Microplastic exposure and effects in aquatic organisms: a physiological perspective
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Silvia Franzellitti, Laura Canesi, Manon Auguste, Rajapaksha H.G.R. Wathsala, Elena FabbriAbstractThe impact of microplastics (MPs) on aquatic life, given their ubiquitous presence in the water compartment, represents a growing concern. Consistently, scientific knowledge is advancing rapidly, although evidence on actual adverse effects is still highly fragmented. This paper summarizes the recent literature on MP impacts on aquatic organisms in an attempt to link routes of uptake, possible alterations of physiological ...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ju-Wook Lee, Hoon Choi, Un-Ki Hwang, Ju-Chan Kang, Yue Jai Kang, Kwang Il Kim, Jun-Hwan KimAbstractLead (Pb) is a highly toxic metal in aquatic environments. Fish are at the top of the food chain in most aquatic environments, and are the most susceptible to the toxic effects of Pb exposure. In addition, fish are one of the most abundant vertebrates, and they can directly affect humans through food intake; therefore, fish can be used to assess the extent of environmental pollution in an aquatic environment. Pb-induced ...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Scrutinizing the interactions between bisphenol analogues and plasma proteins: insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions
Publication date: Available online 9 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Lucia Grumetto, Francesco Barbato, Giacomo RussoAbstractThe interactions between human serum albumin (HSA) and α1- acid glycoprotein (AGP), the main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and some of its structural analogues, bisphenol S (BPS), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol A diglycidyl ether (BADGE) and bisphenol M (BPM), were characterized by biomimetic liquid chromatography (...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells
This study investigated the effects of β-zol and HT-2 on bovine ovarian granulosa cells (BGCs), and how melatonin may counteract these effects. β-zol and HT-2 inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of BGCs. They also yielded upregulation of the apoptosis-related genes Bax/Bcl-2 and Caspase3 and phosphorylation of p38MAPK. Increases in intracellular ROS were observed along with higher levels of mRNA anti-oxidation markers SOD1, SOD2, and CAT. SOD1, SOD2, malonaldehyde (MDA), and glutathione peroxidase (GSH-px) activities increased, as did the levels of SOD1 and SOD2 proteins...
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts
This study provides a rationale for translational studies in the field of cardio-oncology.Graphicala bstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Zong-biao Zhao, Ke Ji, Xin -yue Shen, Wen-wen Zhang, Rui Wang, Wei-ping Xu, Wei WeiAbstractDi(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant that is widely used in medical and consumer products. An epidemiological study has suggested that a large daily intake of DEHP from phthalate-contaminated food may be a risk factor for liver dysfunction. Long-term exposure to DEHP is associated with liver disease and exacerbates the progression of chronic liver injury. However, the effect of DEHP on hepatic fibrosis...
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Microplastics in the marine environment: current trends in environmental pollution and mechanisms of toxicological profile
This study is a review of trend in marine plastic pollution with focus on the current toxicological consequences. Microplastics are capable of absorbing organic contaminants, metals and pathogens from the environment into organisms. This exacerbates its toxicological profile as they interact to induced greater toxic effects. Early studies focused on the accumulation of plastics in the marine environment, entanglement of and ingestions by marine vertebrates, with seabirds used as bioindicators. Entanglement in plastic debris increases asphyxiation through drowning, restrict feeding but increases starvation, skin abrasions a...
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: April 2019Source: Environmental Toxicology and Pharmacology, Volume 67Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Nano-eco toxicity study of gold nanoparticles on aquatic organism Moina macrocopa: As new versatile ecotoxicity testing model
Publication date: May 2019Source: Environmental Toxicology and Pharmacology, Volume 68Author(s): Hemant P. Borase, Abhijeet B. Muley, Satish V. Patil, Rekha S. SinghalAbstractIn the field of nanoecotoxicology, very few reports have focused on biochemical changes in non-target organisms after nanoexposure. A less explored aquatic non-target crustacean, Moina macrocopa, was used in the present study to analyze toxicity effects of gold nanoparticles (AuNPs), an emerging nanomaterial. AuNPs was fabricated using tannic acid and were 29 ± 2 nm in size. The 48 h LC50 value of AuNPs was 14&thinsp...
Source: Environmental Toxicology and Pharmacology - March 6, 2019 Category: Environmental Health Source Type: research

