Dyslipdemia induced by chronic low dose co-exposure to lead, cadmium and manganese in rats: the role of oxidative stress
Publication date: Available online 22 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Olusola Olalekan Oladipo, Joseph Olusegun Ayo, Suleiman Folorunsho Ambali, Bisalla Mohammed, Tanang Aluwong Lead (Pb), cadmium (Cd) and manganese (Mn) have many potential adverse health effects in vitro and in animal models of clinical toxicity. The current study investigated the dyslipidaemic and oxidative stress effects of chronic low-dose oral exposure to Pb, Cd and Mn and the combination (Pb+Cd+Mn) in rats for 15 weeks. Chronic exposure to the metals did not significantly (P>0.05) alter serum lipid profil...
Source: Environmental Toxicology and Pharmacology - June 23, 2017 Category: Environmental Health Source Type: research

Preliminary Evidence for Snail Deformation from a Eutrophic Lake
Publication date: Available online 23 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Kun Lei, Fei Qiao, Qing Liu, Zhanliang Wei, Lihui An, Hongli Qi, Song Cui, Gerald A. LeBlanc The incidence of deformities in snails Bellamya aeruginosa was investigated in a typical eutrophicated lake − Taihu Lake. A total of 15 105 specimens were collected, and 0.18∼0.93% of the snails exhibited abnormal tentacle bifurcations. Abnormally developed snails were all female and were found in regions with relatively high Chlorophyll a levels (12.40±7.23μg/L). As tentacles are sexually dimorphic in B....
Source: Environmental Toxicology and Pharmacology - June 23, 2017 Category: Environmental Health Source Type: research

Influence of electromagnetic pulse on the offspring sex ratio of male BALB/c mice
Publication date: Available online 21 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jin-hui Li, Da-peng Jiang, Ya-feng Wang, Jia-jia Yan, Qi-yan Guo, Xia Miao, Hai-yang Lang, Sheng-long Xu, Jun-ye Liu, Guo-zhen Guo Public concern is growing about the exposure to electromagnetic fields (EMF) and its effect on male reproductive health. Detrimental effect of EMF exposure on sex hormones, reproductive performance and sex-ratio was reported. The present study was designed to clarify whether paternal exposure to electromagnetic pulse (EMP) affects offspring sex ratio in mice. 50 male BALB/c mice aged 5-6...
Source: Environmental Toxicology and Pharmacology - June 22, 2017 Category: Environmental Health Source Type: research

Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways
Publication date: Available online 19 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Zhen-Fang Gu, Zi-Teng Zhang, Jun-Ye Wang, Bao-Bin Xun Esophageal cancer is one of the leading causes of cancer related mortality across the globe. The current treatment options are insufficient and are associated with number of side effects. Therefore there is a pressing need to develop effective and more efficient strategies for the treatment of esophageal cancer. Consistently, natural products are considered potential candidates for develop of cancer chemotherapy. Icariin is a naturally occurring flavonol glucosid...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Transcriptional response in rainbow trout (Oncorhynchus mykiss) B cells and thrombocytes following in vivo exposure to benzo[a]pyrene
Publication date: Available online 19 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Laura J. Phalen, Bernd Köllner, Natacha S. Hogan, Michael R. van den Heuvel Immune toxicity of polycyclic aromatic hydrocarbons (PAHs) in fishes has been frequently reported but the reasons for differential cell toxicity remains unclear. Rainbow trout were exposed in vivo with a single intraperitoneal injection of corn oil or 100mg/kg of the immunotoxic PAH benzo[a]pyrene (B[a]P) in corn oil and leukocytes were harvested from head kidney, spleen and blood after 14 days, the optimal time for B cell depletion fou...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Impact of smoking on the observed levels of apolipoprotein B: Data from NHANES 2007 –2012
Publication date: Available online 20 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Ram B. Jain Impact of smoking on the levels of apolipoprotein B (APOB) was evaluated by analyzing data from National Health and Nutrition Examination Survey for the years 2007–2012 for US adolescents aged 12–19 years and adults aged >=20 years. When adjustments were made for the effects of age, gender, race/ethnicity, body mass index, and poverty income ratio, smoking did not influence the observed levels of APOB for either adolescents or adults. Moreover, even the variables that represented inten...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Effects of 1,4-naphthoquinone Aged Carbon Black Particles on the Cell Membrane of Human Bronchial Epithelium
In this study, carbon black (CB) was used to simulate BC to reveal the adverse effects of 1,4-naphthoquinone aged carbon black (CB/1,4-NQ) particles on the membrane of human bronchial epithelial (16HBE) cells. It was showed that, the cell viability, cell membrane fluidity, membrane potential and mitochondrial membrane potential were significantly decreased after 16HBE cells were treated with CB, 1,4-NQ or CB/1,4-NQ. Meanwhile, the cell membrane permeability and intracellular Ca2+ concentration were increased. CB/1,4-NQ could induce more adverse effects on cell membrane than single CB treated, while less than 1,4-NQ. The re...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

