Imidacloprid Insecticide Exposure Induces Stress and Disrupts Glucose Homeostasis in Male Rats
Publication date: Available online 24 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Samah R. Khalil, Ashraf Awad, Hesham H. Mohammed, Mohamed Abdo Nassan In the present study, we evaluated the stress response in adult rats who were administered imidacloprid (IMI) orally in two doses (0.5 and 1.0mg/kg bw for 60 days). It led to an alteration in the levels of cortisone and catecholamines and induced behavioral deficits, particularly in the animals exposed to the dose of 1.0mg/kg. IMI was further analyzed for the effect on glucose homeostasis in developing and adult rats at a dose of 1.0mg/kg bw whe...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation results in declined mature T cells in rat fetal thymus
This study was designed to observe the effects of maternal food restriction (MFR) on the development of fetal thymus in different gestation periods. Timed pregnant rats were randomized into 3 groups: CN (free access to standard chow throughout gestation), MFR0-21 (50% MFR throughout gestation), MFR0-14 (50% MFR from gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR during early-mid period had few impact on the fetal thymus and T cell subpopulations. However, MFR throughout gestation resulted in thymic atrophy, deceased frequency of both CD4+ and CD8+ single positive (SP) T cells and enhanced thy...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha.
In conclusion, exposure to Ibu has some anti-inflammatory effects to mussels based on COX activity but resulted in increased oxidative damage and lipid catabolism. Exposure to air stress could enhance some of these responses and contribute to decreased resistance to air exposures. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 20, 2017 Category: Environmental Health Source Type: research

Long non-coding RNAs: the novel diagnostic biomarkers for leukemia
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shaoyun Chen, Hairong Liang, Hui Yang, Kairu Zhou, Longmei Xu, Jiaxian Liu, Bei Lai, Li Song, Hao Luo, Jianming Peng, Zhidong Liu, Yongmei Xiao, Wen Chen, Huanwen Tang Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt∼100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomark...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor
This study highlights the critical role of CYP1B1 and AhR in TCDD activity and proposes that inhibition of these key molecules might serve as a potential therapeutic approach for treatment of allergy and cancer. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S.
Conclusion The incidence of palytoxin exposure is low but significant symptoms can occur. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alessandra Cristina Pupin Silvério, Simone Caetani Machado, Luciana Azevedo, Denismar Alves Nogueira, Miriam Monteiro de Castro Graciano, Juliana Savioli Simões, André Luiz Machado Viana, Isarita Martins The aim of the study was to assess of occupational exposure to pesticides in rural workers using genotoxicity test, bioindicators and clinical evaluation. Blood, urine and buccal samples from persons, rural workers exposed to a complex mixture of pesticides with organophosphates (n=94) and wit...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Self-defense of Escherichia coli against damages caused by nanoalumina
In this study, we showed three types of responses of E. coli to damages caused by nano-Al2O3. Live, dead, and injured, bacteria showed improved survival rates reaching 104%, 116%, and 104% after exposure to 0.1, 1, and 10mmol/L of nano-Al2O3 respectively. Survival rates improved from 100% to 114%, corresponding to an exposure time of 0–9h, and from 100% to 127%, corresponding to 0–1000μg/L Al3+. Improvements were noted in survival rates of E. coli K12 MG1655, HB101, DH5α, and K12 MG1655 △lexA treated by nano-Al2O3 in Luria–Bertani (LB) exposure system or K12 MG1655 in LB, normal saline(NS) and ...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Differential tissue regulation of PPAR α and CB1 gene transcription pathways by DEGB: preliminary observations in a seabream (Sparus aurata) in vivo model
Publication date: Available online 19 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Paolo Cocci, Matteo Mozzicafreddo, Mauro Angeletti, Gilberto Mosconi, Francesco Alessandro Palermo Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Multidrug prevention or therapy of ischemia-reperfusion injury of the heart —Mini-review
This study provides information about multidrug strategies for the prevention/treatment of cardiac injury induced by oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

The selective tyrosine kinase-inhibitor nilotinib alleviates experimentally induced cisplatin nephrotoxicity and heptotoxicity
In conclusions these results demonstrated a protective effect of nilotinib in experimentally induced CP kidney and liver damage that could be mediated through combating oxidative stress, reducing inflammation and anti-apoptosis in the two organs. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 18, 2017 Category: Environmental Health Source Type: research