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis
In this study, the clams Mactra veneriformis were exposed to 0.1, 1, and 10 μg/L BDE-209 for 7 days and then maintained in clean seawater for 3 days as the depuration. The bioaccumulation of BDE-209 and the effects on superoxide dismutase, catalase, and glutathione peroxidase were investigated. BDE-209 accumulation was concentration-dependent and decreased by 36%-52% after recovery. Malondialdehyde contents increased in a time- and dose-dependent manner. mRNA expression and activity of antioxidant enzymes changed with different patterns and recovered after depuration. These results suggested that antioxidant syst...
Source: Environmental Toxicology and Pharmacology - March 6, 2019 Category: Environmental Health Source Type: research

Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect
Publication date: Available online 4 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Xiang Yan, Fusheng Zhao, Senfeng Zhang, Fang Lei, Wen Wang, Yu ZhengAbstractWe previously found that hydrogen sulfide (H2S) ameliorated the dysfunction of central chemoreception caused by prenatal cigarette smoke exposure (CSE). In the present study, we further explored whether the parafacial respiratory group (pFRG) is involved in the protection of central chemoreception by H2S against prenatal CSE-induced injury. We found that NaHS, a donor of H2S, restored the expression of Phox2b, which was downregulated by prenat...
Source: Environmental Toxicology and Pharmacology - March 6, 2019 Category: Environmental Health Source Type: research

Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells
Publication date: Available online 5 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kaustav Dutta Chowdhury, Avik Sarkar, Sujan Chatterjee, Debajyoti Patra, Dipanwita Sengupta, Soumi Banerjee, Pratip Chakraborty, Gobinda Chandra SadhukhanAbstractAndrographolide regimen in single or in combination with anticancer drugs is a promising new strategy to reverse chemoresistance in heaptocellular carcinoma. Apoptosis inducing factor (AIF) may regulate a complementary, cooperative or redundant pathway, along with caspase cascades. Despite these findings, mechanisms underlying caspase-dependent and-independen...
Source: Environmental Toxicology and Pharmacology - March 6, 2019 Category: Environmental Health Source Type: research

Nano-eco toxicity study of gold nanoparticles on less explored aquatic organism Moina macrocopa: enzymatic biomarkers and bioaccumulation perspective
Publication date: Available online 22 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Hemant P. Borase, Abhijeet B. Muley, Satish V. Patil, Rekha S. SinghalAbstractIn the field of nanoecotoxicology, very few reports have focused on biochemical changes in non-target organisms after nanoexposure. A less explored aquatic non-target crustacean Moina macrocopa was used in the present study to analyze toxicity effects of gold nanoparticles (AuNPs), an emerging nanomaterial. AuNPs was fabricated using tannic acid and were of 29 ± 2 nm in size. The 48 h LC50 value of AuNP...
Source: Environmental Toxicology and Pharmacology - February 23, 2019 Category: Environmental Health Source Type: research

Effects of the chronic exposure to cerium dioxide nanoparticles in Oncorhynchus mykiss: assessment of oxidative stress, neurotoxicity and histological alterations
Publication date: Available online 23 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): A.T. Correia, D. Rebelo, J Marques, B. NunesAbstractCerium dioxide nanoparticles (CeO2-NPs) have a variety of uses, especially in the production of solar panels, oxygen pumps, gas sensors, computer chips and catalytic converters. Despite their worldwide use, the few published studies demonstrate that metallic nanoparticles, in general, are still not properly characterized in terms of their potencial ecotoxicological effects. CeO2-NPs, in particular, have demonstrated extreme antioxidant activity, but their in vivo...
Source: Environmental Toxicology and Pharmacology - February 23, 2019 Category: Environmental Health Source Type: research

