Decomposition Analysis of Black –White Disparities in Birth Outcomes: The Relative Contribution of Air Pollution and Social Factors in California
Conclusions: Our results suggest that, although the role of individual and neighborhood factors remains prevailing in explaining black–white differences in birth outcomes, the individual contribution of PM2.5 is comparable in magnitude to any single individual- or neighborhood-level factor. https://doi.org/10.1289/EHP490 Received: 10 May 2016 Revised: 16 December 2016 Accepted: 03 January 2017 Published: 04 October 2017 Address correspondence to T. Benmarhnia, Department of Family Medicine and Public Health, and Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, La Joll...
Source: EHP Research - October 4, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Reconciling Sex-Related Bias: An Alternative Method for Data Analysis
PDF Version (605 KB) About This Article Published: 03 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. During development, hormones guide the processes that underlie th...
Source: EHP Research - October 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Prenatal and Postnatal PCB-153 and p,p ′-DDE Exposures and Behavior Scores at 5–9 Years of Age among Children in Greenland and Ukraine
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - October 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal and Postnatal PCB-153 and p,p ’ -DDE Exposures and Behavior Scores at 5 –9 Years of Age among Children in Greenland and Ukraine
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - October 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial
Conclusions: At baseline, several PFAS were cross-sectionally associated with small differences in markers of insulin secretion and β-cell function. However, there was limited evidence suggesting that PFAS concentrations are associated with diabetes incidence or changes in glycemic indicators during the follow-up period. https://doi.org/10.1289/EHP1612 Received: 12 January 2017 Revised: 03 August 2017 Accepted: 04 August 2017 Published: 02 October 2017 Address correspondence to E. Oken, Obesity Prevention Program, Harvard Medical School and Harvard Pilgrim HealthCare Institute, Dept. of Population Medicine, 401 ...
Source: EHP Research - October 3, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California
Conclusions: Residential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699 Received: 31 January 2017 Revised: 18 August 2017 Accepted: 23 August 2017 Published: 29 September 2017 Address correspondence to R.J. Blount, Divisions of Pulmonary and Critical Care Medicine and Pediatric Pulmon...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
Author Affiliations open 1Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada 2Swiss Tropical and Public Health Institute, Basel, Switzerland 3University of Basel, Basel, Switzerland 4Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands 5MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK 6National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA 7University Medical Center Groningen, Gron...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case –control Study
Author Affiliations open 1Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands 2Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands 3Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands 4Department of Neurology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, Netherlands 5Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, Netherla...
Source: EHP Research - September 27, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring
Conclusion: These findings demonstrate that maternal BPA exposure has dose- and sex-specific effects on pancreatic islets of adult F1 and F2 mice offspring. The transmission of these changes across multiple generations may involve either mitochondrial dysfunction and/or epigenetic modifications. https://doi.org/10.1289/EHP1674 Received: 25 January 2017 Revised: 26 July 2017 Accepted: 26 July 2017 Published: 27 September 2017 Please address correspondence to R.A. Simmons, Center for Research on Reproduction and Women’s Health, Perelman School of Medicine, University of Pennsylvania, 1308 BRB II/III, 421 Curie Bl...
Source: EHP Research - September 27, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and Risk of Heart Failure: A Cohort Study
Conclusions: Long-term exposure to NO2 and road traffic noise was associated with higher risk of heart failure, mainly among men, in both single- and two-pollutant models. High exposure to both pollutants was associated with highest risk. https://doi.org/10.1289/EHP1272 Received: 25 October 2016 Revised: 09 August 2017 Accepted: 09 August 2017 Published: 26 September 2017 Address correspondence to M. Sørensen. Diet, Genes and Environment, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark. Telephone: +45 35257626. Email: mettes@cancer.dk Supplemental Material is available online (https://doi...
