Identifying Chemical Groups for Biomonitoring
Conclusion We construct broad functional and structural chemical groups to proactively and efficiently capture chemicals of potential concern for inclusion in Biomonitoring California. These groups encompass chemicals already in high use, as well as related chemicals that may later emerge as exposure and health concerns. Listing of broad groups allows us to keep up with market shifts and respond to other new information in choosing chemicals to measure. The chemical selection strategy described in this paper can be applied in other monitoring, testing, and assessment programs to support early action on emerging chemicals. ...
Source: EHP Research - December 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Perspectives Brief Communications December 2016 Source Type: research

Salting the Earth: The Environmental Impact of Oil and Gas Wastewater Spills
When wastewater from oil and gas extraction is accidentally or illegally released into the environment, the ecological impacts can be immediate and readily visible. Less is known about the potential human health impacts of these briny releases.© Avner Vengosh Most studies of human populations have focused on residential proximity to well pads as a proxy for exposure to drilling-associated chemicals. But studies like these can’t tell which pollutants or factors might be driving associations—or whether observed health problems are even related to oil and gas extraction. © Elise ...
Source: EHP Research - December 1, 2016 Category: Environmental Health Authors: Web Admin Tags: News Focus December 2016 Source Type: research

A Systematic Comparison of Linear Regression –Based Statistical Methods to Assess Exposome-Health Associations
Conclusions: Correlation between exposures is a challenge for exposome research, and the statistical methods investigated in this study were limited in their ability to efficiently differentiate true predictors from correlated covariates in a realistic exposome context. Although GUESS and DSA provided a marginally better balance between sensitivity and FDP, they did not outperform the other multivariate methods across all scenarios and properties examined, and computational complexity and flexibility should also be considered when choosing between these methods. Citation: Agier L, Portengen L, Chadeau-Hyam M, Basaga&ntil...
Source: EHP Research - December 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles December 2016 Source Type: research

Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study
Author Affiliations open 1Centre for Environmental Sciences, Hasselt University, 3500 Hasselt, Belgium; 2Department of Chemistry, Umeå University, 90187 Umeå, Sweden; 3MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, England; 4Belgian Interregional Environment Agency, 1210 Brussels, Belgium; 5Flemish Institute for Technological Research (VITO), 2400 Mol, Belgium; 6Division of Occupational and Environmental Medicine, Umeå University, 90187 Umeå, Sweden; 7Department of Public Health & Primary Care, Leuven University, 3000 Leuven, Belgium ...
Source: EHP Research - November 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles Source Type: research

Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge
Author Affiliations open 1Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK; 2Centre for Cardiovascular Science, University of Edinburgh, UK; 3Adolphe Merkle Institute, University of Fribourg, Switzerland; 4Swansea University Medical School, Singleton Park Campus, Swansea, Wales, UK; 5University of Rochester Medical Center, Rochester, NY; 6Department of Public Health, University of Copenhagen, Denmark; 7IUF Leibniz-Institut für umweltmedizinische Forschung, Düsseldorf, Germany; 8National Research Centre for the Working Environment, Copenhagen, Denma...
Source: EHP Research - November 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Reviews Source Type: research

Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Disease in Male Offspring at Maturity
Conclusions: Results suggest administration of cadmium and mercury to female mice during early development of their offspring (which in this study is the periconception period) was associated with anxiety-like behavior, altered glucose metabolism and insulin resistance in male offspring at adulthood. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through...
Source: EHP Research - November 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles Source Type: research

Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture
Conclusions: We demonstrate that four days following a single neonatal oral exposure to α-, γ-, and CM-HBCD results in different serum metabolomic profiles, indicating stereoisomer- and mixture-specific effects and possible mechanisms of action. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will ...
Source: EHP Research - November 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles Source Type: research

Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice
Conclusions: Our findings suggest that prenatal and adolescent CS exposure have a synergistic effect on lung function in mice. The combined effect did not appear to be a consequence of early pulmonary senescence. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each sta...
Source: EHP Research - November 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles Source Type: research

After the Research Is Done: Legal Obligations for Participants in Household Exposure Studies
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. About This Article open Citation: Barrett JR. 2016. After the research is done: legal obligations for participants in household exposure studies. Environ Health Perspect 124:A206; http://dx.doi.org/10.1289/124-A206 Published: 1 November 2016 PDF Version (438 KB) Related EHP Article The Legal Implications of Report Back in Household Exposure Studies Shaun A. Goho Household chemical exposure studies are essential for assessing hum...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: News Science Selections November 2016 Source Type: research

