Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells in mice offspring
Publication date: Available online 26 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Shimeng Luo, Yun Li, Yingpei Li, Qixing Zhu, Jianhua Jiang, Changhao Wu, Tong Shen Increasing evidence demonstrates that perinatal exposure to Bisphenol A (BPA) can cause immune disorders throughout the life span. However, the biological basis for these immune disorders is poorly understood and the effects of exposure to BPA on Th17 development are unknown. The present study sought to characterize alterations of Th17 cells in childhood and adulthood following gestational and lactational exposure to environmenta...
Source: Environmental Toxicology and Pharmacology - September 26, 2016 Category: Environmental Health Source Type: research

The immune responses and expression of metallothionein (MT) gene and heat shock protein 70 (HSP 70) in juvenile rockfish, Sebastes schlegelii, exposed to waterborne arsenic (As3+)
Publication date: Available online 26 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jun-Hwan Kim, Ju-Chan Kang Juvenile rockfish, Sebastes schlegelii (mean length 16.4±1.9cm, and mean weight 71.6±6.4g) were exposed for 20days with the different levels of waterborne arsenic concentration (0, 50, 100, 200 and 400μg/L). The plasma cortisol of S. schlegelii was significantly increased by the waterborne arsenit exposure. In the immune responses, the immunoglobulin M (IgM) and lysozyme activity of S. schlegelii were significantly increased by the waterborne arsenic exposure. The ace...
Source: Environmental Toxicology and Pharmacology - September 26, 2016 Category: Environmental Health Source Type: research

Heavy metals (Pb, Cd, MeHg, As) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in Brain
Publication date: Available online 26 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Venkatanaidu Karri, Marta Schuhmacher, Vikas Kumar Human exposure to toxic heavy metals is a global challenge. Concurrent exposure of heavy metals, such as lead (Pb), cadmium (Cd), methylmercury (MeHg) and arsenic (As) are particularly important due to their long lasting effects on the brain. Although, the exact mechanism of neurotoxicity of metal mixture (Pb, Cd, As and MeHg) is unclear, but their main target region is hippocampus and they share many common pathways for causing cognitive dysfunction. The combi...
Source: Environmental Toxicology and Pharmacology - September 26, 2016 Category: Environmental Health Source Type: research

The biological activity of cationic liposomes in drug delivery and toxicity test in animal models
Publication date: Available online 26 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Panpan Qi, Mei Cao, Liju Song, Chong Chen, Mingdong Liu, Ningzhe Li, Daoyan Wu, Jingshan Peng, Guoku Hu, Jian Zhao In the study we made use of DOTAP (1,2-dioleoyl-3-trimethylammonium), DOPE (1,2-dioleoyl-snglycero-3-phosphoethanolamine) and PEG-PE (polyethylene glycol- polyethylene) to make cationic PEG-liposomes by ultrasonic dispersion method. The plasmid pGPU6 combined with cationic PEG-liposomes or Liopofectamin 2000 was used to transfect PC3 cells to judge the transfection efficiency. HE staining showed th...
Source: Environmental Toxicology and Pharmacology - September 26, 2016 Category: Environmental Health Source Type: research

Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride
This study gives an insight in sensitivity of heart rate (Hr) of Mytilus galloprovincialis as a physiological biomarker. Impact of tributyltin chloride (TBT-Cl) on Hr was studied in parallel with evaluation of mutagenic, genotoxic and cytotoxic potential of TBT-Cl (10, 100 and 1000μg/L) within 96h treatment in static conditions. Mutagenic potential was assessed by SOS/umuC assay while genotoxicity was assessed in haemocytes of M. galloprovincialis by using the comet assay and the micronucleus test. Benzo(a)pyrene (B(a)P) was used as a positive control. Hr variations detected in TBT-Cl treatments can be linked to data ob...
Source: Environmental Toxicology and Pharmacology - September 26, 2016 Category: Environmental Health Source Type: research

Bisphenol A and its analogs: Do their metabolites have endocrine activity?
Publication date: Available online 22 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Darja GramecSkledar, Lucija Peterlin Mašič Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions on endocrine activities of bisphenols, we conducted a systematic review of the literature. Knowledge about the metabolic pathways and enzymes inv...
Source: Environmental Toxicology and Pharmacology - September 22, 2016 Category: Environmental Health Source Type: research