The Research of Genetic Toxicity of β-phellandrene
This study focused on the genetic toxicity of β-phellandrene. The genetic toxicity of β-phellandrene was evaluated by micronucleus test, comet assay, Ames test, and chromosomal aberration test. In this study, 2850, 1425, 712.5mg/kg β-phellandrene were used in vivo experiments (comet assay and micronucleus test). For Ames test, pure β-phellandrene and different concentrations were used in the experiment. According to the results of cell viability assay (MTT test), the concentration of chromosomal aberration test was formulated. The result of comet assay showed that β-phellandrene can significantly i...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Biosynthesis of vitamin C stabilized tin oxide nanoparticles and their effect on body weight loss in neonatal rats
Publication date: Available online 20 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jie Yang, Ke-qing Yang, Li Qiu The green synthesis of tin oxide nanoparticles (SnO2 NPs) using vitamin C (Vc) as a reducing agent via a biosynthetic approach is described. The effect of Vc-stabilized SnO2 NPs on the body weight of neonatal rats is also studied. The prepared SnO2NPs were characterized using spectroscopic and microscopic instrumental techniques including transmission electron microscopy (TEM), UV–visible spectrophotometry (UV–vis), X-ray diffraction and Fourier transform infrared spectrosc...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

DNA damage and repair, oxidative stress and metabolism biomarker responses in lungs of rats exposed to ambient atmospheric 1-nitropyrene
In this study, the 1-NP solutions at 3 dosages (1.0×10−5, 4.0×10−5 and 1.6×10−4 mg/kg body weight) were respectively given to rats by the intratracheal instillation. The responses of 1-NA on DNA damage and repair, oxidative stress and metabolism biomarkers in rat lungs after exposure to 1-NP were measured. The results showed 1-NP at three dosages induced obvious DNA strand breaks, 8-OH-dG formation and DNA-protein cross-link in rat lungs compared with the control. Higher dosage 1-NP (4.0×10−5 and 1.6×10−4 mg/kg body weight) greatly activated DNA repair gene OGG1 a...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Cyanidin-3-rutinoside increases glucose uptake by activating the PI3K/Akt pathway in 3T3-L1 adipocytes
In this study, the effect of cyanidin-3-rutinoside (C3R) on glucose uptake by 3T3-L1 adipocytes was studied. C3R significantly increased glucose uptake, which was associated with enhanced plasma membrane glucose transporter type 4 (PM-GLUT4) expression in 3T3-L1 adipocytes. The potentiating effect of C3R on glucose uptake and PM-GLUT4 expression was related to enhanced phosphorylation of insulin receptor substrate 1 (IRS-1) and Akt, as well as augmented activation of phosphatidylinositol-3-kinase (PI3K) in the insulin signaling pathway. C3R induced glucose uptake was inhibited only by the PI3K inhibitor, but not by an AMPK...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Study on the interaction between typical phthalic acid esters (PAEs) and human hemoglobin (hHb) by molecular docking
Publication date: Available online 20 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li, Ye Shan This work has evaluated the binding force between hHb and typcial PAEs (DMP, DEP, DPRP, DBP, DIBP, DHP and DPHP) using molecule docking technique. The DPHP with 3 aromatic rings has the strongest binding (-ΔGbinding: 6.0kcalmol−1) than other PAEs (-ΔGbinding: 2.91∼4.48kcalmol−1). The DMP with the lowest molecular weight has a high binding force (-ΔGbinding: 4.48kcalmol−1), while the DHP with the highest molecular weig...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Immune response mechanism of mouse monocytes/macrophages treated with κ-carrageenan polysaccharide
