Strategies to Improve Private-Well Water Quality: A North Carolina Perspective
Conclusions: The Summit recommendations, if undertaken, could improve the health of North Carolinians facing elevated risks of exposure to waterborne contaminants because of their reliance on inadequately monitored and maintained private wells. Because many of the challenges in N.C. are common nationwide, these recommendations could serve as models for other states. https://doi.org/10.1289/EHP890 Received: 29 July 2016 Revised: 22 December 2016 Accepted: 15 March 2017 Published: 07 July 2017 Address correspondence to J. M. Gibson, Dept. of Environmental Sciences and Engineering, Gillings School of Global Public Healt...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort
Conclusion: Our findings suggest that several intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communities. https://doi.org/10.1289/EHP353 Received: 01 May 2016 Revised: 19 December 2016 Accepted: 19 January 2017 Published: 07 July 2017 Address correspondence to B. Eskenazi, Center for Environmental Research and Children’s Health. 1995 University Ave., Suite 265. Berkeley, CA 94704, USA. Email: eskenazi@berkeley.edu Supplemental Material is available online (https://doi.org/10.1289/EHP353). The authors declare they have no actual or potential competing financial interests. No...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Heat-Related Mortality in Japan after the 2011 Fukushima Disaster: An Analysis of Potential Influence of Reduced Electricity Consumption
Conclusions: In the prefectures with the greatest reductions in electricity consumption, heat-related mortality decreased rather than increased following the Great East Japan Earthquake. Additional research is needed to determine whether this finding holds for other populations and regions, and to clarify its implications for policies to reduce the consequences of climate change on health. https://doi.org/10.1289/EHP493 Received: 11 May 2016 Revised: 07 March 2017 Accepted: 13 March 2017 Published: 06 July 2017 Address correspondence to M. Hashizume, Dept. of Pediatric Infectious Diseases, Institute of Tropical Medic...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Vitamin D and Risk of Breast Cancer within Five Years
Conclusions: In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943 About This Article Received: 09 August 2016 Revised: 23 January 2017 Accepted: 06 February 2017 Published: 06 July 2017 Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Rese...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Estimates of Soil Ingestion in a Population of Chinese Children
Conclusions: Based on the BTM, recommended SIR values for the general population of Chinese children (2.5 to 12 years old) are 52 mg/d for the central tendency and 217 mg/d for the upper percentile. We did not differentiate between outside soil and indoor dust. Considering the lower concentration of tracer elements in indoor dust than outside soil, actual soil and dust ingestion rates could be higher. https://doi.org/10.1289/EHP930 Received: 12 August 2016 Revised: 05 January 2017 Accepted: 23 January 2017 Published: 05 July 2017 Address correspondence to C. Lin, School of Environment, Bei...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the apoE-/- Mouse Model and the Role of As3mt-Mediated Methylation
Conclusion: Taken together, our findings indicate that As3MT acts to promote cardiovascular toxicity of arsenic and suggest that human AS3MT SNPs that correlate with enzyme function could predict those most at risk to develop atherosclerosis among the millions that are exposed to arsenic. https://doi.org/10.1289/EHP806 Received: 15 July 2016 Revised: 21 December 2016 Accepted: 21 December 2016 Published: 05 July 2017 Correspondence: K.K. Mann, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Rd., Montreal, QC, H3T 1E2 Canada; Telephone: (514) 340-8222 ext. 2760; Email: koren.mann@...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Rice versus Drinking Water: Estimating the Primary Source of Arsenic in the U.S. Diet
This study will facilitate assessing arsenic exposures and more accurately estimating inorganic exposures.” Limitations to the study were primarily associated with the source data. For example, the dietary data, although extensive, captured only what people ate on two days about a week apart, which prevented accurate assessment of exposures at the extreme ends of consumption. “As you go out on the tails of the statistical distribution of rice consumption rates, this two-day survey starts to become unreliable,” says study coauthor Jack Creed, a research chemist at the EPA’s National Exposure Research...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Web Admin Tags: Science Selections Source Type: research

Erratum: “Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children”
PDF Version (431 KB) About This Article Received: 31 March 2017 Revised: 31 March 2017 Accepted: 06 April 2017 Published: 30 June 2017 Environ Health Perspect 125(4):746–752 (2017), https://doi.org/10.1289/EHP478 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our st...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Erratum Source Type: research

Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study
Conclusions: This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864 Received: 25 July 2016 Revised: 16 December 2016 Accepted: 22 December 2016 Published: 30 June 2017 Address correspondence to J. Schüz, Section of Environment and Radiation, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France. Telephone: +33 (0)4 72 73 84 41. Email: Schuzj@iarc.fr Supplemental Material is available online (https://doi.org/10.1289/EHP864). The authors declare they have no actual or potential competing finan...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children
Author Affiliations open 1Unit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2International Center for Diarrheal Disease Research, Dhaka, Bangladesh PDF Version (802 KB) Abstract About This Article Supplemental Material Background: Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose. Objectives: The aim of the present study was to evaluate children’s hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements ...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Season of Conception, Smoking, and Preeclampsia in Norway
Conclusions: These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963 Received: 14 August 2016 Revised: 24 January 2017 Accepted: 25 January 2017 Published: 29 June 2017 Address correspondence to C.R. Weinberg, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927. Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP963). The authors declare they h...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course
Conclusions The exposome concept was introduced in 2005, yet it remains in a quasi-primordial state. The Emory Exposome Summer Course was established to help advance the development of the exposome. Environmental health sciences is filled with untapped potential for human health discovery, and the exposome captures the excitement, the potential, and the dynamic nature of the field. One important point that arose from the course is the need for academic researchers to include members of the community in exposome research. Participants discussed the need to promote citizen science, and the ethical considerations inherent in ...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Brief Communication Source Type: research

Analysis of Temporal Variability in the Short-term Effects of Ambient Air Pollutants on Nonaccidental Mortality in Rome, Italy (1998 –2014)
Conclusions: Mean concentrations of air pollutants have decreased over the last two decades in Rome, but effect estimates for a fixed increment in each exposure were generally consistent. These findings suggest that there has been little or no change in the overall toxicity of the air pollution mixture over time. https://doi.org/10.1289/EHP19 Received: 23 February 2016 Revised: 07 November 2016 Accepted: 07 November 2016 Published: 28 June 2017 Address correspondence to M. Renzi, Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, via Cristoforo Colombo 112, 00147 Rome, Italy. Telephone: 39-06-9972218...
Source: EHP Research - June 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring
Conclusions: Developmental exposure to 0.5 μg/kg BW/d of BPA, which is 8–10 times lower than the current preliminary EFSA (European Food Safety Authority) tolerable daily intake (TDI) of 4 μg/kg BW/d and is within the range of environmentally relevant levels, was associated with sex-specific differences in the expression of genes in adipose tissue plasma triglyceride levels in males and adipocyte cell density in females when F344 rat offspring of dams exposed to BPA at 0.5 μg/kg BW/d were compared with the offspring of unexposed controls. https://doi.org/10.1289/EHP505 Received: 13 Ma...
Source: EHP Research - June 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site
Conclusions: Maternal blood manganese concentrations were negatively associated with early childhood neurodevelopment scores in our study. Findings highlight the importance of understanding maternal exposures during pregnancy and factors influencing placental transfer. https://doi.org/10.1289/EHP925 Received: 04 December 2015 Revised: 20 November 2016 Accepted: 30 November 2016 Published: 28 June 2017 Address correspondence to B. Claus Henn, Boston University School of Public Health, Department of Environmental Health, 715 Albany St., Boston, MA 02118 USA. Telephone: (617) 638-4653. Email: bclaus@bu.edu Supplemental ...
Source: EHP Research - June 28, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study
Author Affiliations open 1MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA 3Department of Neonatology, International Peace Maternal and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China PDF Version (161 KB) Abstract About This Article Supplemental Material Background: Triclosan (TCS) is a synthetic antibacterial chemical widely used in personal care products. TCS exp...
Source: EHP Research - June 27, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Perfluoroalkyl Substances during Pregnancy and Offspring Weight and Adiposity at Birth: Examining Mediation by Maternal Fasting Glucose in the Healthy Start Study
Conclusions: Follow-up of offspring will determine the potential long-term consequences of lower weight and adiposity at birth associated with prenatal PFAS exposure. https://doi.org/10.1289/EHP641 Received: 10 June 2016 Revised: 30 November 2016 Accepted: 13 December 2016 Published: 26 June 2017 Address correspondence to A. P. Starling, Dept. of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 12474 E. 19th Ave, Campus Box F426, Aurora, CO 80045 USA. Telephone: 303-724-8483. Email: anne.starling@ucdenver.edu Supplemental Material is available online (https://doi.org/10....
Source: EHP Research - June 26, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20 –40 Months of Age: Evidence from Rural Bangladesh
Conclusions: Employing a novel statistical method for the study of the health effects of chemical mixtures, we found evidence of neurotoxicity of the mixture, as well as potential synergism between arsenic and manganese. https://doi.org/10.1289/EHP614 Received: 27 January 2016 Revised: 07 June 2016 Accepted: 18 October 2016 Published: 26 June 2017 Address correspondence to L. Valeri, Laboratory for Psychiatric Biostatistics, McLean Hospital, 115 Mills St., Belmont, MA, USA. Telephone: 617-855-2561. Email: lvaleri@mclean.harvard.edu Supplemental Material is available online (https://doi.org/10.1289/EHP614). The author...
Source: EHP Research - June 26, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Review Source Type: research

Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna
Conclusions: Capture location is an important consideration when assessing the level and risk of human exposure to POPs through ingestion of wild fish. https://doi.org/10.1289/EHP518 Received: 16 May 2016 Revised: 13 September 2016 Accepted: 20 September 2016 Published: 26 June 2017 Address correspondence to A. Hamdoun, Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0202 USA. Telephone: (858) 822-5839. Email: hamdoun@ucsd.edu Supplemental Material is available online (https://doi.org/10.1289/EHP518). The authors declare t...
Source: EHP Research - June 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Statistical Approaches for Estimating Sex-Specific Effects in Endocrine Disruptors Research
Conclusions: Investigators should consider sexual heterogeneity of confounder associations when choosing an analytic approach to estimate sex-specific effects of endocrine disruptors on health. In the presence of sex-dependent confounding, our augmented product term approach may be advantageous over stratification when there is prior knowledge available to fit reduced models or when investigators seek an automated test for effect measure modification. https://doi.org/10.1289/EHP334 Received: 08 April 2016 Revised: 29 November 2016 Accepted: 12 December 2016 Published: 23 June 2017 Address correspondence to J.P. Buckl...
Source: EHP Research - June 24, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Another Side of a Low-Salt Diet: Reductions in the Salinity of Drinking Water May Lower Blood Pressure
PDF Version (365 KB) About This Article Published: 23 June 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Drinking Water Salinity and Raise...
Source: EHP Research - June 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selections Source Type: research

Up in the Air: Does Ground-Level Ozone Trigger Kawasaki Disease?
PDF Version (455 KB) About This Article Published: 23 June 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Ambient Air Pollutant Exposures an...
Source: EHP Research - June 23, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Science Selections Source Type: research

Glycol Ethers and Neurodevelopment: Investigating the Impact of Prenatal Exposures
PDF Version (209 KB) About This Article Published: 22 June 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Prenatal Exposure to Glycol Ether...
Source: EHP Research - June 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selections Source Type: research

Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women
Conclusions: Certain PFASs are associated with abnormal menstruation in humans. https://doi.org/10.1289/EHP1203 Received: 08 October 2016 Revised: 03 January 2017 Accepted: 25 January 2017 Published: 22 June 2017 Address correspondence to J. Zhang, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Telephone: 86-21-2507 8871. E-mail: junjimzhang@sina.com, or Y. Tao, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Telephone: 86-21-663846590-776806. E-mail: taoyx@163.com Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - June 22, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study
Author Affiliations open 1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland, USA 2Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, NICHD, Bethesda, Maryland, USA 3The Emmes Corporation, Rockville, Maryland, USA PDF Version (446 KB) Abstract About This Article Supplemental Material Background: Climate change is expected to have adverse health effects, but the association between extreme ambient temperatures and stillbirth is unclear. Objectiv...
Source: EHP Research - June 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case –Control Study (New England, USA)
Conclusions: We observed a modest association between ingestion of water with higher THMs (>95th percentile vs.45.73 μg/L) vs. the lowest quartile (≤6.83 μg/L) was 1.27 (95% CI: 0.83, 1.96). ORs for all lower categories of exposure were negative but close to the null (p-trend=0.41). The corresponding OR for cumulative intake (>1864.16 mg vs.≤138.05 mg) was 1.45 (95% CI: 0.95, 2.20), with a similar OR for the 90–95th percentile category. For all other exposure categories, the ORs were close to the null (p-trend=0.13). For average daily intake, the OR for the highest exposure grou...
Source: EHP Research - June 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Lessons Learned on Health Adaptation to Climate Variability and Change: Experiences Across Low- and Middle-Income Countries
Conclusions: Our analyses highlight that, irrespective of resource constraints, ministries of health and other institutions working on climate-related health issues in low- and middle-income countries need to continue to prepare themselves to prevent additional health burdens in the context of a changing climate and socioeconomic development patterns. https://doi.org/10.1289/EHP405 Received: 30 April 2016 Revised: 07 November 2016 Accepted: 16 November 2016 Published: 20 June 2017 Address correspondence to K.L. Ebi, Rohm & Haas Endowed Professor in Public Health Sciences; Director, Center for Health and the Glo...
Source: EHP Research - June 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

