A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China
This study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW. Methods: This case-control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012-2014. Tl concentrations were measured in maternal urine collected at delivery and associations with LBW were evaluated using conditional logistic regression. Results: Higher maternal urinary Tl levels were significantly associated with increased risk of LBW (crude OR = 1.52; 95% CI: 1.00, 2.30 for the highest versus lowest tertile), and the association was simila...
Source: EHP Research - May 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)
Conclusion: Results of our simulations suggest that a substantial proportion of the association between prenatal PFAS and birth weight may be attributable to confounding by GFR and that confounding by GFR may be more important in studies with sample collection later in pregnancy. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation,...
Source: EHP Research - May 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Folic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial
Conclusions: In this mixed folate deficient/replete study population, 12 and 24 week treatment with 800µg (but not 400µg) FA lowered bAs to a greater extent than placebo; this was sustained 12 weeks after FA cessation. In future studies, we will evaluate whether FA and/or creatine altered As methylation profiles. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics
Author Affiliations open Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island, USA PDF Version (1.7 MB) Abstract About This Article Article-Level Metrics Article-Level Metrics Background: Carcinogenic hexavalent chromium [Cr(VI)] requires cellular reduction for DNA damage. Cr(VI) metabolism by its principal reducer ascorbate (Asc) lacks Cr(V) intermediate, which is abundant in reactions with a minor reducer glutathione. Cultured cells are widely used in mechanistic studies of Cr(VI) toxicity; however, they typically contain
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

The NIEHS Superfund Research Program: Twenty-Five Years of Translational Research for Public Health
Conclusion: SRP must continue to address the legacy of hazardous waste in the United States, respond to new issues caused by rapid advances in technology, and train the next generation of leaders in environmental health science, while recognizing that most of the world’s worst toxic hotspots are now located in low- and middle-income countries. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version a...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary Source Type: research

A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways
Conclusions: The incorporation of exposure and ADME properties into the conceptual workflow eliminated 10 “low priority” chemicals that may otherwise have undergone additional, resource-consuming analyses. Our workflow also increased confidence in interpretation of in vitro results by identifying possible “false negatives.” This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as ...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Global Association of Cold Spells and Adverse Health Effects: A Systematic Review and Meta-Analysis
Conclusions: Cold spells are associated with increased mortality rates in populations around the world. The body of evidence suggests that cold spells also have other adverse health effects. There was substantial heterogeneity among the studies, and the results must be interpreted with caution. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used i...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States
Conclusions: To our knowledge, this is the first study to examine the relationship between long-term exposure to PM2.5 and time to the first hospitalization for the most common neurodegenerative diseases. We found strong evidence of an association for all three outcomes. Our findings provide the basis for more studies, as the implications to public health can be crucial. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited a...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Ambient Air Pollution and Newborn Size and Adiposity at Birth: Differences by Maternal Ethnicity (the Born in Bradford Study Cohort)
Author Affiliations open 1Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 2CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 3Universitat Pompeu Fabra, Barcelona, Spain; 4Department of Epidemiology and Public Health, Swiss Tropical & Public Health Institute, Basel, Switzerland; 5University of Basel, Basel, Switzerland; 6National Institute of Health and Medical Research (INSERM), U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, Grenoble, France; 7Institute for Risk Asse...
Source: EHP Research - May 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Social Science Collaboration with Environmental Health
Conclusions: A transdisciplinary approach for environmental health practice has emerged that engages the social sciences to paint a full picture of the consequences of contamination so that policy makers, regulators, public health officials, and other stakeholders can better ameliorate impacts and prevent future exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. T...
Source: EHP Research - May 12, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary Source Type: research

