Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Wenjuan Zhang, Youjian Zhang, Jian Hou, Tian Xu, Wenjun Yin, Wei Xiong, Wenhong Lu, Hongyan Zheng, Jun Chen, Jing Yuan Tris (2-chloroethyl) phosphate (TCEP) has been widely used as a plasticizer and flame retardant. TCEP as a potential carcinogen is often detected in the occupational and nature environments. To investigate effects of TCEP on human hepatocytes, we assessed cell growth rate, cellular membrane integrity, senescence-associated β-galactosidase (SA-β-Gal) activity and analyzed expression of regulator...
Source: Environmental Toxicology and Pharmacology - September 6, 2017 Category: Environmental Health Source Type: research

Nonsteroidal mycotoxin alternariol is a full androgen agonist in the yeast reporter androgen bioassay
Publication date: Available online 4 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sylwia Stypuła-Trębas, Maria Minta, Lidia Radko, Piotr Jedziniak, Andrzej Posyniak Alternariol (AOH) is a toxic metabolite of phytopathogenic fungi of the Alternaria spp. and important contaminant of agricultural commodities. According to the recent studies, AOH has a potential to modulate the endocrine system of humans and animals. In the view of these reports, our study addressed the effects of AOH on human estrogen receptor (hERα) and androgen receptor (hAR) signaling with the use of the yeast estroge...
Source: Environmental Toxicology and Pharmacology - September 5, 2017 Category: Environmental Health Source Type: research

A comparison of the effects of copper nanoparticles and copper sulfate on Phaeodactylum tricornutum physiology and transcription
This study delineates the cellular mechanism behind the toxicity of CuNPs and CuSO4 on marine diatoms. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 5, 2017 Category: Environmental Health Source Type: research

BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt
This study shows that BDE-47 and BDE-85 directly act on pancreatic β-cells to stimulate GSIS, and that this effect is mediated by the thyroid receptor (TR) and Akt activation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 4, 2017 Category: Environmental Health Source Type: research

Detection rates, trends in and factors affecting observed levels of selected volatile organic compounds in blood among US adolescents and adults
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Ram B. Jain Data from National Health and Nutrition Examination Survey were analyzed to evaluate detection rates, trend in and factors affecting the observed levels of 1,4-dichlorobenzene, benzene, ethylbenzene, o-xylene, styrene, toluene, and m/p-xylene among US adolescents and adults over 2005–2012. Over 2005–20102, among adolescents, detection rates declined by more than 50% for benzene, ethylbenzene, and o-xylene, and among adults, detection rates declined by more than 50% for ethylbenzene and o-xylene an...
Source: Environmental Toxicology and Pharmacology - September 2, 2017 Category: Environmental Health Source Type: research

Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner
This study aimed to investigate the effects of formaldehyde on triglyceride metabolism in human hepatocellular carcinoma cells (HepG2). Cell viability was detected using a MTT (3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide) assay. Following treatment with different concentrations of formaldehyde for 24 and 48h, the intra and extra-hepatocellular triglyceride (TG) content was determined using a chemical-enzymatic method; Western blotting was used to detect the levels of fatty acid synthesis and VLDL-related proteins. Our results showed that cell viability significantly decreased after formaldehyde treatment (...
Source: Environmental Toxicology and Pharmacology - September 2, 2017 Category: Environmental Health Source Type: research

Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha
In conclusion, exposure to Ibu has some anti-inflammatory effects to mussels based on COX activity but resulted in increased oxidative damage and lipid catabolism. Exposure to air stress could enhance some of these responses and contribute to decreased resistance to air exposures. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 30, 2017 Category: Environmental Health Source Type: research

Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo model
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Paolo Cocci, Matteo Mozzicafreddo, Mauro Angeletti, Gilberto Mosconi, Francesco Alessandro Palermo Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to phthala...
Source: Environmental Toxicology and Pharmacology - August 30, 2017 Category: Environmental Health Source Type: research

