Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte
Publication date: Available online 4 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Huan Xu, Xiaolei Wang, Scott W. BurchielAbstractArsenic is a ubiquitous environmental contaminant that exists in many inorganic and organic forms. In particular, arsenite is known to induce immunotoxicity in humans and animals. There are still major gaps in our understanding of the mechanism(s) of the immunotoxicity induced by arsenic at environmentally-relevant concentrations. T cells are an essential part of the immune system required for host resistance to infections and protection from cancer. Developing T cells in...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Eric A. Rodriguez, Brigitte C. Vanle, Jonathan A. Doorn, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. DuffelAbstractAlthough neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lin...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Sun Young Park, Mei Ling Jin, Eun Hye Yi, Yoon Kim, Geuntae ParkAbstractAcute and chronic inflammatory diseases are associated with excessive inflammation due to the accumulation of pro-inflammatory mediators and cytokines produced by macrophages. In the present study, we investigated the anti-inflammatory properties of neochlorogenic acid (nCGA) from Lonicera japonica on lipopolysaccharide (LPS)-activated inflammation in macrophages and participation of the AMPK/Nrf2 pathway. nCGA pretreatment significantly reduced the p...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Joint toxicity on hepatic detoxication enzymes in goldfish (Carassius auratus) exposed to binary mixtures of lead and paraquat
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Xiaoming Xu, Zhaojie Cui, Shanshan WangAbstractCompared to single exposure, chemical mixtures might induce joint toxicity including additive, synergistic and antagonistic effects on both organisms and environment. Owing to the specific toxicity of oxidative stress and binding to proteins, lead (Pb) is generally recognized a non-essential and threatening heavy metal to animals and human. Paraquat (PQ) is a widely used herbicide in agriculture and can trigger oxidative stress as well as Pb. Little information was available ...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Physiological and anthocyanin biosynthesis genes response induced by vanadium stress in mustard genotypes with distinct photosynthetic activity
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Muhammad Imtiaz, Muhammad Adnan Mushtaq, Muhammad Amjad Nawaz, Muhammad Ashraf, Muhammad Shahid Rizwan, Sajid Mehmood, Omar Aziz, Muhammad Rizwan, Muhammad Safiullah Virk, Qaiser Shakeel, Raina Ijaz, Vasilis P. Androutsopoulos, Aristides M. Tsatsakis, Michael D. ColemanAbstractThe present study aimed to elucidate the photosynthetic performance, antioxidant enzyme activities, anthocyanin contents, anthocyanin biosynthetic gene expression, and vanadium uptake in mustard genotypes (purple and green) that differ in photosynth...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Unraveling CYP2E1 haplotypes in alcoholics from Central Brazil: A comparative study with 1000 genomes population
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Jheneffer Sonara Aguiar Ramos, Leandro Prado Felício, Alessandro Arruda Alves, Mariana Paiva Lopes, Thannya Nascimento Soares, Daniela de Melo e SilvaAbstractWe evaluated genetic variability of single nucleotide polymorphisms (SNPs) situated in the CYP2E1 gene promoter in alcoholics. We also compared 1000 Genomes Project of CYP2E1 polymorphisms with frequencies of genotypes and haplotypes. Eight variation points were exclusively found in Brazilians. The allelic distributions of the rs3813867, rs2031920 and rs203192...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Responses of antioxidant and biotransformation enzymes in Carassius carassius exposed to hexabromocyclododecane
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Huike Dong, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Matthew Nkoom, Haohan YangAbstractThe ubiquitous existence of hexabromocyclododecane (HBCD) in environmental matrices has made it attractive to both field investigators as well as laboratory researchers. However, literature on the biological effects caused by HBCD on aquatic vertebrates seldom exist. This has inevitably increased the difficulty of toxicological assessment in the aquatic environment. Juvenile crucian carp (Carassius carassius) were exposed (flow-through) ...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats
This study may provide a new pathway for studies of the mechanisms of arsenism. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

