Experimental Study of Sucralfate Intervention for Paraquat Poisoning in Rats
Conclusion The results showed that early gastrointestinal lavage with sucralfate effectively reduced the inflammatory response and lung and kidney injuries and improved the survival of the SD rats. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 26, 2017 Category: Environmental Health Source Type: research

Nanoagroparticles emerging trends and future prospect in modern agriculture system
Publication date: Available online 23 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Syed Baker, Tatiana Volova, Svetlana V. Prudnikova, S. Satish, Nagendra Prasad Increment of technical knowledge has remarkably uplifted logical thinking among scientific communities to shape the theoretical concepts into near product-oriented research. The concept of nanotechnology has overwhelmed almost all forms of lives and has traded its applications in myriad fields. Despite rapid expansion of nanotechnology, sustainable competitions still do exist in the field of agriculture. In current scenario, agriculture ...
Source: Environmental Toxicology and Pharmacology - April 23, 2017 Category: Environmental Health Source Type: research

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2hours a day throughout gestation period. Control females were subjected to the same conditions as treated group w...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Harikiran Lingabathula, Narsimhareddy Yellu The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase leakage, alkaline phosphatase, lipid peroxidation and total microprotein levels in BAL fluids after 1day, 1 week and 1 month post exposure periods. All the pa...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca2+ modulation
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xinming Yun, Wenbing Rao, Ciying Xiao, Qingchun Huang Leukemia threatens millions of people's health and lives, and the pesticide-induced leukemia has been increasingly concerned because of the etiologic exposure. In this paper, cytotoxic effect of emamectin benzoate (EMB), an excellent natural-product insecticide, was evaluated through monitoring cell viability, cell apoptosis, mitochondrial membrane potential and intracellular Ca2+ concentration ([Ca2+]i) in leukemia K562 and Molt-4 cells. Following the exposure ...
Source: Environmental Toxicology and Pharmacology - April 20, 2017 Category: Environmental Health Source Type: research

Arsenic absorption and excretion in chronically exposed developing toad Rhinella arenarum
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mariana Mardirosian, Flavia Bieczynski, Carlos Luquet, Carlos A. Pérez, Guillermina Bongiovanni, Cecilia Lascano, Andrés Venturino We assessed the toxicodynamics of As in developing Rhinella arenarum toad embryos and larvae exposed from fertilization to 0.01–10mgAsL−1. We determined As content in toad embryos and larvae by X-ray fluorescence spectrometry. Toad embryos and larvae actively bioaccumulated As, reaching tissue concentrations more than one-thousand higher than control levels aft...
Source: Environmental Toxicology and Pharmacology - April 19, 2017 Category: Environmental Health Source Type: research

The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: a comparative study
Publication date: Available online 17 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Michaela Mináriková, Veronika Fojtikova, Eliška Vyskočilová, Jan Sedláček, Milan Šikut, Lucie Borek-Dohalska, Marie Stiborová, Marketa Martinkova The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenoba...
Source: Environmental Toxicology and Pharmacology - April 18, 2017 Category: Environmental Health Source Type: research

