmental Toxicology and Pharmacology - November 3, 2018 Category: Environmental Health Source Type: research

Glutathione S-transferase M1 and T1 null allele frequencies among Indonesian ethnics toward improved disease risk assessment
This study contributes significant information on the variability of GSTT1 and GSTM1 gene polymorphisms worldwide, which can provide new knowledge about the relationship between ethnicity and the prevalence of certain diseases. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 3, 2018 Category: Environmental Health Source Type: research

Assessment of exogenous melatonin action on mouse liver cells after exposure to soman
In this study, we attempted to evaluate the protective effect of melatonin on liver cells of mice challenged with chemical warfare agent-soman. The study was conducted at the level of ultrastructural and biochemical changes (analysis of the activity of model lysosomal enzymes and assessment of the level of lipid peroxidation). Significant biochemical and ultrastructural changes were found in the studied mouse hepatocytes after administration of soman alone, and soman in combination with melatonin, and the scope of the disclosed changes was dependent on the time of action of the examined factors. Melatonin has shown protect...
Source: Environmental Toxicology and Pharmacology - October 30, 2018 Category: Environmental Health Source Type: research

Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective
Publication date: Available online 28 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Dragos V. Nica, George A. Draghici, Florina-Maria Andrica, Sofia Popescu, Dorina E. Coricovac, Cristina A. Dehelean, Iosif I. Gergen, Leda Kovatsi, Michael D. Coleman, Aristidis TsatsakisAbstractThe available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of ...
Source: Environmental Toxicology and Pharmacology - October 29, 2018 Category: Environmental Health Source Type: research

Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied?
Publication date: Available online 26 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ibrahim Zubairu Hassan, Neil Duncan, Emmanuel O. Adawaren, Vinny NaidooAbstractDiclofenac, a non-steroidal anti-inflammatory pharmaceutical agent was responsible for the death of millions of Gyps vulture’s in the Indian sub-region with the safety of the other non-steroidal anti-inflammatory drugs (NSAIDs) being questionable. With preclinical safety testing not well established for avian species unlike for mammalian and environmental toxicity, we ask the question if a preclinical model could have predicted the...
Source: Environmental Toxicology and Pharmacology - October 27, 2018 Category: Environmental Health Source Type: research

Genotoxicity of three biofuel candidates compared to reference fuels
In this study mutagenicity and genotoxicity of the three biofuel candidates ethyl levulinate (EL), 2-methyltetrahydrofuran (2-MTHF) and 2-methylfuran (2-MF) were investigated in comparison to two petroleum-derived fuels and a biodiesel. None of the samples induced mutagenicity in the Ames fluctuation test. However, the Micronucleus assay revealed significant effects in Chinese hamster (Cricetulus griseus) V79 cells caused by the potential biofuels. 2-MF revealed the highest toxic potential with significant induction of micronuclei below 20.0 mg/L. EL and 2-MTHF induced micronuclei only at very high concentrations (&...
Source: Environmental Toxicology and Pharmacology - October 18, 2018 Category: Environmental Health Source Type: research

Developmental Exposure to Mancozeb Induced Neurochemical and Morphological Alterations in Adult Male Mouse Hypothalamus
Publication date: Available online 17 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yasmin Morales-Ovalles, Leticia Miranda-Contreras, Zulma Peña-ContrerasAbstractMancozeb, a dithiocarbamate widely used in agriculture, is considered a developmental hazard in humans; however, more evidences are still needed concerning the consequences of chronic exposure to this pesticide. Mancozeb neurotoxicity in developing mouse hypothalamus was evaluated by subchronic exposure of male Mus musculus mice to low and high doses of mancozeb (30 and 90 mg/kg body weight, respectively) from late neonatal...
Source: Environmental Toxicology and Pharmacology - October 18, 2018 Category: Environmental Health Source Type: research

Application of a series of biomarkers in Scallop Chlamys farreri to assess the toxic effects after exposure to a priority hazardous and noxious substance (HNS) - Acrylonitrile
Publication date: Available online 12 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Lei Zheng, Luqing Pan, Jingjing Miao, Yufei Lin, Jiangyue WuAbstractThe antioxidant enzymes and detoxification parameters responses of the scallop Chlamys farreri to different degree of acrylonitrile (AN) were investigated. Accordingly, the median lethal concentration (LC50) at 96 h was 98.5 mg/L AN. Results from chronic toxicity test demonstrated that superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were stimulated in the highest two doses of AN (2.0 and 5.0 mg/L), b...
Source: Environmental Toxicology and Pharmacology - October 13, 2018 Category: Environmental Health Source Type: research

Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells
Publication date: Available online 10 October 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Kamila Domińska, Kinga Anna Urbanek, Agnieszka Wanda Piastowska-CiesielskaAbstractA major challenge in the management of prostate cancer (PC) is to limit tumor growth and metastases. Targeted therapies applying natural compounds might be potentially useful in PC treatment. Methylsulfonylmethane (MSM), also known as organic sulfur, is a dietary supplement used for various clinical purposes, mostly known for its anti-inflammatory properties. Therefore, we...
Source: Environmental Toxicology and Pharmacology - October 10, 2018 Category: Environmental Health Source Type: research

Algal Toxicity of Binary Mixtures of Zinc Oxide Nanoparticles and Tetrabromobisphenol A: Roles of Dissolved Organic Matters
Publication date: Available online 25 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yue Meng, Se Wang, Zhuang Wang, Nan Ye, Hao FangAbstractThe present study investigated the impacts of dissolved organic matters (DOM) on joint toxicity involved in zinc oxide nanoparticles (ZnO NPs) and tetrabromobisphenol A (TBBPA) at relevant low-exposure concentrations (
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Effects of sodium fluoride on the reproductive development of Bombyx mori
Publication date: Available online 26 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Wenchao Tang, Xi Zheng, Dan Li, Yuanyuan Xiao, Chengfei Yang, Shan Shang, Min Shi, Yong ZhuAbstractBombyx mori was used as a model to evaluate the reproductive toxicity of NaF in insects. Significant reduction in cocoon quality, survival rate, fecundity, and hatchability were observed upon NaF treatment groups. Fluoride determination indicated that F- has a cumulative effect on the gonad of silkworm. high-performance liquid chromatography revealed that the testosterone content of males was decreased in NaF-treate...
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Oxidative Stress and Hepatotoxicity of Rana chensinensis Exposed to Low Doses of Octylphenol
This study investigated the effects of low doses of octylphenol (OP) on the oxidative stress and hepatotoxicity in amphibian liver. The frog, Rana chensinensis, were exposed to 10-8, 10-7, 10-6 mol/L OP for 10, 20 and 30 days. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) in liver were reduced at first, then recovered slightly, and the content of malondialdehyde (MDA) and hydrogen peroxide (H2O2) were increased significantly. Histopathology showed that in some liver tissues of OP treated frogs, the hematococoel expansion, the fat accumulation, the cytoplasmic vacuolization and e...
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Gene Sequence Screening for Manganese Poisoning-Susceptible Genes and Analysis of Gene Interaction Effects
Publication date: Available online 29 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yutian Tian, Shuhan Guo, Cengceng Chen, Li Zhao, Zhen Li, Yongjian YanAbstractManganese poisoning is a common occupational disease, studies have found that the susceptibility to manganese poisoning differs in individuals. We adopted genome-wide sequencing methods to screen for susceptibility genes involved in gene-mediated metabolic pathways from the perspective of manganese poisoning. We identified 18,439 genes in this study, including 14,272 known genes and 4,398 new genes. We then selected 17 differential gene...
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation
In this study, we found safrole induced the generation of reactive oxygen species (ROS) and myeloperoxidase (MPO) in RAW264.7 macrophages in a concentration-dependent manner. Furthermore, cytotoxicity, DNA damage, and apoptosis were caused by safrole in a concentration-dependent manner. While the activation of antioxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) was reduced, the phosphorylation of Akt was induced by safrole in a concentration-dependent manner. These results indicated that the induction of cytotoxicity, DNA damage, and apoptosis in macrophages by safrole was through generation o...
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: October 2018Source: Environmental Toxicology and Pharmacology, Volume 63Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

The role of minocycline in alleviating aluminum phosphide-induced cardiac hemodynamic and renal toxicity
In conclusion, the findings of this study showed that minocycline could improve cardiac hemodynamic abnormalities and kidney injury following AlP-poisoning, suggesting minocycline might be a possible candidate for the treatment of AlP-poisoning. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 5, 2018 Category: Environmental Health Source Type: research

Time-Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment
This study aimed at demonstrating that effect-based monitoring with passive sampling followed by toxicity profiling is more protective and cost-effective than the current chemical water quality assessment strategy consisting of compound-by-compound chemical analysis of selected substances in grab samples. Passive samplers were deployed in the Dutch river delta and in WWTP effluents. Their extracts were tested in a battery of bioassays and chemically analyzed to obtain toxicity and chemical profiles, respectively. Chemical concentrations in surface water were retrieved from publicly available databases. Seven different stra...
Source: Environmental Toxicology and Pharmacology - September 21, 2018 Category: Environmental Health Source Type: research

