Associations of Cognitive Function Scores with Carbon Dioxide, Ventilation, and Volatile Organic Compound Exposures in Office Workers: A Controlled Exposure Study of Green and Conventional Office Environments
Author Affiliations open 1Exposure, Epidemiology & Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 2Psychiatry and Behavioral Sciences, SUNY-Upstate Medical School, Syracuse, New York, USA; 3Industrial Assessment Center, Center of Excellence, Syracuse University, Syracuse, New York, USA PDF Version (802 KB) Abstract About This Article Background: The indoor built environment plays a critical role in our overall well-being, both due to the amount of time we spend indoors (~90%) and the ability of buildings to positiv...
Source: EHP Research - October 26, 2015 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-Term Self-Renewal of Murine Hematopoietic Stem Cells
Conclusions: Our findings indicate that AHR activation by TCDD in the fetus during pregnancy leads to impairment of long-term self-renewal of hematopoietic stem cells. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. ...
Source: EHP Research - October 23, 2015 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Perfluoroalkyl Acids in Maternal Serum and Indices of Fetal Growth: The Aarhus Birth Cohort
Conclusions: Overall, we did not find strong or consistent associations between PFAAs and birth weight or other indices of fetal growth, though estimated mean birth weights were lower among those with exposures above the lowest quartile for some compounds. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the ci...
Source: EHP Research - October 23, 2015 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Developmental Effects of the ToxCast™ Phase I and II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits
Conclusions: Here we present an assay that quantitatively and reliably describes the effects of chemical toxicants on C. elegans growth and development. We found significant overlap in the activity of chemicals in the ToxCast™ libraries between C. elegans and zebrafish developmental screens. Incorporating C. elegans toxicological assays as part of a battery of in vitro and in vivo assays provides additional information for the development of models predicting a chemical’s potential toxicity to humans. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publica...
Source: EHP Research - October 23, 2015 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California
Conclusions: These results suggest that environmental perchlorate exposures may impact thyroid hormone production during pregnancy. This could have implications for public health given widespread perchlorate exposure and the importance of thyroid hormone in fetal neurodevelopment. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number use...
Source: EHP Research - October 20, 2015 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Air Pollution and Preterm Birth in the U.S. State of Georgia (2002–2006): Associations with Concentrations of 11 Ambient Air Pollutants Estimated by Combining Community Multiscale Air Quality Model (CMAQ) Simulations with Stationary Monitor Measurements
Author Affiliations open 1Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 2Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 3Department of Physics, University of Nevada-Reno, Reno, Nevada, USA; 4School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA; 5Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA PDF Version (2.1 MB) Abstract About This Article Supplemental M...
Source: EHP Research - October 20, 2015 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure
Conclusions: These findings show the utility of HCI data for reconstructing cell state trajectories, and provide insight into adaptation and resilience of in vitro cellular systems based on tipping points. Cellular tipping points could be used to define a point of departure for risk-based prioritization of environmental chemicals. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as ...
Source: EHP Research - October 16, 2015 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Fine-Scale Exposure to Allergenic Pollen in the Urban Environment: Evaluation of Land Use Regression Approach
Conclusions: LUR approach provides new opportunities to estimate the relations between environmental determinants and allergenic pollen concentration in human-modified environments at fine spatial scales. The presented approach could potentially be applied to estimate retrospectively pollen concentrations to be used for long-term exposure assessments. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version...
Source: EHP Research - October 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Cross-Sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001-2002
Conclusions: POPs with high TEFs and AhR affinity were associated with longer LTL. Because many dioxin-associated cancers are also associated with longer LTL, these results may provide insight into the mechanisms underlying PCB and dioxin-related carcinogenesis. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able ...
Source: EHP Research - October 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Pediatric Emergency Visits and Short-Term Changes in PM2.5 Concentrations in the U.S. State of Georgia
Conclusion: Pediatric ED visits for asthma or wheeze and for upper respiratory infections were associated with PM2.5 concentrations in Georgia. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Strickland MJ, Hao H, Hu X, Chang HH, ...
Source: EHP Research - October 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Effect of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice
Conclusions: Acetaminophen, at supratherapeutic levels, induced oxidative stress throughout the respiratory tract and appeared to potentiate some responses to environmentally relevant ETS exposure in female C57Bl/6J mice. These results highlight the potential for this widely used drug to modulate the responsiveness to oxidant air pollutants. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon a...
Source: EHP Research - October 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort
Conclusions: This study provides preliminary evidence of an increased risk of lung adenocarcinoma among daily drivers of diesel tractors and suggests that exposure to endotoxins may modify the impact of diesel exposure on lung cancer risk. Confirmation of these findings with more exposed cases and more detailed exposure information is warranted. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as so...
Source: EHP Research - October 9, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