The neuroprotective effect of hyperoxygenate hydrogen-rich saline on CO-induced brain injury in rats
This study was designed to investigate the neuroprotective effect of hyperoxygenate hydrogen-rich saline (HOHS) against brain injury induced by carbon monoxide (CO) poisoning in rats. A rat model of CO poisoning was established by administering CO via intraperitoneal injection to male Sprague-Dawley rats. Forty-eight adult male rats were randomly divided into the following groups: normal control group (NG), CO poisoning group (CO), HOS treatment group (hyperoxygenated solution, HOS) and HOHS treatment group (HOHS). After CO poisoning, the carboxyhemoglobin (COHb) contents in the blood of rats in all the CO poisoning groups...
Source: Environmental Toxicology and Pharmacology - February 20, 2019 Category: Environmental Health Source Type: research

Identification and characterization of novel bacterial polyaromatic hydrocarbon-degrading enzymes as potential tools for cleaning up hydrocarbon pollutants from different environmental sources
Publication date: Available online 20 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Heba A.R. Abdelhaleem, Haggag S. Zein, Ahmed Z. Abdel Azeiz, Ahmed N. Sharaf, Abdelhadi A. AbdelhadiAbstractPolycyclic aromatic hydrocarbons (PAHs) are recalcitrant hazardous environmental contaminants. Various strategies, including chemical and physical like oxidation, fixation, leaching, and electrokinetic or biological-based techniques are used for remediation of polluted sites. Bioremediation of PAHs, via PAH-degrading endophytic and rhizospheric microbes, represent a time-/cost-effective way for ecorestoratio...
Source: Environmental Toxicology and Pharmacology - February 20, 2019 Category: Environmental Health Source Type: research

Differential toxicity of water versus gavage exposure to trichloroethylene in rats
Publication date: Available online 16 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Angela R Stermer, David Klein, Shelby K. Wilson, Chimeddulam Dalaijamts, Cathy Yue Bai, Susan J. Hall, Samantha Madnick, Enrica Bianchi, Weihsueh A. Chiu, Kim BoekelheideAbstractTrichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. T...
Source: Environmental Toxicology and Pharmacology - February 17, 2019 Category: Environmental Health Source Type: research

Cadmium: toxic effects on placental and embryonic development
In this report, we review published data linking pregnancy exposure to cadmium to placenta and fetal growth and development toxicity and summarize the related mechanisms. An understanding of how cadmium exposure contributes to placental and fetal development is necessary for the development of prevention and control strategies for fetal development defects caused by cadmium exposure during pregnancy. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 16, 2019 Category: Environmental Health Source Type: research

Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice
This study, for the first time, obtained and reports three novel forms (I-III) of cedrol polymorphs. The three forms of cedrol were recrystallized from seven organic solvents by slow cooling or volatilization and identified by thermal analysis, fourier transform infrared spectroscopy, scanning electron microscopy and powder X-ray diffraction analysis. Form I originated from acetone and cyclohexane. Form II was obtained from ethanol, ethyl acetate, acetonitrile and n-hexane. Form III was recrystallized from methanol. The anti-inflammatory and analgesic activities of the three crystalline forms were evaluated by acetic acid ...
Source: Environmental Toxicology and Pharmacology - February 14, 2019 Category: Environmental Health Source Type: research

The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill
Publication date: Available online 11 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Grzegorz PrzydatekAbstractOne of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must be controlled regularly. One of the methods of determining the toxicity of substances contained in landfill leachate is the use of biological tests, based −&thin...
Source: Environmental Toxicology and Pharmacology - February 12, 2019 Category: Environmental Health Source Type: research

CIRCULATING miRNA-126, -145 AND -155 LEVELS IN MEXICAN WOMEN EXPOSED TO INORGANIC ARSENIC VIA DRINKING WATER
Publication date: Available online 7 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Sergio Zarazúa, Leticia Carrizales-Yáñez, Iván N. Pérez-MaldonadoAbstractThe aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 µg/g creatinine was found after urine samples wer...
Source: Environmental Toxicology and Pharmacology - February 8, 2019 Category: Environmental Health Source Type: research

Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure
Publication date: Available online 6 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Pavla Sehonova, Nina Tokanova, Nikola Hodkovicova, Hana Kocour Kroupova, Jitka Tumova, Jana Blahova, Petr Marsalek, Lucie Plhalova, Veronika Doubkova, Radka Dobsikova, Petr Chloupek, Dolezelova Petra, Faldyna Martin, Zdenka Svobodova, Faggio CaterinaAbstractThe purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrat...
Source: Environmental Toxicology and Pharmacology - February 7, 2019 Category: Environmental Health Source Type: research

Toxic effects of nitrogenous compounds (ammonia, nitrite, and nitrate) on acute toxicity and antioxidant responses of juvenile olive flounder, Paralichthys olivaceus
Publication date: Available online 2 February 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Jun-Hwan Kim, Yue Jai Kang, Kwang Il Kim, Jong-Hyun KimAbstractJuvenile Paralichthys olivaceus (mean length 7.29 ± 0.59 cm, mean weight 2.41 ± 0.35 g) were exposed to several concentrations of ammonia (0, 6.25, 12.5, 25, 50, and 100 mg/L), nitrite (0, 50, 100, 200, 400, and 800 mg/L), and nitrate (0, 250, 500, 1000, 2000, and 4000 mg/L) for 96 h in 20-L glass tanks. Lethal concentration 50% (LC50) was determined after removing and c...
Source: Environmental Toxicology and Pharmacology - February 3, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: February 2019Source: Environmental Toxicology and Pharmacology, Volume 66Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 1, 2019 Category: Environmental Health Source Type: research

Cypermethrin-based formulation Barrage® induces histological changes in gills of the Pantanal endemic shrimp Macrobrachium pantanalense
This study shows the high sensitivity of the shrimp M. pantanalense to the pesticide Barrage® highlighting the importance of monitoring agrochemicals residues in the Pantanal region (Brazil) and conduct risk evaluation studies to prevent deleterious effects on the aquatic communities of Pantanal. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 31, 2019 Category: Environmental Health Source Type: research

Antioxidant imbalance and genotoxicity detected in fish induced by titanium dioxide nanoparticles (NpTiO2) and inorganic lead (PbII)
This study evaluated the effects of the associated exposure to both types of contaminant, i.e., lead (a known genotoxic metal) and NpTiO2, in a freshwater fish (Astyanax serratus) through intraperitoneal injection for an acute assay of 96 h. The effects of this exposure were evaluated using the comet assay, DNA diffusion assay and piscine micronucleus test, as well as the quantification of antioxidant enzymes (SOD, CAT, and GST) and metallothioneins. Our findings indicate that co-exposure of PbII with NpTiO2 can provoke ROS imbalances, leading to DNA damage in the blood and liver tissue of A. serratus, as well as mo...
Source: Environmental Toxicology and Pharmacology - January 29, 2019 Category: Environmental Health Source Type: research

Microplastics occurrence in the tyrrhenian waters and in the gastrointestinal tract of two congener species of seabreams
Publication date: Available online 25 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): S. Savoca, G. Capillo, M. Mancuso, T. Bottari, R. Crupi, C. Branca, V. Romano, C. Faggio, G. D’Angelo, N SpanòAbstractIn this work it is reported for the first time the characterization of microplastics from sea water samples and in two congener species of seabreams: Pagellus erythrinus and P. bogaraveo, Mediterranean fish species of great commercial importance. An experimental survey was conducted on May-June 2017 in the southernmost part of the Tyrrhenian Sea. Microplastics found in the sea water and...
Source: Environmental Toxicology and Pharmacology - January 26, 2019 Category: Environmental Health Source Type: research

Effects of Perinatal Di (2-ethylhexyl) phthalate Exposure on Thyroid Function in Rat Offspring
Publication date: Available online 25 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Dong Jing, Cong Zhangzhao, You Mingdan, Fu Yuanyuan, Wang Yi, Wang Yuan, Fu Hui, Wei Lingling, Chen JieAbstractDi (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Pregnant female Wistar rats were randomly divided into f...
Source: Environmental Toxicology and Pharmacology - January 26, 2019 Category: Environmental Health Source Type: research