Source: EHP Research - September 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973 –1974 PBB Contamination of Livestock Feed
Conclusions: We found some evidence to support associations of PBBs and PCBs with thyroid disease and thyroid hormone levels. https://doi.org/10.1289/EHP1302 Received: 28 October 2016 Revised: 31 July 2017 Accepted: 01 August 2017 Published: 26 September 2017 Address correspondence to M.H. Jacobson, 1518 Clifton Rd. NE, CNR 3rd Floor, Atlanta, GA 30322 USA. Telephone: 914-589-3926. Email: mhymanjacobson@emory.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1302). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP&nb...
Source: EHP Research - September 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Inequality of Noise Exposures: A Portrait of the United States
PDF Version (483 KB) About This Article Published: 25 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Race/Ethnicity, Socioeconomic St...
Source: EHP Research - September 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Conducting Science in Disasters: Recommendations from the NIEHS Working Group for Special IRB Considerations in the Review of Disaster Related Research
Conclusion The burgeoning field of disaster research has placed greater demands on IRBs to ensure that the welfare and rights of human research subjects are protected during disaster studies. The review of disaster research protocols requires new tools and training for IRBs to assure the protection of disaster survivors from research-related harms. These recommendations are currently being evaluated and prioritized by NIH officials to determine the process for moving forward with implementation. Although disaster research conducted during response may be challenging, IRBs can play useful roles in achieving careful, balance...
Source: EHP Research - September 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

From Ambient to Personal Temperature: Capturing the Experience of Heat Exposure
PDF Version (831 KB) About This Article Published: 22 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Heat exposure can have a wide range of adverse effects on the h...
Source: EHP Research - September 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Estimated Deficiencies Resulting from Reduced Protein Content of Staple Foods: Taking the Cream out of the Crop?
PDF Version (619 KB) About This Article Published: 22 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Projected changes in climate are expected to play a complicated...
Source: EHP Research - September 22, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Portable Functional Neuroimaging as an Environmental Epidemiology Tool: A How-To Guide for the Use of fNIRS in Field Studies
Conclusion The overarching goal of this paper is to demonstrate the feasibility of employing functional neuroimaging in epidemiological studies regardless of the location or the conditions in which the study is taking place. Critically, this is now possible using readily available, portable fNIRS neuroimaging devices to assess neurobehavioral functioning across multiple domains. Most importantly, in our study, the addition of the fNIRS assessment did not interfere with the goals of the ongoing epidemiological study and was seamlessly integrated into daily operations. This paper provides a set of general guidelines that epi...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells
Conclusions: We propose that the inhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the environmental and occupational chemical carcinogen FA. https://doi.org/10.1289/EHP1275 Received: 25 October 2016 Revised: 19 May 2017 Accepted: 23 May 2017 Published: 21 September 2017 Address correspondence to C. Jin, Dept. of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo Park, NY 10987 USA. Telephone: (845) 731-3602. Email: Chunyuan.jin@nyumc.org *Current affiliation: Medical School of Nanjing University, Nanjing, China. †Current affil...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330 Received: 07 November 2016 Revised: 13 July 2017 Accepted: 21 July 2017 Published: 20 September 2017 Address correspondence to C. B. Manzano-Salgado, ISGlobal–Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader, 8808003 Barcelona, Catalonia, Spain. Phone: +34 932 147 314. Email: cyntia.manzano@isglobal.org Supplemental Material is available online (https...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Integrating Health into Local Climate Response: Lessons from the U.S. CDC Climate-Ready States and Cities Initiative
Conclusion Through relatively small amounts of grant support over the last 6 y, CRSCI has helped local public health agencies in sixteen states and two cities—whose combined population reaches half of the U.S. total—identify critical climate impacts and vulnerable populations. In the process, the program has helped to integrate health more fully into local climate change efforts. As a result of CRSCI support, these local public health agencies—the backbone of public health climate response capacity—have tools to enhance real-life adaptive capacity and increase the effectiveness of existing intervent...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6 –12 Years of Age in Mexico
Conclusions: In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6–12 y. https://doi.org/10.1289/EHP655 Received: 14 June 2016 Revised: 08 May 2017 Accepted: 09 May 2017 Published: 19 September 2017 Please send correspondence to M. Bashash, Dalla Lana School of Public Health, 6th floor, 155 College St., Toronto, Ontario M5R3M7 Canada. Telephone: +1-416-978-6512. Email: m.bashash@utoronto.ca Supplement...