A Curated Database of Rodent Uterotrophic Bioactivity
Conclusions: This uterotrophic database provides a valuable resource for understanding in vivo outcome variability and for evaluating performance of in vitro assays that measure estrogenic activity. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process...
Source: EHP Research - October 2, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

A Curated Database of Rodent Uterotrophic Bioactivity
Conclusions: This uterotrophic database provides a valuable resource for understanding in vivo outcome variability and for evaluating performance of in vitro assays that measure estrogenic activity. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process...
Source: EHP Research - October 2, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

In Memoriam: Louis J. Guillette, Jr.
About This Article open Citation: Helbing CC, Tyler CR, Iguchi T. 2015. In memoriam: Louis J. Guillette, Jr. Environ Health Perspect 123:A250; http://dx.doi.org/10.1289/ehp.1510674. Final Publication: 1 October 2015 PDF Version (307 KB) Louis J. Guillette, Jr., 1954–2015 Louis (Lou) J. Guillette, Jr., one of the most influential research scientists in the field of environmental health, died 6 August 2015 at the age of 60. Lou had been battling non-Hodgkin’s lymphoma for almost a decade, but his passing, caused by bacterial pneumonia, came as a shock to everyone who knew him. He was an extremely energ...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: In Memoriam October 2015 Source Type: research

Comment on “Using Satellite-Based Spatiotemporal Resolved Air Temperature Exposure to Study the Association between Ambient Air Temperature and Birth Outcomes in Massachusetts”
This study considered daily maximum temperatures during heat waves (defined in Madrid during 2001–2009 as daily maximum temperatures above 34°C) and during cold waves (defined in Madrid during 2001–2009 as daily maximum temperatures below –2°C). The results for the influence of high temperatures on low birth weight were similar to those found in Rome, with the same short-term association between temperature rise and increased cases of premature birth and, consequently, low birth weight. This suggests heat waves are an acute stressor on pregnant women, not the chronic stressor described by Kloog et...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Correspondence October 2015 Source Type: research

Erratum: “Pollinator Power: Nutrition Security Benefits of an Ecosystem Service”
This article was originally published under the incomplete title “Pollinator Power: Benefits of an Ecosystem Service.” EHP regrets the error. (Source: EHP Research)
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Erratum October 2015 Source Type: research

Growing a New Study: Environmental Influences on Child Health Outcomes
Charles W. Schmidt, MS, an award-winning science writer from Portland, ME, has written for Discover Magazine, Science, and Nature Medicine. Background image: © Roy Scott About This Article open Citation: Schmidt CW. 2015. Growing a new study: Environmental Influences on Child Health Outcomes. Environ Health Perspect 123:A260–A263; http://dx.doi.org/10.1289/ehp.123-A260 News Topics: Asthma, Birth Defects, Children’s Health, Laws, Regulations, and Policy, Mental Health, Neurologic Health, Obesity, Research Issues and Initiatives, Respiratory Health Published: 1 October 2015 PDF Version (1.6...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence and Policy Asthma Birth Defects Children's Health Laws Mental Health Neurologic Health Obesity October 2015 Regulations Research Issues and Initiatives Respiratory Health Source Type: research

Just What the Doctor Ordered: Using Parks to Improve Children’s Health
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications. Background image: ©ooyo/iStockphoto About This Article open Citation: Seltenrich N. 2015. Just what the doctor ordered: using parks to improve children’s health. Environ Health Perspect 123:A254–A259; http://dx.doi.org/10.1289/ehp.123-A254 News Topics: Children’s Health, Climate Change, Green Spaces, Mental Health, Neurologic Health, Noise Pollution, Obesity, Recreation Publi...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Children's Health Climate Change Green Spaces Mental Health Neurologic Health Noise Pollution Obesity October 2015 Recreation Source Type: research

A One–Two Punch to Bone: Assessing the Combined Impact of Lead and a High-Fat Diet
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. About This Article open Citation: Barrett JR. 2015. A one–two punch to bone: assessing the combined impact of lead and a high-fat diet. Environ Health Perspect 123:A264; http://dx.doi.org/10.1289/ehp.123-A264 News Topics: Lead, Metals, Molecular Biology, Musculoskeletal Health, Obesity Published: 1 October 2015 PDF Version (205 KB) Related EHP Article Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quali...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Lead Metals Molecular Biology Musculoskeletal Health Obesity October 2015 Source Type: research