This study investigated the function of κ-carrageenan polysaccharide in immune regulation. The immune response of RAW 264.7 cells treated with κ-carrageenan polysaccharide was explored by MTT assay, general morphological observation, neutral red phagocytosis assay, Griess method, fluorescence method, and enzyme-linked immunosorbent assay. In addition, TLR4 blocking experiment and double-fluorescence immunostaining were performed on cells to demonstrate their immune response mechanism. Results show that κ-carrageenan polysaccharide not only promotes cell proliferation but also activates RAW 264.7 cells, th...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Connexin 43 mediates changes in protein phosphorylation in HK-2 cells during chronic cadmium exposure
In this study, human renal proximal tubule (HK-2) cells were exposed to Cd (1μM, 10 days). Of the 584 protein residues detected using a Phospho Explorer antibody microarray (PEX100), more than half changed their levels of phosphorylation after chronic Cd exposure. Cx43 siRNA attenuated Cd-induced apoptosis and inhibited proliferation, while also attenuating changes in the levels of phosphorylation of many protein residues. According to DAVID Bioinformatics Resources analysis and KEGG PATHWAY database, AKT signal pathway may be the important one. Focusing on the AKT pathway confirmed that Cx43 mediated increased levels o...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Computational analysis of the ToxCast estrogen receptor agonist assays to predict vitellogenin induction by chemicals in male fish
Publication date: Available online 13 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): David A. Dreier, Nancy D. Denslow, Christopher J. Martyniuk Endocrine disruptors, especially estrogen receptor (ER) agonists, have received considerable research attention. While there are several mechanistic endpoints for ER agonism in the Endocrine Disruptor Screening Program, there have been growing efforts to develop high-throughput screening assays and computational models to reduce testing cost, time, and animal use. For example, there are 16 ER agonist assays and an integrated computational model in ToxCast. ...
Source: Environmental Toxicology and Pharmacology - June 14, 2017 Category: Environmental Health Source Type: research

Histological alterations in gills and liver of rainbow trout (Oncorhynchus mykiss) after exposure to the antibiotic oxytetracycline
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): S. Rodrigues, S.C. Antunes, B. Nunes, A.T. Correia The aim of this study was to investigate the histopathological effects of oxytetracycline (OTC) on the gill and liver tissues of rainbow trouts (Oncorhynchus mykiss) following acute (96h: 0.005–50mg/L) and chronic (28days: 0.3125–5μg/L) exposures. Results suggest the existence of a cause-and-effect relationship between the exposure to OTC and tissue damage. Most predominant disorders observed in gills were progressive (e.g. hypertrophy of mucous cells and hype...
Source: Environmental Toxicology and Pharmacology - June 8, 2017 Category: Environmental Health Source Type: research

QSAR models for predicting acute toxicity of pesticides in rainbow trout using the CORAL software and EFSA ’s OpenFoodTox database
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Andrey A. Toropov, Alla P. Toropova, Marco Marzo, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati Optimal (flexible) descriptors were used to establish quantitative structure – activity relationships (QSAR) for toxicity of pesticides (n=116) towards rainbow trout. A heterogeneous set of hundreds of pesticides has been used, taken from the EFSA’s chemical Hazards Database: OpenFoodTox. Optimal descriptors are preparing from simplified molecular input-line entry system (SMILES). So-called, correlation weights...
Source: Environmental Toxicology and Pharmacology - June 7, 2017 Category: Environmental Health Source Type: research