Source: EHP Research - September 19, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

In Memoriam: Herbert L. Needleman
PDF Version (254 KB) About This Article About This Article Supplemental Material Received: 03 August 2017 Accepted: 03 August 2017 Published: 19 September 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility need...
Source: EHP Research - September 19, 2017 Category: Environmental Health Authors: Web Admin Tags: In Memoriam Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. E...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Lifelong Residential Exposure to Green Space and Attention: A Population-based Prospective Study
Conclusion: Exposure to residential surrounding greenness was associated with better scores on tests of attention at 4–5 y and 7 y of age in our longitudinal cohort. https://doi.org/10.1289/EHP694 Received: 23 June 2016 Revised: 20 July 2017 Accepted: 21 July 2017 Published: 18 September 2017 Address correspondence to P. Dadvand, ISGlobal, Doctor Aiguader, 88, 08003, Barcelona, Spain. Telephone: 34 93 214 7317. Email: payam.dadvand@isglobal.org Supplemental Material is available online (https://doi.org/10.1289/EHP694). The authors declare they have no actual or potential competing financial interests. Note to r...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit ™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY
Conclusions: Potential exposure to Corexit™ EC9527A or EC9500A was associated with a range of health symptoms at the time of the OSRC, as well as at the time of study enrollment, 1–3 y after the spill. https://doi.org/10.1289/EHP1677 Received: 25 January 2017 Revised: 20 June 2017 Accepted: 26 June 2017 Published: 15 September 2017 Address correspondence to D.P. Sandler, Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 TW Alexander Dr., Research Triangle Park, NC 27709-2233 USA. Telephone: 919-541-4668. Email: Dale.Sandler@nih.gov Supplemental Material ...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years
Conclusions: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose–response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314 Received: 02 November 2016 Revised: 23 May 2017 Accepted: 19 June 2017 Published: 15 September 2017 Address correspondence to C. Philippat, Institut for Advanced Biosciences, Site Santé – Allée des Alpes, 38700 La Tronche, France. Phone: +33 4...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Adipogenic Effects and Gene Expression Profiling of Firemaster ® 550 Components in Human Primary Preadipocytes
Conclusions: We found that FM550, and two of its components, induced adipogenesis in human primary preadipocytes. Further, using global gene expression analysis we showed that both TPP and IPTP likely exert their effects through PPARG to induce adipogenesis. In addition, IPTP perturbed signaling pathways that were not affected by TPP. https://doi.org/10.1289/EHP1318 Received: 02 November 2016 Revised: 18 May 2017 Accepted: 23 May 2017 Published: 14 September 2017 Address correspondence to E. Atlas, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Changes in Transportation-Related Air Pollution Exposures by Race-Ethnicity and Socioeconomic Status: Outdoor Nitrogen Dioxide in the United States in 2000 and 2010
Conclusions: Findings suggest that absolute NO2 exposure disparities by race-ethnicity decreased from 2000 to 2010, but relative NO2 exposure disparities persisted, with higher NO2 concentrations for nonwhites than whites in 2010. https://doi.org/10.1289/EHP959 Received: 15 August 2016 Revised: 07 June 2017 Accepted: 09 June 2017 Published: 14 September 2017 Please address correspondence to J.D. Marshall, Dept. of Civil, Environmental, and Geo-Engineering, University of Washington, 201 More Hall, Seattle, WA 98195 USA. Telephone: (206) 685-2591. Email: jdmarsh@uw.edu Supplemental Material is available online (https:/...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Randomized Trial of Interventions to Improve Childhood Asthma in Homes with Wood-burning Stoves
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Children ’s Lead Exposure: A Multimedia Modeling Analysis to Guide Public Health Decision-Making
Conclusions: This methodology advances scientific understanding of the relationship between lead concentrations in drinking water and BLLs in children. It can guide national health-based benchmarks for lead and related community public health decisions. https://doi.org/10.1289/EHP1605 Received: 12 January 2017 Revised: 09 May 2017 Accepted: 18 May 2017 Published: 12 September 2017 Address correspondence to V. Zartarian, 5 Post Office Square, Suite 100, MC ORA 01-3, Boston, MA 02109-3912 USA. Telephone: (617) 918-1541. Email: zartarian.valerie@epa.gov Supplemental Material is available online (https://doi.org/10.1289/...