Crocin attenuates hemorrhagic shock-induced oxidative stress and organ injuries in rats
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Long Yang, Xiujuan Dong We aimed to evaluate the effect of natural antioxidant crocin in alleviating hemorrhagic shock (HS)-induced organ damages. HS rats were treated with crocin during resuscitation. Mortality at 12h and 24h post resuscitation was documented. HS and resuscitation induced organ injuries, as characterized by elevated wet/dry ratio, quantitative assessment ratio, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine aminotransferase, whereas rats received crocin treatment demonstra...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh
This study was aimed to look association of CYP1A1 m1 (T>C) and m2 (A>G) gene polymorphisms in Chhattisgarh population. In this case-control study, we analyzed leukocyte DNA from a total of 200 subjects form Chhattisgarh (100 cases and 100 controls). All subjects were genotyped for CYP1A1 m1 (T>C) and m2 (A>G) using PCR-RFLP with statistical analysis by using SPSS version 16.0 and VassarStats (online). Among the two gene variants rs4646903 (T>C) and rs1048943 (A>G), individuals with AG and GG genotypes of CYP1A1 m2 polymorphism have significantly higher and increased risk of cervic...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Protective effect of artemisinin on chronic alcohol induced-liver damage in mice
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiaoyan Zhao, Liqing Wang, Hao Zhang, Duoduo Zhang, Zhihao Zhang, Jie Zhang The liver disease related to chronic alcohol consumption is one of the leading causes of death for alcoholics. The efficient drug to ameliorate the alcoholic liver injury was needed urgently. The present study was performed to investigate whether artemisinin possessed the protective effect against chronic alcohol consumption. 50 male Kunming mice were divided into 5 groups: control group (C): 10ml/kg saline+10ml/kg saline, alcohol group (A)...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Silver nanoparticle induced toxicity to human sperm by increasing ROS(reactive oxygen species) production and DNA damage
In this study, we exposed human sperm to different doses of AgNPs (0, 50μgml−1, 100μgml−1, 200μgml−1 or 400μgml−1) for various times (15min, 30min, or 60min), followed by analyses of the sperm viability, motility and the ratio of abnormal to normal sperm.Then, transmission electron microscopy(TEM) was used to explore the sperm ultrastructural characteristics. Reactive oxygen species production and DNA fragmentation were tested using standard kits and the sperm chromatin dispersion method, respectively. The results showed a dose- and time-dependent decline in sperm viability and motility ...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Human Neuronal Cell Based Assay: A New In Vitro Model For Toxicity Evaluation Of Ciguatoxin
Publication date: Available online 14 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Teresa Coccini, Francesca Caloni, Uliana De Simone Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabol...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Toxicological effects of phenol on four marine microalgae
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Weiyan Duan, Fanping Meng, Yufei Lin, Guoshan Wang The toxic effects of phenol on four marine microalgae (Dunaliella salina, Platymonas subcordiformis, Phaeodactylum tricornutum Bohlin, and Skeletonema costatum) were evaluated. The 96h EC50 values were 72.29, 92.97, 27.32, and 27.32mgL−1, respectively, which were lower than those values of freshwater microalgae reported in the literature. During a 96-h exposure to a sub-lethal concentration of phenol (1/2 96h EC50) with green alga (D. salina) and diatom (S. c...
Source: Environmental Toxicology and Pharmacology - April 13, 2017 Category: Environmental Health Source Type: research

Chronic Early Childhood Exposure to Arsenic is Associated with a TNF-mediated Proteomic Signaling Response
This study represents the first serum proteomics assessment in children exposed to iAs. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 10, 2017 Category: Environmental Health Source Type: research

Proinflammatory effects of diesel exhaust particles from moderate blend concentrations of 1st and 2nd generation biodiesel in BEAS-2B bronchial epithelial cells − The FuelHealth project
Publication date: Available online 5 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Tonje S. Skuland, Magne Refsnes, Pål Magnusson, Michał Oczkowski, Joanna Gromadzka-Ostrowska, Marcin Kruszewski, Remigiusz Mruk, Oddvar Myhre, Anna Lankoff, Johan Øvrevik Biodiesel fuel fuels are introduced at an increasing extent as a more carbon-neutral alternative to reduce CO2-emissions, compared to conventional diesel fuel. In the present study we have investigated the impact of increasing the use of 1st generation fatty acid methyl ester (FAME) biodiesel from current 7% blend (B7) to 20% blend (B...
Source: Environmental Toxicology and Pharmacology - April 5, 2017 Category: Environmental Health Source Type: research

Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri
Publication date: Available online 4 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shifeng Wang, Yuxin Zhang, Qiao Zhang, Sha Peng, Chen Shen, Yangyang Yu, Minyu Zhang, Wei Yang, Qinghua Wu, Yanling Zhang, Shiyou Li, Yanjiang Qiao Improper usage of unprocessed Radix bupleuri (chaihu) may cause fetal toxicity. Baking herb with vinegar is believed to attenuate the toxicity. However, the chemical and molecular basis remained unclear. To this end, we investigated the in vitro toxicity of saikosaponin a, c, d, and their hydrolysates saikosaponin b1, b2. Results showed that SSa and SSd possessed higher ...
Source: Environmental Toxicology and Pharmacology - April 4, 2017 Category: Environmental Health Source Type: research