The Florence Statement on Triclosan and Triclocarban
Author Affiliations open 1Biodesign Center for Environmental Security, Arizona State University, Tempe, Arizona, USA 2Green Science Policy Institute, Berkeley, California, USA 3Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA 4Environmental Working Group, Washington, District of Columbia, USA 5Department of Civil, Environmental, and Geo-Engineering, University of Minnesota, Minneapolis, Minnesota, USA 6Medical University of South Carolina, Department of Public Health Sciences, Charleston, South Carolina, USA 7Health Research Communicati...
Source: EHP Research - June 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland
Conclusions: There is considerable variation in radon and UV exposure across Switzerland. Our study suggests both are relevant risk factors for skin cancer mortality. A better understanding of the role of the UV radiation and radon exposure is of high public health relevance. https://doi.org/10.1289/EHP825 Received: 19 July 2016 Revised: 28 October 2016 Accepted: 15 November 2016 Published: 16 June 2017 Address correspondence to D. Vienneau, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4051, Basel, Switzerland. Telephone: 41 (0) 61-284-8398. E-mail: dan...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Associations of Prenatal Urinary Bisphenol A Concentrations with Child Behaviors and Cognitive Abilities
Conclusion: Prenatal urinary BPA concentration was associated with some aspects of child behavior in this cohort, and some associations were stronger among boys. https://doi.org/10.1289/EHP984 Received: 18 August 2016 Revised: 09 December 2016 Accepted: 12 December 2016 Published: 16 June 2017 Address correspondence to Joseph M. Braun, Department of Epidemiology, Box G-S121-2, Brown University, Providence, RI 02912 USA. Telephone: (401) 863-5397. E-mail: joseph_braun_1@brown.edu Supplemental Material is available online (https://doi.org/10.1289/EHP984). The authors declare they have no actual or potential competing fi...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children
Author Affiliations open 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France 3Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden 4Department of Paediatrics, Sachs’ Children’s Hospital, Stockholm, Sweden 5Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden PDF Version (136 KB) Abstract About This Article Supplemental Material Background: Long-term exposure to ambient air pollution can lead ...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Author Affiliations open 1Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 3Maternal and Child Health Division, icddr,b, Dhaka, Bangladesh 4Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan PDF Version (995 KB) Abstract About This Article Supplemental Material Background: Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects o...
Source: EHP Research - June 15, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Author Affiliations open 1Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China 2Center on Clinical and Epidemiological Eye Research, Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 3Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 4Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 5Channing ...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Advancing Alternative Analysis: Integration of Decision Science
Conclusions: We advance four recommendations: a) engaging the systematic development and evaluation of decision approaches and tools; b) using case studies to advance the integration of decision analysis into alternatives analysis; c) supporting transdisciplinary research; and d) supporting education and outreach efforts. https://doi.org/10.1289/EHP483 Received: 16 December 2015 Revised: 09 May 2016 Accepted: 19 September 2016 Published: 13 June 2017 Address correspondence to T. F. Malloy, UCLA School of Law, Box 951476, 3113 Law Building, Los Angeles, CA, 90095-1476. Telephone: 310-794-5278. E-mail:malloy@law.ucla.e...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Review Source Type: research