Therapeutic effect of carnosine in rat model of experimental liver carcinogenesis
Publication date: Available online 26 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Amr A. Fouad, Hatem O. Qutub, Abdullatif S. Al Rashed, Walid N. Al-Melhim The possible anticancer effect of carnosine versus doxorubicin was investigated against hepatocellular carcinoma (HCC) induced by trichloroacetic acid (TCA) (500mg/kg/day, p.o., for 5 days) in rats. Following induction of HCC, rats treated with either carnosine (10mg/kg/day, i.p.), or doxorubicin (2.5mg/kg, i.p., once weekly), for 2 weeks. Carnosine significantly decreased serum alanine aminotransferase, and hepatic lipid peroxidation, nitri...
Source: Environmental Toxicology and Pharmacology - August 27, 2017 Category: Environmental Health Source Type: research

Changes of respiratory system in mice exposed to PM4.0 or TSP from exhaust gases of combustion of cashew nut shell
Publication date: Available online 25 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jeanne Batista Josino, Daniel Silveira Serra, Maria Diana Moreira Gomes, Rinaldo Santos Araújo, Mona Lisa Moura de Oliveira, Francisco Sales Ávila Cavalcante Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed to PM4.0 or TSP, present in...
Source: Environmental Toxicology and Pharmacology - August 26, 2017 Category: Environmental Health Source Type: research

The oxidative stress response of oxytetracycline in the ciliate Pseudocohnilembus persalinus
Publication date: Available online 24 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Chongnv Wang, Xuming Pan, Yawen Fan, Ying Chen, Weijie Mu Oxytetracycline (OTC) is commonly employed in fish farms to prevent bacterial infections in China, and because of their widely and intensive use, the potential harmful effects on organisms in aquatic environment are of great concern. Ciliates play an important role in aquatic food webs as secondary producers, and Pseudocohnilembus persalinus, is one kind of them which are easily found in fish farms, surviving in polluted water. Therefore, using P. persalinu...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Imidacloprid Insecticide Exposure Induces Stress and Disrupts Glucose Homeostasis in Male Rats
Publication date: Available online 24 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Samah R. Khalil, Ashraf Awad, Hesham H. Mohammed, Mohamed Abdo Nassan In the present study, we evaluated the stress response in adult rats who were administered imidacloprid (IMI) orally in two doses (0.5 and 1.0mg/kg bw for 60 days). It led to an alteration in the levels of cortisone and catecholamines and induced behavioral deficits, particularly in the animals exposed to the dose of 1.0mg/kg. IMI was further analyzed for the effect on glucose homeostasis in developing and adult rats at a dose of 1.0mg/kg bw whe...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation results in declined mature T cells in rat fetal thymus
This study was designed to observe the effects of maternal food restriction (MFR) on the development of fetal thymus in different gestation periods. Timed pregnant rats were randomized into 3 groups: CN (free access to standard chow throughout gestation), MFR0-21 (50% MFR throughout gestation), MFR0-14 (50% MFR from gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR during early-mid period had few impact on the fetal thymus and T cell subpopulations. However, MFR throughout gestation resulted in thymic atrophy, deceased frequency of both CD4+ and CD8+ single positive (SP) T cells and enhanced thy...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha.
In conclusion, exposure to Ibu has some anti-inflammatory effects to mussels based on COX activity but resulted in increased oxidative damage and lipid catabolism. Exposure to air stress could enhance some of these responses and contribute to decreased resistance to air exposures. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 20, 2017 Category: Environmental Health Source Type: research