Iron prevents demyelination of frog sciatic nerves
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Amina Azzouz, Amel Hanini, Zihad Bouslama, Linda Saili, Sihem Benaceur, Mohsen Sakly, Souhil Tliba, Hafedh Abdelmelek Metal ions are of particular importance in nervous system function, notably iron. However, very little has been done to investigate its physiological role in frog peripheral nervous system. The present research aim to evaluate i) the time-effect of sciatic nerve ligation and/or ii) iron sulphate (1.50mg/kg, in lymphatic sac) on frog myelin sheaths. Histological sections following ligation shows degeneratio...
Source: Environmental Toxicology and Pharmacology - August 18, 2017 Category: Environmental Health Source Type: research

Multidrug prevention or therapy of ischemia-reperfusion injury of the heart- mini-review
This study provides information about multidrug strategies for the prevention/treatment of cardiac injury induced by oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

PKC θ-mediated Ca2+/NF-AT signalling pathway may be involved in T-cell immunosuppression in coal-burning arsenic-poisoned population
This study provides important data for a mechanistic understanding of endemic arsenic poisoning. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

The inhibition of inducible nitric oxide synthase and oxidative stress by agmatine attenuates vascular dysfunction in rat acute endotoxemic model
In conclusion: AGM may represent a potential endogenous therapeutic candidate for sepsis-induced vascular dysfunction through its inhibiting effect on iNOS expression and oxidative stress. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 17, 2017 Category: Environmental Health Source Type: research

Reduction of liver tumerogenic effect of N-nitrosodiethylamine by treatment with ɣ-oryzanol in Balb/C mice
Publication date: Available online 11 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shital S. Panchal, Somsuvra B. Ghatak, Abhishek B. Jha, Raoula Onattu In recent years, naturally occurring phytochemicals with antioxidant capacity have generated surmount interest in their therapeutic usage against a wide range of pathological and toxicological conditions. The present study was designed to evaluate potential of ɣ-oryzanol (OZ), a bio-active natural antioxidant against hepatocellular carcinoma effect of the carcinogen N-nitrosodiethylamine in Balb/c mice. OZ inhibited the proliferation of Hep&nda...
Source: Environmental Toxicology and Pharmacology - August 11, 2017 Category: Environmental Health Source Type: research

Identification of sterols from the soft coral Dendronephthya gigantea and their anti-inflammatory potential
This study highlights the synergistic anti-inflammatory activity of several steroids found in D. gigantea. Their actions may be useful in the development of anti-inflammatory cosmeceuticals, pharmaceutical agents, and other consumer products. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 10, 2017 Category: Environmental Health Source Type: research

The eco-toxic effects of pesticide and heavy metal mixtures towards earthworms in soil
Publication date: Available online 7 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Herman Uwizeyimana, Meie Wang, Weiping Chen, Kifayatullah Khan Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil pollutants that effects risks are very difficult due to the complexity of soil matrix, poor understanding about the fate and effects of chem...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Interaction of erythromycin and ketoconazole on the neurological, biochemical and behavioral responses in crucian carp
This study focused on the uptake of contaminants, acetylcholinesterase (AChE) activity in the brain, swimming and shoaling behavior of fish. After 14days of binary exposure, the addition of KCZ at nominal concentrations of 0.2, 2 and 20μg/L significantly increased the accumulation of ERY in the brain of the fish and the bioconcentration factor of 2.08 was 2.6-fold higher than that calculated from the ERY-alone exposure. The brain AChE activity was significantly inhibited by ERY and KCZ with a significant correlation with respect to the accumulative concentration of the contaminants. The inhibition rates of swimming acti...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Modelling the impact of targeted anthelmintic treatment of cattle on dung fauna
Publication date: Available online 7 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Andrew S. Cooke, Eric R. Morgan, Jennifer A.J. Dungait The insecticidal properties of many anthelmintics pose a risk to dung fauna, through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the d...
Source: Environmental Toxicology and Pharmacology - August 8, 2017 Category: Environmental Health Source Type: research

Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell
In this study, we aim to probe the effects of BPA exposure on induction of autophagy in goat Sertoli Cells (gSCs), as well as the relationship between autophagy and apoptosis. Results indicated that exposure to BPA (100, 200, 300, 400, 500 and 600μM) decreased the cell viability in a concentration-dependent manner. Exposure of gSCs to 500μM BPA for 12h resulted in in vitro triggered loss of mitochondrial membrane potential (ΔΨm) and increased reactive oxygen species (ROS) production. Apoptosis with an increase in Bax:Bcl-2 ratio and higher rates of autophagy, such as autophagosome formation and increased ex...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Mitochondrial Dysfunction and Inflammatory Response in the Cytotoxicity of NR8383 Macrophages Induced by Fine Particulate Matter
Publication date: Available online 29 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Qi Xiong, Qin Ru, Lin Chen, Xiang Tian, Chaoying Li Exposure to fine particulate matter (fine PM) is known to cause severe public health problems. However, the potential mechanisms of alveolar macrophages cytotoxicity induced by fine PM exposure are still unclear. The aim of this study was to determine if both the mitochondrial dysfunction and the inflammatory response of NR8383 macrophages were triggered by Standard Reference Material 2786 (SRM 2786) for fine PM. NR8383 cells were exposed to different concentration...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Effects of Glyphosate Exposure on Sperm Concentration in rodents: A Systematic review and meta-analysis
Conclusions The results of meta-analysis support the hypothesis that glyphosate exposure decreased sperm concentration in rodents. Therefore, we conclude that glyphosate is toxic to male rodent’s reproductive system. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

Vaccination is fundamental but can it escape from a more insightful and critical information about its action?
Publication date: Available online 29 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Salvatore Chirumbolo, Geir Bjørklund The recent news about the US President Donald Trump's tweet on the presumptive relationship between vaccines and autism published in Nature Seven Days (Nature, n 542, Feb 16th, 2017 p 276) raised a crowded outcry of criticisms and concerns not only about the US President's policy but on the safety of vaccines, putting again in the spotlight this fundamental medical issue.Aside from the provocative boutade of the US President, with echoes also in Italy, the scientific commu...
Source: Environmental Toxicology and Pharmacology - July 30, 2017 Category: Environmental Health Source Type: research

1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors
Publication date: Available online 27 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jing Lu, Baochen Fang, Yiying Zheng, Xin Yu, Guoren Huang, Zhenning Wang, Xuming Deng, Shuang Guan 1,3-dichloro-2-propanol (1,3-DCP) is a food born hepatoxic chloropropanol contaminant that has been detected in a wide range of foods. In the present study, we investigated the effects and mechanisms of 1,3-DCP on lipid accumulation in HepG2 cells. The data showed 1,3-DCP significantly increased intracellular content of triglyceride (TG) and total cholesterol (TC) at 0.5–2μg/mL. Further results showed that 1,3...
Source: Environmental Toxicology and Pharmacology - July 28, 2017 Category: Environmental Health Source Type: research

Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens
Publication date: Available online 22 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shiping Bai, Shuqin Pan, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Yue Xuan, Zuowei Su Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35 days. Compared to controls, glucose disappearance rates were lower (p =0.035) 15 to 120min after glucos...
Source: Environmental Toxicology and Pharmacology - July 23, 2017 Category: Environmental Health Source Type: research

X-ray irradiation has positive effects for the recovery of peripheral nerve injury maybe through the vascular smooth muscle contraction signaling pathway
Discussion Pathways involved in cell-substrate adhesion, vascular smooth muscle contraction and cell adhesion molecule signaling may be involved in recovery from peripheral nerve injury. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 23, 2017 Category: Environmental Health Source Type: research

Dynamic responses of antioxidant enzymes in pearl oyster Pinctada martensii exposed to di(2-ethylhexyl) phthalate (DEHP)
In conclusion, GSH activity demonstrated its potential to be used as a biomarker for the monitoring of DEHP pollution in the marine environment. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 21, 2017 Category: Environmental Health Source Type: research

Toxic effects of juvenile sablefish, Anoplopoma fimbria by ammonia exposure at different water temperature
Publication date: Available online 19 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jun-Hwan Kim, Hee-Ju Park, In-Ki Hwang, Jae-Min Han, Do-Hyung Kim, Chul Woong Oh, Jung-Sick Lee, Ju-Chan Kang Juvenile sablefish, Anoplopoma fimbria (mean length 17.1±2.4cm, and mean weight 75.6±5.7g) were used to evaluate toxic effects on antioxidant systems, immune responses, and stress indicators by ammonia exposure (0, 0.25, 0.75, and 1.25mg/L) at different water temperature (12 and 17°C) in 1 and 2 months. In antioxidant responses, superoxide dismutase (SOD) and catalase (CAT) were significant...
Source: Environmental Toxicology and Pharmacology - July 20, 2017 Category: Environmental Health Source Type: research

Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening
Publication date: Available online 18 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sen Zhang, Huan Chen, An Wang, Yong Liu, Hongwei Hou, Qingyuan Hu To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed to show a significant genotoxicity based on the γH2AX assay. However, hydroquinone (one of metabolites of benzene) show...
Source: Environmental Toxicology and Pharmacology - July 19, 2017 Category: Environmental Health Source Type: research

Emodin suppresses cadmium-induced osteoporosis by inhibiting osteoclast formation
Publication date: Available online 18 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiao Chen, Shuai Ren, Guoying Zhu, Zhongqiu Wang, Xiaolin Wen Environmental level of cadmium (Cd) exposure can induce bone loss. Emodin, a naturally compound found in Asian herbal medicines, could influence osteoblast/osteoclast differentiation. However, the effects of emodin on Cd-induced bone damage are not clarified. The aim of this study was to investigate the role of emodin on Cd-induced osteoporosis. Sprague-Dawley male rats were divided into three groups which were given 0mg/L, 50mg Cd/L and 50mg Cd/L plus em...
Source: Environmental Toxicology and Pharmacology - July 19, 2017 Category: Environmental Health Source Type: research

Early oxidative stress, DNA damage and inflammation resulting from subcutaneous injection of sulfur mustard into mice
In conclusion, this research showed that both oxidative stress and DNA damage are earlier events than inflammation in sulfur mustard toxic mouse model. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 18, 2017 Category: Environmental Health Source Type: research

Biocompatibility and fabrication of RGO/Chitosan film for cartilage tissue recovery
Publication date: Available online 17 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lei Cao, Chunwen Lu, Qiugen Wang, Fan Li Graphene oxide (GO) has been successfully deoxygenated via an environmental friendly approach using chitosan. The prepared RGO was characterized using several microscopic and spectroscopic techniques. Also, the synthesized RGO is used to develop a highly compatible film with chitosan. Further, the in-vitro cytotoxicity results showed the biocompatible nature of prepared RGO/chitosan composite towards the human articular chondrocytes indicating their use in future cartilage ti...
Source: Environmental Toxicology and Pharmacology - July 18, 2017 Category: Environmental Health Source Type: research

Environmental Estrogen(s) Induced Swimming Behavioural Alterations in Adult Zebrafish (Danio rerio)
Publication date: Available online 11 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Basavaraj B. Goundadkar, Katti Pancharatna The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins...
Source: Environmental Toxicology and Pharmacology - July 12, 2017 Category: Environmental Health Source Type: research

Zebrafish Have an Ethanol-Inducible Hepatic 4-Nitrophenol Hydroxylase that is Not CYP2E1-like
Publication date: Available online 10 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jessica H. Hartman, Jordan S. Kozal, Richard T. Di Giulio, Joel N. Meyer Zebrafish are an attractive model organism for toxicology; however, an important consideration in translating between species is xenobiotic metabolism/bioactivation. CYP2E1 metabolizes small hydrophobic molecules, e.g. ethanol, cigarette smoke, and diesel exhaust components. CYP2E1 is thought to only be conserved in mammals, but recent reports identified homologous zebrafish cytochrome P450s. Herein, ex vivo biochemical measurements show that u...
Source: Environmental Toxicology and Pharmacology - July 11, 2017 Category: Environmental Health Source Type: research

Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium
The objective of this study was to determine the effect of ligustrazine (TMP) on cadmium (Cd)-induced nephrotoxicity and its relevant mechanism. TMP (50mg/kg) was injected intraperitoneally (i.p.) into rats 1h prior to CdCl2 exposure (at a Cd dose of 0.6mg/kg). TMP reversed Cd-induced nephrotoxicity, evidenced by the relatively normal architecture of the renal cortex. Additionally, TMP alleviated renal oxidative stress of rats that were exposed to Cd, evidenced by the decreased levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), elevated levels of glutathione (GSH) and GSH/GSSG (glutathione disulfide) ratios. Furthe...
Source: Environmental Toxicology and Pharmacology - July 10, 2017 Category: Environmental Health Source Type: research

