Gestational Exposure to Bisphenol-A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice
Conclusions: Our study provides mechanistic support for the hypothesis that gestational exposure to BPA alters sperm function and fertility via down-regulation of tyrosine phosphorylation through a PKA-dependent mechanism. In addition, we anticipate that the BPA-induced changes in the sperm proteome might be partly responsible for the observed effects in spermatozoa. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replace...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data
Conclusions: The SNCD may serve as a reference level that guides the determination of standardized BMDs for risk assessment based on HTS concentration-response data. The SNCD may also have potential application as a POD for low-dose extrapolation. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you wil...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Biomonitoring in the Era of the Exposome
Conclusions: To understand the complexity of exposures faced across the lifespan, traditional and nontraditional biomonitoring methods should both be used. Through hybrid approaches and integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is avail...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review
Conclusions: The studies conducted to date were limited in number with suggestive but methodologically weak findings related to chronic exposure. Given the wide-scale use of neonics, more needs to be known about their human health effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways
Conclusions: Our results show that MEHP can induce a pro-inflammatory state in differentiated adipocytes. This effect is at least partially mediated PPAR-γ. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citat...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study
Conclusions: Our findings suggest some positive associations between maternal exposure to ambient PM10 during the first two months of pregnancy and fetal cardiovascular malformations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication...
Source: EHP Research - July 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

India Leads the Way: A Health-Centered Strategy for Air Pollution
We describe here the salient recommendations of the report. The health burden from air pollution comes from outdoor exposures in both urban and rural areas as well as from within households. In fact, approximately 170 million households, primarily in rural areas, are exposed indoors and near the household to pollution resulting from poor combustion of solid fuels such as wood, crop residues, and dung in traditional cookstoves (Bonjour et al. 2013). The result is more premature deaths from this cause (> 0.9 million annually) than in any other country (IHME 2015). Unfortunately, in spite of significant economic dev...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Editorial July 2016 Source Type: research

Project TENDR: Targeting Environmental Neuro-Developmental Risks. The TENDR Consensus Statement
CONCLUSION: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developi...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication July 2016 Source Type: research

Erratum: “New Link in the Food Chain? Marine Plastic Pollution and Seafood Safety”
About This Article open Citation: Seltenrich N. 2016. Erratum: “New Link in the Food Chain? Marine Plastic Pollution and Seafood Safety.” Environ Health Perspect 124:A123; http://dx.doi.org/10.1289/EHP465 Final Publication: 1 July 2016 PDF Version (53 KB) Related EHP Article New Link in the Food Chain? Marine Plastic Pollution and Seafood Safety Nate Seltenrich Environ Health Perspect 123(2):A34–A41 (2015), http://dx.doi.org/10.1289/ehp.123-A34 In the following sentence, the amount of plastics produced in 1950 was incorrectly cited as “approximately 1.9 tons”: “World ...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Erratum July 2016 Source Type: research

Lasting Impact of an Ephemeral Organ: The Role of the Placenta in Fetal Programming
Recent advances in molecular and imaging technologies, “omics” fields, and data sciences are offering researchers an unprecedented look at the placenta, the master regulator of the fetal environment.© EPA/National Geographic Channel/Alamy Studies of infants conceived during the Dutch “Hunger Winter” provided some of the earliest clues that prenatal stress could affect health much later in life.© Nationaal Archief  © Evan Oto/Science Source In one study, the placental microbiome had a similar taxonomic profile as the oral...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News July 2016 Source Type: research

Stroma Insights: Potential Mechanism for Arsenic-Induced Prostate Cancer
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. About This Article open Citation: Barrett JR. 2016. Stroma insights: potential mechanism for arsenic-induced prostate cancer. Environ Health Perspect 124:A130; http://dx.doi.org/10.1289/ehp.124-A130 Published: 1 July 2016 PDF Version (668 KB) Related EHP Article Inorganic Arsenic–Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model Joseph J. Shearer, Eric A. Wold...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection July 2016 Source Type: research

Different People, Different Outcomes: Assessing Genetic Susceptibility to Lead Exposures
This study was not intended to gauge the level at which lead is toxic, and it did not reveal the mechanisms by which lead causes adverse effects. However, if these results are echoed in humans, they could help us understand why and how the effects from lead exposure are expressed differently in different people, says Schneider. “This kind of work shows how much we still have to learn about the potential effects that lead has on the body,” he says. “We know a lot, but there’s still a lot we don’t know.” References 1. ATSDR. Toxicological Profile for Lead. CAS# 7439-92-1. Atlanta, GA:Divi...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection July 2016 Source Type: research

Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood
Conclusions: In this cohort, prenatal exposure to PFASs was associated with small increases in adiposity measurements in mid-childhood, but only among girls. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: ...
Source: EHP Research - June 28, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Association of Cardiometabolic Genes with Arsenic Metabolism Biomarkers in American Indian Communities: The Strong Heart Family Study (SHFS)
We examined variants previously associated with cardiometabolic traits (~200,000 from Illumina Cardio MetaboChip) or arsenic metabolism and toxicity (670) among 2,428 American Indian participants in SHFS. Urine arsenic species were measured by HPLC-ICPMS, and percent arsenic species (iAs, monomethylarsonate [MMA], and dimethylarsinate [DMA], divided by their sum x 100) were logit transformed. We created two orthogonal principal components that summarized iAs, MMA, and DMA and were also phenotypes for genetic analyses. Linear regression was performed for each phenotype, dependent on allele dosage of ...
Source: EHP Research - June 28, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Case for Environment in All Policies: Lessons from the Health in All Policies Approach in Public Health
Conclusions: We encourage further exploration of the feasibility of EiAP as an approach that could make explicit the sometimes surprising environmental implications of a whole range of strategic policies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at ea...
Source: EHP Research - June 28, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Conclusions: This demonstrates mediation of the phthalate-preterm relationship by oxidative stress, and the utility of complex regression models in capturing mediated associations when repeated measures of exposure and mediator are available and an exposure-mediator interaction may exist. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Thro...
Source: EHP Research - June 28, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Urban and Transport Planning Related Exposures and Mortality: A Health Impact Assessment for Cities
Conclusions: PA factors and environmental exposures can be modified by changes in urban and transport planning. We emphasize the need for (1) the reduction of motorized traffic through the promotion of active and public transport and (2) the provision of green infrastructure, which are both suggested to provide PA opportunities and mitigation of air pollution, noise, and heat. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will ...
Source: EHP Research - June 27, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Delineation of Spatial Variability in the Temperature-Mortality Relationship on Extremely Hot Days in Greater Vancouver, Canada
Conclusions: Our methods provide a data-driven framework for spatial delineation of the temperature-mortality relationship by heat exposure and social vulnerability. Results can be used to map and target the most vulnerable areas for public health intervention. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the cit...
Source: EHP Research - June 27, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Feasibility of Deploying Inhaler Sensors to Identify the Impacts of Environmental Triggers and Built Environment Factors on Asthma Short-Acting Bronchodilator Use
Conclusions: Utilizing a sensor to capture the signal of rescue inhaler use in space-time offered a passive and objective signal of asthma activity. This approach enabled detailed analyses to identify environmental triggers and built environment factors that are associated with asthma symptoms beyond the residential address. The application of these new technologies has the potential to improve our surveillance and understanding of asthma. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely cit...
Source: EHP Research - June 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Historical Prediction Modeling Approach for Estimating Long-Term Concentrations of PM2.5 in Cohort Studies before the 1999 Implementation of Widespread Monitoring
Conclusions: Our prediction modeling approach will allow health effects estimation associated with long-term exposures to PM2.5 over extended time periods of up to 30 years. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. ...
Source: EHP Research - June 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Towards More Comprehensive Projections of Urban Heat-Related Mortality: Estimates for New York City under Multiple Population, Adaptation, and Climate Scenarios
Conclusions: These findings provide a more complete picture of the range of potential future heat-related mortality risks across the 21st century in New York, and highlight the importance of both demographic change and adaptation responses in modifying future risks. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in th...
Source: EHP Research - June 23, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy
Conclusions: Our smoking methylation score represents a promising novel biomarker of sustained maternal smoking during pregnancy easily calculated with Illumina450K or IlluminaEPIC data. It may help identify novel health impacts and improve adjustment for smoking when studying other risk factors with more subtle effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version...
Source: EHP Research - June 21, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice
Conclusions: These data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult offspring. A key mechanism underpinning this hypertension, is an overactivated renin angiotensin system, since ACE inhibition reverses the hypertension induced by perinatal DDT exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it i...
Source: EHP Research - June 21, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change
Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels, is the strong moral imperative to protect our most vulnerable populations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at eac...
Source: EHP Research - June 21, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