NSCA-1; A Novel N-substituted Coumalamide Derivative; Increases Adriamycin Sensitivity in HepG2/adriamycin Cells through Modulating Akt/GSK-3 β Signaling and p53-dependant Apoptotic Pathway
In this study, we report the synthesis and biological evaluation of a novel N-substituted coumalamide derivative (NSCA-1). The results indicated that NSCA-1 exerts synergistic cytotoxicity with Adriamycin in HepG2/ADR (HepG2/adriamycin) cells. Furthermore, both of the Akt kinase activity and phosphorylated Akt (Ser473) were found to be inhibited by NSCA-1 and subsequently resulting in decreased phosphorylation of GSK-3β. The intracellular accumulation of Adriamycin was also boosted by NSCA-1 via reducing the expression of p-gp. In addition, we found that combined treatment with NSCA-1 enhance cell apoptosis induced by...
Source: Environmental Toxicology and Pharmacology - September 22, 2016 Category: Environmental Health Source Type: research

Hydroxylation of multi-walled carbon nanotubes: enhanced biocompatibility through reduction of oxidative stress initiated cell membrane damage, cell cycle arrestment and extrinsic apoptotic pathway
In this study, we carried out a comprehensive evaluation of hydroxylated multi-walled carbon nanotubes (MWCNTs-OH) on the human normal liver L02 cell line, and compared it with that of pristine multi-walled carbon nanotubes (p-MWCNTs). Results demonstrated that compared with p-MWCNTs, MWCNTs-OH induced significantly lower oxidative stress as indicated by the level of intracellular antioxidant glutathione (GSH), subsequently lead to less cell membrane damage as demonstrated by lactate dehydrogenase (LDH) leakage assay, and showed slightly decreased arrestment of cell cycle distribution at G0/G1. More interestingly, MWCNTs-O...
Source: Environmental Toxicology and Pharmacology - September 21, 2016 Category: Environmental Health Source Type: research

Avoidance behavior of Eisenia fetida in oxytetracycline- and heavy metal-contaminated soils
Publication date: Available online 19 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Minling Gao, Mengting Lv, Meng Han, Wenhua Song, Dong Wang To determine the behavior of oxytetracycline (OTC) and heavy metals in soil, this study assessed the pollutant-induced avoidance behavior of earthworms (E. fetida) exposed to zinc (Zn2+), lead (Pb2+), and OTC in soil. The results showed a clear avoidance response within 48h of exposure to the highest concentrations of pollutants. Moreover, E. fetida was shown to be more sensitive to Zn2+ than to Pb2+ and OTC. Compared with OTC alone, the net response of...
Source: Environmental Toxicology and Pharmacology - September 19, 2016 Category: Environmental Health Source Type: research

An improved in vitro method for screening toxin and medicine targeting CYP2E1
Publication date: October 2016 Source:Environmental Toxicology and Pharmacology, Volume 47 Author(s): Meng Wang, Zhaoxiang Zhou, Jian Wang, Xiaoying Zhang The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 inducers (ethanol and pyrazole) and inhibitors (diallyldisulfide and kaempferol) were applied to evaluate the effectiveness of homogenate-mitochondrial system...
Source: Environmental Toxicology and Pharmacology - September 18, 2016 Category: Environmental Health Source Type: research

Influence of silver and titanium dioxide nanoparticles on in vitro blood-brain barrier permeability
This study provided the new insight of toxic potency of AgNPs and TiO2NPs in BBB. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 15, 2016 Category: Environmental Health Source Type: research

Effect of Dibutyl Phthalate on Expression of Connexin 43 and Testosterone Production of Leydig Cells in Adult Rats
Publication date: Available online 15 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jing Zhang, Shuguang Jin, Jinchang Zhao, Huan Li To investigate the adverse effect of dibutyl phthalate (DBP) on Leydig cells and its mechanism related to gap junction, Leydig cells isolated from adult rats were treated with 0.1% dimethylsulfoxide (DMSO), 50mg/L DBP, 50mg/L DBP+10μM prostaglandin E2 (PGE2) and 40μM flutamide respectively. Radioimmunoassay, semi-quantitative RT-PCR, immunofluorescence and Western blot were applied to determine the expression of testosterone and Connexin 43 (Cx43) in Leydig...
Source: Environmental Toxicology and Pharmacology - September 15, 2016 Category: Environmental Health Source Type: research

