Urinary Concentrations of Organophosphate Flame Retardant Metabolites and Pregnancy Outcomes among Women Undergoing in Vitro Fertilization
Conclusions: Using IVF to investigate human reproduction and pregnancy outcomes, we found that concentrations of some urinary PFR metabolites were negatively associated with proportions of successful fertilization, implantation, clinical pregnancy, and live birth. https://doi.org/10.1289/EHP1021 Received: 26 August 2016 Revised: 10 April 2017 Accepted: 02 June 2017 Published: 25 August 2017 Address correspondence to C. Carignan, Department of Environmental Health, Building 1, 14th Floor, 665 Huntington Avenue, Boston, MA 02115 USA. Phone: (617) 432-4572. Email: carignan@hsph.harvard.edu Supplemental Material is avail...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

A Method for Identifying Prevalent Chemical Combinations in the U.S. Population
Conclusions: We demonstrated how FIM can be used in conjunction with biomonitoring data to narrow a large number of possible chemical combinations down to a smaller set of prevalent chemical combinations. https://doi.org/10.1289/EHP1265 Received: 24 October 2016 Revised: 17 April 2017 Accepted: 19 April 2017 Published: 24 August 2017 Address correspondence to D.F. Kapraun, National Center for Computational Toxicology, U.S. Environmental Protection Agency, Mail Drop D143-02, 109 T.W. Alexander Dr., Research Triangle Park, NC 27711 USA. Phone: (919) 541-4045. Fax: (919) 541-1194. Email: kapraun.dustin@epa.gov Supplemen...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Erratum: “Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation”
PDF Version (176 KB) About This Article Received: 26 June 2017 Revised: 26 June 2017 Accepted: 29 June 2017 Published: 24 August 2017 Environ Health Perspect 125(6):067002 (2017), https://doi.org/10.1289/EHP347 Address correspondence to R. Gondalia, University of North Carolina, Dept. of Epidemiology, 137 East Franklin Street, Chapel Hill, NC 27514 USA. Phone: (919) 966-1967. Fax: (919) 966-6650. Email: rahgonda@unc.edu Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP&n...
Source: EHP Research - August 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Erratum Source Type: research

Toward Consistent Methodology to Quantify Populations in Proximity to Oil and Gas Development: A National Spatial Analysis and Review
Conclusions: The well inventory guidelines we present provide an improved methodology for hydrocarbon proximity studies by acknowledging the importance of both conventional and unconventional well counts as well as the relative exposure risks associated with different primary production categories (e.g., oil, wet gas, dry gas) and developmental stages of wells. https://doi.org/10.1289/EHP1535 Received: 21 December 2016 Revised: 30 May 2017 Accepted: 05 June 2017 Published: 23 August 2017 Address correspondence to S.B.C. Shonkoff, 1440 Broadway, Suite 205, Oakland, CA 94612 USA. Phone: (510) 899-9706. Email: sshonkoff...
Source: EHP Research - August 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants
Conclusions: Our estimates corroborate reports from several recent epidemiological studies of associations between PBDE exposures and neurobehavioral outcomes, and they support the inclusion of BDE-209 in the persistent organic pollutant (POP) convention as well as the need for strategies to reduce exposures to PBDE mixtures, including maximum residue limits for PBDEs in food and measures for limiting the release of PBDEs from consumer waste. https://doi.org/10.1289/EHP826 Received: 18 July 2016 Revised: 06 May 2017 Accepted: 09 May 2017 Published: 23 August 2017 Address correspondence to A. Kortenkamp, Brunel Univer...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride
Conclusions: Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK. https://doi.org/10.1289/EHP1404 Received: 22 November 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 22 August 2017 Address correspondence to G. Cortopassi, 1089 Veterinary Medicine Drive, Davis, CA 95616 USA. Phone: (530)...