Silica nanoparticles and lead acetate co-exposure triggered synergistic cytotoxicity in A549 cells through potentiation of mitochondria-dependent apoptosis induction
Publication date: Available online 3 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Chun-Feng Lu, Li-Zhong Li, Wei Zhou, Jun Zhao, Yi-Mei Wang, Shuang-Qing Peng The adverse effects of PM2.5 are the results of combined toxicities of finer particles and their adsorbed toxic pollutants. Nevertheless, the combined toxicity of finer particles and air pollutants still remains unclear. The present study was therefore undertaken to investigate the combined cytotoxicity of silica nanoparticles (nano-SiO2, a typical atmospheric ultrafine particle) and lead acetate (Pb, a representative air pollutant) in A549...
Source: Environmental Toxicology and Pharmacology - April 3, 2017 Category: Environmental Health Source Type: research

Coenzyme Q10 Protects Against Statin-Induced Myotoxicity in Zebrafish Larvae (Danio rerio)
Publication date: Available online 1 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Rand Pasha, Thomas W. Moon 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme of the mevalonic acid pathway and is required for cholesterol biosynthesis and the synthesis of Coenzyme Q10 (CoQ10). Statins inhibit HMGCR, thus inhibiting the downstream products of this pathway including the biosynthesis of decaprenyl-pyrophosphate that is critical for the synthesis of Coenzyme Q10 (CoQ10). We show that zebrafish (Danio rerio) larvae treated in tank water with Atorvastatin (ATV; Lipitor) exhibi...
Source: Environmental Toxicology and Pharmacology - April 1, 2017 Category: Environmental Health Source Type: research

Molecular cloning, characterization and expression analysis of metallothionein in the liver of the teleost Acrossocheilus fasciatus exposed to cadmium chloride
Publication date: Available online 29 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Guo-Di Liu, Zhang Sheng, Cong-Cong Hou, Jie Ni, Ying-Li Han, You-Fa Wang, Yang Zhou, Su-Yan Fu, Jun-Quan Zhu Metallothionein (MT) has a characteristic molecular structure with a cysteine-rich content. This unique structure provides metal-binding and redox capabilities and promoting metal homeostasis and detoxification in living animals. In order to evaluate the effects of cadmium (Cd) on hepatic MT expression in the liver of Acrossocheilus fasciatus, we obtained the complete cDNA of the A. fasciatus liver MT for th...
Source: Environmental Toxicology and Pharmacology - March 29, 2017 Category: Environmental Health Source Type: research

Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3 β pathway in the hippocampus of neonatal rats
Publication date: Available online 28 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jing Lv, Yi Wei, Yehua Chen, Xu Zhang, Zheng Gong, Yage Jiang, Qin Gong, Lifang Zhou, Hao Wang, Yubo Xie Recent studies have demonstrated that propofol causes neurodegeneration in developing brains. Evidence has shown that dexmedetomidine has neuroprotective effects. However, whether dexmedetomidine can reduce propofol-induced neuroapoptosis and by what mechanisms it acts remain unclear. We investigated whether dexmedetomidine can attenuate propofol-induced neuroapoptosis by disturbing the PI3K/Akt/GSK3β pathw...
Source: Environmental Toxicology and Pharmacology - March 28, 2017 Category: Environmental Health Source Type: research

Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose
Publication date: Available online 28 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Rongrong Ma, Yuan Wang, Xiong Zou, Kun Hu, Beibei Sun, Wenhong Fang, Guihong Fu, Xianle Yang The tissue distribution and depletion of sulfamethoxazole (SMZ) and trimethoprim (TMP) were studied in Pacific white shrimp, Litopenaeus vannamei, after single-dose and multiple-dose oral administration of SMZ-TMP (5:1) via medicated feed. In single-dose oral administration, shrimps were fed once at a dose of 100 mg/kg (drug weight/body weight). In multiple-dose oral administration, shrimps were fed three times a day...
Source: Environmental Toxicology and Pharmacology - March 28, 2017 Category: Environmental Health Source Type: research

