Responses of Chlorella vulgaris exposed to boron: Mechanisms of toxicity assessed by multiple endpoints
This study aimed to assess SPP toxicity using multiple endpoints, specially detecting the intracellular metal ion concentrations, malondialdehyde (MDA) content and extracellular polymeric substance (EPS) classes for the very first time during SPP exposure to Chlorella vulgaris (C. vulgaris). Our findings indicated that the inhibitory effects of SPP on C. vulgaris may be related to nutrient absorption and utilization. The changes in intracellular starch grains, MDA and the protein-like substances in EPS probably acted as a defense mechanism, helping to alleviate the toxic effects. This work may contribute to the understandi...
Source: Environmental Toxicology and Pharmacology - June 11, 2019 Category: Environmental Health Source Type: research

Effects of cyclophosphamide on the phenotypes and functions of THP-1 cells
In this study, effects of immunosuppressant cyclophosphamide (CY) on THP-1 cells were observed while 2, 4-Dinitrochlorobenzene (DNCB) was used as a control. The phenotypes of THP-1 cells, the ability to activate naïve T cells, intracellular reactive oxygen species (ROS) level, gene markers, phagocytic ability and cell apoptosis were detected after THP-1 cells being exposed to different concentrations of CY and DNCB. Both CY and DNCB were able to activate THP-1 cells, but there were a lot of differences in their effects on THP-1 cells, such as the changes in phenotypes, in the ability to activate naïve T cells, in...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Investigating the inotropic effect of pyruvic acid on the isolated rat heart and its underlying mechanism
This study sought to explore the inotropic effects of pyruvic acid on the function of the isolated rat hearts and investigate its underlying mechanism. Pyruvic acid produced a greater negative inotropic effect compared to HCl and sodium pyruvate in a concentration-dependent pattern in the hearts. The role of low dose of pyruvic acid on heart function was regulated by pyruvic acid molecules and high dose pyruvic acid may be influenced by pyruvic acid molecules and pH. Kv channels may be involved in the pyruvic acid-induced negative inotropic effect. Finally, pyruvic acid markedly increased the level of LDH and CK and reduce...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae
This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae were fed with 4% high-cholesterol diet (HCD) and treated with I3C 2.5μmol/L and 5μmol/L for two weeks. Confocal image analysis, oil Red O staining were used to analysis vascular lipid accumulation and western blotting was used to evaluate possible mechanics. In addition, zebrafish embryos were treated with I3C for 96 hours to assess the general toxicity and cardiotoxicity. We found that lipid deposition on vasculature was dose-dependently decreased ...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Evaluation of Lapatinib Cytotoxicity and Genotoxicity on MDA-MB-231 Breast Cancer Cell line
In conclusion, lapatinib induced cytotoxic and genotoxic effects on MDA-MB-231 cell line. However, laptinib reduced the EGFR protein expression and EGFR signals, it raised the apoptotic cells and TP53 gene signals, which triggered extensive DNA damage. Therefore, lapatinib is an effective TKI in triple negative breast cancer cells as elucidated by its mode of cell death. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Evaluation of cytogenotoxicity and oxidative stress parameters in male Swiss mice co-exposed to titanium dioxide and zinc oxide nanoparticles
Publication date: Available online 5 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Opeoluwa Fadoju, Olusegun Ogunsuyi, Olubukola Akanni, Okunola Alabi, Chibuisi Alimba, Oluwatosin Adaramoye, Sebastien Cambier, Santhana Eswara, Arno C. Gutleb, Adekunle BakareAbstractA number of studies have investigated the adverse toxic effects of titanium dioxide (TiO2) nanoparticles (NPs) or zinc oxide (ZnO) NPs. Information on the potential genotoxic effects of the interactions of TiO2 NPs and ZnO NPs in vivo is lacking. Therefore, this study was designed to investigate the cytogenotoxicity of TiO2 NPs or ZnO NPs ...
Source: Environmental Toxicology and Pharmacology - June 6, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2019Source: Environmental Toxicology and Pharmacology, Volume 69Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 6, 2019 Category: Environmental Health Source Type: research

Species-specific models in toxicology: in vitro epithelial barriers
Publication date: Available online 1 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): A. Bertero, J. Augustyniak, L. Buzanska, F. CaloniAbstractSpecies-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy.The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from b...
Source: Environmental Toxicology and Pharmacology - June 1, 2019 Category: Environmental Health Source Type: research

Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress mouse model
Publication date: Available online 30 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Chen Xu, Tanran Chang, Yaqi Du, Chaohui Yu, Xin Tan, Xiangdong LiAbstractCannabidiol (CBD) exhibits significant efficacy in mental and inflammatory diseases. Several studies have recently reported on the rapid antidepressant-like effects of CBD, suggesting that CBD is a potential anti-depressant or anti-stress drug. However, CBD is mainly administered orally or by inhalation with poor bioavailability, resulting in high costs. We aim to explore the efficacy of long-term periodic administration of CBD in chronic mild str...
Source: Environmental Toxicology and Pharmacology - May 31, 2019 Category: Environmental Health Source Type: research

Prediction and risk assessment of five heavy metals in maize and peanut: a case study of Guangxi, China
Publication date: Available online 27 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Qiubei Gu, Tao Yu, Zhongfang Yang, Junfeng Ji, Qingye Hou, Lei Wang, Xueji Wei, Qizuan ZhangAbstractTo assess the contamination levels and health risk of cadmium (Cd), copper (Cu), mercury (Hg), lead (Pb), and zinc (Zn) to human beings, the concentrations of these heavy metals in soil were surveyed and the concentrations in maize and peanut grains were estimated by models. The geo-accumulation index (I geo) was calculated, and chronic daily intake (CDI), hazard quotient (HQ) and hazard index (HI) were estimated. Result...
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research

Bioinformatic and experimental data decipher the pharmacological targets and mechanisms of plumbagin against hepatocellular carcinoma
ConclusionCollectively, the pharmacological targets and mechanisms of plumbagin-treating HCC were predicted and integrated through the method of network pharmacology, followed by some investigative validations. Interestingly, these 5 predominant biomolecules may be the potential targets for screening and treating HCC.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research

Mechanisms mediating the cardioprotective effect of carvedilol in cadmium induced cardiotoxicity. Role of eNOS and HO1/Nrf2 pathway
Publication date: Available online 28 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Marwa M.M. Refaie, Maram El-Hussieny, Asmaa M.A. Bayoumi, Sayed ShehataAbstractCadmium (Cd) is a highly toxic heavy metal with several harmful effects including cardiotoxicity. For the first time, we aimed to evaluate the possible cardioprotective effect of carvedilol (CAR) in Cd induced cardiotoxicity and study the mechanisms involved in such protection including endothelial nitric oxide synthase (eNOS) and HO1/Nrf2 pathway. CAR (1,10 mg/kg/d) was administered orally for 4 weeks with Cd induced cardiac injury (...
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research

The Interaction Effects of Coke Oven Emissions Exposure and Metabolic Enzyme Gene Variants on Total Antioxidant Capacity of Workers
This study shows that the T-AOC in exposure group (12.02 ± 4.72) was significantly lower than that in control group (15.32 ± 7.19) (P 
Source: Environmental Toxicology and Pharmacology - May 25, 2019 Category: Environmental Health Source Type: research

Genotoxicity and Carcinogenicity of Ivermectin and Amoxicillin in vivo systems
Publication date: Available online 23 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Francielle Aparecida de Sousa, Cássio de MoraisGraphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 25, 2019 Category: Environmental Health Source Type: research

Corrigendum to “The probable roles of valsartan in alleviating chronic obstructive pulmonary disease following co-exposure to cold stress and fine particulate matter” [Environ. Toxicol. Pharmacol. 60 (2018) 230–236]
Publication date: Available online 21 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 22, 2019 Category: Environmental Health Source Type: research

Silver nanoparticles testicular toxicity in rat
Publication date: Available online 21 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Eman E. El-Sharkawy, Mahmoud. Abd El-Nasser, Heba F. KamalyAbstractTo evaluate the potential testicular toxicity induced by silver nanoparticles (AgNPs) in Sprague Dawley rate. The protocol study was designed as follows: G1: 30 adult male rats were kept as control. G2: 30 adult male rats were administered 5.36 mg/kg of AgNPs orally, twice weekly for six months. G3: 30 adult male rats were administered 13.4 mg/kg of AgNPs orally, twice weekly for six months. The results of hormonal assay revealed that a si...
Source: Environmental Toxicology and Pharmacology - May 21, 2019 Category: Environmental Health Source Type: research