Ecotoxicological effects on Scenedesmus obliquus and Danio rerio Co-exposed to polystyrene nano-plastic particles and natural acidic organic polymer
Publication date: Available online 22 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yinghan Liu, Zhuang Wang, Se Wang, Hao Fang, Nan Ye, Degao WangAbstractThe importance of attention to unravel the interaction of nano-plastic particles (NPs) with natural acidic organic polymer (NAOP) in freshwater environment should not be neglected. However, toxicological data available for the interaction between NPs and NAOP remain limited. Here, we investigate the toxicological effects of three model polystyrene (PS) NPs with different functional groups (unmodified, amino- and carboxyl-modified PS NPs) on two ...
Source: Environmental Toxicology and Pharmacology - January 23, 2019 Category: Environmental Health Source Type: research

Nanoplastics and marine organisms: what has been studied?
Publication date: Available online 21 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Inês Ferreira, Cátia Venâncio, Isabel Lopes, Miguel OliveiraAbstractNowadays, there is an increased awareness on the threat that marine litter may pose to the marine environment. This review describes the major concerns related to plastic pollution, namely in terms of toxicity of different types and sizes of nanoplastics (particles smaller than 100 nm) to marine organisms, either producers or consumers. The available data show that nanoplastics may affect negatively organisms from differen...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Gills CYP1A of Oncorhynchus mykiss as a sensitive biomarker of crude oil pollution in freshwater environments
Publication date: Available online 21 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Leonardo Ramón Leggieri, Julieta S De Anna, Juan G. Cárcamo, Gerardo A. Cerón, Luis Arias Darraz, Antonella Panebianco, Carlos M. LuquetAbstractThe induction of CYP1 A activity (EROD) and protein expression was compared in liver and gills of rainbow trout from a stream polluted with crude oil, and through laboratory exposures to 1% and 5% of water accommodated fraction of the crude oil (WAF) for 1 and 4 days. Gills EROD increased 1.6-2.7-fold in fish from the polluted stream and during e...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Mechanisms of Engineered Nanoparticle induced Neurotoxicity in Caenorhabditis Elegans
Publication date: Available online 22 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sotirios I. Sinis, Konstantinos I. Gourgoulianis, Chrissi Hatzoglou, Sotirios G. ZarogiannisAbstractThe wide-spread implementation of nanoparticles poses a major health concern. Unique biokinetics allow them to transfer to neurons throughout the body and inflict neurotoxicity, which is challenging to evaluate solely in mammalian experimental models due to logistics, financial and ethical limitations. In recent years, the nematode Caenorhabditis elegans has emerged as a promising nanotoxicology experimental surrogat...
Source: Environmental Toxicology and Pharmacology - January 22, 2019 Category: Environmental Health Source Type: research

Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project
Publication date: Available online 18 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Pål Magnusson, Katarzyna Dziendzikowska, Michał Oczkowski, Johan Øvrevik, Dag M. Eide, Gunnar Brunborg, Kristine B. Gutzkow, Christine Instanes, Malgorzata Gajewska, Jacek Wilczak, Rafał Sapierzynski, Dariusz Kamola, Tomasz Królikowski, Marcin Kruszewski, Anna Lankoff, Remigiusz Mruk, Nur Duale, Joanna Gromadzka-Ostrowska, Oddvar MyhreAbstractIncreased use of 1st and 2nd generation biofuels raises concerns about health effects of new emissions. We analyzed cellular and molecular lung effects i...
Source: Environmental Toxicology and Pharmacology - January 20, 2019 Category: Environmental Health Source Type: research

Corrigendum to “Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China” [Environ. Toxicol. Pharmacol. 65 (January) 2019 82–89]
Publication date: Available online 18 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Mingxiao Di, Xiaoning Liu, Wenfeng Wang, Jun Wang (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 20, 2019 Category: Environmental Health Source Type: research