Source: EHP Research - August 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study
We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. Methods: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004–2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Air Pollution and Risk of Parkinson ’s Disease in a Large Prospective Study of Men
Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD in men. https://doi.org/10.1289/EHP259 Received: 01 April 2016 Revised: 07 November 2016 Accepted: 10 November 2016 Published: 18 August 2017 Address correspondence to N. Palacios, Dept. of Public Health, University of Massachusetts, Lowell; Lowell, Massachusetts. Telephone: 617-304-4254. Email: natalia_palacios@uml.edu Statistical analysis was done by N.P. and K.C.F. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensu...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Review of Epidemiological Studies of Drinking-Water Turbidity in Relation to Acute Gastrointestinal Illness
Conclusions: The observed associations suggest a detectable incidence of waterborne AGI from drinking water in the systems and time periods studied. However, some discrepant results indicate that the association may be context specific. Combining turbidity with seasonal and climatic factors, additional water quality measures, and treatment data may enhance predictive modeling in future studies. https://doi.org/10.1289/EHP1090 Received: 12 September 2016 Revised: 24 February 2017 Accepted: 27 February 2017 Published: 17 August 2017 Address correspondence to A.J. De Roos, Nesbitt Hall, Room 658, 3215 Market St., Philad...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Outdoor Light at Night and Breast Cancer Incidence in the Nurses ’ Health Study II
Conclusions: Although further work is required to confirm our results and to clarify potential mechanisms, our findings suggest that exposure to residential outdoor light at night may contribute to invasive breast cancer risk. https://doi.org/10.1289/EHP935 Received: 08 August 2016 Revised: 17 March 2017 Accepted: 20 March 2017 Published: 17 August 2017 Address correspondence to P. James, 401 Park Dr., 3rd Floor West, Boston, MA 02215 USA. Telephone: (617) 525-2567; Email: pjames@hsph.harvard.edu Supplemental Material is available online (https://doi.org/10.1289/EHP935). The authors declare they have no actual or pot...
Source: EHP Research - August 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Adaptation to Climate Change: A Comparative Analysis of Modeling Methods for Heat-Related Mortality
Conclusions: Researchers should carefully consider how to model adaptation because it is a source of uncertainty that can be greater than the uncertainty in emissions and climate modeling. We recommend absolute threshold shifts and reductions in slope. https://doi.org/10.1289/EHP634 Received: 09 June 2016 Revised: 15 September 2016 Accepted: 24 October 2016 Published: 16 August 2017 Address correspondence to S.N. Gosling, School of Geography, University of Nottingham, Nottingham NG7 2RD, UK. Telephone: +44(0)115 951 5437. Email: simon.gosling@nottingham.ac.uk Supplemental Material is available online (https://doi.org...
Source: EHP Research - August 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Quantitative Microbial Risk Assessment for Spray Irrigation of Dairy Manure Based on an Empirical Fate and Transport Model
Conclusions: Our model-based estimates suggest that reducing pathogen prevalence and concentration in source manure would reduce the risk of AGI from exposure to manure irrigation, and that increasing the distance from irrigated manure (i.e., setbacks) and limiting irrigation to times of low wind speed may also reduce risk. https://doi.org/10.1289/EHP283 Received: 30 March 2016 Revised: 07 March 2017 Accepted: 13 March 2017 Published: 16 August 2017 Address Correspondence to M.A. Borchardt, USDA-ARS, 2615 Yellowstone Dr., Marshfield, WI 54449 USA. Telephone: 715-387-4943. Email: Mark.Borchardt@ars.usda.gov Supplement...
Source: EHP Research - August 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures
Conclusions: These new resources offer substantial advances to classical toxicity testing paradigms by including genetically sensitive individuals that may inform toxicity risks for sensitive subpopulations. Both in vivo and complementary in vitro resources provide platforms with which to reduce uncertainty by providing population-level data around biological variability. https://doi.org/10.1289/EHP1274 Received: 25 October 2016 Revised: 19 April 2017 Accepted: 27 April 2017 Published: 15 August 2017 Address correspondence to K.A. McAllister, Program Administrator, Genes, Environment, and Health Branch, Division of E...