Montreal ’s Strategy for Hot Days: Evaluating the Effectiveness of One City’s Heat Action Plan
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications. About This Article open Citation: Seltenrich N. 2016. Montreal’s strategy for hot days: evaluating the effectiveness of one city’s heat action plan. Environ Health Perspect 124:A207; http://dx.doi.org/10.1289/124-A207 Published: 1 November 2016 PDF Version (600 KB) Related EHP Article A Difference-in-Differences Approach to Assess the Effect of a Heat Action Plan on Heat-Related Mortality, and ...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: News Science Selections November 2016 Source Type: research

Pacific Island Countries and Climate Change: Examining Associated Human Health Vulnerabilities
Nancy Averett writes about science and the environment from Cincinnati, OH. Her work has been published in Pacific Standard, Audubon, Discover, E/The Environmental Magazine, and a variety of other publications. About This Article open Citation: Averett N. 2016. Pacific island countries and climate change: examining associated human health vulnerabilities. Environ Health Perspect 124:A208; http://dx.doi.org/10.1289/124-A208 Published: 1 November 2016 PDF Version (645 KB) Related EHP Article Health Impacts of Climate Change in Pacific Island Countries: A Regional Assessment of Vulnerabilities and Adaptation Prioriti...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: News Science Selections November 2016 Source Type: research

Institutes in the Lead: Identifying Environmental Factors in Breast Cancer
Since the early 1990s the National Institute of Environmental Health Sciences and the National Cancer Institute have conducted and funded countless studies on potential environmental risk factors for breast cancer. While clear answers are still hard to come by in this highly complex field, increasingly sophisticated research questions and methods have yielded intriguing evidence.© Agence Photographique BSIP/Getty Images A suspected cluster of breast cancer cases on Long Island launched what has become a robust body of evidence on environmental risk factors for breast cancer. The hatching on this ma...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: News Focus November 2016 Source Type: research

Erratum: “Zika in the United States: How Are We Preparing?”
About This Article open Citation: Schmidt CW. 2016. Erratum: “Zika in the United States: How Are We Preparing?” Environ Health Perspect 124:A198; http://dx.doi.org/10.1289/EHP1096 Final Publication: 1 November 2016   PDF Version (54 KB) Related EHP Article Zika in the United States: How Are We Preparing? Charles W. Schmidt Environ Health Perspect 124(9):A157–A165 (2016), http://dx.doi.org/10.1289/ehp.124-A157 In the following sentence, the 147 cases of microcephaly reported in Brazil in 2014 were incorrectly characterized as being about 10 times higher than the average baseline rate seen in ...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Perspectives Erratum November 2016 Source Type: research

Commemorating Toxicology at the National Institute of Environmental Health Sciences on the Occasion of Its 50th Anniversary
Author Affiliations open 1Division of the National Toxicology Program (NTP), and 2National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina USA PDF Version (3 MB) Summary About This Article In 1978, the National Toxicology Program (NTP) was established and headquartered at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina. On the occasion of the 50th Anniversary of the NIEHS, this article documents some of the historical and current NTP progr...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Perspectives Brief Communication November 2016 Source Type: research

Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures”
1Rheumatology Department, Royal Cornwall Hospital, Truro, Cornwall, United Kingdom; 2University of Exeter Medical School, Truro, Cornwall, United Kingdom About This Article open Citation: Murphy D, Pay J, Benham R, James B, Hutchinson D. 2016. Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures.” Environ Health Perspect 124:A196; http://dx.doi.org/10.1289/EHP730 Address correspondence to D. Murphy, Rheumatology Department, Royal Cornwall Hospital, Truro, Cornwall, TR1 3LJ United Kingdom. E-mail: daniel.murphy8@nhs.net Support for the ...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Perspectives Correspondence November 2016 Source Type: research

Response to “Comment on ‘Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures’”
1Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 2Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA; 3Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania, USA; 4Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. About This Article open Citation: Parks CG, Hoppin JA, De Roos AJ, ...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Perspectives Correspondence November 2016 Source Type: research