Brominated Flame Retardants and Other Persistent Organohalogenated Compounds in Relation to Timing of Puberty in a Longitudinal Study of Girls
Conclusions: This first longitudinal study of puberty in girls with serum POPs measurements (to our knowledge) reveals a delay in onset with higher concentrations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Windham GC, Pinney...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Prospective Study of Ambient Particulate Matter Exposure and Risk of Pulmonary Embolism in the Nurses’ Health Study Cohort
Conclusions: We provide evidence that PM in the prior 1 and 12 months is associated with PE risk. Our results also suggest that women with underlying health conditions may be more susceptible to PE after PM exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the p...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model
Conclusions: Our results indicate that the syncytiotrophoblast is the key player in regulating nanoparticle transport across the human placenta. The main mechanism underlying this translocation is not based on passive diffusion, but is likely to involve an active, energy-dependent transport pathway. These findings will be important for reproductive toxicology as well as for pharmaceutical engineering of new drug carriers. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. ...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Evaluation of an Elementary School–based Educational Intervention for Reducing Arsenic Exposure in Bangladesh
This study estimates associations between a school-based intervention and various outcome measures of As mitigation. Methods: We recruited 840 children from 14 elementary schools in Araihazar, Bangladesh. Teachers from 7 schools were trained on an As education curriculum, whereas the remaining seven schools without any training formed the control group. Surveys, knowledge tests and well-water testing were conducted on 773 children both at baseline and post-intervention follow-up. Urine samples were collected from 210 children from four intervention schools and the same number of children from four control schools. One low As (
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Biased Exposure–Health Effect Estimates from Selection in Cohort Studies: Are Environmental Studies at Particular Risk?
Conclusions: Careful attention to the underlying structure of the observed data is critical to identifying potential biases and methods to mitigate them. Understanding factors that influence initial study participation and study loss to follow-up is critical. Recruitment of population-based samples, and enrolling participants at a younger age, before the potential onset of exposure-related health effects, can help reduce these potential pitfalls. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number ...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making
Conclusions: We agreed to carry out the complete read-across exercise for at least one chemical category per read-across scenario in the context of SEURAT-1 and the results of this exercise will be completed and presented by the end of the research initiative in December 2015. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, yo...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach
Conclusions: Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation:...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Association of Supply Type with Fecal Contamination of Source Water and Household Stored Drinking Water in Developing Countries: A Bivariate Meta-analysis
Author Affiliations open 1The Water Institute, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA; 2UNICEF, New York, New York, USA; 3Geography and Environment, University of Southampton, Southampton, United Kingdom PDF Version (899 KB) Abstract About This Article Supplemental Material Article-Level Metrics Background: Access to safe drinking water is essential for health. Monitoring access to drinking water focuses on water supply type at the source, but there is limited evidence on whether quality differences at the source persist in water stored i...
Source: EHP Research - May 8, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Dietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers
Conclusions: Short-term exposure to CAP induced vascular endothelial dysfunction. OO supplementation attenuated CAP-induced reduction of FMD and changes in blood markers associated with vasoconstriction and fibrinolysis, suggesting that OO supplementation may be an efficacious intervention to protect against vascular effects of exposure to PM. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Temporal Variation in Heat–Mortality Associations: A Multicountry Study
Conclusions: We estimated a statistically significant decrease in the RR for heat-related mortality in 2006 compared to 1993 in the majority of countries included in the analysis. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Ga...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc
Conclusions: Low-dose BPA exerted c-Myc-dependent genotoxic and mitogenic effects on ERα-negative mammary cells. These findings provide significant evidence of adverse effects of low-dose BPA on mammary cells. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the pu...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Chemical Footprinting: Identifying Hidden Liabilities in Manufacturing Consumer Products
Lindsey Konkel is a Worcester, MA–based journalist who reports on science, health, and the environment. Background image: © Roy Scott About This Article open Citation: Konkel L. 2015. Chemical footprinting: identifying hidden liabilities in manufacturing consumer products. Environ Health Perspect 123:A130–A133; http://dx.doi.org/10.1289/ehp.123-A130 News Topics: Economics, Green Chemistry, Industry Issues, Trade and Commerce Published: 1 May 2015 PDF Version (3.7 MB) Hidden liabilities arise when companies don’t know or don’t disclose the chemicals in their products and supply...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence Economics Green Chemistry Industry Issues May 2015 Trade and Commerce Source Type: research

More than Cosmetic Changes: Taking Stock of Personal Care Product Safety
Joe Greco, principal scientist in beauty care product development for Johnson & Johnson, works on reformulating an acne gel cleanser. Johnson & Johnson is one of several companies investing considerable resources to remove specific chemicals from their products.© Rebecca Kessler An infographic prepared by the PCPC lays out the order of events and estimated timeframe for reformulating products.© Personal Care Products Council In 2013 Johnson & Johnson completed reformulation of about 100 baby products, a process that involved approximately 1,500 prototypes. Some ...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Allergies and Policy Chemical Sensitivities Chemical Testing Children's Health Endocrine Disruptors Health Disparities Industry Issues Laws May 2015 Organic Farming and Products Personal Care Products Regu Source Type: research