Blood pressure in indoor and outdoor workers
CONCLUSIONS The results suggest that outdoor working affects the blood pressure, contributing to an increased cardiovascular risk. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 9, 2017 Category: Environmental Health Source Type: research

Study on the interaction between typical phthalic acid esters (PAEs) and human haemoglobin (hHb) by molecular docking
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li, Ye Shan This work has evaluated the binding force between hHb and typcial PAEs (DMP, DEP, DPRP, DBP, DIBP, DHP and DPHP) using molecule docking technique. The DPHP with 3 aromatic rings has the strongest binding (-ΔGbinding: 6.0kcalmol−1) than other PAEs (-ΔGbinding: 2.91∼4.48kcalmol−1). The DMP with the lowest molecular weight has a high binding force (-ΔGbinding: 4.48kcalmol−1), while the DHP with the highest molecular weight has th...
Source: Environmental Toxicology and Pharmacology - July 7, 2017 Category: Environmental Health Source Type: research

Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus
Publication date: Available online 5 July 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nevien K.M. Abdelkhalek, Ismail A.M. Eissa, Eman Ahmed, Omnia E. Kilany, Mohamed El-Adl, Mahmoud A.O. Dawood, Ahmed M. Hassan, Mohamed M. Abdel-Daim The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile. At the end of experiment after 28 days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and c...
Source: Environmental Toxicology and Pharmacology - July 5, 2017 Category: Environmental Health Source Type: research

Protective Effect of Ferulic Acid on Cisplatin Induced Nephrotoxicity in Rats
This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p< 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme ...
Source: Environmental Toxicology and Pharmacology - July 2, 2017 Category: Environmental Health Source Type: research

Resveratrol improves prostate fibrosis during progression of urinary dysfunction in chronic prostatitis
Conclusion CP induced significantly prostate fibrosis, which exhibits a close relationship with urinary dysfunction. Resveratrol improved fibrosis, which may be associated with the suppression of C-kit/SCF and TGF-β/Wnt/β-catenin pathway. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 2, 2017 Category: Environmental Health Source Type: research

Effect of Fluoride Exposure on mRNA Expression of Cav1.2 and Calcium Signal Pathway Apoptosis Regulators in PC12 Cells
This study investigated the effects of fluoride exposure on the mRNA expression of Cav1.2 calcium signaling pathway and apoptosis regulatory molecules in PC12 cells. The viability of PC12 cell receiving high fluoride (5.0mM) and low fluoride (0.5mM) alone or fluoride combined with L-type calcium channel (LTCC) agonist/inhibitor (5 umol/L FPL6417/2 umol/L nifedipine) was detected using cell counting kit-8 at different time points (2, 4, 6, 8, 12, 10, and 24h). Changes in the cell configuration were observed after exposing the cells to fluoride for 24h. The expression levels of molecules related to the LTCC were examined, pa...
Source: Environmental Toxicology and Pharmacology - July 1, 2017 Category: Environmental Health Source Type: research

Metabolomics study of Cadmium-induced diabetic nephropathy and Protective effect of Caffeic acid phenethyl ester using UPLC-Q-TOF-MS combined with Pattern Recognition
In conclusion, the study suggested that the pathogenesis of DN caused by Cd probably owes to the perturbations of lipid metabolism and AA metabolism; CAPE seems to be effective agent and may be related to its potent antioxidant, anti-inflammatory properties and action as an Nrf2 activator. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 29, 2017 Category: Environmental Health Source Type: research

Oral warfarin intake affects skin inflammatory cytokine responses in rats
Publication date: Available online 28 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Aleksandra Popov Aleksandrov, Ivana Mirkov, Lidija Zolotarevski, Marina Ninkov, Dina Mileusnic, Dragan Kataranovski, Milena Kataranovski Warfarin is an anticoagulant used in prevention/prophylaxis of thromboembolism. Besides the effects on coagulation, non-hemorrhagic reactions have also been documented. Although cutaneous reactions were reported in some patients, the impact on skin immunity was not explored. In the present paper, the effect of 30-day oral warfarin intake on skin cytokine responses in rats was analy...
Source: Environmental Toxicology and Pharmacology - June 29, 2017 Category: Environmental Health Source Type: research