The in vitro toxicity analysis of titanium dioxide (TiO2) nanoparticles on kinematics and biochemical quality of rainbow trout sperm cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Mustafa Erkan Özgür, Sevgi Balcıoğlu, Ahmet Ulu, İmren Özcan, Fatih Okumuş, Süleyman Köytepe, Burhan AteşAbstractIn recent years, titanium dioxide (TiO2) nanoparticles (NPs) as metal oxide nanoparticles are widely used in industry, agriculture, personal care products, cosmetics, sun protection and toothpaste, electronics, foodstuffs and food packaging. This use of nano-TiO2 has been associated with environmental toxicity concerns. Therefore, the aim of this study was to evaluate the in vitro ...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Selection of reference genes for quantitative real-time PCR in Octopus minor (Cephalopoda: Octopoda) under acute ammonia stress
Publication date: Available online 14 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Ran Xu, Xiaodong Zheng High concentration of ammonia is a common issue in the aquaculture industry and often causes detrimental effects to aquatic products. Exploring expression regulation of genes involved in acute ammonia stress can help to understand the molecular mechanisms of ammonia response. Quantitative real-time PCR (qRT-PCR) with proper reference genes is an effective way to normalize the expression of target genes. To identify the most suitable reference genes for Octopus minor (Mollusca: Cephalopoda: Oc...
Source: Environmental Toxicology and Pharmacology - April 15, 2018 Category: Environmental Health Source Type: research

18 β-glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways
This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18β-GA treatment decreased the production of IL-1β, IL-6, PGE2 and decreased p38MAPK phosphorylation, DNA-binding activity of AP-1, and NF-κB activation in irradiated RAW264.7 macrophages. Additionally, 18β-GA suppressed NF-κB activation by inhibiting NF-κB/p65 and IκB-α phosphorylation and alleviated ROS overproduction in irradiated RAW264.7 macrophages. In vivo assay showed 18β-GA alleviated severity of radiation-indu...
Source: Environmental Toxicology and Pharmacology - April 14, 2018 Category: Environmental Health Source Type: research

Gestational glucocorticoid exposure disrupts glucose homeostasis that is accompanied by increased endoglin and DPP-4 activity instead of GSK-3 in rats
Publication date: Available online 13 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Olufunto O. Badmus, Olugbenga S. Michael, Saheed Rabiu, Lawrence A. Olatunji Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring’s in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflamma...
Source: Environmental Toxicology and Pharmacology - April 14, 2018 Category: Environmental Health Source Type: research

Protective Role of Nimbolide against Chemotherapeutic Drug Hydroxyurea Induced Genetic and Oxidative Damage in an Animal Model
Publication date: Available online 12 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Md Fahim Ahmad, Mohd Owais Ansari, Sana Jameel, Ab Latif Wani, Nuzhat Parveen, Hifzur R. Siddique, G.G.H.A. Shadab Nimbolide is known to be an antioxidant found in neem plant. Hydroxyurea is a medication frequently used in sickle-cell disease, different cancers and HIV infection. The present study aimed to evaluate the adverse effect of HU and possible amelioration by nimbolide in Wistar rats. To test our hypothesis, we performed genotoxicity tests, biochemical assays, and histopathological studies. We observed tha...
Source: Environmental Toxicology and Pharmacology - April 13, 2018 Category: Environmental Health Source Type: research

DNA damaging and apoptotic potentials of Bisphenol A and Bisphenol S in human bronchial epithelial cells
Publication date: Available online 11 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Vazhappilly Cijo George, H.P.Vasantha Rupasinghe DNA damage caused by environmental agents often lead to many chronic diseases, including cancer. The present study aimed to understand the relative toxicity possessed by Bisphenol A (BPA) and Bisphenol S (BPS) on human bronchial epithelial cells (BEAS-2B). The cells were exposed to either BPA or BPS and evaluated for its cytotoxicity, reactive oxygen species (ROS), DNA fragmentation, phosphorylated histone protein (γ-H2AX) and DNA tail damage levels. Further, w...
Source: Environmental Toxicology and Pharmacology - April 12, 2018 Category: Environmental Health Source Type: research