Inhibition Effects of Quinones on Aldose Reductase: Antidiabetic Properties
In this study, we purified AR from sheep kidney with a specific activity of 2.00 EU/mg protein and 133.33- fold purification After the purification of the AR enzyme, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed and the molecular weight of the enzyme was found approximately as 38 kDa. The inhibition effects of eight quinones were studied against AR. The quinones were potent inhibitors of AR with Ki values in the range of 0.07–20.04 μM. Anthraquinone showed the best potential inhibitory effects against AR. All compounds exhibited noncompetitive inhibition against AR. Thes...
Source: Environmental Toxicology and Pharmacology - May 14, 2019 Category: Environmental Health Source Type: research

Toxicity of ammonia, nitrite and nitrate to Litopenaeus vannamei juveniles in low-salinity water in single and ternary exposure experiments and their environmental implications
Publication date: Available online 8 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Gladys Valencia-Castañeda, Martín G. Frías-Espericueta, Ruth C. Vanegas-Pérez, María C. Chávez-Sánchez, Federico Páez-OsunaAbstractInformation on toxicity of nitrogen compounds for Litopenaeus vannamei in coastal ecosystems and culture under low salinity is scarce. Acute toxicity trials were conducted in L. vannamei to determine the single and combined effects of ammonia, nitrite and nitrate at a salinity of 3 g/L. The 96 h-LC50 was 29.0 mg/L f...
Source: Environmental Toxicology and Pharmacology - May 10, 2019 Category: Environmental Health Source Type: research

D-limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway
Publication date: Available online 2 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Xue-ping Tang, Xiao-hua Guo, Di Geng, Lian-Jin WengAbstractThe stress-induced hormone corticosterone initiates oxidative stress and inflammatory responses, culminating in cell apoptosis and neurological changes. We assessed the effects of d-limonene on a PC12 cellular model of corticosterone-induced neurotoxicity, and whether these effects involved the AMP-activated protein kinase (AMPKα) pathway. PC12 cells were treated with corticosterone with or without d-limonene for 24 h. Western blots were performed t...
Source: Environmental Toxicology and Pharmacology - May 4, 2019 Category: Environmental Health Source Type: research

Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure
Publication date: Available online 1 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kristin N. Bridges, Jason T. Magnuson, Thomas E. Curran, Andrew Barker, Aaron P. Roberts, Barney J. VenablesAbstractSynthetic sex steroids, like the synthetic progestin norethindrone (NET), can affect a wide variety of biological processes via highly conserved mechanisms. NET is prevalent in surface waters, yet the sub-lethal effects of NET exposure are not are net yet well characterized in aquatic biota. A few targeted gene expression and behavioral studies have concluded that NET affects the vision of adult fish; howe...
Source: Environmental Toxicology and Pharmacology - May 2, 2019 Category: Environmental Health Source Type: research

Differential detoxifying responses to crude oil water-accommodated fraction in Hyallela curvispina individuals from unpolluted and contaminated sites
Publication date: Available online 1 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): J. Del Brio, B.A. Lares, L.B. Parra-Morales, V.G. Sanchez, C.M. Montagna, A. VenturinoAbstractSublethal effects of water-accommodated fraction (WAF) from crude oil of Neuquén basin, Northern Patagonia-Argentina, were examined on both antioxidant and detoxification system of Hyalella curvispina adults collected in Los Barreales (LB) lake and in an oil-polluted stream (DS). The effects of WAF exposure during 6, 24 and 48 h were evaluated in the glutathione content (GSH) and glutathione S-transferase (GST), c...
Source: Environmental Toxicology and Pharmacology - May 2, 2019 Category: Environmental Health Source Type: research

Copper effect on the biomarker state of the Mizuhopecten yessoensis tissues in the prespawning period
Publication date: Available online 30 April 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Aleksandra Istomina, Viktor Chelomin, Sergey Kukla, Aleksandr Zvyagintsev, Aleksandr Karpenko, Elena Slinko, Nadezhda Dovzhenko, Valentina Slobodskova, Lyudmila KolosovaAbstractThe aim of this study was to investigate the sensitivity of the marine scallop Mizuhopecten yessoensis to different copper concentrations (10 and 30 μgl-1) in the prespawning period. Reaction of the scallop to this effect was evaluated by a set of biomarkers, including general metabolism enzymes (acid and alkaline phosphatase activities - A...
Source: Environmental Toxicology and Pharmacology - May 1, 2019 Category: Environmental Health Source Type: research