The influence of maternal smoking on transferrin sialylation and fetal biometric parameters
Conclusion It has been shown the relationship between Cd from tobacco smoking and fetal biometric parameters observed only in the irondeficient group suggesting an additive effect of these two factors, and indicate that mothers with anemia may be more susceptible to Cd toxicity and disturbed fetal development. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 15, 2016 Category: Environmental Health Source Type: research

An improved method for screening toxin and medicine targeting CYP2E1 in vitro
Publication date: Available online 14 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Meng Wang, Zhaoxiang Zhou, Jian Wang, Xiaoying Zhang The cytochrome P450 enzyme 2E1 (CYP2E1) presented in both microsome and mitochondria, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondria was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 inducers (ethanol and pyrazole) and inhibitors (diallyldisulfide and kaempferol) were applied to evaluate the effectiveness of homogenate-mitochondr...
Source: Environmental Toxicology and Pharmacology - September 14, 2016 Category: Environmental Health Source Type: research

Role of miR-199b-5p in regulating angiogenesis in mouse myocardial microvascular endothelial cells through HSF1/VEGF pathway
Publication date: Available online 14 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Peizhao Du, Fangjie Dai, Yaowei Chang, Chunyan Wei, Jing Yan, Jiming Li, Xuebo Liu Our study explored effects of miR-199b-5p on angiogenesis in mouse myocardial microvascular endothelial cells (MMVECs) and the involved working mechanisms. We applied explant culture to incubate C57/BL6 mouse MMVECs. Lipofection was used to transfect miR-199b-5p mimic, miR-199b-5p inhibitor and miR-199b-5p scramble respectively. MMVECs were divided into miR-199b-5p up-regulation, miR-199b-5p down-regulation and control groups bas...
Source: Environmental Toxicology and Pharmacology - September 14, 2016 Category: Environmental Health Source Type: research

Naringin protects against lipopolysaccharide-induced cardiac injury in mice
Publication date: Available online 13 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Liu Xianchu, Professor Zheng Lan, Li Qiufang, Liu Yi, Ruan Xiangcheng, Hou Wenqi, Ding Yang (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 13, 2016 Category: Environmental Health Source Type: research

Molecular docking study to evaluate the carcinogenic potential and mammalian toxicity of thiophosphonate pesticides by cluster and discriminant analysis
Publication date: Available online 8 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Alina-Maria Petrescu, Gheorghe Ilia In this paper, the carcinogenic potential and mammalian toxicity on rodents, based on the quantitative relationship models between structure and biological activity (QSAR), were evaluated. The carcinogenicity and acute toxicity were evaluated by docking molecular physicochemical descriptors, on a series of 33 thiophosphonates. These properties, mainly hydrophobicity, electronic distribution, hydrogen bonding characteristics, molecule size and flexibility, and the presence of v...
Source: Environmental Toxicology and Pharmacology - September 8, 2016 Category: Environmental Health Source Type: research

Protective role of selenium in the activities of antioxidant enzymes in piglet splenic lymphocytes exposed to deoxynivalenol
Publication date: Available online 6 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Xuemei Wang, Zhicai Zuo, Chuanping Zhao, Zhuo Zhang, Guangneng Peng, Suizhong Cao, Yanchun Hu, Shumin. Yu, Zhijun Zhong, Junliang Deng, Zhihua Ren We evaluated the effects of selenium (Se) on antioxidant enzymes of piglet splenic lymphocytes exposed to deoxynivalenol (DON). We measured cell viability, the activities of several antioxidant enzymes, and lactate dehydrogenase (LDH), as well as total antioxidant capacity (T-AOC) and the levels of malonaldehyde (MDA) and hydrogen peroxide (H2O2). We found that DON ex...
Source: Environmental Toxicology and Pharmacology - September 6, 2016 Category: Environmental Health Source Type: research