Source: EHP Research - September 12, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Scientific Challenges in the Risk Assessment of Food Contact Materials
Conclusion: We think that exposures to hazardous substances migrating from FCAs require more attention. We recommend a) limiting the number and types of chemicals authorized for manufacture and b) developing novel approaches for assessing the safety of chemicals in FCAs, including unidentified chemicals that form during or after production. https://doi.org/10.1289/EHP644 Received: 10 June 2016 Revised: 08 June 2017 Accepted: 09 June 2017 Published: 11 September 2017 Address correspondence to J. Muncke, Food Packaging Forum, Staffelstrasse 8, 8045 Zurich, Switzerland. Telephone: 41-44-5155255. Email: jane.muncke@fp-fo...
Source: EHP Research - September 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Early-Life Phthalate Exposure and Adiposity at 8 Years of Age
Conclusion: In this cohort, we did not find evidence of an obesogenic effect of prenatal phthalate exposure. Positive associations between postnatal MEP and ∑DEHP concentrations depended on the timing of exposure. https://doi.org/10.1289/EHP1022 Received: 29 August 2016 Revised: 17 February 2017 Accepted: 28 February 2017 Published: 11 September 2017 Address Correspondence to J.R. Shoaff, Brown University School of Public Health, Box G-S121-2, Providence, RI 02912 USA. Email: jessica_shoaff@brown.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1022). The authors declare they have no actu...
Source: EHP Research - September 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder
This study focuses on exposures during the index period, defined as the 3 mo before conception, and during pregnancy. The date of conception was calculated by subtracting gestational age (reported by mothers) from the child’s date of birth. Maternal FA intake. Maternal intake of FA and other nutrients was determined using data collected through telephone interviews on intake of multivitamins, prenatal vitamins, nutrient-specific vitamins, cereals, and other fortified foods or supplements (i.e., breakfast shakes and protein bars), for each month of the index period as described previously (Schmidt et al. 2012, 2014)....
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study
Conclusion: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. https://doi.org/10.1289/EHP1015 Received: 25 August 2016 Revised: 12 January 2017 Accepted: 26 January 2017 Published: 08 September 2017 Address correspondence to C. Vernet, Institute for Advanced Biosciences (IAB), Centre de Recherche INSERM&n...
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population
Author Affiliations open 1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA 2Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA 3Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA 4Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA PDF Version (188 KB) Abstract About This Article Supplemental Material Background: Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin ...
Source: EHP Research - September 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Road, Railway, and Aircraft Noise and Arterial Stiffness in the SAPALDIA Study: Annual Average Noise Levels and Temporal Noise Characteristics
Conclusions: Long-term exposure to railway noise, particularly in an intermittent nighttime noise environment, and to nighttime noise events, mainly related to road noise, may affect arterial stiffness, a major determinant of cardiovascular disease. Ascertaining noise exposure characteristics beyond average noise levels may be relevant to better understand noise-related health effects. https://doi.org/10.1289/EHP1136 Received: 23 September 2016 Revised: 20 March 2017 Accepted: 31 March 2017 Published: 07 September 2017 Address correspondence to M. Foraster, Swiss Tropical and Public Health Institute, Dept. of Epidemi...