Cadmium, arsenic, selenium and iron – Implications for tumor progression in breast cancer
This study support the role of Cd in breast cancer risk and progression. The possible link between As exposure and breast cancer is still not clear. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 4, 2017 Category: Environmental Health Source Type: research

Role of PI3K/AKT/mTOR signaling pathway in DBP-induced apoptosis of testicular sertoli cells in vitro
This study was to investigate the injury effect induced by DBP on rat testicular Sertoli cells in vitro. MTT results showed that DBP can significantly reduce the survival rate of Sertoli cells; Hoechst staining results showed that the Sertoli cells treated with DBP emerged with typical morphological characteristics of apoptosis, nuclear condensation and chromatin condensation; flow cytometry results showed that DBP significantly increased the apoptotic rate of Sertoli cells, and dose-dependent; Western blotting showed that the expression of PTEN protein in Sertoli cells was significantly higher than that in the control gro...
Source: Environmental Toxicology and Pharmacology - June 2, 2017 Category: Environmental Health Source Type: research

Application of novel metal organic framework, MIL-53(Fe) and its magnetic hybrid: For removal of pharmaceutical pollutant, doxycycline from aqueous solutions
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Shakiba Naeimi, Hossein Faghihian As a pharmaceutical pollutant, doxycycline causes contamination when enters into the environment. In this research MIL-53(Fe), and its magnetic hybrid MIL-53(Fe)/Fe3O4 were synthesized and employed for removal of doxycycline from aqueous solutions. The adsorbents were characterized by XRD, SEM, BET, FTIR, EDAX, VSM and TG-DTG technique. The effect of different variables such as DOC concentration, pH, contacting time, and adsorbent dose on the removal efficiency was studied and under optimize...
Source: Environmental Toxicology and Pharmacology - May 23, 2017 Category: Environmental Health Source Type: research

Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Radosław Czernych, Milena Chraniuk, Paweł Zagożdżon, Lidia Wolska The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of co...
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

Corrigendum to “The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice” [Environ. Toxicol. Pharmacol. 51 (2017) 16–22]
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Binggan Wei, Jiangping Yu, Jing Wang, Linsheng Yang, Hairong Li, Chang Kong, Yajuan Xia, Kegong Wu The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and %MMA, and lower SMI (secondary arsenic methylation index) comp...
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

Application of novel metal organic framework, MIL-53(Fe) and its magnetic hybrid; for removal of pharmaceutical pollutant, doxycycline from aqueous solutions
Publication date: Available online 11 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shakiba Naeimi, Hossein Faghihian As a pharmaceutical pollutant, doxycycline causes contamination when enters into the environment. In this research MIL-53(Fe), and its magnetic hybrid MIL-53(Fe)/Fe3O4 were synthesized and employed for removal of doxycycline from aqueous solutions. The adsorbents were characterized by XRD, SEM, BET, FTIR, EDAX, VSM and TG-DTG technique. The effect of different variables such as DOC concentration, pH, contacting time, and adsorbent dose on the removal efficiency was studied and under ...
Source: Environmental Toxicology and Pharmacology - May 12, 2017 Category: Environmental Health Source Type: research

Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells
Publication date: Available online 11 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mayu Nishikawa, Hideki Mori, Masayuki Hara Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 an...
Source: Environmental Toxicology and Pharmacology - May 12, 2017 Category: Environmental Health Source Type: research

Silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation using gold nanoparticles
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor...
Source: Environmental Toxicology and Pharmacology - May 11, 2017 Category: Environmental Health Source Type: research