The Legal Implications of Report Back in Household Exposure Studies
Conclusions: Researchers should still report back to participants who want to see their results, but they should disclose the risks of obtaining the information as part of the informed consent process. Citation: Goho SA. 2016. The legal implications of report back in household exposure studies. Environ Health Perspect 124:1662–1670; http://dx.doi.org/10.1289/EHP187 Address correspondence to S.A. Goho, Suite 4119, 6 Everett St., Cambridge, MA 02138 USA. Telephone: (617) 496-5692. E-mail: sgoho@law.harvard.edu This research derives from an idea developed by J. Brody and R. Rudel. P. Brown, J. Brody, R. Rudel, and W. ...
Source: EHP Research - November 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Reviews November 2016 Source Type: research

Advancing Alternative Analysis: Integration of Decision Science
Conclusions: We advance four recommendations: (1) engaging the systematic development and evaluation of decision approaches and tools; (2) using case studies to advance the integration of decision analysis into alternatives analysis; (3) supporting transdisciplinary research; and (4) supporting education and outreach efforts. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon a...
Source: EHP Research - October 28, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

The Prevalence of Antibiotic-Resistant Staphylococcus aureus Nasal Carriage among Industrial Hog Operation Workers, Community Residents, and Children Living in Their Households: North Carolina, USA
Conclusion: Our findings support the importance of further research on the prevalence and potential sources of exposure to ABR S. aureus among children living with IHO workers. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation...
Source: EHP Research - October 18, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Children's Health Source Type: research

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women
Conclusions: Expression of the sex-specific candidate genes identified in the discovery population predicted PM10 exposure in an independent cohort of adults from the same area. Confirmation in other populations may further support this as a new approach for exposure assessment, and may contribute to the discovery of molecular mechanisms for PM-induced health effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the...
Source: EHP Research - October 14, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study
Author Affiliations open 1INSERM U1085-IRSET, University Rennes 1, Rennes, France; 2University Hospital Rennes, Rennes, France; 3Research Centre for Psychology, Cognition and Communication (CRPCC EA 1285), University of Rennes 2, Rennes, France; 4Department of Pediatrics, Rennes University Hospital, Rennes, France; 5LABOCEA, Plouzané, France PDF Version (328 KB) Abstract About This Article Supplemental Material Background: Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurod...
Source: EHP Research - October 14, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Children's Health Source Type: research

Poultry Consumption and Arsenic Exposure in the U.S. Population
Conclusions: Poultry intake was associated with increased urine total arsenic and DMA in NHANES 2003-2010, reflecting arsenic exposure. Seasonally stratified analyses by poultry type provide strong suggestive evidence that the historical use of arsenic-based poultry drugs contributed to arsenic exposure in the U.S. population. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon ...
Source: EHP Research - October 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Children's Health Source Type: research

Nitarsone, Inorganic Arsenic, and Other Arsenic Species in Turkey Meat: Exposure and Risk Assessment Based on a 2014 U.S. Market Basket Sample
Conclusions: Nitarsone use can expose turkey consumers to iAs and MA. Our study supports the FDA’s removal of nitarsone from the US market, and further supports its removal from the global marketplace. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of...
Source: EHP Research - October 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL6/J Diet-Induced Obesity Mouse Model
Conclusions: Exposure to TCDD amplifies the impairment of liver functions observed in mice fed an enriched fat diet as compared to a low fat diet. The results provide new evidence that environmental pollutants promote the development of liver fibrosis in obesity-related NAFLD C57BL/6J in mice. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DO...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Associations between Environmental Quality and Mortality in the Contiguous United States, 2000-2005
Conclusions: These results suggest that poor environmental quality, particularly air quality, was associated with increased mortality, and that associations vary by urbanicity and climate regions. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the public...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

An Analysis of the Potential Impact of Climate Change on Dengue Transmission in the Southeastern United States
Conclusions: Our findings suggest that dengue virus transmission is limited by low winter temperatures in the mainland US, which are likely to prevent its permanent establishment. Although future climate conditions may increase the length of the mosquito season in many locations, projected increases in dengue transmission are limited to the southernmost locations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the cop...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis
This study aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. Methods: We recruited 21,656 adults as subjects from 2007-2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m2 were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Population-Level Exposure to Particulate Air Pollution during Active Travel: Planning for Low-Exposure, Health-Promoting Cities
Conclusions: Public health officials and urban planners may use our findings to promote healthy transportation choices. When designing health-promoting cities, benefits (physical activity) as well as hazards (air pollution) should be evaluated. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to ...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Air Pollution and Deaths among Elderly Residents of S ão Paulo, Brazil: An Analysis of Mortality Displacement
Conclusions: We found evidence of mortality displacement within 30 days for non-accidental and circulatory deaths in elderly residents of São Paulo. We did not find evidence of mortality displacement within 30 days for respiratory or cancer deaths. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will ...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children ’ s Study
Conclusion: Higher peripubertal serum TCDD concentrations and PCDD TEQs were associated with poorer semen parameters. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Mínguez-Alarcón L, Sergeyev O, Burns JS, Wi...
Source: EHP Research - October 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Children's Health Source Type: research