Air Pollution and Diabetes Risk: Assessing the Evidence to Date
Wendee Nicole was awarded the inaugural Mongabay Prize for Environmental Reporting in 2013. She writes for Discover, Scientific American, National Wildlife, and other magazines. About This Article open Citation: Nicole W. 2015. Air pollution and diabetes risk: assessing the evidence to date. Environ Health Perspect 123:A134; http://dx.doi.org/10.1289/ehp.123-A134 News Topics: Air Pollution, Endocrine Health, Endocrine Disruptors, Inflammation, Ozone, Particulate Matter (PM) Published: 1 May 2015 PDF Version (861 KB) Related EHP Article Association Between Ambient Air Pollution and Diabetes Mellitus in Europe and Nort...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Air Pollution Endocrine Disruptors Endocrine Health Inflammation May 2015 Ozone Particulate Matter (PM) Source Type: research

Tracking Organophosphates: New Method for Assessing Long-Term Dietary Exposures
Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2015. Tracking organophosphates: new method for assessing long-term dietary exposures. Environ Health Perspect 123:A135; http://dx.doi.org/10.1289/ehp.123-A135 News Topics: Exposure Science, Food Safety and Regulation, Metabolism, Organic Farming and Products, Organophosphate (OPs), Pesticides, Surveillance and Monitoring Published: 1 May 2015 PDF Version (670 KB) Related EHP Article Estimating Pesticide Exposure From Dietary Intake and Organic Food ...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Exposure Science Food Safety and Regulation May 2015 Metabolism Organic Farming and Products Organophosphates (OPs) Pesticides Surveillance and Monitoring Source Type: research

Profiles in Cytotoxicity: A First Step Toward Chemical-Specific Adjustment Factors
This study accomplished its primary goal of confirming that in vitro cytotoxicity testing can be used to gather information on the range of interindividual differences in response to toxicants. In addition, the data recently proved useful in supporting computer-based toxicity predictions based on chemical structures and an individual’s genetic makeup.9 “We really are trying to provide the science to inform decisions and to get away from default assumptions that one size fits all for interspecies and interindividual variability,” says Rusyn. “Understanding the range of interindividual variability is ...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Chemical Testing High-Throughput Screening May 2015 Molecular Biology Research Issues and Initiatives Risk Assessment Source Type: research

Arsenic Exposure in Infancy: Estimating the Contributions of Well Water and Human Milk
Charles W. Schmidt, MS, an award-winning science writer from Portland, ME, has written for Discover Magazine, Science, and Nature Medicine. About This Article open Citation: Schmidt CW. 2015. Arsenic exposure in infancy: estimating the contributions of well water and human milk. Environ Health Perspect 123:A137; http://dx.doi.org/10.1289/ehp.123-A137 News Topics: Arsenic, Children’s Health, Diet and Nutrition, Drinking Water Quality, Food Safety and Regulation Published: 1 May 2015 PDF Version (306 KB) Related EHP Article Estimated Exposure to Arsenic in Breastfed and Formula-Fed Infants in a United State...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Arsenic Children's Health Diet and Nutrition Drinking Water Quality Food Safety and Regulation May 2015 Source Type: research

Editor’s Note
About This Article open Published: 1 May 2015 PDF Version (55 KB) In the February 2014 issue of Environmental Health Perspectives, Albanito et al. retracted their article “G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells” because they discovered that errors were introduced during the sorting of files related to the presentation of the Western blots in Figures 6 and 8 [Environ Health Perspect 122:A42 (2014); doi:10.1289/ehp.11297RET]. There was no evidence that the errors that led to the retraction were ...
Source: EHP Research - May 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Editorial May 2015 Source Type: research