Source: EHP Research - August 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplem...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Heat Wave and Mortality: A Multicountry, Multicommunity Study
Conclusions: Results indicate that high temperatures create a substantial health burden, and effects of high temperatures over consecutive days are similar to what would be experienced if high temperature days occurred independently. People living in moderate cold and moderate hot areas are more sensitive to heat waves than those living in cold and hot areas. Daily mean and maximum temperatures had similar ability to define heat waves rather than minimum temperature. https://doi.org/10.1289/EHP1026 Received: 26 August 2016 Revised: 20 March 2017 Accepted: 31 March 2017 Published: 14 August 2017 Address correspondence...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Detecting and Attributing Health Burdens to Climate Change
Conclusions: The results of detection and attribution studies can inform evidence-based risk management to reduce current, and plan for future, changes in health risks associated with climate change. Gaining a better understanding of the size, timing, and distribution of the climate change burden of disease and injury requires reliable long-term data sets, more knowledge about the factors that confound and modify the effects of climate on health, and refinement of analytic techniques for detection and attribution. At the same time, significant advances are possible in the absence of complete data and statistical certainty:...
Source: EHP Research - August 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS)
Conclusions: The LEnS concept is a practical refinement to the exposome that accounts for total exposures during particular windows of susceptibility in target organ systems. Application of the LEnS framework in risk assessment and regulation will improve protection of children’s health by enhancing protection of sensitive developing organ systems that are critical for lifelong health and well-being. https://doi.org/10.1289/EHP1250 Received: 19 October 2016 Revised: 08 March 2017 Accepted: 04 April 2017 Published: 07 August 2017 Please address correspondence to E.M. Faustman, Dept. of Environmental and Occupati...
Source: EHP Research - August 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease
Conclusion: Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c promoter in livers of BPA-exposed mice was observed. Overall, the underlying mechanisms described a broader impact beyond BPA exposure and can be applied to understand other models of NAFLD. https://doi.org/10.1289/EHP664 Received: 15 June 2016 Revised: 28 January 2017 Accepted: 31 January 2017 Published: 04 August 2017 Address correspondence to A.L. Slitt, Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Gre...
Source: EHP Research - August 5, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants
Conclusions: Our results with the FEGA provide the foundations of a predictive human mixture risk assessment approach for anti-androgenic exposures in fetal life. https://doi.org/10.1289/EHP1014 Received: 25 August 2016 Revised: 02 March 2017 Accepted: 20 March 2017 Published: 04 August 2017 Address correspondence to B. Jégou, EHESP, IRSET-UMR Inserm 1085, 9 Ave. du professeur Léon Bernard, F-35000 Rennes, France. Telephone: 33.2.23.23.61.25. Email: bernard.jegou@ehesp.fr Supplemental Material is available online (https://doi.org/10.1289/EHP1014). The authors declare they have no actual or potential com...
Source: EHP Research - August 4, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis
Conclusion: We concluded there was sufficient evidence supporting an association between developmental PBDE exposure and reduced IQ. Preventing developmental exposure to PBDEs could help prevent loss of human intelligence. https://doi.org/10.1289/EHP1632 Received: 16 January 2017 Revised: 28 April 2017 Accepted: 28 April 2017 Published: 03 August 2017 Address correspondence to J. Lam, Program on Reproductive Health and the Environment, University of California, San Francisco, Mail Stop 0132, 550 16th St., 7th floor, San Francisco, CA 94143 USA. Telephone: (415) 476-3219. Email: Juleen.Lam@ucsf.edu Supplemental Materi...
Source: EHP Research - August 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

The Case for Universal Screening of Private Well Water Quality in the U.S. and Testing Requirements to Achieve It: Evidence from Arsenic
Conclusions: Universal screening, achieved through local testing requirements complemented by greater community engagement targeting biologically and socioeconomically vulnerable groups, would reduce population arsenic exposure greater than any promotional efforts to date. Universal screening of private well water will identify the dangers hidden in America’s drinking water supply and redirect attention to ensure safe water among affected households. https://doi.org/10.1289/EHP629 Received: 08 June 2016 Revised: 13 December 2016 Accepted: 29 December 2016 Published: 03 August 2017 Address correspondence to Y. Z...