Are Fish Consumption Advisories for the Great Lakes Adequately Protective from Chemical Mixture?
Conclusions: Improvements in the advisories may be needed to ensure that the health of humans consuming fish from the Great Lakes is protected. In this region, total PCB and mercury are the major contaminants causing restriction on consuming fish, while dioxins/furans, toxaphene and mirex/photomirex are of a minor concern. Regular monitoring of most organochlorine pesticides and metals in fish can be discontinued. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the ...
Source: EHP Research - October 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union
Conclusions: There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens, and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission). Citation: Slama R, Bourguignon JP, Demeneix B, Ivell R, Panzica G, Kortenkamp A, Zoeller RT. 2016. Scientific issues relevant to setting regulatory criteria to identify endocri...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary October 2016 Source Type: research

A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses ’ Health Study and Health Professionals Follow-up Study
Conclusions: Estimated intakes of meat mutagens were not significantly associated with CRC risk over 14 years of follow-up in the NHS and HPFS cohorts. Results for PhIP from red but not from white meat warrant further investigation. Citation: Le NT, Michels FA, Song M, Zhang X, Bernstein AM, Giovannucci EL, Fuchs CS, Ogino S, Chan AT, Sinha R, Willett WC, Wu K. 2016. A prospective analysis of meat mutagens and colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study. Environ Health Perspect 124:1529–1536; http://dx.doi.org/10.1289/EHP238 *These authors contributed equally to this...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article October 2016 Source Type: research

Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain
Author Affiliations open 1Leonard Davis School of Gerontology, 2USC Dornsife College, 3Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA PDF Version (1.4 MB) Abstract About This Article Supplemental Material Background: Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. Objective: We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nanosized subfraction of urban traf...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article October 2016 Source Type: research

The Water Quality in Rio Highlights the Global Public Health Concern Over Untreated Sewage
Conclusion This situation illustrates the complexity of testing and monitoring sewage in the environment. Standard bacterial indicators were predictive of gastrointestinal illness in one of the few recreational water studies that measured health risks in a tropical setting where sewage is largely untreated (Lamparelli et al. 2015). On the surface, it may seem beneficial and informative to test for viral pathogens, but the additional expertise and resources to conduct these tests may divert resources from routine monitoring without substantially increasing our understanding of the risks or improving health outcomes. The glo...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication October 2016 Source Type: research

Public Health Stops at the School House Door
Conclusions Recommendations from the Meeting’s Participants In November 2015, Healthy Schools Network, Inc. convened the first national facilitated discussion of children’s environmental health in schools and child care centers (Healthy Schools Network 2015). The authors organized the meeting that consisted of a public forum with presentations from the U.S. EPA, the National Institute of Occupational Safety and Health (NIOSH), and indoor air researchers; a facilitated workshop was also organized and attended by representatives of more than two dozen federal and state health agencies, as well as an array of nong...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication October 2016 Source Type: research

Managing and Mitigating the Health Risks of Climate Change: Calling for Evidence-Informed Policy and Action
Discussion Human health is already affected by climate change, and its effects will increase over time. In the longer term, a greater health hazard for many populations will arise from disturbances to environmental, ecological, and social living conditions. As the protection and improvement of human health is one of the ultimate goals of sustainable development, epidemiologists and public health professionals should play an active role in the development of plans for reducing the adverse health effects of climate change at national, regional, and international levels, just like the phasing out of lead from gasoline and tak...
Source: EHP Research - September 30, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication October 2016 Source Type: research