Source: EHP Research - September 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Estimated Changes in Life Expectancy and Adult Mortality Resulting from Declining PM2.5 Exposures in the Contiguous United States: 1980 –2010
Conclusions: Our estimates suggest that declines in PM2.5 exposures between 1980 and 2010 have benefitted public health. https://doi.org/10.1289/EHP507 Received: 13 May 2016 Revised: 19 June 2017 Accepted: 20 June 2017 Published: 06 September 2017 Address correspondence to N. Fann, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr., Mail drop C539-07; RTP, NC 27711 USA. Phone: (919) 541-0209. Email: Fann.neal@epa.gov Supplemental Material is available online (https://doi.org/10.1289/EHP507). The authors declare they have no actual or potential competing financial interests. The views in this manuscript are ...
Source: EHP Research - September 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Insecticide Use and Breast Cancer Risk among Farmers ’ Wives in the Agricultural Health Study
Conclusion: Use of several organophosphate insecticides was associated with elevated breast cancer risk. However, associations for the women’s and husbands’ use of these insecticides showed limited concordance. Ongoing cohort follow-up may help clarify the relationship, if any, between individual insecticide exposures and breast cancer risk. https://doi.org/10.1289/EHP1295 Received: 28 October 2016 Revised: 25 April 2017 Accepted: 08 May 2017 Published: 06 September 2017 Address correspondence to L. Engel, Dept. of Epidemiology, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435 USA. Telep...
Source: EHP Research - September 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Application of Adverse Outcome Pathways to U.S. EPA ’s Endocrine Disruptor Screening Program
Conclusions: A variety of biological systems affect apical end points used in regulatory risk assessments, and without mechanistic data, an endocrine mode of action cannot be determined. Because the EDSP was designed to consider mode of action, toxicity pathway and AOP concepts are a natural fit. Pathway frameworks have diverse applications to endocrine screening and testing. An estrogen pathway example is presented, and similar approaches are being used to evaluate alternative methods and develop predictive models for androgen and thyroid pathways. https://doi.org/10.1289/EHP1304 Received: 31 October 2016 Revised: 13 ...
Source: EHP Research - September 1, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice
Conclusions: These data demonstrate the critical role of neural AR in courtship vocalizations and raises the possibility that the vulnerability of this signaling pathway to exposure to endocrine disrupters may be detrimental for courtship communication and mating in several species. https://doi.org/10.1289/EHP1443 Received: 01 December 2016 Revised: 08 June 2017 Accepted: 09 June 2017 Published: 01 September 2017 Address correspondence to S. Mhaouty-Kodja, INSERM U1130, CNRS UMR 8246, Université P. & M. Curie, 7 quai St Bernard, Bât A 3ème étage 75005, Paris, France. Phone: +331 44 27 9...
Source: EHP Research - September 1, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Conclusions: Our results provide suggestive evidence of the potential for environmental exposure to phthalates and/or BPA to disrupt circulating vitamin D levels in pregnancy. https://doi.org/10.1289/EHP1178 Received: 03 October 2016 Revised: 10 May 2017 Accepted: 12 May 2017 Published: 31 August 2017 Address correspondence to J.D. Meeker, Dept. of Environmental Health Sciences, University of Michigan School of Public Health, 1835 SPH I, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029 USA. Telephone: (734) 764-7184. Email: meekerj@umich.edu Supplemental Material is available online (https://doi.org/10.1289/EH...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study
We examined the influence of transportation noise exposure over a 5-y period (1994–1998) on incident diabetes cases in a population-based prospective cohort study (n=380,738) of metropolitan Vancouver (BC) residents who were 45–85 y old, with 4-y of follow-up (1999–2002). Annual average transportation noise (Lden), air pollution [black carbon, particulate matter with aerodynamic diameter 10% of the population was of South Asian ethnicity, and nearly one-half of the sample lived in neighborhoods where>10% of the population was of Chinese ethnicity. All covariates were significantly associated with all o...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology
Conclusions: Our findings indicate that the transformation of the field of toxicology is partly implemented, but significant barriers to acceptance and adoption remain. https://doi.org/10.1289/EHP1435 Received: 29 November 2016 Revised: 15 June 2017 Accepted: 17 June 2017 Published: 30 August 2017 Address correspondence to P. Allard, Institute for Society and Genetics, 3360 Life Science Building, University of California, Los Angeles, Los Angeles, CA 90095 USA. Telephone: (310) 825-5257. Email: pallard@ucla.edu Supplemental Material is available online (https://doi.org/10.1289/EHP1435). The authors declare they have ...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case –Control Study in California
Conclusions: Contrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079 Received: 09 September 2016 Revised: 18 May 2017 Accepted: 25 May 2017 Published: 30 August 2017 Address correspondence to K. Lyall, 3200 Market St., Suite 560, A.J. Drexel Autism Institute, Philadelphia, PA 19104 USA. Telephone: (215) 571-3215. Email: kld98@drexel.edu Supplemental Material is available online (https://doi.org/10...