Green synthesis of Au –Cu2−xSe heterodimer nanoparticles and their in-vitro cytotoxicity, photothermal assay
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Sireesh Babu Maddinedi We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2−xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au–Cu2−xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the density...
Source: Environmental Toxicology and Pharmacology - May 11, 2017 Category: Environmental Health Source Type: research

3 β-Hydroxy-urs-12-en-28-oic acid confers protection against ZnONPs induced adversity in Caenorhabditis elegans
Publication date: Available online 8 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.7...
Source: Environmental Toxicology and Pharmacology - May 9, 2017 Category: Environmental Health Source Type: research

Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure
This study aimed to evaluate the effects of the paracetamol on reproductive, biochemical, genetic, morphological and hematogical biomarkers by waterborne exposure. Male fish of Rhamdia quelen were exposed to environmental concentrations of paracetamol (0, 0.25, 2.5μg/L) in a semi-static bioassay for 21 days. Hemoglobin and hematocrit were reduced upon exposure to 0.25μg/L of paracetamol. Leukocytes and thrombocytes increased after paracetamol exposure. Paracetamol reduced testosterone levels in all exposed groups and increased estradiol levels at higher concentration. Serotonin and dopamine levels increased at exposu...
Source: Environmental Toxicology and Pharmacology - May 9, 2017 Category: Environmental Health Source Type: research

Green synthesis of Au −Cu2−xSe heterodimer nanoparticles and their in-vitro cytotoxicity, photothermal assay
Publication date: Available online 5 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sireesh Babu Maddinedi We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2−xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au−Cu2−xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the ...
Source: Environmental Toxicology and Pharmacology - May 7, 2017 Category: Environmental Health Source Type: research

Cellular uptake mechanism and clearance kinetics of fluorescence-labeled glycyrrhetinic acid and glycyrrhetinic acid –modified liposome in hepatocellular carcinoma cells
Publication date: Available online 5 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yuqi Sun, Jinghua Lu, Dongxue Yan, Liping Shen, Haiyang Hu, Dawei Chen Glycyrrhetinic acid (GA) is a natural pentacyclic triterpene derivative that exerts significant effects in the suppression of liver cancer. The receptors of GA on liver cells and hepatocellular carcinoma (HCC) cells have drawn broad attention. The effects of GA might depend on its transport into and out of cells. However, the question has not been previously addressed despite its obvious and fundamental importance. In this paper, GA and GA-modified...
Source: Environmental Toxicology and Pharmacology - May 7, 2017 Category: Environmental Health Source Type: research

Associations between the levels of thyroid hormones and lipid/lipoprotein levels: Data from National Health and Nutrition Examination Survey 2007-2012
Publication date: Available online 4 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Ram B. Jain Data from National Health and Nutrition Examination Survey for the years 2007-2012 were used to investigate associations between thyroid hormones and lipid/lipoprotein levels for a representative sample of general US population aged >=20 years. There were no statistically significant differences for adjusted high density lipoprotein levels among thyroid function groups, namely, subclinical hyperthyroid (SCHPR), clinical hyperthyroid (CHPR), euthyroid (EU), clinical hypothyroid (CHYP), and subclinica...
Source: Environmental Toxicology and Pharmacology - May 5, 2017 Category: Environmental Health Source Type: research

The protective study about alleviation of simvastatin on the damages of PEG-BNs in mice
This study provides some basic data and useful information for the treatment of damages caused by the nanoparticles in mice in the future. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

Model-based optimization of parameters for degradation reaction of an organophosphorus pesticide, Paraoxon, using CeO2 nanoparticles in water media
Publication date: Available online 1 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alicia Salerno, Isabelle Pitault, Thierry Devers, Jocelyne Pelletier, Stéphanie Briançon Degradation and body surface decontamination is vital to prevent the skin penetration of paraoxon (POX), an organophosphorus pesticide, and victims poisoning. CeO2 demonstrated a good efficacy for the degradation of POX. The aim of the study was to develop a model which includes the impact of weight of CeO2, POX and diluent volumes on the degradation kinetics. The modelling was realized with rapid and simple experime...
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