InP/ZnS QDs exposure induces developmental toxicity in rare minnow (Gobiocypris rarus) embryos
Publication date: June 2018 Source:Environmental Toxicology and Pharmacology, Volume 60 Author(s): Yao Chen, Yang Yang, Fang Ou, Li Liu, Xiao-hong Liu, Zhi-Jian Wang, Li Jin We investigated the in vivo toxicity of InP/ZnS quantum dots (QDs) in Chinese rare minnow (Gobiocypris rarus) embryos. The 72 h post-fertilization (hpf) LC50 (median lethal concentration) was 1678.007 nmol/L. Rare minnows exposed to InP/ZnS QDs exhibited decreased spontaneous movement, decreased survival and hatchability rates, and an increased malformation rate. Pericardial edema, spinal curvature, bent tails and vitelline cysts were observed. Em...
Source: Environmental Toxicology and Pharmacology - April 12, 2018 Category: Environmental Health Source Type: research

Effect of in vivo exposure to ambient fine particles (PM2.5) on the density of dopamine D2-like receptors and dopamine-induced [35S]-GTP γS binding in rat prefrontal cortex and striatum membranes
Publication date: Available online 10 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): María-de-los-Angeles Andrade-Oliva, Octavio-Gamaliel Aztatzi-Aguilar, Francisco García-Sierra, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montaño Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3). In membranes from rat prefrontal cortex (PFC) or striatum, the density and function of dopam...
Source: Environmental Toxicology and Pharmacology - April 11, 2018 Category: Environmental Health Source Type: research

Biological Effects of Airborne Fine Particulate Matter (PM2.5) Exposure on Pulmonary Immune System
Publication date: Available online 8 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Tingting Wei, Tang Meng Airborne fine particulate matter (PM2.5) attracts more and more attention due to its environmental effects. The immune system appears to be a most sensitive target organ for the environmental pollutants. Inhaled PM2.5 can deposit in different compartments in the respiratory tract and interact with epithelial cells and resident immune cells. Exposed to PM2.5 can induce local or systematic inflammatory responses. This review focus on the effects of respiratory tract exposed to PM2.5. Firstly, w...
Source: Environmental Toxicology and Pharmacology - April 9, 2018 Category: Environmental Health Source Type: research

Toxic effect of [Omim]BF4 and [Omim]Br on antioxidant stress and oxidative damage in earthworms (Eisenia fetida)
Publication date: Available online 8 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Yuting Shao, Jun Wang, Zhongkun Du, Bing Li, Lusheng Zhu, Jinhua Wang, Shumin Zhang In this paper, model soil organism, earthworms (Eisenia fetida), were selected to examine the chronic toxic effect of two different ionic liquids (ILs) [Omim]BF4 and [Omim]Br. Earthworms were put into different ILs concentrations (0, 5, 10, 20, 40 mg/kg) in artificial soil and random selected on days 7, 14, 21 and 28. Reactive oxygen species (ROS), three antioxidant enzymes and detoxifying enzyme glutathione-S-transferase (GST) were...
Source: Environmental Toxicology and Pharmacology - April 9, 2018 Category: Environmental Health Source Type: research

Histological and ultrastructural alterations of the Italian newt (Lissotriton italicus) skin after exposure to ecologically relevant concentrations of nonylphenol ethoxylates
Publication date: Available online 7 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Elvira Brunelli Nonylphenol ethoxylates (NPEs) are well known endocrine disruptors. Widespread environmental contamination from NPEs is an issue of great concern. Despite amphibians are often exposed to such contaminants, very little attention has been dedicated to this vertebrate group. No information is available on the effects of NPEs onto the amphibian skin and only few reports have been conducted on fish. Here, histological and ultrastructural modifications of the skin have been evaluated in the Italian newt Li...
Source: Environmental Toxicology and Pharmacology - April 8, 2018 Category: Environmental Health Source Type: research