Modulatory Role of Gabapentin against Ovalbumin-Induced Asthma, Bronchial and Airway Inflammation in Mice
In conclusion; Gabapentin's modulatory effect on IL-4, IL-13 and TNFα activities accounts for the observed anti-inflammatory and anti-allergic properties. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 19, 2018 Category: Environmental Health Source Type: research

9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells
Publication date: Available online 17 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Shijie Cao, Shengyang Yu, Lina Cheng, Jiankun Yan, Yan Zhu, Yanru Deng, Feng Qiu, Ning KangAbstractBerberine is an isoquinoline alkaloid extracted from Rhizoma coptidis and shows anti-hyperlipidemia effect in vivo and in vitro. We previously found that berberine could decrease the intracellular triglyceride content in human hepatoma HepG2 cells through activation of AMP-activated protein kinase (AMPK), a major regulator of lipid metabolism. Herein, to find a more effective agent, several berberine analogues (A1-A...
Source: Environmental Toxicology and Pharmacology - September 18, 2018 Category: Environmental Health Source Type: research

Maternal exposure to traffic pollutant causes impairment of spermatogenesis and alterations of genome-wide mRNA and microRNA expression in F2 male mice
In this study, healthy C57BL/6 J mice were used to establish an animal model of maternal exposure to traffic pollutant during pregnancy, and the toxic effects on the reproductive system of F2 male mice were analysed using mRNA and miRNA microarray. Our results showed that 54 miRNAs and 1927 mRNAs were significantly altered in the exposed group. Gene Ontology (GO) analysis revealed that the most significant GO terms for biological process, molecular function and cellular component were myeloid cell differentiation, growth factor binding and main axon. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis de...
Source: Environmental Toxicology and Pharmacology - September 18, 2018 Category: Environmental Health Source Type: research

Dietary co-exposure to methylmercury and monosodium glutamate disrupts cellular and behavioral responses in the lobster cockroach, Nauphoeta cinerea model
Publication date: Available online 16 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Blessing A. Afolabi, Isaac A. Adedara, Diogo O. Souza, João B.T. RochaAbstractThe present study aims to investigate the effect of monosodium glutamate (MSG) both separately and combined with a low dose of methylmercury (MeHg) on behavioral and biochemical parameters in Nauphoeta cinerea (lobster cockroach). Cockroaches were fed with the basal diet alone, basal diet + 2% NaCl, basal diet + 2% MSG; basal diet + 0.125 mg/g MeHg, basal diet + 0.125 mg/g MeHg + 2% NaCl;...
Source: Environmental Toxicology and Pharmacology - September 17, 2018 Category: Environmental Health Source Type: research

Hazardous effects of chemical pesticides on human health–Cancer and other associated disorders
Publication date: October 2018Source: Environmental Toxicology and Pharmacology, Volume 63Author(s): Akash Sabarwal, Kunal Kumar, Rana P. SinghAbstractPoisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes through which humans get exposed to pesticides. The mode of exposure is an important factor as it also signifies the concentration of pesticides exposure. Pesticides are used extensively in agricultural and domestic settings. These chemicals are believed to cause many disorders in humans and w...
Source: Environmental Toxicology and Pharmacology - September 8, 2018 Category: Environmental Health Source Type: research

Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress
Publication date: Available online 6 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Hu Yimeng, Liu Jie, Yuan Yin, Chen Jing, Cheng Siyuan, Wang Huawei, Xu YanchengAbstractSodium butyrate (NaB), a histone deacetylase (HDAC) inhibitors, has been reported to attenuate hyperglycemia in rats. Our objective was to explore the effect and underlying mechanism of NaB on islet β-cell dysfunction and apoptosis in type 2 diabetic (T2DM) rats. T2DM models were induced by the combination of streptozotocin (STZ, 40 mg/kg) and high-fat-diet, while NaB (500 mg/kg/d) was intraperitoneally inject...
Source: Environmental Toxicology and Pharmacology - September 7, 2018 Category: Environmental Health Source Type: research

Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway
Publication date: Available online 6 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): E.O. Adegoke, Chen Wang, N.S Machebe, Xue Wang, Hao Wang, S.O Adeniran, Han Zhang, Peng Zheng, Guixue ZhangAbstractSertoli cells were treated with 0, 20, 40, 60 and 80 µg/L of MC-LR to investigate its toxic effects, mechanism of action and immune response of the cells. Our results revealed that treatment containing 20 µg/L of MC-LR was non-toxic to the cells. Treatments containing 40, 60 and 80 µg/L of MC-LR reduced the cell viability, induced nuclear morphological changes an...
Source: Environmental Toxicology and Pharmacology - September 7, 2018 Category: Environmental Health Source Type: research