Differences in Birth Weight Associated with the 2008 Beijing Olympic Air Pollution Reduction: Results from a Natural Experiment
Author Affiliations open 1Department of Public Health Sciences, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA; 2Department of Maternal and Child Health, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; 3Department of Environmental Pollution and Health, Chinese Research Academy of Environmental Health Sciences, Beijing, China; 4Department of Biostatistics and Computational Biology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA; 5Department of Pediatrics, University of Rochester, S...
Source: EHP Research - April 28, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Interweaving Knowledge Resources to Address Complex Environmental Health Challenges
Conclusions: By providing structure for interweaving science with its stakeholders, we are better able to leverage resources, increase potential for innovation, and proactively ensure a more fully developed spectrum of beneficial outcomes of research investments. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able...
Source: EHP Research - April 24, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary Source Type: research

Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother–Child Cohort (Crete, Greece)
Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantako...
Source: EHP Research - April 24, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Exposure to Elemental Carbon, Organic Carbon, Nitrate, and Sulfate Fractions of Fine Particulate Matter and Risk of Preterm Birth in New Jersey, Ohio, and Pennsylvania (2000–2005)
Conclusion: EC and SO4 may contribute to associations between PM2.5 and PTB. Associations varied according to the timing of exposure and the timing of PTB. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Rappazzo KM, Daniels JL, M...
Source: EHP Research - April 24, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Satellite-Based Estimates of Long-Term Exposure to Fine Particles and Association with Mortality in Elderly Hong Kong Residents
Author Affiliations open 1School of Public Health, The University of Hong Kong, Hong Kong; 2School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; 3Nuffield Department of Population Health, University of Oxford, United Kingdom; 4School of Nursing, The Hong Kong Polytechnic University, Hong Kong; 5Division of Environment, Hong Kong University of Science and Technology, Hong Kong; 6Department of Health, the Government of Hong Kong, Hong Kong PDF Version (1.3 MB) Abstract About This Article Supplemental Material Article-Level Metrics Backg...
Source: EHP Research - April 24, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides
Conclusions: Phycobiliprotein complexes in M. aeruginosa have been identified as the relevant sensitizing proteins. Our finding that allergenicity is inhibited in a dose-dependent manner by microcystin toxin suggests that further investigation is warranted to understand the interplay between immunogenicity and toxicity of cyanobacteria under diverse environmental conditions. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedit...
Source: EHP Research - April 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Manganese Exposure and Neurocognitive Outcomes in Rural School-Age Children: The Communities Actively Researching Exposure Study (Ohio, USA)
Conclusions: Both low and high Mn concentrations in blood and hair were negatively associated with child IQ scores. Serum cotinine was negatively associated with child cognitive function. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation:...
Source: EHP Research - April 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA
Conclusions: These findings suggest maternal PBDE exposure, particularly BDE-28 and -47, are associated with maternal concentrations of T4 and T3 during pregnancy. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Vuong AM, Webster ...
Source: EHP Research - April 17, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis
Conclusion: We found consistent evidence of a relationship between NO2 and NOx, as proxies for traffic sourced air pollution exposure, with lung cancer. Studies of lung cancer related to residential proximity to roadways also suggest increased risk, which may be due in part to air pollution exposure. The International Agency for Research on Cancer recently classified outdoor air pollution and particulate matter as carcinogenic (Group 1). These meta-analyses support this conclusion, drawing particular attention to traffic sourced air pollution. This EHP Advance Publication article has been peer-reviewed, revised, and acce...
Source: EHP Research - April 14, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Ambient Coarse Particulate Matter and Hospital Admissions in the Medicare Cohort Air Pollution Study, 1999-2010
Conclusions: We found statistically significant evidence that daily variation in PM10-2.5 is associated with emergency hospitalizations for cardiovascular diseases amongst Medicare enrollees aged 65 years and above. This association was robust to adjustment for concentrations of PM2.5. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the cit...
Source: EHP Research - April 14, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice
Conclusions: Pb and HFD produce selective deficits in bone accrual that are associated with alterations in progenitor cell activity that may involve reduced Wnt signaling. This study emphasizes the need to assess toxicants together with other risk factors relevant to human health and disease. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in ...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities
Conclusions: This article demonstrates growing use of NHANES chemical biomarker data in studies that can impact risk assessments. Best practices for analysis and interpretation must be defined and adopted to allow the full potential of the NHANES to be realized. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able ...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Effect of Organic Diet Intervention on Pesticide Exposures in Young Children Living in Low-Income Urban and Agricultural Communities
Author Affiliations open 1Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA; 2Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, College Park, Maryland, USA; 3Emory University, Rollins School of Public Health, Atlanta, Georgia, USA. *These authors share lead authorship. PDF Version (605 KB) Abstract About This Article Supplemental Material Article-Level Metrics Background: Recent organic diet intervention studies suggest that diet is a signi...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