Association of Maternal Arsenic Exposure with Birth Size: A Systematic Review and Meta-Analysis
ConclusionsMaternal arsenic exposure is associated with the decrease of the birth weight, length and head circumference. Millions of people are still exposured to high-level arsenic, therefore, high quality epidemiologic studies that involve large samples are necessary to determine the precise relationships between maternal arsenic exposure with birth size. And that effective mitigation measures are also need to prevent arsenic exposure in women of reproductive age. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 20, 2019 Category: Environmental Health Source Type: research

Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells
Publication date: Available online 19 April 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Furong Zhu, Han Cheng, Ruoqian Lei, Chaowei Shen, Jie Liu, Lijuan Hou, Chao Zhang, Yachun Xu, Rui Ding, Jiyu CaoAbstractIn China, cooking oil fume derived fine particulate matter (COF-derived PM2.5) is a principal source of indoor air pollution. Here, we investigated cytotoxicity of COF-derived PM2.5, as well as the roles of VEGF, VEGFR2, MEK1/2, ERK1/2, and mTOR cascade in the inhibitory effects of COF-derived PM2.5, on angiogenesis in human umbilical vein endothelial cells (HUVECs). After exposure to COF-derived PM...
Source: Environmental Toxicology and Pharmacology - April 20, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: May 2019Source: Environmental Toxicology and Pharmacology, Volume 68Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 19, 2019 Category: Environmental Health Source Type: research

Different biological effects of PM2.5 from coal combustion, gasoline exhaust and urban ambient air relate to the PAH/metal compositions
In this study, PM2.5 samples from coal combustion, gasoline exhaust and urban ambient air were analyzed for 16 PAHs and 23 metals. Cytotoxic and inflammatory effects of different PM2.5 were evaluated on differentiated THP-1 and A549 cells, respectively. We found that the coal combustion PM2.5 samples induced stronger cytotoxic and inflammatory effects (p
Source: Environmental Toxicology and Pharmacology - April 19, 2019 Category: Environmental Health Source Type: research

Oxidative stress: One potential factor for arsenite-induced increase of N6-methyladenosine in human keratinocytes
Publication date: Available online 13 April 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tianhe Zhao, Xinyang Li, Donglei Sun, Zunzhen ZhangAbstractN6-methyladenosine (m6A) modification is affected by oxidative stress and gets involved in arsenite toxicity. However, whether oxidative stress is one factor in arsenite-induced alteration of m6A levels remains unclear. Here, reactive oxygen species (ROS), product of lipid peroxidation (MDA), antioxidants (GSH and SOD), m6A levels, m6A methyltransferases (METTL3, METTL14, and WTAP) and demethylases (FTO and ALKBH5) were detected in human keratinocytes exposed...
Source: Environmental Toxicology and Pharmacology - April 14, 2019 Category: Environmental Health Source Type: research

Mono-2-Ethylhexyl Phthalate Induces the Expression of Genes Involved in Fatty Acid Synthesis in HepG2 Cells
Publication date: Available online 9 April 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Yu Hongmei, Qing TanAbstractMono-2-ethylhexyl phthalate (MEHP) is a major bioactive metabolite in the widely used industrial plasticizer diethylhexyl phthalate (DEHP) that has been found to be toxic to the liver. The aim of this study is to determine whether MEHP exposure can change the expression of fatty acid metabolism-related genes in HepG2 cells, which might be related to non-alcoholic fatty liver disease (NAFLD). The results revealed that exposure to MEHP promoted l...
Source: Environmental Toxicology and Pharmacology - April 10, 2019 Category: Environmental Health Source Type: research

Toxicity Effects of Captan on Different Life Stages of Zebrafish (Danio rerio)
The objective of this study was to evaluate the toxicity and developmental effects of captan on different life stages (embryo and adult) of zebrafish (Danio rerio). The results showed that the 96-h lethal concentration 50 (LC50) values of embryo and adult zebrafish (exposed to captan) were 0.81(0.75-0.87) mg/L and 0.65(0.62-0.68) mg/L, respectively. The results of developmental effect experiment showed that captan can significantly decrease the heartbeats and inhibit the hatching rate and growth of zebrafish embryos. Moreover, captan exposure can induce a series of deformities, including pericardial edema, yolk sac edema, ...
Source: Environmental Toxicology and Pharmacology - April 5, 2019 Category: Environmental Health Source Type: research