Occurrence and risk assessment of estrogenic compounds in the East Lake, China
Publication date: Available online 27 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jun Wang, Yindi Zhu Forty two surface water samples were collected in May and June of 2013 in five lakelets of the East Lake, China. Four steroid hormones (17β-estradiol (βE2), estrone (E1), 17α-estradiol (αE2) and 17α-ethinylestradiol (αEE2)) were analyzed in these samples. Determination of four estrogenic compounds was performed on high performance liquid chromatography/mass spectrometry (HPLC/MS). βE2 was detected with the highest detection frequency of 62% and its concentr...
Source: Environmental Toxicology and Pharmacology - March 27, 2017 Category: Environmental Health Source Type: research

Endo-symbiont mediated synthesis of gold nanobactericides and their activity against human pathogenic bacteria
Publication date: Available online 27 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Baker Syed, M.N. Nagendra Prasad, K. Mohan Kumar, B.L. Dhananjaya, Sreedharamurthy Satish Synthesis of gold nanobactericides (AuNBs) were achieved by treating 1mM chloroaurate with cell free supernatant of Aneurinibacillus migulanus. Formation of AuNBs was initially was monitored with change in color to ruby red. Further confirmation was assessed with UV-Visible spectra with maximum absorption occurring at 510nm. Transmission electron microscopy (TEM) analysis revealed the polydispersity of AuNBs with size distribu...
Source: Environmental Toxicology and Pharmacology - March 27, 2017 Category: Environmental Health Source Type: research

PM2.5-induced alterations of cell cycle associated gene expression in lung cancer cells and rat lung tissues
In conclusion, PM2.5 can induce significantly alterations of p53 and CDK2 in the early phase, Cdc2 and cyclin B in mid-term and p21 in long-term exposure. The degree of PM2.5-induced damage to the trachea and lung tissue was time-dependent. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 24, 2017 Category: Environmental Health Source Type: research

Effects of puerarin on intracellular Ca2+ and cell viability of MDCK renal tubular cells
This study examined whether puerarin affected Ca2+ physiology in MDCK renal tubular cells. Cytosolic free Ca2+ levels ([Ca2+]i) were measured using the fluorescent dye fura-2. Cell viability was examined by using WST-1 assay. Puerarin induced [Ca2+]i rises and the response was reduced by removing extracellular Ca2+. Puerarin-induced Ca2+ entry was not altered by protein kinase C (PKC) activity, but was inhibited by nifedipine. In Ca2+-free medium, treatment with the endoplasmic reticulum Ca2+ pump inhibitor 2,5-di-tert-butylhydroquinone (BHQ) or thapsigargin partly inhibited puerarin-evoked [Ca2+]i rises. Inhibition of pho...
Source: Environmental Toxicology and Pharmacology - March 24, 2017 Category: Environmental Health Source Type: research

Toxicity and accumulation of Copper Oxide (CuO) Nanoparticles in different life stages of Artemia salina
Publication date: Available online 22 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): M.R. Madhav, S. Einstein Mariya David, R.S. Suresh Kumar, J.S. Swathy, M. Bhuvaneshwari, Amitava Mukherjee, N. Chandrasekaran Metal nanoparticles production rate and its applications have raised concerns about their release and toxicity to the aquatic and terrestrial organisms. The primary size of Copper Oxide nanoparticles (CuO NP’s) was found to be 114±36nm using Scanning Electron Microscopy (SEM) and a significant increase in the hydrodynamic diameter of CuO NP was seen within 1h of interaction. The...
Source: Environmental Toxicology and Pharmacology - March 23, 2017 Category: Environmental Health Source Type: research