Hazardous Effects of Chemical Pesticides on Human Health- Cancer and Other Associated Disorders
Publication date: Available online 1 September 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Akash Sabarwal, Kunal Kumar, Rana P. SinghAbstractPoisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes through which humans get exposed to pesticides. The mode of exposure is an important factor as it also signifies the concentration of pesticides exposure. Pesticides are used extensively in agricultural and domestic settings. These chemicals are believed to cause many disorders in hu...
Source: Environmental Toxicology and Pharmacology - September 2, 2018 Category: Environmental Health Source Type: research

Study of the spread of antimicrobial-resistant Enterobacteriaceae from wild mammals in the National Park of Aspromonte (Calabria, Italy)
Publication date: Available online 28 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Foti Maria, Siclari Antonino, Mascetti Antonietta, Fisichella VittorioAbstractAntimicrobial-resistant (AMR) bacteria are a threat to global health. Epidemiological studies are necessary to gain a more detailed understanding of the transmission modality of resistant bacteria to wild animals and their diffusion into the environment to ensure a broader evaluation of the epidemiological role of wildlife. The study aimed to identify little-known epidemiological aspects by focusing on the isolation of Enterobacteriaceae i...
Source: Environmental Toxicology and Pharmacology - August 30, 2018 Category: Environmental Health Source Type: research

Captan-induced increase in the concentrations of intracellular Ca2+ and Zn2+ and its correlation with oxidative stress in rat thymic lymphocytes
Publication date: Available online 27 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tomomi Inoue, Maika Kinoshita, Keisuke Oyama, Norio Kamemura, Yasuo OyamaAbstractCaptan, a phthalimide fungicide, is considered to be relatively nontoxic to mammals. There is a possibility that captan affects membrane and cellular parameters of mammalian cells, resulting in adverse effects, because of high residue levels. To test the possibility, we examined the effects of captan on rat thymic lymphocytes using flow-cytometry with appropriate fluorescent probes. Treatment with 10 and 30 µM captan induced apopt...
Source: Environmental Toxicology and Pharmacology - August 28, 2018 Category: Environmental Health Source Type: research

Cellular uptake and apoptotic potential of rhenium labeled magnetic protein cages in MDA-MB-231 cells
Publication date: Available online 25 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Elif Aşık, Tuğba Nur Aslan, N. Tülin Güray, Mürvet VolkanGraphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 26, 2018 Category: Environmental Health Source Type: research

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals
Publication date: Available online 25 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Gunnar Carlsson, Maria Blomberg, Johannes Pohl, Stefan ÖrnAbstractVeterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects also might be of concern in non-target animals such as fish. We tested if exposure to antiparasitic pharmaceuticals affect swimming activity in 6 days old zebrafish larvae. The results revealed that most pharmaceuticals did not cause any effects in s...
Source: Environmental Toxicology and Pharmacology - August 26, 2018 Category: Environmental Health Source Type: research

Exposure of cadmium via smoking and drinking water on zinc levels of biological samples of malnutrition pregnant women: A Prospective cohort study
Publication date: Available online 19 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Faiza Ali, Tasneem Gul Kazi, Hassan Imran Afridi, Jameel Ahmed BaigAbstractIn present study, the interaction of a toxic (cadmium) and essential element (zinc) was determined in scalp hair of pregnant and non-pregnant women resident in a rural area of Thraparkar, Pakistan, where malnutrition is prevalent. In the malnourished group (pregnant and nonpregnant women), deficiency of the essential element (zinc) due to malnutrition and exposure of toxic metal (cadmium) via non-branded cigarette smoking and drinking groundw...
Source: Environmental Toxicology and Pharmacology - August 20, 2018 Category: Environmental Health Source Type: research