Modulation of homologous recombination repair gene polymorphisms on genetic damage in chromate exposed workers
Publication date: Available online 16 January 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Changmao Long, Jiaxing Liu, Guiping Hu, Huimin Feng, Di Zhou, Jing Wang, Xinxia Zhai, Zuchang Zhao, Shanfa Yu, Tiancheng Wang, Guang JiaAbstractHexavalent chromium [Cr(VI)] is one of the most common environmental carcinogens, which is associated with DNA damage, genetic instability and increase the risk of cancer development. However, the mechanisms of genetic damage induced by Cr(VI) remains to be thoroughly illustrated. A molecular epidemiological study was conducted on 120 chromate exposed workers and 97 control...
Source: Environmental Toxicology and Pharmacology - January 17, 2019 Category: Environmental Health Source Type: research

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 15, 2019 Category: Environmental Health Source Type: research

A comparative study on influences of static electric field and power frequency electric field on cognition in mice
This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFEF with the same strength (35 kV/m) for 49 days, respectively. Behaviors in Morris water maze test and amino acid neurotransmitter levels in hippocampus were examined during exposure. Results indicated that the exposure of 35 kV/m SEF would not cause significant influences on learning and memory ability in mice, while the exposure of 35 kV/m PFEF would cause significant positive effects on learning and memory ability in mice on day 33. This di...
Source: Environmental Toxicology and Pharmacology - January 5, 2019 Category: Environmental Health Source Type: research

Bioconcentration and ecotoxicity of sulfadiazine in the aquatic midge Chironomus riparius
Publication date: Available online 31 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Zhengxin Xie, Jun Tang, Xiangwei Wu, Shisuo Fan, Haomiao Cheng, Xuede Li, Rimao HuaAbstractAlthough sulfadiazine (SDZ) is widespread in aquatic environments, information regarding the effects of SDZ on aquatic insects is still limited. In the present study, the bioconcentration and the effects of SDZ on the antioxidant system and the expression of endocrine and stress-related genes in Chironomus riparius larvae were investigated. The larvae were exposed to SDZ at the nominal concentrations of 2, 20 and 200 μg/L...
Source: Environmental Toxicology and Pharmacology - December 31, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: January 2019Source: Environmental Toxicology and Pharmacology, Volume 65Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 31, 2018 Category: Environmental Health Source Type: research

Investigation of the differential transport mechanism of cinnabar and mercury containing compounds
ConclusionThis study demonstrates that differential transport and accumulation of mercury in 293 T cells exists among cinnabar and the three mercury-containing compounds HgCl2, MeHg and HgS, leading to distinct sensitivity to mercury induced cytotoxicity. The kidney organic anion transporters OAT1 and OAT3 are partially involved in the regulation of the transport of HgCl2 and MeHg, but not in the regulation of the transport of cinnabar. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 27, 2018 Category: Environmental Health Source Type: research

Acute Exposure to a Glyphosate-Containing Herbicide Formulation Inhibits Complex II and Increases Hydrogen Peroxide in the Model Organism Caenorhabditis elegans
Publication date: Available online 24 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Shelbie L. Burchfield, Denise C. Bailey, Callie E. Todt, Rachel D. Denney, Rekek Negga, Vanessa A. FitsanakisAbstractGlyphosate-based herbicides, such as Touchdown (TD) and Roundup, are among the most heavily-used herbicides in the world. While the active ingredient is generally considered non-toxic, the toxicity resulting from exposure to commercially-sold formulations is less clear. In many cases, cell cultures or various model organisms exposed to glyphosate formulations show toxicity and, in some cases, lethal...
Source: Environmental Toxicology and Pharmacology - December 25, 2018 Category: Environmental Health Source Type: research

Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up
ConclusionsPCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 24, 2018 Category: Environmental Health Source Type: research

Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)
Publication date: Available online 21 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Eloy Gasca-Pérez, Marcela Galar-Martínez, Sandra García-Medina, Isabel A. Pérez-Coyotl, Karina Ruiz-Lara, Selene Cano-Viveros, Ricardo Pérez-Pastén Borja, Leobardo M. Gómez-OlivánAbstractThe aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L-1) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxid...
Source: Environmental Toxicology and Pharmacology - December 22, 2018 Category: Environmental Health Source Type: research

Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis
This study evaluated if MMP2, MMP9 and MMP20 are expressed during enamel development and assessed the association between polymorphisms in these genes with DF. Mice susceptible and resistant to DF were used to evaluate if MMPs were candidate genes for DF. The animals received fluoride and their enamels were used for immunohistochemistry. Additionally, 481 subjects from a city with fluoridation of public water supplies were recruited. Genotyping was performed using real time PCR. Allele/genotype frequencies were compared between groups. MMP2, MMP9 and MMP20 immunostaining was detected in both animal groups. DF was observed ...
Source: Environmental Toxicology and Pharmacology - December 21, 2018 Category: Environmental Health Source Type: research

Evaluating the protective efficacy of Silybum marianum against deltamethrin induced hepatotoxicity in piscine model
Publication date: Available online 21 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Rajinder Jindal, Reshma Sinha, Prabhjeet BrarAbstractWith the known facts of deltamethrin toxicity in aquaculture, efforts have been made to ameliorate its toxicity with supplementation of Silybum marianum plant extract in Cyprinus carpio. For validating its efficacy, standard techniques of histopathology, anti-oxidant profile and RAPD-PCR were used. By performing acute toxicity bioassay, 96 h LC50 of the pesticide to C. carpio was determined and was found to be 2 µg/L. Histopathological alterations were com...
Source: Environmental Toxicology and Pharmacology - December 21, 2018 Category: Environmental Health Source Type: research

Temperature affects the toxicity of lead-contaminated food in Geophagus brasiliensis (QUOY & GAIMARD, 1824)
The objective of this work was to evaluate the effects of lead-contaminated feed in fish (Geophagus brasiliensis) exposed to different temperatures. A factorial experiment was performed with two temperatures (25 and 28°C), and two feeds (control and lead contaminated - 60 mg/kg) for a sum of four treatments (25°C, Control = 25/C; 25°C, 60 mg/kg = 25/60; 28°C, Control = 28/C and 28°C, 60 mg/kg = 28/60). Analyses of the lead accumulation, oxidative stress and genotoxic damage were performed. The gills and liver showed increased lead concentrations in fish receiving lead-contaminated food at both temperatu...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Effects of deltamethrin on the antioxidant defense and heat shock protein expression in Chinese mitten crab, Eriocheir sinensis
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yuhang Hong, Yi Huang, Guangwen Yan, Zhiqiu HuangAbstractIn the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in hepatopancreas. The results showed that activity of superoxide dismutase (SOD) and catalase (CAT) decreased remarkably in all treatments except t...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Yawei Wang, Yazhen Hu, Zuntao Wu, Yanbin Su, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui HuangAbstractBoth β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results indicated that in SH-SY5Y cells exposed to Pb, the expression...
Source: Environmental Toxicology and Pharmacology - December 20, 2018 Category: Environmental Health Source Type: research

Haemato-immunological studies in ZnO and TiO2 nanoparticles exposed euryhaline fish, Oreochromis mossambicus
Publication date: Available online 19 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): P. Suganthi, M. Murali, P. Athif, A. Sadiq Bukhari, H.E. Syed Mohamed, H. Basu, R.K. SinghalAbstractThe present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 hrs) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ppm) NPs were identified by using probit analysis. RBC, Hb and ...
Source: Environmental Toxicology and Pharmacology - December 19, 2018 Category: Environmental Health Source Type: research

Manuscript prepared for submission to Environmental Toxicology and Pharmacology Pollution in drinking water source areas: Microplastics in the Danjiangkou Reservoir, China
Publication date: Available online 17 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Mingxiao Di, Xiaoning Liu, Wenfeng Wang, Jun WangAbstractAs the source of water for the South-to-North Water Diversion Project of China, the water quality of the Danjiangkou Reservoir (DJKR) is related to the safety of drinking water for billions of residents. Consequently, microplastics in surface water and sediment samples of the DJKR were investigated in this study. Microplastics were observed in all water and sediment samples with abundances varying from 467 to 15017 n/m3 and 15 to 40 n/kg wet weight, respecti...
Source: Environmental Toxicology and Pharmacology - December 18, 2018 Category: Environmental Health Source Type: research