Recent Advances in the Study of 11 β-Hydroxysteroid Dehydrogenase Type 2 (11β-HSD2)Inhibitors
Publication date: Available online 21 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Chunchun Zhou, Fan Ye, He Wu, Hui Ye, Quanxu Chen 11β-Hydroxysteroid dehydrogenase (11β-HSD), which interconverts hormonally active cortisol and inactive cortisone in multiple human tissues, has two distinct isoforms named 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). 11β-HSD2 is an NAD+-dependent oxidase which lowers cortisol by converting it to cortisone while 11β-HSD1 mainly catalyzes the reduction which converts cortisone...
Source: Environmental Toxicology and Pharmacology - March 22, 2017 Category: Environmental Health Source Type: research

Severe Camphor Poisoning, A Seven-Year Observational Study
Publication date: Available online 21 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mitra Rahimi, Fatemeh Shokri, Hossein Hassanian-Moghaddam, Nasim Zamani, Abdolkarim Pajoumand, Shahin Shadnia In a retrospective case series from 2007-2014, we searched for any accidental/intentional, and recreational cases of pure camphor poisoning through hospital records. Epidemiological data, as well as factors correlated with seizure, were evaluated. Thirty cases including 29 males were recruited with a median age of 18 years (range; 0.2 to 87). Patient’s reported ingestion rate of camphor was 1.5 to 15 ...
Source: Environmental Toxicology and Pharmacology - March 22, 2017 Category: Environmental Health Source Type: research

18 β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model
Publication date: Available online 20 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Seung-Hyung Kim, Jung-hee Hong, Ji-Eun Lee, Young-Cheol Lee 18β-Glycyrrhetinic acid (18Gly), the major bioactive component of Glycyrrhizae Radix, possesses anti-ulcerative, anti-inflammatory, and other pharmacological properties. Although 18Gly is associated with immunoregulatory functions of allergic diseases, the pathophysiological mechanisms of 18Gly action in allergic inflammatory lung disease have not been examined. Moreover, there are no in vivo studies on the anti-asthmatic effects of 18Gly in allergic ...
Source: Environmental Toxicology and Pharmacology - March 20, 2017 Category: Environmental Health Source Type: research

Combined oral contraceptive and nitric oxide synthesis inhibition synergistically causes cardiac hypertrophy and exacerbates insulin resistance in female rats
Publication date: Available online 20 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lawrence A. Olatunji, Kehinde S. Olaniyi, Taofeek O. Usman, Bilikis A. Abolarinwa, Caleb J. Achile, In-kyeom Kim Combined oral contraceptive (COC) use or inhibition of nitric oxide (NO) synthesis has been shown to cause hypertension and insulin resistance. However, the concomitant effects of COC and NO deficiency on the heart and glucose regulation are not well known. We therefore hypothesized that COC treatment during NO deficiency would lead to the development of cardiac hypertrophy that is associated with aggrav...
Source: Environmental Toxicology and Pharmacology - March 20, 2017 Category: Environmental Health Source Type: research

The effect of ozone on the expression of metallothionein in tissues of rats chronically exposed to cadmium.
Publication date: Available online 18 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Halina Milnerowicz, Mariola Śliwińska-Mossoń, Krzysztof A. Sobiech Our aims were to evaluate the expression of metallothionein (MT) in an experimental rat model which experienced chronic exposure to cadmium (Cd) and to measure its expression after ozone therapy (OT) or oxygen (Ox) in the same model, as compared to the control group, which was exposed to neither cadmium nor ozone. Forty male Wistar rats were divided into 5 groups: control, Cd, Cd and Ox, Cd and Oz, and Oz. During our research, Cd concentration (A...
Source: Environmental Toxicology and Pharmacology - March 18, 2017 Category: Environmental Health Source Type: research