Airborne Fine Particles and Risk of Hospital Admissions for Understudied Populations: Effects by Urbanicity and Short-Term Cumulative Exposures in 708 U.S. Counties
Author Affiliations open 1Yale University, School of Forestry and Environmental Studies. mbravo@med.umich.edu; 2Yale University, School of Forestry and Environmental Studies. keita.ebisu@yale.edu; 3Harvard University, Biostatistics Department. fdominic@hsph.harvard.edu; 4Harvard University, Biostatistics Department. yunwang@hsph.harvard.edu; 5Johns Hopkins University, Bloomberg School of Public Health. rpeng@jhsph.edu; 6Michelle L. Bell, Yale University, School of Forestry and Environmental Studies. michelle.bell@yale.edu PDF Version (1.2 MB) Abstract About This Article Supplemental Material Background: Evidence...
Source: EHP Research - September 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Pre-Pregnancy Obesity on Childhood Overweight or Obesity
Author Affiliations open 1Department of Preventive Medicine, School of Environmental Science & Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China; 2Center on Clinical and Epidemiological Eye Research, the Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; 3Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; 4Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; 5Channing ...
Source: EHP Research - September 16, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Gender-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice
Conclusions: An environmental dose of cadmium at early stages of life causes gut microbiota alterations, accelerates hepatic lipid metabolism, and leads to life-long metabolic consequences in a gender-dependent manner. These findings provide a better understanding of the health risk of cadmium in the environment. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is avail...
Source: EHP Research - September 16, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs)
Conclusion: mERβ2 showed weaker estrogenic activity than mERβ1 in our in vitro system, and can dampen mERβ1 activity. In vivo models of EDC activity and ER-mediated toxicity should consider the role of mERβ2, as rodent tissue responses involving mERβ2 may not be reproduced in human biology. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is availa...
Source: EHP Research - September 16, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Climate and Health Co-Benefits in Low-Income Countries: A Case Study of Carbon Financed Water Filters in Kenya and a Call for Independent Monitoring
Conclusion: Independent monitoring should be a key requirement for carbon credit verification in future international carbon trading mechanisms to ensure programs achieve benefits in line with sustainable development goals. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document ...
Source: EHP Research - September 16, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study
Conclusions: In our study population of normal healthy pregnancies, third trimester exposure to PM2.5 air pollution was associated with differences in fetal thyroid hormone levels that may contribute to reduced birth weight. Additional research is needed to confirm our findings in other populations and to evaluate potential consequences later in life. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and f...
Source: EHP Research - September 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort
Conclusions: LEP methylation status in the placenta was negatively associated with PM2.5 exposure during the second trimester, and with placental 3-NTp, a marker of oxidative/nitrosative stress. Additional research is needed to confirm our findings and to assess whether oxidative/nitrosative stress might contribute to associations between PM2.5 and placental epigenetic events. Potential consequences for health during the neonatal period and later in life warrant further exploration. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publicat...
Source: EHP Research - September 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Comparing the Health Effects of Ambient Particulate Matter Estimated Using Ground-Based versus Remote Sensing Exposure Estimates
Conclusions: We found significant associations between PM2.5 and mortality in every model; however, relative risks estimated from exposure models using ground-based information were generally larger than those estimated with RS alone. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access thi...
Source: EHP Research - September 9, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Aerobic Fitness and Neurocognitive Function Scores in Young Faroese Adults and Potential Modification by Prenatal Methylmercury Exposure
Conclusions: Higher aerobic capacity was associated with better performance in short-term memory and processing speed. However, prenatal methylmercury exposure seemed to attenuate these positive associations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage o...
Source: EHP Research - September 9, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Estimating State-Specific Contributions to PM2.5 ‐ and O3-Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States
Conclusions: Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the p...
Source: EHP Research - September 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Association of Dietary Intake and Biomarker Levels of Arsenic, Cadmium, Lead, and Mercury among Asian Populations in the U.S.: NHANES 2011 –2012
Author Affiliations open 1The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, U.S.A.; 2CH2M HILL, Inc., Houston Texas, U.S.A. PDF Version (1.1 MB) Abstract About This Article Supplemental Material Objective: To evaluate dietary intake of toxic metals as a source of increased biomarker levels of metals among US Asians. Methods: We estimated daily food consumption and dietary intake of arsenic, cadmium, lead, and mercury by combining 24-hour dietary intake recall data from the 2011–2012 National Health and Nutrition Examination Survey (NHANES) with data fro...
Source: EHP Research - September 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Early Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function
Conclusions: We found no evidence for an adverse effect of early life PFAS exposure on metabolic function in mid-childhood. In fact, children with higher PFAS concentrations had lower insulin resistance. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the...
Source: EHP Research - September 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline. Citation: Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353–1360; http://dx.doi.org/10.1289/ehp.1510269 Address correspondence to A.J. Mehta, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Landmar...
Source: EHP Research - September 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article September 2016 Source Type: research