Age at Menopause: Do Chemical Exposures Play a Role?
PDF Version (2.2 MB) About This Article Published: 12 June 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. With its associated hot flashes, mood swings, and insomnia, menop...
Source: EHP Research - June 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: News Focus Source Type: research

Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice
Conclusion: CYP2F1 is an active enzyme. Both CYP2A13 and CYP2F1 are active toward NA in the CYP2A13/2F1-humanized mice, where they play significant roles in NA-induced respiratory tract toxicity. https://doi.org/10.1289/EHP844 Received: 20 July 2016 Revised: 22 October 2016 Accepted: 07 November 2016 Published: 08 June 2017 Address correspondence to L. Van Winkle, Center for Health and the Environment, Building 3792, Room 129, Old Davis Rd., UC Davis, Davis, CA 95616 USA. Telephone: (530) 754-9060. E-mail: lsvanwinkle@ucdavis.edu , and X. Ding, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute,...
Source: EHP Research - June 9, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Environmental Exposures to Lead, Mercury, and Cadmium and Hearing Loss in Adults and Adolescents: KNHANES 2010 –2012
We examined the association between environmental exposures to lead, mercury, and cadmium and the risk of hearing loss in adults and adolescents while controlling for potential confounding factors, including noise exposures and clinical factors. Methods: We analyzed cross-sectional data from 5,187 adults and 853 adolescents in the Korean National Health and Nutrition Examination Survey 2010–2012. Pure-tone average (PTA) of hearing thresholds at high frequency (3, 4, and 6 kHz) were computed, and hearing loss was defined as a PTA>25 dB in adults and PTA>15 dB in adolescents. Results: In adults, the...
Source: EHP Research - June 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Genome-wide Association Study of Susceptibility to Particulate Matter –Associated QT Prolongation
Conclusions: The findings suggest that biologically plausible genetic factors may alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Environmental Protection Agency’s National Ambient Air Quality Standards. Independent replication and functional characterization are necessary to validate our findings. https://doi.org/10.1289/EHP347 Received: 11 April 2016 Revised: 07 September 2016 Accepted: 19 September 2016 Published: 08 June 2017 Address correspondence to R. Gondalia, Department of Epidemiology, University of North Carolina, 137 E. Franklin St., Chapel Hill, NC 27514...
Source: EHP Research - June 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Assessment of the Probability of Autochthonous Transmission of Chikungunya Virus in Canada under Recent and Projected Climate Change
In this study we explore the potential for autochthonous, but not necessarily sustained, transmission of CHIKV in Canada. We used a stochastic mathematical model parameterized for Ae. albopictus under climatic conditions in the warmest months of the year in locations across Canada. We then combined the climatic suitability for CHIKV transmission potential in the warmest months of the year (condition C4) with climatic suitability indicators for the endemic presence of Ae. albopictus (condition C3) to produce risk maps identifying areas in Canada most suitable for autochthonous CHIKV transmission under recent and projected c...
Source: EHP Research - June 5, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies
Conclusions: This is, to our knowledge, the first report of an association between house dust endotoxin and leukocyte count in a national survey. The finding was replicated in a farming population. Peripheral leukocyte count may be influenced by residential endotoxin exposure in diverse settings. https://doi.org/10.1289/EHP661 Received: 15 June 2016 Revised: 13 September 2016 Accepted: 27 September 2016 Published: 31 May 2017 Address correspondence to: M.B. Fessler, MD, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709. Tele...
Source: EHP Research - May 31, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Time-series Analysis of Heat Waves and Emergency Department Visits in Atlanta, 1993 to 2012
Conclusions: Heat waves can confer additional risks of ED visits beyond those of daily air temperature, even in a region with high air-conditioning prevalence. https://doi.org/10.1289/EHP44 Received: 29 February 2016 Revised: 13 October 2016 Accepted: 24 October 2016 Published: 31 May 2017 Address correspondence to H.H. Chang, Department of Biostatistics and Bioinformatics, Emory University, 1518 Clifton Rd. NE, Atlanta, Georgia 30322. Telephone: (404) 712-4627; E-mail: howard.chang@emory.edu Supplemental Material is available online (https://doi.org/10.1289/EHP44). The authors declare they have no actual ...
Source: EHP Research - May 31, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Expansion of the Lyme Disease Vector Ixodes scapularis in Canada Inferred from CMIP5 Climate Projections
Conclusion: Our results highlight the potential for climate change to have an effect on future Lyme disease risk in Canada even if the Paris Agreement’s goal to keep global warming below 2°C is achieved, although mitigation reducing emissions from RCP8.5 levels to those of RCP6.0 or less would be expected to slow tick invasion after the 2030s. https://doi.org/10.1289/EHP57 Received: 02 March 2016 Revised: 26 August 2016 Accepted: 30 August 2016 Published: 31 May 2017 Address correspondence to H. Beltrami, Earth Science Department, Physical Sciences Center, PO Box 5000, 1 West St, Antigonish, NS B2G 1W5. Tel...
Source: EHP Research - May 31, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Drinking Water Salinity and Raised Blood Pressure: Evidence from a Cohort Study in Coastal Bangladesh
Conclusions: DWS is an important source of daily sodium intake in salinity-affected areas and is a risk factor for hypertension. Considering the likely increasing trend in coastal salinity, prompt action is required. Because MAR showed variable effects, alternative technologies for providing reliable, safe, low-sodium fresh water should be developed alongside improvements in MAR and evaluated in “real-life” salinity-affected settings. https://doi.org/10.1289/EHP659 Received: 01 February 2016 Revised: 14 June 2016 Accepted: 31 August 2016 Published: 30 May 2017 Address correspondence to Dr. Pauline Sche...
Source: EHP Research - May 30, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population
Conclusions: Using the CC mouse population model, we have demonstrated a complex and highly variable relationship between PERC and TCA toxicokinetics and toxicodynamics at the population level. https://doi.org/10.1289/EHP788 Received: 11 July 2016 Revised: 26 September 2016 Accepted: 25 October 2016 Published: 30 May 2017 Address correspondence to I. Rusyn, TAMU, Texas A&M University, College Station, TX 77843, USA. Telephone: (979) 458-9866. E-mail: irusyn@cvm.tamu.edu Supplemental Material is available online (https://doi.org/10.1289/EHP788). The authors declare they have no actual or potential competing financ...
Source: EHP Research - May 30, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Estimating Inorganic Arsenic Exposure from U.S. Rice and Total Water Intakes
Conclusions: An average consumer drinking 1.5 L of water daily that contains between 2 and 3 ng iAs/mL is exposed to approximately the same amount of iAs as a mean Tribal, Asian, and Pacific consumer is exposed to from rice. https://doi.org/10.1289/EHP418 Received: 31 July 2015 Revised: 02 May 2016 Accepted: 18 July 2016 30 May 2017 Address correspondence to J.T. Creed, U.S. EPA, 26 W. Martin Luther King Dr., Cincinnati, OH 45268 USA. Telephone: (513) 569-7833. E-mail: creed.jack@epa.gov Supplemental Material is available online (https://doi.org/10.1289/EHP418). The authors declare they have no actual o...
Source: EHP Research - May 30, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