Source: EHP Research - August 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Conclusion: Greenness, ISA, and NTL were associated with increased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for the relationship between urbanization and increased CVD prevalence in urban India. https://doi.org/10.1289/EHP541 Received: 20 May 2016 Revised: 03 January 2017 Accepted: 23 January 2017 Published: 02 August 2017 Address correspondence to K.J. Lane, Yale School of Forestry and Environmental Studies, 195 Prospect Street, New Haven, CT 06511 USA. Telephone: (781) 696-4537; Email: kevin.lane@yale.edu Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Estimated Effects of Future Atmospheric CO2 Concentrations on Protein Intake and the Risk of Protein Deficiency by Country and Region
Conclusions: Anthropogenic CO2 emissions threaten the adequacy of protein intake worldwide. Elevated atmospheric CO2 may widen the disparity in protein intake within countries, with plant-based diets being the most vulnerable. https://doi.org/10.1289/EHP41 Received: 27 February 2016 Revised: 12 September 2016 Accepted: 19 September 2016 Published: 02 August 2017 Address correspondence to D. Medek, North Shore Hospital, Shakespeare Ave., Takapuna, Auckland, New Zealand 0622. Telephone: 649 486 8900. Email: danielle.medek@gmail.com Supplemental Material is available online (https://doi.org/10.1289/EHP41). The authors d...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Opportunities and Challenges for Personal Heat Exposure Research
Conclusions: Personal heat exposure research provides more valid and precise insights into how often people encounter heat conditions and when, where, to whom, and why these encounters occur. Published literature on personal heat exposure is limited to date, but existing studies point to opportunities to inform public health practice regarding extreme heat, particularly where fine-scale precision is needed to reduce health consequences of heat exposure. https://doi.org/10.1289/EHP556 Received: 24 May 2016 Revised: 17 January 2017 Accepted: 20 January 2017 Published: 01 August 2017 Address correspondence to D.M. Hondu...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Nature Contact and Human Health: A Research Agenda
Conclusions: Nature contact may offer a range of human health benefits. Although much evidence is already available, much remains unknown. A robust research effort, guided by a focus on key unanswered questions, has the potential to yield high-impact, consequential public health insights. https://doi.org/10.1289/EHP1663 Received: 26 January 2017 Revised: 12 May 2017 Accepted: 25 May 2017 Published: 31 July 2017 Address correspondence to H. Frumkin, Dept. of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Box 354695, Seattle, WA 98195-4695 USA; Telephone: 206-897-1723;...
Source: EHP Research - July 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

The Imperial County Community Air Monitoring Network: A Model for Community-based Environmental Monitoring for Public Health Action
Author Affiliations open 1California Department of Public Health, Richmond, California, USA 2Comite Civico Del Valle, Brawley, California, USA 3Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USA 4California Environmental Health Tracking Program, Public Health Institute, Oakland, California, USA 5School of Public Health, University of California, Los Angeles, California, USA 6Department of Environmental and Occupational Health Sciences, George Washington University, Washington, D.C., USA PDF Version (723 KB) Abstract About This Article Summary: T...
Source: EHP Research - July 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Assessing Exposure to Household Air Pollution: A Systematic Review and Pooled Analysis of Carbon Monoxide as a Surrogate Measure of Particulate Matter
Conclusions: Our results suggest that exposure to CO is not a consistently valid surrogate measure of exposure to PM2.5. Studies measuring CO exposure as a surrogate measure of PM exposure should conduct local validation studies for different stove/fuel types and seasons. https://doi.org/10.1289/EHP767 Received: 06 July 2016 Revised: 19 December 2016 Accepted: 20 December 2016 Published: 28 July 2017 Address correspondence to J. Baumgartner, Institute for Health and Social Policy and Department of Epidemiology, Biostatistics and Occupational Health, 1130 des Pins Ave. Ouest, Montréal, Québec H3A 1A3 Can...
Source: EHP Research - July 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Exposure to Ambient Particulate Matter during Specific Gestational Periods Produces Adverse Obstetric Consequences in Mice
Conclusions: Adverse PM2.5-induced outcomes such as PTB and LBW are dependent upon the periods of maternal exposure. The results of these experimental studies could contribute significantly to air pollution policy decisions in the future. https://doi.org/10.1289/EHP1029 Received: 26 August 2016 Revised: 12 December 2016 Accepted: 23 January 2017 Published: 27 July 2017 Address correspondence to J. Zelikoff, Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo, NY 10987 USA. Telephone: (845) 731-3528. Email: Judith.Zelikoff@nyumc.org The authors declare they have no ac...