CInP/ZnS QD exposure induces developmental toxicity in rare minnow (Gobiocypris rarus) embryos
Publication date: Available online 5 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Yao Chen, Yang Yang, Fang Ou, Li Liu, Xiao-hong Liu, Zhi-Jian Wang, Li Jin We investigated the in vivo toxicity of InP/ZnS quantum dots (QDs) in Chinese rare minnow (Gobiocypris rarus) embryos. The 72 h post-fertilization (hpf) LC50 (median lethal concentration) was 1678.007 nmol/L. Rare minnows exposed to InP/ZnS QDs exhibited decreased spontaneous movement, decreased survival and hatchability rates, and an increased malformation rate. Pericardial edema, spinal curvature, bent tails and vitelline cysts were obs...
Source: Environmental Toxicology and Pharmacology - April 6, 2018 Category: Environmental Health Source Type: research

Aflatoxin B1-contaminated diet disrupts the blood –brain barrier and affects fish behavior: Involvement of neurotransmitters in brain synaptosomes
Publication date: Available online 4 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Matheus D. Baldissera, Carine F. Souza, Carla Cristina Zeppenfeld, Sharine N. Descovi, Karen Luise S. Moreira, Maria Izabel U.M. da Rocha, Marcelo L. da Veiga, Aleksandro S. da Silva, Bernardo Baldisserotto It is known that the cytotoxic effects of aflatoxin B1 (AFB1) in endothelial cells of the blood–brain barrier (BBB) are associated with behavioral dysfunction. However, the effects of a diet contaminated with AFB1 on the behavior of silver catfish remain unknown. Thus, the aim of this study was to evaluate ...
Source: Environmental Toxicology and Pharmacology - April 5, 2018 Category: Environmental Health Source Type: research

Thiamethoxam induced hepatic energy changes in silver catfish via impairment of the phosphoryl transfer network pathway: Toxicological effects on energetics homeostasis
Publication date: Available online 3 April 2018 Source:Environmental Toxicology and Pharmacology Author(s): Matheus D. Baldissera, Carine F. Souza, Jaqueline I. Golombieski, Débora Seben, Letícia R. Sippert, Joseânia Salbego, Renato Zanella, Bernardo Baldisserotto Precise coupling of spatially separated intracellular adenosine triphosphate (ATP)-producing and ATP-consuming processes exerts a pivotal role in bioenergetic homeostasis of living organisms, and the phosphotransfer network pathway, catalyzed by adenylate kinase (AK) and pyruvate kinase (PK), is fundamental in cellular and tissue energetic ho...
Source: Environmental Toxicology and Pharmacology - April 3, 2018 Category: Environmental Health Source Type: research

Acute toxicity and associated mechanisms of four strobilurins in algae
This study investigated the acute toxicity of Kresoxim-methy (KRE), Pyraclostrobin (PYR), Trifloxystrobin (TRI) and Picoxystrobin (PIC) on two algae and their toxicity mechanisms. Four strobilurins showed lower toxic effects on Chlorella pyrenoidsa but higher on Chlorella vulgaris. bc1 complex activities in C. vulgaris were significantly inhibited by all strobilurins, suggesting bc 1 complex might be the target of strobilurin toxicity in algae. Moreover, SOD, CAT and POD activities were significantly up-regulated by all doses of KRE, PYR and PIC. In contrast, low concentrations of TRI stimulated SOD and POD activities but ...
Source: Environmental Toxicology and Pharmacology - April 3, 2018 Category: Environmental Health Source Type: research

Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP)
Publication date: Available online 30 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Elvira Mennillo, Åse Krøkje, Carlo Pretti, Valentina Meucci, Augustine Arukwe Pharmaceuticals such as racemate ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are highly detectable non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment and therefore are designated as one of the most emerging groups of pollutants that can affect environmental and human health. The potential impact of these pharmaceuticals was assessed for the first time in vitro using a rat hepatocellul...
Source: Environmental Toxicology and Pharmacology - March 31, 2018 Category: Environmental Health Source Type: research