A Case –Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Conclusions: Our results suggest that maternal exposure to BDE-99, -100, and -154 may be associated with abnormal migration of testes in the male fetus. This may be due to the anti-androgenic properties of the PBDEs. https://doi.org/10.1289/EHP522 Received: 17 May 2016 Revised: 22 September 2016 Accepted: 08 October 2016 Published: 26 May 2017 Address correspondence to C.G. Goodyer, Research Institute of McGill University Health Centre, Centre for Translational Biology, EM0.3211, 1001 Decarie Blvd., Montreal, QC, Canada H4A 3J1. Telephone: (514) 934-1934, ext. 22481. E-mail: cindy.goodyer@muhc.mcgill.ca Supplemental Mat...
Source: EHP Research - May 27, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children
Conclusions: This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children. https://doi.org/10.1289/EHP504 Received: 08 January 2016 Revised: 13 May 2016 Accepted: 14 June 2016 Published: 25 May 2017 Address correspondence to R. Gunier, Center for Environmental Research and Childrens Health (CERCH), School of Public Health, University of California at Berkeley, 1995 University Ave., Suite 265, Berkeley, CA 94704. Telephone: (510) 847-3858. E-mail: gunier@berkeley.edu. A.B. is a volunteer member of the Board for...
Source: EHP Research - May 27, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research