Source: EHP Research - August 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood
Conclusions: Prenatal mercury exposure was associated with lower %-5hmC genomic content and a corresponding increase in the ratio of %-5mC to %-5hmC in cord blood. This association was persistent in early but not midchildhood blood. Our results demonstrate the potential malleability of epigenetic modifications associated with mercury exposure in utero. https://doi.org/10.1289/EHP1467 Received: 06 December 2016 Revised: 04 May 2017 Accepted: 19 May 2017 Published: 29 August 2017 Address correspondence to A. Cardenas, Dept. of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Pa...
Source: EHP Research - August 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Value of Traditional Ecological Knowledge for the Environmental Health Sciences and Biomedical Research
Conclusions: This article provides recommendations for researchers and federal funders to ensure respect for the contributions of TEK to research and to ensure equity and self-determination for Tribal nations who participate in research. https://doi.org/10.1289/EHP858 Received: 22 July 2016 Revised: 10 April 2017 Accepted: 27 April 2017 Published: 29 August 2017 Address correspondence to S. Finn, National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Population Health Branch, 530 Davis Drive, Durham, NC 27713 USA. Telephone: 919-541-4258. Email: finns@niehs.nih.gov The auth...
Source: EHP Research - August 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Updated Global Estimates of Respiratory Mortality in Adults ≥ 30 Years of Age Attributable to Long-Term Ozone Exposure
Conclusions: These findings suggest that the potential magnitude of health benefits of air quality policies targeting O3, health co-benefits of climate mitigation policies, and health implications of climate change-driven changes in O3 concentrations, are larger than previously thought. https://doi.org/10.1289/EHP1390 Received: 17 November 2016 Revised: 19 June 2017 Accepted: 20 June 2017 Published: 28 August 2017 Address correspondence to C.S. Malley, Stockholm Environment Institute, Environment Dept., Environment Building, Wentworth Way, University of York, York, YO10 5NG, UK. Telephone: 44 1904 323685. Email: chri...
Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Arsenic and Obesity: A Comparison of Urine Dilution Adjustment Methods
Conclusions: Our findings suggest that arsenic exposure is not associated with obesity, and that urinary creatinine and osmolality may be colliders on the causal pathway from arsenic exposure to obesity, as common descendants of hydration and body composition. In studies of urinary biomarkers and obesity or obesity-related outcomes, alternative metrics such as urinary flow rate or analytic strategies such as covariate-adjusted standardization should be considered. https://doi.org/10.1289/EHP1202 Received: 07 October 2016 Revised: 21 March 2017 Accepted: 30 March 2017 Published: 28 August 2017 Address correspondence t...
Source: EHP Research - August 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study
Author Affiliations open 1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China 2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA 3Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA 4Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA 5Department of Biostatistics, Harvard T.H. Chan School of Public Hea...
Source: EHP Research - August 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research