Associations between Source-Specific Fine Particulate Matter and Emergency Department Visits for Respiratory Disease in Four U.S. Cities
Conclusions: We introduced an approach for comparing chemical compositions of PM2.5 sources across cities and conducted one of the first multicity studies of source-specific PM2.5 and ED visits. Across four US cities, among the primary PM2.5 sources assessed, biomass burning PM2.5 was most strongly associated with respiratory health. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted versio...
Source: EHP Research - June 17, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Neurotoxicity of the Parkinson’s Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos
In this study, we utilized zebrafish (ZF) embryos to study the mechanisms of ziram’s neurotoxicity in vivo. Nanomolar concentrations of ziram caused selective loss of dopaminergic (DA) neurons and impaired swimming behavior. Since ziram increases α-synuclein (α-syn) concentrations in rat primary neuronal cultures, we investigated the effect of ziram on ZF γ-synuclein 1 (γ1). ZF express 3 synuclein isoforms and ZF γ1 appears to be a functional homologue of α-syn. We found that recombinant ZF γ1 formed fibrils in vitro and overexpression of ZF γ1 i...
Source: EHP Research - June 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Effects of Ambient Air Pollution Exposure on Olfaction: A Review
Conclusions: Ambient air pollution may impact human olfactory function. Additional studies are needed that examine air pollution-related olfactory impacts on the general population by use of measured pollution exposures, and that link pollution exposure with olfactory dysfunction and related pathology. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is a...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures
Conclusions: Our results suggest that specific agricultural pesticides, solvents and chemical fertilizers may increase risk of RA in women, while exposures involving animal contact may be protective. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each st...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania
Conclusions: Fetal thrombosis may contribute to the adverse outcomes associated with household air pollution from cook stoves during pregnancy. Larger studies are necessary for confirmation. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of th...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age
Conclusions: Reverse causality may have resulted in prenatal PBDEs, particularly BDE-153, and decreased BMI, waist circumference, and body fat. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Vuong AM, Brau...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Male Breast Cancer Incidence and Mortality Risk in the Japanese Atomic Bomb Survivors – Differences in Excess Relative and Absolute Risk from Female Breast Cancer
Author Affiliations open 1Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA; 2Institute of Occupational Medicine, Edinburgh, UK PDF Version (1.1 MB) Abstract About This Article Supplemental Material Background: There are well-known associations of ionizing radiation with female breast cancer, and emerging evidence also for male breast cancer. In the UK, female breast cancer following occupational radiation exposure is among that set of cancers eligible for state compensation and consideration is currently be...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Ambient Air Pollution Exposures and Risk of Parkinson Disease
Conclusions: Overall we found limited evidence for an association between exposures to ambient PM10, PM2.5, or NO2 and PD risk. The suggestive evidence that exposures to PM2.5 and PM10 may increase PD risk among female never smokers warrants further investigations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citat...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity
Author Affiliations open 1Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA; 2Biostatics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA; 3Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New ...
Source: EHP Research - June 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Aged 7 to 9 Years: A Prospective Cohort Study
Conclusion: The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the pu...
Source: EHP Research - June 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Nitrate from Drinking Water and Diet and Bladder Cancer among Postmenopausal Women in Iowa
Conclusions: Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Jon...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes
Conclusions: Our results suggested a U-shaped association between plasma manganese and T2D; both low and high levels of plasma manganese were associated with higher odds of newly diagnosed T2D. The U-shaped association was not modified by MnSOD rs4880 polymorphism. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Temperature Variability and Mortality: A Multi-Country Study
Conclusions: Results indicate that more attention should be paid to unstable weather conditions in order to protect health. These findings may have implications for developing public health policies for managing health risks of climate change. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will ...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, ...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study
Conclusions: CIMT was associated with exposure to PM10, PM2.5 and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal one. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replace...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Importance of the Biological Impact of Exposure to the Concept of the Exposome
Conclusions: Through linking exposures to specific biological responses, exposome research could serve to improve understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the lifespan. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you w...
Source: EHP Research - June 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

Erratum: “Marking a New Understanding of Climate and Health”
About This Article open Citation: Birnbaum LS, Balbus JM, Tart KT. 2016. Erratum: “Marking a New Understanding of Climate and Health.” Environ Health Perspect 124:A105; http://dx.doi.org/10.1289/EHP350 Final Publication: 1 June 2016 PDF Version (52 KB) Related EHP Article Marking a New Understanding of Climate and Health Linda S. Birnbaum, John M. Balbus, and Kimberly Thigpen Tart Environ Health Perspect 124(4):A59 (2016), http://dx.doi.org/10.1289/ehp.1611410 In the original article, the URL for the report titled “The Impacts of Climate Change on Human Health in the United States: A Scienti...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Erratum June 2016 Source Type: research

Erratum: “Associations of Fine Particulate Matter Species with Mortality in the United States: A Multicity Time-Series Analysis”
About This Article open Citation: Dai L, Zanobetti A, Koutrakis P, Schwartz JD. 2016. Erratum: “Associations of Fine Particulate Matter Species with Mortality in the United States: A Multicity Time-Series Analysis.” Environ Health Perspect 124:A104; http://dx.doi.org/10.1289/EHP301 Final Publication: 1 June 2016 PDF Version (74 KB) Related EHP Article Associations of Fine Particulate Matter Species with Mortality in the United States: A Multicity Time-Series Analysis Lingzhen Dai, Antonella Zanobetti, Petros Koutrakis, and Joel D. Schwartz Environ Health Perspect 122(8):837–842 (2014),...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Erratum June 2016 Source Type: research