Long non-coding RNAs: the novel diagnostic biomarkers for leukemia
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shaoyun Chen, Hairong Liang, Hui Yang, Kairu Zhou, Longmei Xu, Jiaxian Liu, Bei Lai, Li Song, Hao Luo, Jianming Peng, Zhidong Liu, Yongmei Xiao, Wen Chen, Huanwen Tang Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt∼100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomark...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor
This study highlights the critical role of CYP1B1 and AhR in TCDD activity and proposes that inhibition of these key molecules might serve as a potential therapeutic approach for treatment of allergy and cancer. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S.
Conclusion The incidence of palytoxin exposure is low but significant symptoms can occur. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alessandra Cristina Pupin Silvério, Simone Caetani Machado, Luciana Azevedo, Denismar Alves Nogueira, Miriam Monteiro de Castro Graciano, Juliana Savioli Simões, André Luiz Machado Viana, Isarita Martins The aim of the study was to assess of occupational exposure to pesticides in rural workers using genotoxicity test, bioindicators and clinical evaluation. Blood, urine and buccal samples from persons, rural workers exposed to a complex mixture of pesticides with organophosphates (n=94) and wit...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Self-defense of Escherichia coli against damages caused by nanoalumina
In this study, we showed three types of responses of E. coli to damages caused by nano-Al2O3. Live, dead, and injured, bacteria showed improved survival rates reaching 104%, 116%, and 104% after exposure to 0.1, 1, and 10mmol/L of nano-Al2O3 respectively. Survival rates improved from 100% to 114%, corresponding to an exposure time of 0–9h, and from 100% to 127%, corresponding to 0–1000μg/L Al3+. Improvements were noted in survival rates of E. coli K12 MG1655, HB101, DH5α, and K12 MG1655 △lexA treated by nano-Al2O3 in Luria–Bertani (LB) exposure system or K12 MG1655 in LB, normal saline(NS) and ...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Differential tissue regulation of PPAR α and CB1 gene transcription pathways by DEGB: preliminary observations in a seabream (Sparus aurata) in vivo model
Publication date: Available online 19 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Paolo Cocci, Matteo Mozzicafreddo, Mauro Angeletti, Gilberto Mosconi, Francesco Alessandro Palermo Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Multidrug prevention or therapy of ischemia-reperfusion injury of the heart —Mini-review
This study provides information about multidrug strategies for the prevention/treatment of cardiac injury induced by oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

The selective tyrosine kinase-inhibitor nilotinib alleviates experimentally induced cisplatin nephrotoxicity and heptotoxicity
In conclusions these results demonstrated a protective effect of nilotinib in experimentally induced CP kidney and liver damage that could be mediated through combating oxidative stress, reducing inflammation and anti-apoptosis in the two organs. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 18, 2017 Category: Environmental Health Source Type: research

Iron prevents demyelination of frog sciatic nerves
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Amina Azzouz, Amel Hanini, Zihad Bouslama, Linda Saili, Sihem Benaceur, Mohsen Sakly, Souhil Tliba, Hafedh Abdelmelek Metal ions are of particular importance in nervous system function, notably iron. However, very little has been done to investigate its physiological role in frog peripheral nervous system. The present research aim to evaluate i) the time-effect of sciatic nerve ligation and/or ii) iron sulphate (1.50mg/kg, in lymphatic sac) on frog myelin sheaths. Histological sections following ligation shows degeneratio...
Source: Environmental Toxicology and Pharmacology - August 18, 2017 Category: Environmental Health Source Type: research

Multidrug prevention or therapy of ischemia-reperfusion injury of the heart- mini-review
This study provides information about multidrug strategies for the prevention/treatment of cardiac injury induced by oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

PKC θ-mediated Ca2+/NF-AT signalling pathway may be involved in T-cell immunosuppression in coal-burning arsenic-poisoned population
This study provides important data for a mechanistic understanding of endemic arsenic poisoning. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

The inhibition of inducible nitric oxide synthase and oxidative stress by agmatine attenuates vascular dysfunction in rat acute endotoxemic model
In conclusion: AGM may represent a potential endogenous therapeutic candidate for sepsis-induced vascular dysfunction through its inhibiting effect on iNOS expression and oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

Reduction of liver tumerogenic effect of N-nitrosodiethylamine by treatment with ɣ-oryzanol in Balb/C mice
Publication date: Available online 11 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shital S. Panchal, Somsuvra B. Ghatak, Abhishek B. Jha, Raoula Onattu In recent years, naturally occurring phytochemicals with antioxidant capacity have generated surmount interest in their therapeutic usage against a wide range of pathological and toxicological conditions. The present study was designed to evaluate potential of ɣ-oryzanol (OZ), a bio-active natural antioxidant against hepatocellular carcinoma effect of the carcinogen N-nitrosodiethylamine in Balb/c mice. OZ inhibited the proliferation of Hep&nda...
Source: Environmental Toxicology and Pharmacology - August 11, 2017 Category: Environmental Health Source Type: research