High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38/JNK-mediated epithelial apoptosis
Publication date: Available online 30 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Chenming Xu, Qiwen Shi, Leifang Zhang, Hang Zhao Inhalation of fine particulate matter (PM2.5) is asscoiated with lung injury. High molecular weight hyaluronan (HMW-HA) is an essential constituent of extracellular matrix (ECM), exhibiting anti-oxidative and anti-inflammatory properties when administered by injection, inhalation, nebulization or gene delivery of HA synthases. The aim of the present study is to determine whether HMW-HA alleviates PM2.5-induced acute lung injury (ALI) and investigate the underlying me...
Source: Environmental Toxicology and Pharmacology - March 31, 2018 Category: Environmental Health Source Type: research

Regional variation in percutaneous absorption in the tree frog Litoria caerulea
This study investigated the in vitro percutaneous absorption of three model chemicals - benzoic acid, caffeine, and ibuprofen - through dorsal and ventral skin of the tree frog Litoria caerulea. Flux was significantly higher through the ventral skin for all chemicals. Relative lipophilicity affected flux differently in different skin regions. These differences are likely due to significantly thicker dorsal skin increasing absorption path length, and also possibly owing to lipoid secretions on the dorsum providing an additional diffusional barrier. This knowledge can advise risk mitigation of xenobiotics in agricultural and...
Source: Environmental Toxicology and Pharmacology - March 29, 2018 Category: Environmental Health Source Type: research

Crocin Reverses Unilateral Renal Ischemia Reperfusion Injury-Induced Augmentation of Oxidative Stress and Toll like receptor-4 Activity
In conclusion, crocin induced restoration of normal kidney functions is mediated through multiple mechanisms including mainly attenuation of oxidative stress and inflammation via down-regulation of renal TLR4 and IL6 expression. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 28, 2018 Category: Environmental Health Source Type: research

Genotoxic effect of Lippia alba (Mill.) N. E. Brown essential oil on fish (Oreochromis niloticus) and mammal (Mus musculus)
The objective of this study was to evaluate the genotoxic effect of Lippia alba essential oil in fish and mammals. The oil was extracted by hydrodistillation with a Clevenger apparatus and analyzed by gas chromatography coupled to mass spectrometry (GC-MS), where the compounds linalool, eucalyptol, γ-muurolene, and caryophyllene were identified as the most abundant compounds. Lippia alba essential oil showed inhibitory activity on LPS-stimulated Nitric Oxide (NO) production (77% at 20 µg.mL-1) in RAW 264.7 macrophages without influence cellular viability. Genotoxic action was observed by micronucleus and come...
Source: Environmental Toxicology and Pharmacology - March 26, 2018 Category: Environmental Health Source Type: research

IGFBP-3 plays an important role in senescence as an aging marker
In conclusion, IGFBP-3 up-regulates PI3K/Akt/mTOR signaling pathway and down-regulates autophagy during cell aging. These results suggest that IGFBP-3 could play a key role in aging study as an important aging marker. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Urine Cotinine Level with Smoking History Predicts a Risk of Coronary Artery Calcification
Publication date: Available online 21 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Hui-Jin Yu, Sangeun Lim, Min-Kyeong Kim, Seungjun Lee, Min-Jung Kwon, Hyosoon Park, Hee-Yeon Woo We investigated whether urine cotinine level, alone or combined with smoking status and cumulative smoking amount, could predict coronary calcium (CAC) score increase over time. The study population included 10,980 subjects. We analysed an association between CAC score increase over time and single or combined smoking-related factors. Urine cotinine level of ≥100 ng/mL, current or ex-smokers, and cumulative smoking...
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Toxicological effects of cadmium and lead on two freshwater diatoms
In this study, the cell growth, chlorophyll a content and superoxide dismutase activity in Halamphora veneta (Kützing) Levkov and Surirella crumena Brébisson exposed to cadmium and lead, were investigated. Furthermore, in order to explore the potential function of H. veneta on environmental monitoring and environmental remediation, expression of two genes (psbA, psaB) and morphological analysis of H. veneta were carried out. The cells growth of H. veneta and S. crumena were generally inhibited with cadmium and lead exposure during 96 h, while cells density of H. veneta was significantly increased under the lo...
Source: Environmental Toxicology and Pharmacology - March 21, 2018 Category: Environmental Health Source Type: research