Source: EHP Research - July 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis
Conclusions: Alterations to RV structure may represent a mechanism by which long-term PM10–2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658 Received: 14 June 2016 Revised: 24 February 2017 Accepted: 16 March 2017 Published: 27 July 2017 Address correspondence to S. D. Adar, University of Michigan School of Public Health, 1415 Washington Heights, SPH II-5539, Ann Arbor, MI 48109 USA. Telephone: (734) 615-9207; Email: sadar@umich.edu Supplemental Material is available online (https://doi.org/10.1289/E...
Source: EHP Research - July 27, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds
Conclusions: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275 Received: 09 February 2016 Revised: 06 June 2016 Accepted: 12 July 2016 Published: 26 July 2017 Address correspondence to P. Grandjean, HSPH-EOME, 401 Park Dr., 3E L3-045, Boston, MA 02215 USA. Telephone: 617-384-8907. Email: pgrandjean@health.sdu.dk The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figure...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds
Conclusions: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275 Received: 09 February 2016 Revised: 06 June 2016 Accepted: 12 July 2016 Published: 26 July 2017 Address correspondence to P. Grandjean, HSPH-EOME, 401 Park Dr., 3E L3-045, Boston, MA 02215 USA. Telephone: 617-384-8907. Email: pgrandjean@health.sdu.dk The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figure...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Updating the NIEHS Strategic Plan
Author Affiliations open 1Director, National Institute of Environmental Health Sciences, and 2Director, National Toxicology Program, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Email: birnbaumls@niehs.nih.gov PDF Version (56 KB) About This Article About This Article Published: 26 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the c...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Editorial Source Type: research

Location Is Everything: The Pollutants in Yellowfin Tuna Depend on Where It ’s Caught
PDF Version (312 KB) About This Article Published: 25 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Geographic Differences in Persiste...
Source: EHP Research - July 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States
Conclusions: We found evidence of racial/ethnic and socioeconomic differences in model-based estimates of noise exposure throughout the United States. Additional research is needed to determine if differences in noise exposure may contribute to health disparities in the United States. https://doi.org/10.1289/EHP898 Received: 01 August 2016 Revised: 06 February 2017 Accepted: 06 February 2017 Published: 25 July 2017 Address correspondence to J.A. Casey, University of California, Berkeley, 13B University Hall, Berkeley, CA 94610 USA. Telephone: 541-760-8477; Email: joanacasey@berkeley.edu Supplemental Material is avail...
Source: EHP Research - July 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maiden Voyage of the Collaborative Cross Mouse: Exploring Variability in Animals ’ Response to Perchloroethylene
PDF Version (742 KB) About This Article Published: 24 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Characterization of Variability i...
Source: EHP Research - July 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Northern Trek: The Spread of Ixodes scapularis into Canada
This study is an extension of previous work published in 20141 showing the predicted expansion of the distribution of the Lyme disease tick vector into Canada,” says Maria Diuk-Wasser, a professor at Columbia University who focuses on the emergence of vector-borne diseases. “Although the results are not qualitatively different, it represents an improvement on the previous study by incorporating the full range of and most up-to-date climate models and emission scenarios.” Importantly, she says, the new study accounts for the inherent uncertainty in such models and scenarios but also indicates that an incre...
Source: EHP Research - July 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Weekly Personal Ozone Exposure and Respiratory Health in a Panel of Greek Schoolchildren
Conclusions: The study provides evidence that airway inflammation and the frequency of respiratory symptoms increase, whereas lung function decreases with increased ozone exposure in schoolchildren. https://doi.org/10.1289/EHP635 Received: 09 June 2016 Revised: 08 March 2017 Accepted: 13 March 2017 Published: 21 July 2017 Please address correspondence to A. Karakatsani, 2nd Pulmonary Department, ATTIKON University Hospital, School of Medicine, National and Kapodistrian University of Athens, 1, Rimini St., 124 62 Haidari, Greece. Telephone: 30-210-5831184. Email: annakara@otenet.gr, akarakats@med.uoa.gr The authors de...