Limnothrix sp. KO05: A newly characterized cyanobacterial biosorbent for cadmium removal: The enzymatic and non-enzymatic antioxidant reactions to cadmium toxicity
In this study, we isolated five indigenous cyanobacterial strains from different aqueous environments, with heavy metals contamination, in East Azerbaijan Province (northwest portion of Iran). A strain was identified by morphological and 16S rRNA sequence analysis as Limnothrix sp. KO05 and selected for further studies as having the greatest potential for cadmium uptake. Scanning electron microscopy (SEM) demonstrated cyanobacterium Limnothrix sp. KO05 forms filamentous structures and is straight or curved to some extent. The utmost biosorption capacity was found to be 82.18±1.22mgg−1 at a Cd (II) concentratio...
Source: Environmental Toxicology and Pharmacology - March 18, 2017 Category: Environmental Health Source Type: research

Industrial release of Fluoroquinolones (FQs) in the waste water bodies with their associated ecological risk in Pakistan
Publication date: Available online 15 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Luqman Riaz, Tariq Mahmood, Atif Kamal, Mateen Shafqat, Audil Rashid The unchecked use of Fluoroquinolones (FQs) for the treatment of infections in human and livestock is increasing in Pakistan. In the current study, the prevalence and associated ecological risk of three FQs were investigated in waste-water bodies and sludge samples of Kahuta and Hattar industrial zones. The average concentrations of ciprofloxacin (CIP), enrofloxacin (ENR) and levofloxacin (LEV) in the waste-water samples were slightly higher in Ka...
Source: Environmental Toxicology and Pharmacology - March 15, 2017 Category: Environmental Health Source Type: research

Toxic effect of cadmium adsorbed by different sizes of nano-hydroxyapatite on the growth of rice seedlings
Publication date: Available online 14 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yifan Huang, Weiwen Qiu, Zhihong Yu, Zhengguo Song Information regarding the toxic effects of cadmium (Cd) adsorbed by nano-hydroxyapatite (NHAP-Cd) on the growth of crop plants remain limited. We investigated the mechanism of NHAP-Cd (diameters, 20 and 40nm; NHAP20-Cd and NHAP40-Cd, respectively) phytotoxicity. Rice seedlings treated with Cd and NHAP20-Cd showed more severe growth retardation compared to those treated with NHAP40-Cd, for the same Cd concentration. Transmission electron microscopy revealed NHAP in ...
Source: Environmental Toxicology and Pharmacology - March 14, 2017 Category: Environmental Health Source Type: research

Cadmium and α-lipoic acid activate similar de novo synthesis and recycling pathways for glutathione balance
This study aimed to investigate de novo synthesis and recycling pathways for GSH balance by different Cd2+ concentrations and ALA in HepG2 cells. ALA activates Nrf2 pathway leading to GSH increment. Pre-treatment with 1μM Cd2+ or ALA produces tolerance to 5μM Cd2+ toxic effects. 5μM Cd2+ exposure significantly augmented nuclear Nrf2, GSH and GCLC, GCLM, HMOX1, TNFα and IL-6 mRNA expression but not GSR, however these upsurges were significantly abrogated by ALA or 1μM Cd2+ pre-treatments. Exposure to low Cd2+ concentration generate timely protective responses, similar to that elicited by ALA, maintaining a...
Source: Environmental Toxicology and Pharmacology - March 9, 2017 Category: Environmental Health Source Type: research

Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells
In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells.Abbreviations: AA, arachidonic acid; CYP7A1, cholesterol 7α-hydroxylase; FA, fatty acid; HFD, high-fat diet; NAFLD, non-alcoholic fatty liver disease; Nrf2, nuclear factor erythroid-derived 2-like 2; siRNA, small interfering RNA. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 7, 2017 Category: Environmental Health Source Type: research

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive system
Publication date: Available online 6 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Stavros Sifakis, Vasilis P. Androutsopoulos, Aristeidis M. Tsatsakis, Demetrios A. Spandidos Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental exposure, and has been ...
Source: Environmental Toxicology and Pharmacology - March 6, 2017 Category: Environmental Health Source Type: research