Response to “Comment on ‘Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes’”
In conclusion, we stand by our work and the facts presented in our paper: diacetyl and other flavoring chemicals are in many flavored e-cigarettes, including flavors, like cupcake and cotton candy, that we deem are particularly appealing to kids. Considering the history of severe and irreversible lung disease associated with some workers who inhaled diacetyl, and the similar exposure pathways for consumers of flavored e-cigarettes, it is prudent to evaluate this potential hazard further, restrict access by youth, and provide consumers with information and warnings similar to those given to workers. References ASHRAE. 2013...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence June 2016 Source Type: research

Comment on “Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes”
1Cardno ChemRisk, Chicago, Illinois, USA; 2Cardno ChemRisk, Brooklyn, New York, USA About This Article open Citation: Pierce JS, Abelmann A, Finley BL. 2016. Comment on “Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes.” Environ Health Perspect 124:A100–A101; http://dx.doi.org/10.1289/ehp.1611350 Address correspondence to J.S. Pierce, 30 North LaSalle St., Ste. 3910, Chicago, IL 60602 USA. E-mail: jennifer.pierce@cardno.com All the authors are employed by Cardno ChemRisk, a consulti...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence June 2016 Source Type: research

Comment on “Effects of Arsenite during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Diseases in Male Mice” and “Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Trends and Scientific Gaps”
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom; 2University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom; 3Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; 4Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom; 5TESLA (Trace Element Speciation Laboratory) and Marine Biodiscovery Laboratory, University of Aberdeen, Aberdeen, United Kingdom; 6School o...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence June 2016 Source Type: research

Emerging Waste-to-Energy Technologies: Solid Waste Solution or Dead End?
Three emerging thermal waste-to-energy technologies seek to turn municipal solid waste from a burden to an asset. Adherents of these technologies say they produce fewer toxic emissions and virtually eliminate landfilling. But none of the technologies have yet been proven on a commercial scale in the United States.© Bloomberg via Getty Images Gasification, plasma gasification, and pyrolysis all involve the super-heating of a feedstock—be it MSW, coal, or agricultural residues—in an oxygen-controlled environment to avoid combustion. The primary differences among them relate to heat source...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News June 2016 Source Type: research

New Home, New Prognosis? Reduced Hypertension Risk after Moving to a High-Walkability Neighborhood
Nancy Averett writes about science and the environment from Cincinnati, OH. Her work has been published in Pacific Standard, Audubon, Discover, E/The Environmental Magazine, and a variety of other publications. About This Article open Citation: Averett N. 2016. New home, new prognosis? Reduced hypertension risk after moving to a high-walkability neighborhood. Environ Health Perspect 124:A112; http://dx.doi.org/10.1289/ehp.124-A112 Published: 1 June 2016 PDF Version (232 KB) Related EHP Article Moving to a Highly Walkable Neighborhood and Incidence of Hypertension: A Propensity-Score Matched Cohort Study Maria Chiu, M...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection June 2016 Source Type: research

Making Sense of Carcinogens: A New Method for Navigating Mechanistic Data
Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2016. Making sense of carcinogens: a new method for navigating mechanistic data. Environ Health Perspect 124:A113; http://dx.doi.org/10.1289/ehp.124-A113 Published: 1 June 2016 PDF Version (143 KB) Related EHP Article Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis Martyn T. Smith, Kathryn Z. Guyton, Catherine F. Gibbons, Jason M. Fritz, Christopher J. Portier, Ivan Rusyn, David M. DeMarini, Jane C. C...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection June 2016 Source Type: research

Impeded Immunity? Reduced Tuberculosis Vaccine Response with Exposure to Environmental Chemicals
Lindsey Konkel is a New Jersey–based journalist who reports on science, health, and the environment. About This Article open Citation: Konkel L. 2016. Impeded immunity? Reduced tuberculosis vaccine response with exposure to environmental chemicals. Environ Health Perspect 124:A114; http://dx.doi.org/10.1289/ehp.124-A114 Published: 1 June 2016 PDF Version (259 KB) Related EHP Article A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination Todd A. Jusko, Anneclaire J. De Roos, Sue Y. Lee, Kelly Thevenet-Morrison, Stephen M. Schwartz, Marc-A...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection June 2016 Source Type: research

On the Vapor Trail: Examining the Chemical Content of E-Cigarette Flavorings
Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, Smithsonian, and more. About This Article open Citation: Arnold C. 2016. On the vapor trail: examining the chemical content of e-cigarette flavorings. Environ Health Perspect 124:A115; http://dx.doi.org/10.1289/ehp.124-A115 Published: 1 June 2016 PDF Version (246 KB) Related EHP Article Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes Joseph G. Allen, Skye S. Flan...
Source: EHP Research - June 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection June 2016 Source Type: research