Identification of sterols from the soft coral Dendronephthya gigantea and their anti-inflammatory potential
This study highlights the synergistic anti-inflammatory activity of several steroids found in D. gigantea. Their actions may be useful in the development of anti-inflammatory cosmeceuticals, pharmaceutical agents, and other consumer products. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 10, 2017 Category: Environmental Health Source Type: research

The eco-toxic effects of pesticide and heavy metal mixtures towards earthworms in soil
Publication date: Available online 7 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Herman Uwizeyimana, Meie Wang, Weiping Chen, Kifayatullah Khan Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil pollutants that effects risks are very difficult due to the complexity of soil matrix, poor understanding about the fate and effects of chem...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Interaction of erythromycin and ketoconazole on the neurological, biochemical and behavioral responses in crucian carp
This study focused on the uptake of contaminants, acetylcholinesterase (AChE) activity in the brain, swimming and shoaling behavior of fish. After 14days of binary exposure, the addition of KCZ at nominal concentrations of 0.2, 2 and 20μg/L significantly increased the accumulation of ERY in the brain of the fish and the bioconcentration factor of 2.08 was 2.6-fold higher than that calculated from the ERY-alone exposure. The brain AChE activity was significantly inhibited by ERY and KCZ with a significant correlation with respect to the accumulative concentration of the contaminants. The inhibition rates of swimming acti...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna
Publication date: Available online 7 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Andrew S. Cooke, Eric R. Morgan, Jennifer A.J. Dungait The insecticidal properties of many anthelmintics pose a risk to dung fauna, through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the d...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell
In this study, we aim to probe the effects of BPA exposure on induction of autophagy in goat Sertoli Cells (gSCs), as well as the relationship between autophagy and apoptosis. Results indicated that exposure to BPA (100, 200, 300, 400, 500 and 600μM) decreased the cell viability in a concentration-dependent manner. Exposure of gSCs to 500μM BPA for 12h resulted in in vitro triggered loss of mitochondrial membrane potential (ΔΨm) and increased reactive oxygen species (ROS) production. Apoptosis with an increase in Bax:Bcl-2 ratio and higher rates of autophagy, such as autophagosome formation and increased ex...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Mitochondrial Dysfunction and Inflammatory Response in the Cytotoxicity of NR8383 Macrophages Induced by Fine Particulate Matter
Publication date: Available online 29 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Qi Xiong, Qin Ru, Lin Chen, Xiang Tian, Chaoying Li Exposure to fine particulate matter (fine PM) is known to cause severe public health problems. However, the potential mechanisms of alveolar macrophages cytotoxicity induced by fine PM exposure are still unclear. The aim of this study was to determine if both the mitochondrial dysfunction and the inflammatory response of NR8383 macrophages were triggered by Standard Reference Material 2786 (SRM 2786) for fine PM. NR8383 cells were exposed to different concentration...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Effects of Glyphosate Exposure on Sperm Concentration in rodents: A Systematic review and meta-analysis
Conclusions The results of meta-analysis support the hypothesis that glyphosate exposure decreased sperm concentration in rodents. Therefore, we conclude that glyphosate is toxic to male rodent’s reproductive system. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Vaccination is fundamental but can it escape from a more insightful and critical information about its action?
Publication date: Available online 29 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Salvatore Chirumbolo, Geir Bjørklund The recent news about the US President Donald Trump's tweet on the presumptive relationship between vaccines and autism published in Nature Seven Days (Nature, n 542, Feb 16th, 2017 p 276) raised a crowded outcry of criticisms and concerns not only about the US President's policy but on the safety of vaccines, putting again in the spotlight this fundamental medical issue.Aside from the provocative boutade of the US President, with echoes also in Italy, the scientific commu...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors
Publication date: Available online 27 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jing Lu, Baochen Fang, Yiying Zheng, Xin Yu, Guoren Huang, Zhenning Wang, Xuming Deng, Shuang Guan 1,3-dichloro-2-propanol (1,3-DCP) is a food born hepatoxic chloropropanol contaminant that has been detected in a wide range of foods. In the present study, we investigated the effects and mechanisms of 1,3-DCP on lipid accumulation in HepG2 cells. The data showed 1,3-DCP significantly increased intracellular content of triglyceride (TG) and total cholesterol (TC) at 0.5–2μg/mL. Further results showed that 1,3...
Source: Environmental Toxicology and Pharmacology - July 28, 2017 Category: Environmental Health Source Type: research

Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens
Publication date: Available online 22 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shiping Bai, Shuqin Pan, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Yue Xuan, Zuowei Su Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35 days. Compared to controls, glucose disappearance rates were lower (p =0.035) 15 to 120min after glucos...
Source: Environmental Toxicology and Pharmacology - July 23, 2017 Category: Environmental Health Source Type: research

X-ray irradiation has positive effects for the recovery of peripheral nerve injury maybe through the vascular smooth muscle contraction signaling pathway
Discussion Pathways involved in cell-substrate adhesion, vascular smooth muscle contraction and cell adhesion molecule signaling may be involved in recovery from peripheral nerve injury. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 23, 2017 Category: Environmental Health Source Type: research

Dynamic responses of antioxidant enzymes in pearl oyster Pinctada martensii exposed to di(2-ethylhexyl) phthalate (DEHP)
In conclusion, GSH activity demonstrated its potential to be used as a biomarker for the monitoring of DEHP pollution in the marine environment. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 21, 2017 Category: Environmental Health Source Type: research

Toxic effects of juvenile sablefish, Anoplopoma fimbria by ammonia exposure at different water temperature
Publication date: Available online 19 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jun-Hwan Kim, Hee-Ju Park, In-Ki Hwang, Jae-Min Han, Do-Hyung Kim, Chul Woong Oh, Jung-Sick Lee, Ju-Chan Kang Juvenile sablefish, Anoplopoma fimbria (mean length 17.1±2.4cm, and mean weight 75.6±5.7g) were used to evaluate toxic effects on antioxidant systems, immune responses, and stress indicators by ammonia exposure (0, 0.25, 0.75, and 1.25mg/L) at different water temperature (12 and 17°C) in 1 and 2 months. In antioxidant responses, superoxide dismutase (SOD) and catalase (CAT) were significant...
Source: Environmental Toxicology and Pharmacology - July 20, 2017 Category: Environmental Health Source Type: research

Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening
Publication date: Available online 18 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sen Zhang, Huan Chen, An Wang, Yong Liu, Hongwei Hou, Qingyuan Hu To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed to show a significant genotoxicity based on the γH2AX assay. However, hydroquinone (one of metabolites of benzene) show...
Source: Environmental Toxicology and Pharmacology - July 19, 2017 Category: Environmental Health Source Type: research

Emodin suppresses cadmium-induced osteoporosis by inhibiting osteoclast formation
Publication date: Available online 18 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiao Chen, Shuai Ren, Guoying Zhu, Zhongqiu Wang, Xiaolin Wen Environmental level of cadmium (Cd) exposure can induce bone loss. Emodin, a naturally compound found in Asian herbal medicines, could influence osteoblast/osteoclast differentiation. However, the effects of emodin on Cd-induced bone damage are not clarified. The aim of this study was to investigate the role of emodin on Cd-induced osteoporosis. Sprague-Dawley male rats were divided into three groups which were given 0mg/L, 50mg Cd/L and 50mg Cd/L plus em...
Source: Environmental Toxicology and Pharmacology - July 19, 2017 Category: Environmental Health Source Type: research

Early oxidative stress, DNA damage and inflammation resulting from subcutaneous injection of sulfur mustard into mice
In conclusion, this research showed that both oxidative stress and DNA damage are earlier events than inflammation in sulfur mustard toxic mouse model. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 18, 2017 Category: Environmental Health Source Type: research