Combination of the Electro/Fe3+/peroxydisulfate (PDS) process with activated sludge culture for the degradation of sulfamethazine
Publication date: Available online 1 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Amina Ledjeri, Idris Yahiaoui, Hakima Kadji, Farida Aissani-Benissad, Abdeltif Amrane, Florence Fourcade In this paper, the major factors affecting the degradation and the mineralization of sulfamethazine by Electro/Fe3+/peroxydisulfate (PDS) process (e.g. current density, PDS concentration, Fe3+ ions concentration and initial sulfamethazine (SMT) concentration) were evaluated. The relevance of this process as a pretreatment prior to activated sludge culture was also examined. Regarding the impact on SMT degradation a...
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

The effect of passive and active exposure to tobacco smoke on lipid profile parameters and the activity of certain membrane enzymes in the blood of women in the first trimester of pregnancy
Publication date: Available online 27 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Anna Bizoń, Halina Milnerowicz The effect of tobacco smoke on lipid peroxidation, the lipid profile and membrane-bound enzymatic activity in the first trimester of pregnancy was investigated. In the plasma of women with active exposure to tobacco smoke, we have found increased lipid peroxidation and higher total concentrations of cholesterol, triglycerides and low-density lipoproteins in the blood, as well as a decreased concentration of high-density lipoproteins. A higher concentration of low-density lipoproteins...
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Uranium (238U) bioaccumulation and its persuaded alterations on hematological, serological and histological parameters in freshwater fish Pangasius sutchi
This study can be useful indicators of 238U toxicity to assess fish health in Uranium (238U) biomonitoring programs. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Silencing of DNA repair sensitizes pediatric brain tumor cells to ɣ-irradiation using gold nanoparticles
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor...
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells
Publication date: Available online 26 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano We investigated the synergic effects of components of particulate matter with aerodynamic diameters ≤2.5μm (PM2.5) on airway inflammation. Co-exposure to cadmium (Cd) and 9,10-phenanthrenequinone (9,10-PQ) additively/synergistically increased pro-inflammatory responses in airway epithelial cells, whereas co-exposure to Cd and phenanthrene resulted in no acceleration. These results suggest ...
Source: Environmental Toxicology and Pharmacology - April 27, 2017 Category: Environmental Health Source Type: research

Experimental Study of Sucralfate Intervention for Paraquat Poisoning in Rats
Conclusion The results showed that early gastrointestinal lavage with sucralfate effectively reduced the inflammatory response and lung and kidney injuries and improved the survival of the SD rats. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 26, 2017 Category: Environmental Health Source Type: research

Nanoagroparticles emerging trends and future prospect in modern agriculture system
Publication date: Available online 23 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Syed Baker, Tatiana Volova, Svetlana V. Prudnikova, S. Satish, Nagendra Prasad Increment of technical knowledge has remarkably uplifted logical thinking among scientific communities to shape the theoretical concepts into near product-oriented research. The concept of nanotechnology has overwhelmed almost all forms of lives and has traded its applications in myriad fields. Despite rapid expansion of nanotechnology, sustainable competitions still do exist in the field of agriculture. In current scenario, agriculture ...
Source: Environmental Toxicology and Pharmacology - April 23, 2017 Category: Environmental Health Source Type: research

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2hours a day throughout gestation period. Control females were subjected to the same conditions as treated group w...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Harikiran Lingabathula, Narsimhareddy Yellu The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase leakage, alkaline phosphatase, lipid peroxidation and total microprotein levels in BAL fluids after 1day, 1 week and 1 month post exposure periods. All the pa...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca2+ modulation
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xinming Yun, Wenbing Rao, Ciying Xiao, Qingchun Huang Leukemia threatens millions of people's health and lives, and the pesticide-induced leukemia has been increasingly concerned because of the etiologic exposure. In this paper, cytotoxic effect of emamectin benzoate (EMB), an excellent natural-product insecticide, was evaluated through monitoring cell viability, cell apoptosis, mitochondrial membrane potential and intracellular Ca2+ concentration ([Ca2+]i) in leukemia K562 and Molt-4 cells. Following the exposure ...
Source: Environmental Toxicology and Pharmacology - April 20, 2017 Category: Environmental Health Source Type: research