The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells
Publication date: Available online 2 April 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Qianlei Yang, Zhen Zhu, Luna Wang, Haixuan Xia, Jiayuan Mao, Jing Wu, Koichi Kato, Heran Li, Jie Zhang, Kenzo Yamanaka, Yan AnAbstractThe therapeutic use of silk-derived materials such as fibroin in biomedicine is well-established in Southeast Asian countries. Studies indicated that silk fibroin (SF) peptide enhances insulin sensitivity and glucose metabolism phenomena associated with type 2 diabetes mellitus (T2DM) suggesting this peptide may be beneficial to treat this disease. However, the mechanisms underlying pro...
Source: Environmental Toxicology and Pharmacology - April 3, 2019 Category: Environmental Health Source Type: research

Responses of biomarkers belonging to different metabolic systems of rats following oral administration of aluminium nanoparticle
This study demonstrated that most biomarkers in the tissues of rats were affected by Al-NP, showing the signal of toxic effects and suggests further studies to understand better the effects of Al NPs, especially in their use for pharmacology. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 3, 2019 Category: Environmental Health Source Type: research

Human exposure to banned pesticides reported to the French Poison Control Centers: 2012–2016
This study suggests persistent use of carbamate insecticides, the existence of illegal imports of dichlorvos or paraquat-based products, and the use of certain banned fungicides in the professional agricultural sector. Information and collection campaigns are therefore essential after the withdrawal of marketing authorization for the plant protection products. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 31, 2019 Category: Environmental Health Source Type: research

Lethality, neurotoxicity, morphological, histological and cellular alterations of Ni-Al nanoceramics on the embryo-larval development of Rhinella arenarum
Publication date: Available online 28 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Gabriela Svartz, Maria Teresa Sandoval, Marina Gosatti, Soledad Perez Catán, Cristina Pérez CollAbstractAlumina nanoparticles (NP-Al2O3) are widely used but their environmental effects are unknown, so they can become potentially dangerous. The aim of this study was to evaluate the toxicity of a nanoceramic catalyst Ni/γ-Al2O3 (NC) and NPs involved in their synthesis, γ-Al2O3 support (SPC) and NiO/γ-Al2O3 precursor (PC) on Rhinella arenarum embryo-larval development. The NPs toxicity si...
Source: Environmental Toxicology and Pharmacology - March 30, 2019 Category: Environmental Health Source Type: research

Oral exposure to cadmium and mercury alone and in combination causes damage to the lung tissue of Sprague-Dawley rats
This study identified the lungs as target of heavy metals toxicity following oral exposure resulting in cellular damage, inflammation and fibrosis and increased risk of respiratory disease where Hg showed the greatest fibrotic effect, which was further, aggravated in combination with Cd. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 30, 2019 Category: Environmental Health Source Type: research

Polystyrene nanoplastics alter the cytotoxicity of human pharmaceuticals on marine fish cell lines
Publication date: Available online 29 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Mónica Almeida, Manuel A. Martins, Amadeu M.V. Soares, Alberto Cuesta, Miguel OliveiraAbstractThere is an increasing concern on the consequences of the presence of micro(nano)plastics to marine organisms. The present study aimed to provide information on the effects of polystyrene nanoplastics (PSNPs) to fish cells alone and combined with human pharmaceuticals, other emerging contaminants, using as biological models marine fish cell lines SAF-1 and DLB-1. Cells were exposed for 24 h to 100 nm PSN...
Source: Environmental Toxicology and Pharmacology - March 30, 2019 Category: Environmental Health Source Type: research

Modulation of eNOS/iNOS by nebivolol protects against cyclosporine A-mediated nephrotoxicity through targeting inflammatory and apoptotic pathways
Publication date: Available online 21 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Azza A.K. El-Sheikh, Mohamed A. Morsy, Rania G. Abdel-latifAbstractThe aim of this study was to investigate effect of nitric oxide (NO) modulation on possible nephroprotective mechanisms of nebivolol (NEB) in cyclosporine A (CsA)-induced nephrotoxicity. Rats were treated with 20 mg/kg/day s.c. of CsA for 21 days, with NEB alone (10 mg/kg/day orally) or together with a NOS inhibitor, L-NAME (10 mg/kg/day i.p.). NEB conferred nephroprotection against CsA-induced toxicity, significantly decreasing s...
Source: Environmental Toxicology and Pharmacology - March 21, 2019 Category: Environmental Health Source Type: research