Nicorandil alleviates ovalbumin-induced airway inflammation in a mouse model of asthma
In conclusion, our results proposed that nicorandil is equipotent to dexamethasone in ameliorating allergic asthma by restoring oxidant/antioxidant balance and reducing inflammation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 20, 2018 Category: Environmental Health Source Type: research

SET Promotes H2AK9 Acetylation by Suppressing HDAC1 in Trichloroethylene-induced Hepatic Cytotoxicity
In this study, we found a total of 136 histone acetylation sites involved in TCE-induced hepatic cytotoxicity with the technique of Triton-acid-urea polyacrylamide gel electrophoresis (TAU-PAGE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Importantly, 17 histone acetylation sites were revealed to be mediated by SET in TCE-induced cytotoxicity. The acetylation of histone H2AK9 (H2AK9ac) was further validated by Western-blot analysis. The data showed that TCE treatment increased the acetylation of H2AK9 in hepatic L-02 cell and decreased the one in SET-knockdown L-02 cells. Besides, levels of the ...
Source: Environmental Toxicology and Pharmacology - March 19, 2018 Category: Environmental Health Source Type: research

Urinary phthalate metabolite concentrations in girls with premature thelarche
Publication date: Available online 17 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Erdem Durmaz, Pinar Erkekoglu, Ali Asci, Sema Akçurin, İffet Bircan, Belma Kocer-Gumusel In girls, breast development before eight years of age is called “premature thelarche (PT)”. There are few studies in literature that show the interaction between PT and phthalate exposure. The aim of this study was to determine the urinary levels of di-(2-ethylhexyl) phthalate (DEHP) metabolites and other phthalate metabolites in girls with PT. PT group consisted of 29 newly diagnosed subjects. Control grou...
Source: Environmental Toxicology and Pharmacology - March 19, 2018 Category: Environmental Health Source Type: research

Effects of mancozeb, metalaxyl and tebuconazole on steroid production by bovine luteal cells in vitro
Publication date: Available online 13 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Nurgul Atmaca, Sevket Arikan, Dinc Essiz, Hakan Kalender, Ozkan Simsek, Fatih Sultan Bilmen, Ruhi Kabakci Mancozeb, metalaxyl and tebucanazole are widely used pesticides in agriculture and industry to treat plant pathogenic fungi. Livestock may be exposed to such substances by consuming contaminated plants. The present study was designed to evaluate the effects of these three fungicides on bovine luteal cell steroidogenesis. Luteal slices from mid-cycle corpus luteum were dissociated into single cell suspension in ...
Source: Environmental Toxicology and Pharmacology - March 14, 2018 Category: Environmental Health Source Type: research

Sensitivity of Arbor Acres broilers and Chemoprevention of Aflatoxin B1-induced liver injury by Curcumin, a natural potent inducer of Phase-II enzymes and Nrf2
In this study, we scrutinized the effects of curcumin and AFB1 supplemented diet alone or in combination on phase-ӀӀ enzymes. Histopathological examination showed that after 28 days, AFB1 (5.0 mg/kg diet) induced liver injury in broilers, but curcumin supplementation partially ameliorated liver injury in a dose-dependent manner. RT-PCR data revealed that AFB1 significantly (p < 0.01) down-regulated Nrf2 and its downstream genes mRNA expression level. Moreover, Western blot analysis showed that Nrf2, GSTM2, and GSTA3 protein expression level was markedly (p < 0.01) reduced in AFB1-fed group. However,...
Source: Environmental Toxicology and Pharmacology - March 12, 2018 Category: Environmental Health Source Type: research