Arsenic absorption and excretion in chronically exposed developing toad Rhinella arenarum
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mariana Mardirosian, Flavia Bieczynski, Carlos Luquet, Carlos A. Pérez, Guillermina Bongiovanni, Cecilia Lascano, Andrés Venturino We assessed the toxicodynamics of As in developing Rhinella arenarum toad embryos and larvae exposed from fertilization to 0.01–10mgAsL−1. We determined As content in toad embryos and larvae by X-ray fluorescence spectrometry. Toad embryos and larvae actively bioaccumulated As, reaching tissue concentrations more than one-thousand higher than control levels aft...
Source: Environmental Toxicology and Pharmacology - April 19, 2017 Category: Environmental Health Source Type: research

The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: a comparative study
Publication date: Available online 17 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Michaela Mináriková, Veronika Fojtikova, Eliška Vyskočilová, Jan Sedláček, Milan Šikut, Lucie Borek-Dohalska, Marie Stiborová, Marketa Martinkova The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenoba...
Source: Environmental Toxicology and Pharmacology - April 18, 2017 Category: Environmental Health Source Type: research

Crocin attenuates hemorrhagic shock-induced oxidative stress and organ injuries in rats
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Long Yang, Xiujuan Dong We aimed to evaluate the effect of natural antioxidant crocin in alleviating hemorrhagic shock (HS)-induced organ damages. HS rats were treated with crocin during resuscitation. Mortality at 12h and 24h post resuscitation was documented. HS and resuscitation induced organ injuries, as characterized by elevated wet/dry ratio, quantitative assessment ratio, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine aminotransferase, whereas rats received crocin treatment demonstra...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh
This study was aimed to look association of CYP1A1 m1 (T>C) and m2 (A>G) gene polymorphisms in Chhattisgarh population. In this case-control study, we analyzed leukocyte DNA from a total of 200 subjects form Chhattisgarh (100 cases and 100 controls). All subjects were genotyped for CYP1A1 m1 (T>C) and m2 (A>G) using PCR-RFLP with statistical analysis by using SPSS version 16.0 and VassarStats (online). Among the two gene variants rs4646903 (T>C) and rs1048943 (A>G), individuals with AG and GG genotypes of CYP1A1 m2 polymorphism have significantly higher and increased risk of cervic...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Protective effect of artemisinin on chronic alcohol induced-liver damage in mice
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiaoyan Zhao, Liqing Wang, Hao Zhang, Duoduo Zhang, Zhihao Zhang, Jie Zhang The liver disease related to chronic alcohol consumption is one of the leading causes of death for alcoholics. The efficient drug to ameliorate the alcoholic liver injury was needed urgently. The present study was performed to investigate whether artemisinin possessed the protective effect against chronic alcohol consumption. 50 male Kunming mice were divided into 5 groups: control group (C): 10ml/kg saline+10ml/kg saline, alcohol group (A)...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Silver nanoparticle induced toxicity to human sperm by increasing ROS(reactive oxygen species) production and DNA damage
In this study, we exposed human sperm to different doses of AgNPs (0, 50μgml−1, 100μgml−1, 200μgml−1 or 400μgml−1) for various times (15min, 30min, or 60min), followed by analyses of the sperm viability, motility and the ratio of abnormal to normal sperm.Then, transmission electron microscopy(TEM) was used to explore the sperm ultrastructural characteristics. Reactive oxygen species production and DNA fragmentation were tested using standard kits and the sperm chromatin dispersion method, respectively. The results showed a dose- and time-dependent decline in sperm viability and motility ...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research