Source: EHP Research - July 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Prevalence of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant Escherichia Coli in Poultry Chickens and Variation According to Farming Practices in Punjab, India
Author Affiliations open 1Center for Disease Dynamics, Economics & Policy, Washington, DC, USA 2Public Health Foundation of India, New Delhi, Delhi, India 3Dept. of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA 4School of Public Health and Zoonoses, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India 5Dept. of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA 6SRL Diagnostics, FORTIS Hospital, Noida, Uttar Pradesh, India 7SRL Diagnostics, Mumbai, Maharashtra, India 8Veterinary & Animal Husbandry Extension, Guru Angad...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

The Saliva Exposome for Monitoring of Individuals ’ Health Trajectories
Conclusions: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. https://doi.org/10.1289/EHP1011 Received: 23 August 2016 Revised: 08 November 2016 Accepted: 18 November 2016 Published: 20 July 2017 Address correspondence to V. Bessonneau, Silent Spring Institute, 320 Nevada St., Suite 302, Newton, Massachusetts 02460 USA. Telephone: (617) 332-4288. Email: vincent.bessonneau@gmail.com The authors declare they have no actual or po...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study
Conclusions: Exposures to specific pesticides may be modifiable risk factors for AMD. https://doi.org/10.1289/EHP793 Received: 12 July 2016 Revised: 17 March 2017 Accepted: 18 March 2017 Published: 19 July 2017 Address correspondence to F. Kamel, Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Dr., Bldg. 101, Room 327, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709 USA. Telephone: 919-541-1581; Email: kamel@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP793). The authors declare they have no actual or potential competing financi...
Source: EHP Research - July 19, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors
Conclusions: These results demonstrate the possibility to predict large-scale mixture effects for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput ranking and risk assessment. The size of the effects predicted is consistent with an increased risk of infertility in women from everyday exposures to our chemical environment. https://doi.org/10.1289/EHP742 Received: 30 June 2016 Revised: 07 December 2016 Accepted: 24 February 2017 Published: 19 July 2017 Address correspondence to F.Y. Bois, INERIS, DRC/VIVA, Parc ALATA, BP 2, 60550 Verneuil en Halatte, France. Telephone: 33-...
Source: EHP Research - July 19, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a Prospective Cohort Study
Conclusions: In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827 Received: 18 July 2016 Revised: 16 November 2016 Accepted: 09 December 2016 Published: 18 July 2017 Address correspondence to A.J. White, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233 USA. Telephone: (919) 316-4867. Email: alexandra.white@nih.gov Supp...
Source: EHP Research - July 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study
Conclusions: Our results provide novel evidence of associations between exposure to some pesticides and RA in male farmers. https://doi.org/10.1289/EHP1013 Received: 24 August 2016 Revised: 19 January 2017 Accepted: 13 February 2017 Published: 14 July 2017 Address correspondence to C.G. Parks, Epidemiology Branch, A3-05, National Institite of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27599 USA; Telephone: (919) 541-2577; Email: Parks1@mail.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1013). The authors declare that they have...
Source: EHP Research - July 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

A Longitudinal Analysis of the Influence of the Neighborhood Environment on Recreational Walking within the Neighborhood: Results from RESIDE
Conclusions: Our findings provide urban planners and policy makers with stronger causal evidence of the positive impact of well-connected neighborhoods and access to local parks of varying sizes on local residents’ recreational walking and health. https://doi.org/10.1289/EHP823 Received: 19 July 2016 Revised: 29 January 2017 Accepted: 10 February 2017 Published: 12 July 2017 Address correspondence to H. Christian, School of Population Health (M707), The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia. Telephone: 61-8-6488 8501. Email: hayley.christian@uwa.edu.au Supplemental Mat...
Source: EHP Research - July 12, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Conclusion: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875 Received: 27 July 2016 Revised: 18 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to E. S. Barrett, Dept. of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, 170 Frelinghuysen Road, Piscataway, NJ 08854...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose –Response Analysis
Conclusions: Developmental BPA exposures heighten prostate cancer susceptibility in a complex dose- and lobe-specific manner. Importantly, elevated carcinogenic risk is found at doses that yield undetectable serum free BPA. Dose-specific epigenetic modifications of selected genes provide a mechanistic framework that may connect early-life BPA to later-life predisposition to prostate carcinogenesis. https://doi.org/10.1289/EHP1050 Received: 1 September 2016 Revised: 13 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to G.S. Prins, Dept. of Urology, University of Illinois at Chicago...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research