MiR-132, miR-204 and BDNF-TrkB signaling pathway may be involved in spatial learning and memory impairment of the offspring rats caused by fluorine and aluminum exposure during the embryonic stage and into adulthood
This study showed that exposure to fluorine and aluminium, either alone or combined, during the embryonic stage and into adulthood caused spatial learning and memory impairment in offspring rats; its mechanism may be associated with increases in miR-132 and miR-204 expression and downregulation of the BDNF-TrkB pathway in the hippocampus. The effects of F were obvious, but the effects of Al were slight. There were antagonistic effects between F and Al, with Al reducing the toxicity of F. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Reduced testosterone and Ddx3y expression caused by long-term exposure to arsenic and its effect on spermatogenesis in mice
The objective of this investigation was to explore these effects and the underlying mechanisms. Male mice were treated with 5 and 50 ppm arsenic for 6 months via drinking water. The results showed that arsenic reduced sperm count and sperm motility and enhanced the abnormal sperm percentage. The decrease in the number of spermatogenic cells and sperm in seminiferous tubules and the decline in the Johnsen score were observed in both arsenic-treated groups, suggesting spermatogenesis disorders. Moreover, arsenic diminished serum testosterone, along with the reduced expression of luteinizing hormone receptor (LHR), ste...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

iTRAQ-based secretome reveals that SiO2 induces the polarization of RAW264.7 macrophages by activation of the NOD-RIP2-NF-κB signaling pathway
Publication date: Available online 17 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Rong Fu, Qian Li, Rong Fan, Qinye Zhou, Xiaohan Jin, Jin Cao, Jiabao Wang, Yongqiang Ma, Tailong Yi, Maobin Zhou, Sanqiao Yao, Hongsheng Gao, Zhongwei Xu, Zhen YangAbstractSilicosis is characterized by inflammation and pulmonary fibrosis due to long-term inhalation of crystalline silica (SiO2). To clarify the role of macrophage polarization in the inflammatory response of silicosis, we used iTRAQ-coupled 2D LC-MS/MS to study the change in the secretome in RAW264.7 macrophages. We successfully screened 330 differenti...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population
Publication date: Available online 17 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Haoran Guo, Enmin Ding, Rongjian Sheng, Jian Cheng, Wenyan Cai, Jiadi Guo, Ning Wang, Hengdong Zhang, Baoli ZhuAbstractNoise-induced hearing loss (NIHL), one of the most widespread occupational health risks worldwide, is a kind of complex disorder resulting from both genetic and environmental factors. KCNQ4 channels are crucial to the internal ear potassium recycling. To explore whether KCNQ4 polymorphism is associated with individual susceptibility to NIHL, we performed this genetic association study on 571 NIHL ca...
Source: Environmental Toxicology and Pharmacology - August 18, 2018 Category: Environmental Health Source Type: research

Evidence of risks of renal function reduction due to occupational exposure to agrochemicals: a systematic review
Publication date: Available online 15 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ivângela Raphaela Gouveia Prudente, Candice Lima Cruz, Laranda de Carvalho Nascimento, Claúdia Cristina Kaiser, Adriana Gibara GuimarãesABSTRACTAgriculture accounts for an important economic activity worldwide and the search for the increased productivity incorporated the use of pesticides in this practice. Such compounds have significant environmental and human health effects, especially for workers exposed to them. Among the main health problems caused by pesticides are the renal alterations, w...
Source: Environmental Toxicology and Pharmacology - August 15, 2018 Category: Environmental Health Source Type: research

Different radiation dose rate as radioprotection and the cross effect with chromium using in vivo somatic cells of Drosophila
Publication date: Available online 13 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): L.M. Vidal, E. Pimentel, M.P. Cruces, J.C. Sánchez-MezaAbstractIonizing radiation plays a key role in the adaptation of an individual organism to environmental pollution, at the same time, it has biological effects that depend on radiation intensity or dose rate (DR). Although the effect of DR has been studied in vitro, the phenomenon known as the inverse effect of DR, which indicates as it decreases that the induction of damage is greater, has not been widely studied in vivo. The present study is aimed to te...
Source: Environmental Toxicology and Pharmacology - August 14, 2018 Category: Environmental Health Source Type: research

Phthalates Promote Prostate Cancer Cell Proliferation through Activation of ERK5 and p38
In this report we found that three typical phthalates, diethylhexyl phthalate (DEHP), Butyl benzyl phthalate (BBP) and Dibutyl phthalate (DBP), up-regulated cyclinD1 and PCNA, down-regulated P21, inducing proliferation of prostate cancer cells. Furthermore, we found that phthalates increased the expression of p-ERK5 and p-p38, along with upregulation of AP-1 (p-c-fos and p-c-jun). In studies with ERK5 and a p38 inhibitor, our data showed that downregulation of p-ERK5 or p38 inhibited phthalate-triggered cell proliferation. Taken together, findings from this study suggest that phthalates activate MAPK/AP-1 pathway and may p...
Source: Environmental Toxicology and Pharmacology - August 14, 2018 Category: Environmental Health Source Type: research