An Assessment of Participatory Integrated Vector Management for Malaria Control in Kenya
Author Affiliations open 1International Centre of Insect Physiology and Ecology, Nairobi, Kenya; 2University of Pretoria Centre for Sustainable Malaria Control, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa; 3Kenya Medical Research Institute – Wellcome Trust Research Programme, Kilifi, Kenya; 4School of Biological and Life Sciences, Technical University of Kenya, Nairobi, Kenya; 5School of Public Health, KU Leuven, Leuven, Belgium; 6The Presbyterian University of East Africa, Nairobi, Kenya; 7School of Biological Sciences, University of Nairo...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Identification and Prioritization of Relationships between Environmental Stressors and Adverse Human Health Impacts
Conclusions: Due to the computational efficiency of the FIM method, all chemicals and health effects can be considered in a single analysis. The resulting list provides a comprehensive summary of the chemical/health co-occurrences from NHANES that are higher than expected by chance. This information enables ranking and prioritization on chemicals or health effects of interest for evaluation of published results and design of future studies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assign...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Estrogen-Deficient Female Mice
Conclusions: Our findings suggest that estrogen deficiency plays an important role in arsenic-altered glucose metabolism/homeostasis in females. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Huang CF, Yang CY, Chan DC, Wang CC, ...
Source: EHP Research - April 10, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Predictors of Indoor Radon Concentrations in Pennsylvania, 1989–2013
Author Affiliations open 1Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 2Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 3Center for Health Research, Geisinger Health System, Danville, Pennsylvania, USA; 4Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 5Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA PDF Version (2.4 MB) Abstract About This Article Supplementa...
Source: EHP Research - April 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Extreme Precipitation and Emergency Room Visits for Gastrointestinal Illness in Areas with and without Combined Sewer Systems: An Analysis of Massachusetts Data, 2003–2007
Conclusions: Rate of ER visits for GI illness was associated with extreme precipitation in the area with CSO discharges to a drinking water source. Our findings suggest an increased risk for gastrointestinal illness among consumers whose drinking water source may be impacted by CSOs after extreme precipitation. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the ...
Source: EHP Research - April 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Prenatal Phthalate Exposure and Childhood Growth and Blood Pressure: Evidence from the Spanish INMA-Sabadell Birth Cohort Study
Conclusions: This study suggests that prenatal phthalate exposure may be associated with postnatal growth and blood pressure in a sex-specific manner. Inconsistencies with previous cross-sectional findings highlight the necessity for evaluating phthalate health effects in prospective studies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in ...
Source: EHP Research - April 7, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Using Satellite-Based Spatiotemporal Resolved Air Temperature Exposure to Study the Association between Ambient Air Temperature and Birth Outcomes in Massachusetts
Author Affiliations open 1Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel; 2Department of Environmental Health – Exposure, Epidemiology and Risk Program, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA PDF Version (1.8 MB) Abstract About This Article Article-Level Metrics Article-Level Metrics Background: Studies looking at air temperature (Ta) and birth outcomes are rare. Methods: We evaluated birth outc...
Source: EHP Research - April 7, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Transdermal Uptake of Diethyl Phthalate and Di(n-butyl) Phthalate Directly from Air: Experimental Verification
Conclusions: This study shows that dermal uptake directly from air can be a meaningful exposure pathway for DEP and DnBP. For other semivolatile organic compounds (SVOCs) whose molecular weight and Kow are in the appropriate range, direct absorption from air is also anticipated to be significant. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used...
Source: EHP Research - April 7, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Spatial Variation and Land Use Regression Modeling of the Oxidative Potential of Fine Particles
Conclusion: LUR models explained a large fraction of the spatial variation of the two OP metrics. The moderate correlations among the predictions of OPDTT, OPESR, and PM2.5 models offer the potential to investigate which metric is the strongest predictor of health effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you wi...
Source: EHP Research - April 3, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research