Chemosensitizer effect of cisplatin-treated bladder cancer cells by phenazine-5,10-dioxides
Publication date: Available online 19 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Paola Hernández, Diego Alem, Marcos Nieves, Hugo Cerecetto, Mercedes González, Wilner Martínez-López, María Laura LavaggiAbstractWe determined the chemosensitizer effect of phenazine dioxide derivatives to cisplatin and the possible mechanism of action on bladder cancer cells. Anti-proliferative activity of nine phenazine dioxide derivatives in presence or absence of cisplatin was evaluated in two bladder tumor human cells T24 and 253 J and one non tumor cell line V79-4.The s...
Source: Environmental Toxicology and Pharmacology - March 21, 2019 Category: Environmental Health Source Type: research

Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia, Oreochromis niloticus
Publication date: Available online 18 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Mohamed M. Abdel-Daim, Ismail A.M. Eissa, Ahmed Abdeen, Hany M.R. Abdel-Latif, Mona Ismail, Mahmoud A.O. Dawood, Ahmed M. HassanAbstractIndustrial products contained nano-zinc oxide (ZnONP) can gain access to the aquaculture environment causing hazardous effects on the living biota. Therefore, this work was planned to examine the ameliorative effects of dietary supplementation of lycopene (LYC), resveratrol (RES) against ZnONP toxicity in Nile tilapia. Five groups with 20 fish each were used; Control, received tap wa...
Source: Environmental Toxicology and Pharmacology - March 19, 2019 Category: Environmental Health Source Type: research

Microarray-based data mining reveals key genes and potential therapeutic drugs for Cadmium-induced prostate cell malignant transformation
Publication date: Available online 15 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ying Xiang, Liang Zhang, Yu Huang, Junjun Ling, Wenlei ZhuoAbstractIncreasing evidence showed that Cadmium (Cd) can accumulate in the body and damage cells, resulting in cancerigenesis of prostate with complex mechanisms. In the present study, we aimed to explore the possible key genes, pathways and therapeutic drugs using bioinformatics methods. Microarray-based data were retrieved and analyzed to screen differentially expressed genes (DEGs) between Cd-treated prostate cells and controls. Then, functions of the DEGs...
Source: Environmental Toxicology and Pharmacology - March 16, 2019 Category: Environmental Health Source Type: research

Environmental Inhibitors of the Expression of Cytochrome P450 17A1 in Mammals
Publication date: Available online 14 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Zhiheng Peng, Ailin Zhang, Wenci Chen, Shenglong XiaAbstractCytochrome P450 17A1 (CYP17A1; EC: 1.14.14.19) is a critically important bifunctional enzyme with nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor that catalyzes the formation of all endogenous androgens. Its hydroxylase activity catalyzes the 17α-hydroxylation of pregnenolone (PREG)/progesterone (P4) to 17α-OH-pregnenolone/17α-OH-progesterone, and its 17,20-lyase activity converts 17α-OH-pregnenolone/17α-OH-p...
Source: Environmental Toxicology and Pharmacology - March 15, 2019 Category: Environmental Health Source Type: research

Acute exposure to 4-OH-A, not PCB1254, alters brain aromatase activity but does not adversely affect growth in zebrafish
Publication date: Available online 14 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Cassie J. Gould, Colin J. Saldanha, Victoria P. ConnaughtonAbstractAcute developmental exposure to pharmaceuticals or environmental contaminants can have deleterious, long lasting effects. Many of these compounds are endocrine disruptors (EDCs) that target estrogen signaling, with effects on reproductive and non-reproductive tissues. We recently reported that zebrafish larvae transiently exposed to the pharmaceutical EDC 4-OH-A display visual deficits as adults. Here, we examine whether these long-term effects are du...
Source: Environmental Toxicology and Pharmacology - March 15, 2019 Category: Environmental Health Source Type: research

Death of captive-bred vultures caused by flunixin poisoning in Italy
Publication date: Available online 11 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Claudia Eleni, Bruno Neri, Luigi Giannetti, Goffredo Grifoni, Roberta Meoli, Fiorentino Stravino, Klaus Gunther Friedrich, Francesco Scholl, Pilar Di Cerbo, Antonio BattistiAbstractAmong non steroidal anti-inflammatory drugs (NSAIDs) diclofenac is considered the main cause for the decline of vulture populations in the Indian subcontinent since the ‘90 s. Chemical analysis showed high levels of flunixin (31350 µg/kg) in beef which three captive Gyps vultures fed on, later dying with severe vi...
Source: Environmental Toxicology and Pharmacology - March 12, 2019 Category: Environmental Health Source Type: research