Sulfur dioxide inhalation lowers sperm quality and alters testicular histology via increasing expression of CREM and ACT proteins in rat testes
Publication date: Available online 4 September 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jianhai Zhang, Fei Zheng, Chen Liang, Yuchen Zhu, Yan Shi, Yongli Han, Jundong Wang Sulfur dioxide (SO2) is one of the main atmospheric pollutants worldwide, and is reported to be responsible for the formation of severe haze in China. Some studies have demonstrated a potential harmful effect of SO2 on the male reproductive system; however the underlying mechanism is still unknown. The purpose of this study is to investigate the roles of cytochrome P450 (P450), cAMP-responsive element modulator (CREM), and activa...
Source: Environmental Toxicology and Pharmacology - September 3, 2016 Category: Environmental Health Source Type: research

The Effects of Chlormequat Chloride on the Development of Pubertal Male Rats
In this study, CCC was administered to rats daily by gavage on postnatal days 23-60 at doses of 0, 75, 150 and 300mg/kg bw/d. The results showed that body weight and the length of the right femur were significantly decreased in the 300mg/kg bw/d group. Histological analysis of proximal growth plates of the right femurs showed narrowed proliferative zones and hypertrophic zones in CCC-treated groups. The mRNA expression of growth hormone, growth hormone receptor and insulin like growth factor 1 were decreased in the CCC-treated group. The results indicated that CCC may affect the expression of growth hormone and insulin-lik...
Source: Environmental Toxicology and Pharmacology - September 3, 2016 Category: Environmental Health Source Type: research

The toxicology mechanism of endophytic fungus and swainsonine in locoweed
Publication date: Available online 31 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Chenchen Wu, Tiesuo Han, Hao Lu, Baoyu Zhao Locoweed is a perennial herbaceous plant included in Astragalus spp. and Oxytropis spp. that contains the toxic indolizidine alkaloid swainsonine. The livestock that consume locoweed can suffer from a type of toxicity called locoism. There are aliphaticnitro compounds, selenium, selenium compounds, and alkaloids in locoweed. The toxic component in locoweed has been identified as swainsonine, an indolizidine alkaloid. Swainsonine inhibits lysosomal a-mannosidase and manno...
Source: Environmental Toxicology and Pharmacology - August 31, 2016 Category: Environmental Health Source Type: research

Effect of exposure to staphylococcus aureus, particulate matter, and their combination on the neurobehavioral function of mice
Publication date: Available online 30 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Fan Wang, Fei Liu, Haifang Liu Neurotoxicity in Kunming mice caused by Staphylococcus aureus (S. aureus) and Particulate matter (PM) as individual matter and mixtures was studied in this paper. Male Kunming mice were instilled intratracheally with PM at doses of 0.2mg/mouse and S. aureus at doses of 5.08×106 CFU/mouse as individual matter and mixtures two times at 5-day intervals. Morris water maze (MWM) test was performed during the exposure experiment. One day following the exposure experiment, the express...
Source: Environmental Toxicology and Pharmacology - August 30, 2016 Category: Environmental Health Source Type: research

Biosynthesis of size-controllable silver nanoparticles and their in vitro antidiabetic activity
Publication date: Available online 29 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Rui-xia Liu A simple biosynthetic approach for the size-controllable production of silver nanoparticles (AgNPs) using the leaf extract of Cinnamomum tsoi as a reducing and capping agent was developed. The polyphenolic functionalities present in the extract were responsible for synthesis and stabilization of the AgNPs. The size and morphology of the AgNPs were effectively adjusted by changing the volume of the extract. The AgNPs were characterized by X-ray diffraction, UV-visible spectroscopy, transmission electron...
Source: Environmental Toxicology and Pharmacology - August 29, 2016 Category: Environmental Health Source Type: research