Investigating the affinity of BDE154 and 3OH-BDE154 with HSA: Experimental and simulation validation
Publication date: Available online 6 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Wu Yang, Lulu Yang, Zhongsheng Yi, Zhiwei Wu, Jinfang Nie, Aiqian Zhang The physicochemical properties of polybrominated diphenyl ethers are important for modeling their transport, but these data are often missing. Here, satisfactory bioactivity results were obtained using human serum albumin as the carrier, 2,2′,4,4′,5,6′-hexabromodiphenyl ether (BDE154) and 3-hydroxy-2,2′,4,4′, 5,6′-hexabromodiphenyl ether (3OH-BDE154) as the ligands, using UV–visible absorbance, fluoresce...
Source: Environmental Toxicology and Pharmacology - March 6, 2017 Category: Environmental Health Source Type: research

Synthesis and Toxicity Assessment of 3-oxobutanamides against Human Lymphocytes and Isolated Mitochondria
Publication date: Available online 7 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nima Razzaghi-Asl, Enaytollah Seydi, Radin Alikhani, Saba Rezvani, Ramin Miri, Ahmad Salimi To reduce costly late-phase compound scrubbing, there has been an increased focus on assessing compounds within in vitro assays that predict properties of human safety liabilities, before preclinical in vivo studies. The aim of our study was to answer the questions that whether the toxicity risk of a series of 3-oxobutanamide derivatives could be predicted by using of human lymphocytes and their isolated mitochondria. Using b...
Source: Environmental Toxicology and Pharmacology - March 6, 2017 Category: Environmental Health Source Type: research

Secreted phosphoprotein 24kD (Spp24) inhibits growth of hepatocellular carcinoma in vivo
In this study, we observed the inhibitory effect of spp24 on hepatocellular carcinoma in vivo. A subcutaneous hepatocellular carcinoma mice model was established by using Hep G2 cells. After sacrifice at day 40, tumor growth was assessed and tumor cell apoptosis and tumor cells proliferation were assessed by TUNEL assay and immunochemical analysis, respectively. BMP2 slightly stimulated the subcutaneous tumor growth compared with the control. Spp24 significantly inhibited the tumor growth and also abolished the BMP2-induced tumor growth (p<0.05). TUNEL assay and immunochemical analysis further showed that spp24 coul...
Source: Environmental Toxicology and Pharmacology - March 4, 2017 Category: Environmental Health Source Type: research

The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice
Publication date: Available online 28 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song Dioscorea bulbifera L. (DB) is a traditional Chinese herb used in thyroid disease and cancer. However, the clinical use of DB remains a challenge due to its hepatotoxicity, which is caused, in part, by the presence of Diosbulbin B (DIOB), a toxin commonly found in DB extracts. As abnormal expression of hepatobiliary transporters plays an important role in drug-induced liver injury, we assessed the hepatotoxicity induced by...
Source: Environmental Toxicology and Pharmacology - February 28, 2017 Category: Environmental Health Source Type: research

Lower concentrations of receptor for advanced glycation end products and epiregulin in amniotic fluid correlate to chemically induced cleft palate in mice
This study investigated the correlation between differentially expressed proteins in amniotic fluid (AF) and cleft palate induced by all-trans retinoic acid (atRA), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Seven proteins were differentially expressed at embryonic day (E) 16.5 in atRA and control groups as revealed by label-based mouse antibody array. Enzyme-linked immunosorbent assay was further used to detect the expression levels of these proteins in AF from E13.5 to E16.5 in atRA, TCDD, and control groups. The cleft palate groups showed lower concentrations of receptor for advanced glycation end products ...
Source: Environmental Toxicology and Pharmacology - February 28, 2017 Category: Environmental Health Source Type: research

Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity
Publication date: Available online 27 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jiayu Zhang, Xue Zhou, Wenbo Wu, Jiachun Wang, Hong Xie, Zhigang Wu Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of Nrf2 to alleviate cadmium-induced cytotoxicity in HepG2 cells. In the present study, we found that cadmium induce...
Source: Environmental Toxicology and Pharmacology - February 27, 2017 Category: Environmental Health Source Type: research