Melatonin protect the development of preimplantation mouse embryos from sodium fluoride-induced oxidative injury
Publication date: Available online 29 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jiamin Zhao, Beibei Fu, Wei Peng, Tingchao Mao, Haibo Wu, Yong Zhang Recently study shows that melatonin can protect embryos from the culture environment oxidative stress. However, the protective effect of melatonin on the mouse development of preimplantation embryos under sodium fluoride (NaF) induced oxidative stress is still unclear. Here, we showed that exposure to NaF significantly increased the reactive oxygen species (ROS) level, decreased the blastocyst formation rates, and increased the fragmentation, apopt...
Source: Environmental Toxicology and Pharmacology - June 29, 2017 Category: Environmental Health Source Type: research

Assessing Human Metal Accumulations in an Urban Superfund Site
This study seeks to establish baseline metal concentrations in the hair and blood of individuals living in Butte, MT and possible routes of exposure. Volunteers from Butte (n=116) and Bozeman (n=86) were recruited to submit hair and blood samples and asked to complete a lifestyle survey. Elemental analysis of hair and blood samples was performed by ICP-MS. Three air monitors were stationed in Butte to collect particulate and filters were analyzed by ICP-MS. Soil samples from the yards of Butte volunteers were quantified by ICP-MS. Hair analysis revealed concentrations of Al, As, Cd, Cu, Mn, Mo, and U to be statistically el...
Source: Environmental Toxicology and Pharmacology - June 28, 2017 Category: Environmental Health Source Type: research

The metabolic effects of diuron in the rat liver
Publication date: Available online 27 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mellina da Silva Simões, Lívia Bracht, Angela Valderrama Parizotto, Jurandir Fernando Comar, Rosane Marina Peralta, Adelar Bracht A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are dependent of ATP generated within the mitochondria. Converse...
Source: Environmental Toxicology and Pharmacology - June 28, 2017 Category: Environmental Health Source Type: research

Evaluation of whole cigarette smoke induced oxidative stress in A549 and BEAS –2B cells
Publication date: Available online 27 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shimin Zhang, Xiang Li, Fuwei Xie, Kejian Liu, Huimin Liu, Jianping Xie Cigarette smoke is a complex and oxidative aerosol. Previous researches on the hazards of cigarette smoke mainly focused on the adverse bioeffects induced by its condensates or gas vapor phase, which ignored the dynamic processes of smoking and the cigarette smoke aging. To overcome these disadvantages, we performed air-liquid interface exposure of whole smoke, which used native and unmodified smoke and ensured the exposure similar to physiologi...
Source: Environmental Toxicology and Pharmacology - June 27, 2017 Category: Environmental Health Source Type: research

Interaction studies of polybrominated diphenyl ethers (PBDEs) with human serum albumin (HSA): Molecular docking investigations
Publication date: Available online 24 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Songwen Tan, Zhenxing Chi, Ye Shan, Zhengzhong Wen, Weiguo Li This work has evaluated the interactions of HSA and typical PBDEs (BDE47, BDE99, BDE100, BDE153 and BDE209) at molecular level by modelling. Apart from the BDE209, PBDEs with higher molecular weight show higher binding energy with the residues of HSA. The BDE209 without H atoms has the lowest binding energy (-ΔGbinding: 4.30calmol−1) than other PBDEs (-ΔGbinding: 7.93–8.42calmol−1). The BDE99 shows a higher binding energy tha...
Source: Environmental Toxicology and Pharmacology - June 25, 2017 Category: Environmental Health Source Type: research

Effect of styrene exposure on plasma parameters, molecular mechanisms and gene expression in rat model islet cells
Publication date: Available online 23 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Kamal Niaz, Fatima Ismail Hassan, Faheem Mabqool, Fazlullah Khan, Saeideh Momtaz, Maryam Baeeri, Mona Navaei-Nigjeh, Mahban Rahimifard, Mohammad Abdollahi Styrene is an aromatic hydrocarbon compound present in the environment and have primary exposure through plastic industry. The current study was designed to evaluate styrene-induced toxicity parameters in rat plasma fasting blood glucose (FBG) level, oral glucose tolerance, insulin secretion, oxidative stress, and inflammatory cytokines in cellular and molecular l...
Source: Environmental Toxicology and Pharmacology - June 24, 2017 Category: Environmental Health Source Type: research