Influence of humic substances on the toxic effects of cadmium and SDBS to the green alga Scenedesmus obliquus
Publication date: Available online 11 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ying Zhang, Ruixin Yang, Siyang Wang, Xiaohui Si, Xingwei Duan, Jiti ZhouAbstractThe joint toxicity of chemicals mixture in the aquatic environment was still not well clear. To clarify the joint toxicity of the mixtures of metals and organic pollutants, as well as the influence of dissolved organic matter (DOM) in field water-body on their toxic effects, we conducted the toxicity tests with cadmium (Cd) and sodium dodecyl benzene sulfonate (SDBS) on Scenedesmus obliquus (S. obliquus) with or without the presence of f...
Source: Environmental Toxicology and Pharmacology - March 12, 2019 Category: Environmental Health Source Type: research

Fine Particulate Matter (PM2.5) Enhances Airway Hyperresponsiveness (AHR) by Inducing Necroptosis in BALB/c Mice
ConclusionOur findings suggest that PM2.5 can enhance AHR and these changes are induced by necroptosis-related inflammation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 12, 2019 Category: Environmental Health Source Type: research

Microplastics in cosmetics: environmental issues and needs for global bans
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): C. Guerranti, T. Martellini, G. Perra, C. Scopetani, A. CincinelliAbstractDespite the microbeads from cosmetic products does not contribute with high percentages to environmental pollution from microplastics, they can pose a threat to the environment, being discharged into the water bodies and just partially blocked by the wastewater treatment plants. As environmental associations have been fighting for the abolition of microplastics in PCCPs, in many countries measures have been taken and bans are already operational...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Microplastic exposure and effects in aquatic organisms: a physiological perspective
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Silvia Franzellitti, Laura Canesi, Manon Auguste, Rajapaksha H.G.R. Wathsala, Elena FabbriAbstractThe impact of microplastics (MPs) on aquatic life, given their ubiquitous presence in the water compartment, represents a growing concern. Consistently, scientific knowledge is advancing rapidly, although evidence on actual adverse effects is still highly fragmented. This paper summarizes the recent literature on MP impacts on aquatic organisms in an attempt to link routes of uptake, possible alterations of physiological ...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review
Publication date: Available online 8 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ju-Wook Lee, Hoon Choi, Un-Ki Hwang, Ju-Chan Kang, Yue Jai Kang, Kwang Il Kim, Jun-Hwan KimAbstractLead (Pb) is a highly toxic metal in aquatic environments. Fish are at the top of the food chain in most aquatic environments, and are the most susceptible to the toxic effects of Pb exposure. In addition, fish are one of the most abundant vertebrates, and they can directly affect humans through food intake; therefore, fish can be used to assess the extent of environmental pollution in an aquatic environment. Pb-induced ...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Scrutinizing the interactions between bisphenol analogues and plasma proteins: insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions
Publication date: Available online 9 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Lucia Grumetto, Francesco Barbato, Giacomo RussoAbstractThe interactions between human serum albumin (HSA) and α1- acid glycoprotein (AGP), the main plasma proteins binding drugs/xenobiotics, and some endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA) and some of its structural analogues, bisphenol S (BPS), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol A diglycidyl ether (BADGE) and bisphenol M (BPM), were characterized by biomimetic liquid chromatography (...
Source: Environmental Toxicology and Pharmacology - March 9, 2019 Category: Environmental Health Source Type: research

Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells
This study investigated the effects of β-zol and HT-2 on bovine ovarian granulosa cells (BGCs), and how melatonin may counteract these effects. β-zol and HT-2 inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of BGCs. They also yielded upregulation of the apoptosis-related genes Bax/Bcl-2 and Caspase3 and phosphorylation of p38MAPK. Increases in intracellular ROS were observed along with higher levels of mRNA anti-oxidation markers SOD1, SOD2, and CAT. SOD1, SOD2, malonaldehyde (MDA), and glutathione peroxidase (GSH-px) activities increased, as did the levels of SOD1 and SOD2 proteins...
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research

Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts
This study provides a rationale for translational studies in the field of cardio-oncology.Graphicala bstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 8, 2019 Category: Environmental Health Source Type: research