Effects of low concentrations of ibuprofen on freshwater fish Rhamdia quelen
This study evaluated the effects of ibuprofen in environmental concentrations (0, 0.1, 1 and 10 μg/L) on the freshwaterspecies Rhamdia quelen exposed for 14 days. In the posterior kidney, ibuprofen increased glutathione-S-transferase activity in all groups exposed. Furthermore, increased glutathione peroxidase activity and the levels of reduced glutathione in the group exposed to 10 μg/L. Ibuprofen decreased the carbonic anhydrase activity in the posterior kidney in all exposed groups, and increased the activity in the gills in group exposed to 0.1 μg/L. The levels of plasma magnesium increased in groups exp...
Source: Environmental Toxicology and Pharmacology - March 11, 2018 Category: Environmental Health Source Type: research

Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn2+
In conclusion, chlorothalonil at low (sublethal) micromolar concentrations is cytotoxic to mammalian cells under oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

Are we closer to the vision? A proposed framework for incorporating omics into environmental assessments
Publication date: Available online 8 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Christopher J. Martyniuk Environmental science has benefited a great deal from omics-based technologies. High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals. While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in “real-world” exposure scenarios. Clarity in the interpretation of these data limits their...
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury
Publication date: Available online 8 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Sh Mohammadi, M Gholamin, M. Mohammadi, A. Mansouri, R. Mahmoodian, S. Attari, S.M. Kebriaei, B. Zibaei, M. Roshanaei, F. Daneshvar, M. Khandehro, M.A. Khodadadegan, A. Delshad, F. Mohammadzadeh, Mostafa Peyvandi, Majid Ghayour-Mobarhan, Shima Tavallaie, Samaneh Boroumand-Noughabi, Gordon A.A. Ferns In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expr...
Source: Environmental Toxicology and Pharmacology - March 9, 2018 Category: Environmental Health Source Type: research

TOXICOLOGICAL EFFECT OF Al2O3 NANOPARTICLES ON HISTOARCHITECTURE OF THE FRESHWATER FISH OREOCHROMIS MOSSAMBICUS
Publication date: Available online 5 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Murali M., Athif P., Suganthi P., Sadiq Bukhari A., Syed Mohamed H.E., Basu H., Singhal R.K. In the present study, freshwater fish Oreochromis mossambicus were exposed to sub lethal concentrations (120, 150 and 180ppm) of Aluminium oxide nanoparticles (Al2O3 NPs) for 96 hours. Histological abnormalities were not observed in the organs of control fishes whereas severe damages and extensive architectural loss was found in the brain, gill, intestine, kidney and muscle tissues of treated fishes with more pronounced effe...
Source: Environmental Toxicology and Pharmacology - March 6, 2018 Category: Environmental Health Source Type: research

Non-metric multidimensional scaling and human risks of heavy metal concentrations in wild marine organisms from the Maowei Sea, the Beibu Gulf, South China Sea
Publication date: Available online 5 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Gu Yang-Guang, Huang Hong-Hui, Liu Yong, Gong Xiu-Yu, Liao Xiu-Li We investigated heavy metal concentrations in wild marine organisms from Maowei Sea, a significant gulf of low-latitude developing regions of the Beibu Gulf, South China Sea. Twenty species, comprising fish, cephalopods, and crustaceans were collected and analyzed for heavy metals. Heavy metal levels (mg/kg, wet weight) in the aquatic organism samples were: 0.003–1.800 for Cd, 0.02–0.14 for Pb, 0.10–0.63 for Cr, 0.20–77.50 for ...
Source: Environmental Toxicology and Pharmacology - March 6, 2018 Category: Environmental Health Source Type: research

Effects of topical exposure to a mixture of chlorpyrifos, cypermethrin and captan on the hematological and immunological systems in male Wistar rats
Publication date: Available online 2 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Soraya Aroonvilairat, Chanthana Tangjarukij, Thiwaree Sornprachum, Papada Chaisuriya, Taweeratana Siwadune, Kavi Ratanabanangkoon Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three groups of 10 rats were dermally exposed to three different doses (high,...
Source: Environmental Toxicology and Pharmacology - March 3, 2018 Category: Environmental Health Source Type: research