Applications in environmental risk assessment of biochemical analysis on the Indian fresh water fish, Labeo rohita exposed to monocrotophos pesticide
Publication date: Available online 22 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): S. Binukumari, K.Anusiya Devi, J. Vasanthi Pesticides are widely used in modern agriculture to aid in the production of high quality food. However, some pesticides have the potential to cause serious health and environmental damage. Repeated exposure to sub-lethal doses of pesticides can cause physiological and behavioral changes in fish that reduce populations such as abandonment of nests and broods, decreased immunity to disease and increased failure to avoid predators. Monocrotophos is one of the organophosphor...
Source: Environmental Toxicology and Pharmacology - August 22, 2016 Category: Environmental Health Source Type: research

Role of HSF1-Upregulated AC6 in Ameliorating Heart Failure in Mice
Conclusion In the pressure overload heart failure model, HSF1 can ameliorate heart failure by positively regulating the pathway of AC6/cAMP/PKA. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 22, 2016 Category: Environmental Health Source Type: research

Does environmental exposure to the greenhouse gas, N2O, contribute to etiological factors in neurodevelopmental disorders? A Mini-Review of the Evidence
Conclusions The current evidence and subsequent hypotheses suggest that a renewed interest be taken in the toxicological assessment of environmental N2O exposure using validated biomarkers and psychiatric endpoints. Given the relevance of N2O as a greenhouse gas, societies may also wish to engage in a more robust monitoring and reporting of N2O levels in the environment for climactic benefit as well. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 18, 2016 Category: Environmental Health Source Type: research

Oxidative stress, genotoxicity and cytotoxicity of 1-methyl-3-octylimidazolium chloride on Paramisgurnus dabryanus
This study evaluated the toxicity of 1-methyl-3-octylimidazolium chloride ([C8mim]Cl) on Paramisgurnus dabryanus by enzyme analysis, comet assay, and apoptosis analysis. The study showed that [C8mim]Cl had an obvious toxic effect inducing oxidative stress, genotoxicity, and cytotoxicity to fish liver cells. [C8mim]Cl also induced changes in the activities of superoxide dismutase and catalase, and the glutathione content and malondialdehyde level in fish exposed at 20–80mgL−1. With increased exposure concentration and time, the four antioxidant enzyme activities, three different comet parameters and apoptosis ra...
Source: Environmental Toxicology and Pharmacology - August 17, 2016 Category: Environmental Health Source Type: research

Ethambutol induces testicular damage and decreases the sperm functional competence in Swiss albino mice
In conclusion, the result of the present study indicates that EMB has adverse effect on testicular function and impairs the sperm functional competence. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 12, 2016 Category: Environmental Health Source Type: research

2,2 ′,4,4′-Tetrabromodiphenyl ether injures cell viability and mitochondrial function of mouse spermatocytes by decreasing mitochondrial proteins Atp5b and Uqcrc1
Publication date: Available online 11 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Shaoping Huang, Jing Wang, Yiqiang Cui Our object was to explore direct effects and mechanism of BDE47 on GC2 (immortalized mouse spermatocyte). GC2 were exposed to DMSO, 0.1, 1, 10, 100μM BDE47 for 48hours. Cell viability was detected by trypan-blue exclusion; ultrastructure by electron-microscopy; cell cycle, mitochondrial membrane motential (MMP), reactive oxygen species (ROS) by flow-cytometry; ATP production by luminometer; Atp5b, Uqcrc1, Bcl-2 level by WB. To explore whether the decreased mitochondrial pr...
Source: Environmental Toxicology and Pharmacology - August 11, 2016 Category: Environmental Health Source Type: research

Glyphosate induces cardiovascular toxicity in Danio rerio
Publication date: September 2016 Source:Environmental Toxicology and Pharmacology, Volume 46 Author(s): Nicole M. Roy, Jeremy Ochs, Ewelina Zambrzycka, Ariann Anderson Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled “safe” by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Given the widespread uses of and exposure to glyphosate, studies on developmental toxicity are needed. Here we utilize the zebrafish v...
Source: Environmental Toxicology and Pharmacology - August 11, 2016 Category: Environmental Health Source Type: research

Pollution by metals: is there a relationship in glycemic control?
Publication date: Available online 10 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Adriana González-Villalva, Laura Colín-Barenque, Bizarro-Nevares Patricia, Marcela Rojas-Lemus, Vianey Rodríguez-Lara, García-Pelaez Isabel, Martha Ustarroz-Cano, Nelly López-Valdéz, Juan Carlos Albarrán-Alonso, Teresa I Fortoul There are evidences of environmental pollution and health effects. Metals are pollutants implicated in systemic toxicity. One of the least studied effects, but which is currently becoming more important, is the effect of metals on glycemic c...
Source: Environmental Toxicology and Pharmacology - August 10, 2016 Category: Environmental Health Source Type: research

Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide
In conclusion, thyroid structure and thyroid function were both affected by excess fluoride and/or iodide. IRE1-induced apoptosis were involved in this cytotoxic process caused by fluoride or the combination of two microelements. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 9, 2016 Category: Environmental Health Source Type: research

Peroxisome proliferator-activated receptor gamma (PPAR γ) in brown trout: Interference of estrogenic and androgenic inputs in primary hepatocytes
Publication date: Available online 9 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Célia Lopes, Tânia Vieira Madureira, Nádia Ferreira, Ivone Pinheiro, L.Filipe C. Castro, Eduardo Rocha Peroxisome proliferator-activated receptor gamma (PPARγ) is a pivotal regulator of lipid and glucose metabolism in vertebrates. Here, we isolated and characterized for the first time the PPARγ gene from brown trout (Salmo trutta f. fario). Hormones have been reported to interfere with the regulatory function of PPARγ in various organisms, albeit with little focus on fish. Thus...
Source: Environmental Toxicology and Pharmacology - August 9, 2016 Category: Environmental Health Source Type: research

Characterization of a cadmium resistance lactococcus lactis subsp. lactis strain by antioxidant assays and proteome profiles methods
In this study, resistance properties of a newly isolated lactococcus lactis subsp. lactis for cadmium were studied by antioxidant assays and proteomics analysis. Antioxidant capacity of this strain was significantly activated under cadmium stress indicated by Fenton reaction, DPPH assay, SOD assay and GSH assay. Intracellular antioxidant enzyme systems, such as superoxide dismutase, glutathione reductase and catalase were suggested to play vital roles in the activated antioxidant capacity. The up-regulated cadA was associated with the activated P-type ATPases that plays an important role in cadmium resistance. Proteomics a...
Source: Environmental Toxicology and Pharmacology - August 6, 2016 Category: Environmental Health Source Type: research

Relationship between fluoride exposure and osteoclast markers during RANKL-induced osteoclast differentiation
In this study, osteoclasts were formed from bone marrow cells of C57BL/6 mice-treated with macrophage colony stimulating factor and receptor activator of nuclear factor kappa-B ligand. The mRNA expression of tartrate-resistant acid phosphatase 5b (TRAP5b), osteoclast-associated receptor (OSCAR), calcitonin receptor (CTR), matrix metalloproteinase 9 (MMP9) and cathepsin K (CK) were detected using real-time PCR (RT-PCR). Results showed that fluoride between 0.5 and 8mg/L had no effect on osteoclast formation. However fluoride at 0.5mg/L level significantly decreased the activity of osteoclast bone resorption. Fluoride concen...
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

Zinc enhances CDKN2A, pRb1 expression and regulates functional apoptosis via upregulation of p53 and p21 expression in human breast cancer MCF-7 cell
In conclusion, physiological level of zinc is important to prevent DNA damage and MCF-7 cell proliferation via regulation of tumor suppressor gene. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

Emodin Protects Mice against Radiation-induced Mortality and Intestinal Injury via Inhibition of Apoptosis and Modulation of p53
Publication date: Available online 3 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun Li The aim of this study was to explore the protective effect of emodin, a plant-derived anthraquinone, against gamma radiation-induced mortality and intestinal injury in mice, and to investigate the radioprotective molecular mechanism. C57BL/6 male mice were pre-treated with emodin for 7days via oral gavage before gamma radiation. We found that pretreatment with emodin prolonged mice survival time after 9Gy total body irradiation (TBI). ...
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