Hepatotoxicity and proteomic mechanism of Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) in vivo
Publication date: Available online 24 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Li Tang, Jie-ran Luo, Yun-lan Li, Rui Ge, Qing-shan Li Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) is an anti-tumour organotin(IV) compound with hepatotoxicity. To investigate the hepatotoxicity and mechanisms of DBDCT in vivo, proteomic technology 2D gel combined with MALDI-TOF-MS was used in our research. Results indicated that DBDCT increased AST, AKP and ACP activities and decreased ALT activity. Further, sporadic eosinophilic changes and nuclear pyknosis were visible in hepatic pathological obse...
Source: Environmental Toxicology and Pharmacology - February 23, 2017 Category: Environmental Health Source Type: research

Tyrosine assisted size controlled synthesis of silver nanoparticles and their catalytic, in-vitro cytotoxicity evaluation
Publication date: Available online 23 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sireesh babu Maddinedi, Badal Kumar Mandal, Kiran Kumar Anna A simple, green approach for the size controllable preparation of silver nanoparticles (SNPs) using tyrosine as reducing and capping agent is shown here. The size of SNPs is controlled by varying the pH of tyrosine solution. The as synthesized SNPs are characterized by using XRD, UV-Vis, DLS, TEM and SAED. Zeta potential measurements revealed the stability of tyrosine capped silver nanocolloids. Furthermore, catalytic activity studies concluded that th...
Source: Environmental Toxicology and Pharmacology - February 22, 2017 Category: Environmental Health Source Type: research

Chrysin and baicalin in diabetic nephropathy
Publication date: Available online 22 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Salvatore Chirumbolo, Geir Bjørklund (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 21, 2017 Category: Environmental Health Source Type: research

Effect of ammonia on the gene expression levels of the freshwater cyclopoid Eucyclops serrulatus
In this study, the response of stress-related genes to a sublethal ammonia concentration has been investigated in the adults of the freshwater cyclopoid Eucyclops serrulatus. Two short-term exposures (12h and 24h) at 12mg/L NH4 + have been tested. Results indicate that 12mg/L NH4 + causes a significant increase in the expression of some proteins, namely CAT, HSP90 and HSP40, suggesting an activation of the protecting antioxidant system after both 12h and 24h. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 20, 2017 Category: Environmental Health Source Type: research

Effects of octylphenol on the expression of StAR, CYP17 and CYP19 in testis of Rana chensinensis
Publication date: Available online 21 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yao Bai, Xin-Yi Li, Zhi-Jun Liu, Yu-Hui Zhang It has been proposed that a decline in sperm quality is associated with exposure to environmental chemicals with estrogenic activity. Seeking possible explanations for this effect, this study investigated the effects of octylphenol (OP) on the synthesis of steroid hormones in amphibian. Rana chensinensis were exposed to 10-8, 10-7 and 10-6 mol/L OP after 10, 20, 30 and 40 days. The cDNA fragments of StAR (274bp), CYP17 (303bp) and CYP19 (322bp) were cloned. In situ h...
Source: Environmental Toxicology and Pharmacology - February 20, 2017 Category: Environmental Health Source Type: research

Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (Danio rerio) livers
Publication date: Available online 21 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Cheng Zhang, Yuting Shao, Lusheng Zhu, Jinhua Wang, Jun Wang, Yingying Guo The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20–160mg/L) on 7 and 14 days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, reactive oxygen species (ROS), antioxidant enzymes, glutathione S-transferase (GST), malondialdehyde (MDA), and DNA d...
Source: Environmental Toxicology and Pharmacology - February 20, 2017 Category: Environmental Health Source Type: research

Zinc oxide nanoparticles hepatotoxicity: Histological and histochemical study
Publication date: Available online 16 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mansour I. Almansour, Mosaid A. Alferah, Ziad A. Shraideh, Bashir M. Jarrar Zinc oxide nanoparticles (ZnO NPs) are widely used in industry and cosmetic products with promising investment in medical diagnosis and treatment. However, these particles may reveal a high potential risk for human health with no information about hepatotoxicity that might be associated with their exposure. The present work was carried out to investigate the histological and histochemical alterations induced in the hepatic tissues by nak...
Source: Environmental Toxicology and Pharmacology - February 16, 2017 Category: Environmental Health Source Type: research