Biocompatibility and fabrication of RGO/Chitosan film for cartilage tissue recovery
Publication date: Available online 17 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lei Cao, Chunwen Lu, Qiugen Wang, Fan Li Graphene oxide (GO) has been successfully deoxygenated via an environmental friendly approach using chitosan. The prepared RGO was characterized using several microscopic and spectroscopic techniques. Also, the synthesized RGO is used to develop a highly compatible film with chitosan. Further, the in-vitro cytotoxicity results showed the biocompatible nature of prepared RGO/chitosan composite towards the human articular chondrocytes indicating their use in future cartilage ti...
Source: Environmental Toxicology and Pharmacology - July 18, 2017 Category: Environmental Health Source Type: research

Environmental Estrogen(s) Induced Swimming Behavioural Alterations in Adult Zebrafish (Danio rerio)
Publication date: Available online 11 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Basavaraj B. Goundadkar, Katti Pancharatna The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins...
Source: Environmental Toxicology and Pharmacology - July 12, 2017 Category: Environmental Health Source Type: research

Zebrafish Have an Ethanol-Inducible Hepatic 4-Nitrophenol Hydroxylase that is Not CYP2E1-like
Publication date: Available online 10 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jessica H. Hartman, Jordan S. Kozal, Richard T. Di Giulio, Joel N. Meyer Zebrafish are an attractive model organism for toxicology; however, an important consideration in translating between species is xenobiotic metabolism/bioactivation. CYP2E1 metabolizes small hydrophobic molecules, e.g. ethanol, cigarette smoke, and diesel exhaust components. CYP2E1 is thought to only be conserved in mammals, but recent reports identified homologous zebrafish cytochrome P450s. Herein, ex vivo biochemical measurements show that u...
Source: Environmental Toxicology and Pharmacology - July 11, 2017 Category: Environmental Health Source Type: research

Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium
The objective of this study was to determine the effect of ligustrazine (TMP) on cadmium (Cd)-induced nephrotoxicity and its relevant mechanism. TMP (50mg/kg) was injected intraperitoneally (i.p.) into rats 1h prior to CdCl2 exposure (at a Cd dose of 0.6mg/kg). TMP reversed Cd-induced nephrotoxicity, evidenced by the relatively normal architecture of the renal cortex. Additionally, TMP alleviated renal oxidative stress of rats that were exposed to Cd, evidenced by the decreased levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), elevated levels of glutathione (GSH) and GSH/GSSG (glutathione disulfide) ratios. Furthe...
Source: Environmental Toxicology and Pharmacology - July 10, 2017 Category: Environmental Health Source Type: research

Blood pressure in indoor and outdoor workers
CONCLUSIONS The results suggest that outdoor working affects the blood pressure, contributing to an increased cardiovascular risk. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 9, 2017 Category: Environmental Health Source Type: research

Study on the interaction between typical phthalic acid esters (PAEs) and human haemoglobin (hHb) by molecular docking
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li, Ye Shan This work has evaluated the binding force between hHb and typcial PAEs (DMP, DEP, DPRP, DBP, DIBP, DHP and DPHP) using molecule docking technique. The DPHP with 3 aromatic rings has the strongest binding (-ΔGbinding: 6.0kcalmol−1) than other PAEs (-ΔGbinding: 2.91∼4.48kcalmol−1). The DMP with the lowest molecular weight has a high binding force (-ΔGbinding: 4.48kcalmol−1), while the DHP with the highest molecular weight has th...
Source: Environmental Toxicology and Pharmacology - July 7, 2017 Category: Environmental Health Source Type: research

Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus
Publication date: Available online 5 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nevien K.M. Abdelkhalek, Ismail A.M. Eissa, Eman Ahmed, Omnia E. Kilany, Mohamed El-Adl, Mahmoud A.O. Dawood, Ahmed M. Hassan, Mohamed M. Abdel-Daim The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile. At the end of experiment after 28 days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and c...
Source: Environmental Toxicology and Pharmacology - July 5, 2017 Category: Environmental Health Source Type: research