Simultaneous Effects of Endocrine Disruptor Bisphenol A and Flavonoid Fisetin on Progesterone Production by Granulosa Cells
Publication date: Available online 2 March 2018 Source:Environmental Toxicology and Pharmacology Author(s): Alzbeta Bujnakova Mlynarcikova, Sona Scsukova In the present study, we aimed to examine effects of different concentrations of the endocrine disruptor Bisphenol A (BPA; 1 nM, 1 µM, 100 µM) and the flavonoid fisetin (1, 10, 25, 50 µM), individually and in combinations, on steroidogenic function of porcine ovarian granulosa cells (GCs) represented by progesterone production. We confirmed that BPA inhibited progesterone production by GCs at the highest concentration. Fisetin reduced gonadotropin-stimu...
Source: Environmental Toxicology and Pharmacology - March 3, 2018 Category: Environmental Health Source Type: research

Cadmium treatment induces echinocytosis, DNA damage, inflammation, and apoptosis in cardiac tissue of albino Wistar rats
This study was designed to investigate the effects of Cd intake on erythrocytes and cardiac tissue in male albino Wistar rats. We treated male albino Wistar rats with cadmium chloride (CdCl2) by intra-gastric administration for 30 days and examined Cd burden and changes in blood constituents and antioxidant status of blood and cardiac tissue. We also studied the structural alterations in the erthrocytes, elemental changes and Cd burden in cardiac tissue using scanning electron microscope (SEM/EDX). Inflammation and apoptosis were analysed in the cardiac tissue by polymerase chain reaction (PCR), western blotting, and DNA f...
Source: Environmental Toxicology and Pharmacology - February 28, 2018 Category: Environmental Health Source Type: research

Toxicity assessment of sediments from the Liaohe River Protected Area (China) under the influence of ammonia nitrogen, heavy metals and organic contaminants
Publication date: Available online 27 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Xin Ke, Qinghua Bao, Yifang Qi, Xiaoyan Huang, Haijun Zhang The aim of this study was to evaluate the toxicity of ammonia nitrogen, metals and organic contaminants in sediment collected from the Liaohe River Protected Areas. The TIE was applied to 16 samples. The zeolite, resin, and coconut charcoal were used to mask toxicity of the three kinds of pollutants, respectively. Then quantitative analyses together with a battery of bioassays were performed to evaluate toxic effects. At last, the spiking tests were use...
Source: Environmental Toxicology and Pharmacology - February 28, 2018 Category: Environmental Health Source Type: research

Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway
In conclusion, ALA possess protective effects against CPF-induced liver injury through attenuation of apoptosis and oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 24, 2018 Category: Environmental Health Source Type: research

Cytotoxic activity of fucoxanthin, alone and in combination with the cancer drugs imatinib and doxorubicin, in CML cell lines
This study unveiled in vitro cytotoxicity of Fx by inhibition of cell proliferation in both cell lines. Further studies are needed to elucidate the signal transduction pathways and molecular targets involved in that effect. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - February 17, 2018 Category: Environmental Health Source Type: research

Role of voltage-gated calcium channels on striatal dopamine release induced by inorganic mercury in freely moving rats
Publication date: Available online 12 February 2018 Source:Environmental Toxicology and Pharmacology Author(s): Lilian R. Ferreira Faro, Miguel Alfonso, Vania Moraes Ferreira, Rafael Durán The possible role of voltage-sensitive calcium channels (VSCC) activation on the HgCl2-induced dopamine release was investigated using selective VSCC blockers and the dopamine levels were measured by HPLC from samples obtained by in vivo brain microdialysis. Infusion of HgCl2 in nicardipine (10 or 100 μM) or flunaricine (10 μM) pretreated animals had no significant effect on dopamine release induced by HgCl2. Pretreatme...
Source: Environmental Toxicology and Pharmacology - February 13, 2018 Category: Environmental Health Source Type: research