High fat diet aggravates the nephrotoxicity of berberrubine by influencing on its pharmacokinetic profile
In this study, we found BRB showed not only a stronger lipid-lowering effect than berberine but also a specific nephrotoxicity in mice fed with high fat diet (HFD). To explore the underlying mechanism, the pharmacokinetics of BRB were evaluated. There was a greater in vivo exposure of BRB in C57BL/6J mice fed with HFD than with routine chows, in terms of Cmax, AUC0-t, levels of BRB in kidney and urinary excretion. Moreover, in vitro assessment clearly showed BRB had a toxic effect on renal cell lines, while the primary metabolite, berberrubine-9-O-β-D-glucuronide (BRBG), did not show any obvious toxicity. These result...
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2
Publication date: Available online 3 August 2016 Source:Environmental Toxicology and Pharmacology Author(s): Lijun Chen, Yuan Li, Wenqin Yin, Wenqi Shan, Jinfeng Dai, Ye Yang, Lei LiGraphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

MAP4K4 deficiency in CD4+ T cells aggravates lung damage induced by ozone-oxidized black carbon particles
This study aims to observe the effect of oBC on lung damage in mice and discuss how the functional MAP4K4 defect CD4+ T cells (conditional knockout of MAP4K4) presents its role in this process. In our study, MAP4K4 deletion in CD4+ T cells (MAP4K4 cKO) could increase cell number of macrophages, lymphocytes and neutrophils in bronchoalveolar lavage fluid (BALF) exposed to oBC. MAP4K4 deletion in CD4+ T cell also affected CD4+ T cell differentiation in mediastinal lymph nodes after oBC stimulation. The number of CD4+ IL17+ T cell increased obviously. The levels of IL-6 mRNA of lung in MAP4K4 cKO mice was higher than that in ...
Source: Environmental Toxicology and Pharmacology - August 3, 2016 Category: Environmental Health Source Type: research

The immune responses in juvenile rockfish, Sebastes schlegelii for the stress by the exposure to the dietary lead (II)
Publication date: Available online 30 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Jun-Hwan Kim, Ju-Chan Kang The aim of this study was to evaluate the lead toxic effects on the stress parameters and immune responses of Sebastes schlegelii. Juvenile rockfish, S. schlegelii (mean length 14.2±1.9cm, and mean weight 57.3±5.2g) were exposed for 4 weeks with the different levels of dietary lead (Pb2+) at 0, 30, 60, 120 and 240mg/L. The plasma cortisol and heat shock protein 70 was evaluated as stress indicators. The plasma cortisol of S. schlegelii was significantly increased in respon...
Source: Environmental Toxicology and Pharmacology - July 30, 2016 Category: Environmental Health Source Type: research

β-eudesmol, a sesquiterpene from Teucrium ramosissimum, inhibits superoxide production, proliferation, adhesion and migration of human tumor cell
In this study we examined the effect of β-eudesmol, a sesquiterpenoid alcohol isolated from Teucrium ramosissimum leaves, on proliferation, superoxide anion production, adhesion and migration of human lung (A549) and colon (HT29 and Caco-2) cancer cell lines. Proliferation of tumor cells was inhibited by β-eudesmol. It also significantly inhibited superoxide production in A549 cells. Furthermore, β-eudesmol inhibited adhesion and migration of A549 and HT29 cell. These results demonstrate that β-eudesmol may be a novel anticancer agent for the treatment of lung and colon cancer by different ways: by inhi...
Source: Environmental Toxicology and Pharmacology - July 30, 2016 Category: Environmental Health Source Type: research

Tanshinone IIA sensitizes oral squamous cell carcinoma to radiation due to an enhanced autophagy
Conclusions TanIIA exerted a strong radiosensitizing effect on SCC090 comparing with the simple drug or single radiation treatment, which was due to an enhanced ROS generation and autophagy. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 30, 2016 Category: Environmental Health Source Type: research

Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice
Publication date: Available online 30 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Shan-shan Chen, Yan Zhang, Qiu-li Lu, Zhe Lin, Yuqing Zhao Although numerous hypotheses have been proposed to prevent chemotherapy-induced alopecia (CIA), effective pharmaceuticals have yet to be developed. In our study, the back hairs of C57BL/6 mice were factitiously removed. These mice were then treated with cedrol or minoxidil daily. Mice with early-stage anagen VI hair follicles were treated with cyclophosphamide (CYP, 125mg/kg) to induce alopecia. The CYP-damaged hair follicles were observed and quantifi...
Source: Environmental Toxicology and Pharmacology - July 30, 2016 Category: Environmental Health Source Type: research

Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review
Publication date: Available online 30 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Yi Cao, Juan Li, Fang Liu, Xiyue Li, Qin Jiang, Shanshan Cheng, Yuxiu Gu Nanoparticles (NPs) are increasingly used in food, and the toxicity of NPs following oral exposure should be carefully assessed to ensure the safety. Indeed, a number of studies have shown that oral exposure to NPs, especially solid NPs, may induce toxicological responses both in vivo and in vitro. However, most of the toxicological studies only used NPs for oral exposure, and the potential interaction between NPs and food components in...
Source: Environmental Toxicology and Pharmacology - July 30, 2016 Category: Environmental Health Source Type: research

A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry
Publication date: Available online 28 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Wenmin Xing, Lili Gu, Xinyue Zhang, Jiadong Xu, Hong Lu Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were randomly divided into four groups: a 0.9% NaCl solution group, and 100, 300, and 600mg/kg ACV-treated groups; the ACV or vehicle solution was admi...
Source: Environmental Toxicology and Pharmacology - July 28, 2016 Category: Environmental Health Source Type: research

Removal of Oxytetracycline and Determining Its Biosorption Properties on Aerobic Granular Sludge
This study investigates biosorption of Oxytetracycline, a broad-spectrum antibiotic, using aerobic granular sludge as an adsorbent in aqueous solutions. A sequencing batch reactor fed by a synthetic wastewater was operated to create aerobic granular sludge. Primarily, the pore structure and surface area of granular sludge, the chemical structure and the molecular sizes of the pharmaceutical, operating conditions, such as pH, stirring rate, initial concentration of Oxytetracycline, during adsorption process were verified. Subsequently, thermodynamic and kinetic aspects of the adsorption were examined and adsorption isotherm...
Source: Environmental Toxicology and Pharmacology - July 27, 2016 Category: Environmental Health Source Type: research

Zidovudine and Isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin
This study investigate the hepatotoxic potentials of AZT alone, INH alone and AZT+INH treatments and the mitigating potentials of SBN against these drugs induced toxic insults of liver in rats. Separate groups of rats (n=6 in each group) were administered AZT alone (50mg/kg b.w.), INH alone (25mg/kg, b.w.), AZT+INH (50mg/kg, b.w. and 25mg/kg, b.w.), SBN alone (100mg/kg, b.w.) and SBN+AZT+INH daily for sub-chronic period of 45days orally. The control rats received saline/propyleneglycol. INH alone and AZT+INH-induced parenchymal cell injury and cholestasis of liver was evidenced by highly significant increase in the activit...
Source: Environmental Toxicology and Pharmacology - July 26, 2016 Category: Environmental Health Source Type: research

Effects of inducers of cytochrome P450s on enrofloxacin N-deethylation in crucian carp Carassius auratus gibelio
In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (12mg/kg), respectively. First, reversed-phase high-performance liquid chromatography (RP-HPLC) was used to detect the pharmacokinetics of EF with continual blood sampling. In RIF-treated, BNF-treated and control groups, the value of the CmaxCF/CmaxEF ratio was 4.41, 0.81 and 0.95, and the corresponding value o...
Source: Environmental Toxicology and Pharmacology - July 26, 2016 Category: Environmental Health Source Type: research

Effects of dietary green tea polyphenol supplementation on the health of workers exposed to high-voltage power lines
Publication date: Available online 26 July 2016 Source:Environmental Toxicology and Pharmacology Author(s): Yang Zhang, Dan Zhang, Baoyu Zhu, He Zhang, Ye Sun, Chengxun Sun Although it has been several decades since the focus on the effect of extremely low frequency electromagnetic fields (ELF-EMF) of high-voltage power lines on human health, no consistent conclusion has been drawn. The present study aimed to investigate the change in oxidative stress after exposure to ELF-EMFs, and potential protective effects of green tea polyphenol supplementation (GTPS) on ELF-EMFs induced oxidative stress. A total of 867 subje...
Source: Environmental Toxicology and Pharmacology - July 25, 2016 Category: Environmental Health Source Type: research