Obesogen Holdover: Prenatal Exposure Predicts Cardiometabolic Risk Factors in Childhood
Lindsey Konkel is a New Jersey–based journalist who reports on science, health, and the environment. About This Article open Citation: Konkel L. 2015. Obesogen holdover: prenatal exposure predicts cardiometabolic risk factors in childhood. Environ Health Perspect 123:A265; http://dx.doi.org/10.1289/ehp.123-A265 News Topics: Cardiovascular Health, Children’s Health, Metabolism, Obesity, Persistent Organic Pollutants (POPs), Pesticides, Polychlorinated Biphenyls (PCBs) Published: 1 October 2015 PDF Version (182 KB) Related EHP Article Association of Prenatal Exposure to Persistent Organic Pollutants w...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Cardiovascular Health Children's Health Metabolism Obesity October 2015 Persistent Organic Pollutants (POPs) Pesticides Polychlorinated Biphenyls (PCBs) Source Type: research

POPs and Pubertal Timing: Evidence of Delayed Development
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications. About This Article open Citation: Seltenrich N. 2015. POPs and pubertal timing: evidence of delayed development. Environ Health Perspect 123:A266; http://dx.doi.org/10.1289/ehp.123-A266 News Topics: Endocrine Disruptors, Endocrine Health, Organochlorines (OCs), Persistent Organic Pollutants (POPs), Pesticides, Polybrominated Diphenyl Ethers (PBDEs), Polychlorinated Biphenyls (PCBs) Published: 1 October 2015 PD...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Endocrine Disruptors Endocrine Health October 2015 Organochlorines (OCs) Persistent Organic Pollutants (POPs) Pesticides Polybrominated Diphenyl Ethers (PBDEs) Polychlorinated Biphenyls (PCBs) Source Type: research

Exploring a Little-Known Pathway: Dermal Exposure to Phthalates in Indoor Air
This study, as proof of concept, successfully confirms predictions about that pathway,” says Gerald Kasting, a professor of pharmaceutics and cosmetic science at the University of Cincinnati. Kasting was not involved in the study. DEP and DnBP are not the only indoor organic pollutants predicted to have meaningful uptake via dermal absorption directly from the air. More than 30 semivolatile organic compounds commonly found indoors are predicted to have dermal uptakes similar to or greater than inhalation intake.9 “Our findings suggest that risk assessment models should not ignore the dermal pathway. There are o...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Exposure Science Indoor Air Quality October 2015 Phthalates Risk Assessment Source Type: research

The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health
Conclusion: SRP must continue to address the legacy of hazardous waste in the United States, respond to new issues caused by rapid advances in technology, and train the next generation of leaders in environmental health science while recognizing that most of the world’s worst toxic hot spots are now located in low- and middle-income countries. Citation: Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. 2015. The NIEHS Superfund Research Program: 25 years of translational research for public health. Environ Health Perspect 123:909–918;&...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary October 2015 Source Type: research

Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts
Conclusions: Data pooling was complicated by Center-related differences in subject characteristics, eligibility, and changes in regulations governing residential use of OPs during the study periods. Pooled summary estimates of prenatal exposure to OPs and neurodevelopment should be interpreted with caution due to significant heterogeneity in associations by Center, race/ethnicity and PON1 genotype. Subgroups with unique exposure profiles or susceptibilities may be at higher risk for adverse neurodevelopment following prenatal exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for...
Source: EHP Research - September 29, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

E-Waste and Harm to Vulnerable Populations: A Growing Global Problem
Conclusion: Global, national, and local levels efforts must aim to create safe recycling operations that consider broad security issues for people who rely on e-waste processing for survival. Paramount to these efforts is reducing pregnant women and children’s e-waste exposures to mitigate harmful health effects. With human environmental health in mind, novel dismantling methods and remediation technologies, and intervention practices are needed to protect communities. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely ...
Source: EHP Research - September 29, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary Source Type: research

In Memoriam: Louis J. Guillette, Jr.
About This Article open Citation: Helbing CC, Tyler CR, Iguchi T. 2015. In Memoriam: Louis J. Guillette, Jr. Environ Health Perspect 123:A250; http://dx.doi.org/10.1289/ehp.1510674. Final Publication: 1 October 2015 PDF Version (307 KB) Louis J. Guillette, Jr., 1954–2015 Louis (Lou) J. Guillette, Jr., one of the most influential research scientists in the field of environmental health, died 6 August 2015 at the age of 60. Lou had been battling non-Hodgkin’s lymphoma for almost a decade, but his passing, caused by bacterial pneumonia, came as a shock to everyone who knew him. He was an extremely energ...
Source: EHP Research - September 24, 2015 Category: Environmental Health Authors: Web Admin Tags: In Memoriam October 2015 Source Type: research

Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother-Child PELAGIE Cohort (France)
Author Affiliations open 1INSERM U1085-IRSET, Université Rennes I, Rennes, France; 2Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada; 3Centre de Recherches en Psychologie, Cognition et communication (CRPCC EA 1285), Université Rennes2, France; 4“Bien Naître en Ille et Vilaine” network, Rennes, France; 5LABOCEA Laboratoire, Plouzané, France; 6Centre de recherche et département d’ophtalmologie, CHU Sainte-Justine, Montréal, (Québec), Canada PDF Ve...
Source: EHP Research - September 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Comment on “Using Satellite-Based Spatiotemporal Resolved Air Temperature Exposure to Study the Association between Ambient Air Temperature and Birth Outcomes in Massachusetts”
This study considered daily maximum temperatures during heat waves (defined in Madrid during 2001–2009 as daily maximum temperatures above 34°C) and during cold waves (defined in Madrid during 2001–2009 as daily maximum temperatures below –2°C). The results for the influence of high temperatures on low birth weight were similar to those found in Rome, with the same short-term association between temperature rise and increased cases of premature birth and, consequently, low birth weight. This suggests heat waves are an acute stressor on pregnant women, not the chronic stressor described by Kloog et...
Source: EHP Research - September 21, 2015 Category: Environmental Health Authors: Web Admin Tags: Correspondence October 2015 Source Type: research

Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene–Pesticide Interactions in a Case-Control Study of Parkinson’s Disease, California (USA)
Conclusions: We found OP pesticides were more strongly associated with PD among participants with variant genotypes in NOS1, consistent with the importance of oxidative stress-inducing mechanisms. Our data provide evidence for NOS1 modifying PD risk in OP exposed populations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you...
Source: EHP Research - September 18, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using the Antioxidant Response Element Reporter Gene Assay Models and Big Data
Conclusion: Profiling the chemical IVIVCs created an opportunity to fully explore the source-to-outcome continuum of modern experimental toxicology using cheminformatics approaches and big data sources. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication pro...
Source: EHP Research - September 18, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

A Prospective Study of Marine Phytoplankton and Reported Illness among Recreational Beachgoers in Puerto Rico, 2009
Conclusions: We found associations between recreational exposure to marine phytoplankton and reports of eye irritation, respiratory illness, and rash. We also found that associations varied by phytoplankton group, with Cyanobacteria having the strongest and most consistent associations. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the ci...
Source: EHP Research - September 18, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Variability of Metal Levels in Spot, First Morning, and 24-Hour Urine Samples over a 3-Month Period in Healthy Adult Chinese Men
Conclusions: The high variability observed in the urinary levels of As, Co, Cu, Pb, Mo and Ni suggest that a single measurement provides only a brief snapshot in time of the exposure levels of an individual, which can result in a moderate degree of exposure misclassification. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling
Conclusion: Our data show transcriptome wide anti-estrogenic properties of ligand-activated AHR on ER-mediated processes in the mammary gland, thereby contributing to evaluate the chemopreventive and endocrine disrupting potential of AHR-ligands. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this d...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Urinary Dialkyl Phosphate Concentrations and Lung Function Parameters in Adolescents and Adults: Results from the Canadian Health Measures Survey
Conclusions: The negative association between ΣDAP and lung function in adult participants suggests a detrimental effect of OP pesticides on lung function in the adult general population. Further studies using prospective designs are warranted to confirm the findings reported in this study. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

TNFα and IL-6 Responses to Particulate Matter in Vitro: Variation According to PM Size, Season, and Polycyclic Aromatic Hydrocarbon and Soil Content
Conclusions: Variations in PM soil and PAHs content underlie seasonal and PM size related patterns in TNFα secretion. These results suggest that the mixture of components in PM explains some seasonal differences in associations between health outcomes and PM in epidemiologic studies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Exposure Classification and Temporal Variability in Urinary Bisphenol-A Concentrations among Couples in Utah—The HOPE Study
Conclusion: Repeated urinary specimens are required to characterize typical BPA exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Cox KJ, Porucznik CA, Anderson DJ, Brozek EM, Szczotka KM, Bailey NM, Wilkins DG, Stanford J...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners
Conclusions: An IL-6 promoter variant was associated with lung cancer in uranium miners and never smokers in two external study populations. The associations are strongly supported by the functional relevance that IL-6 promoter SNP affects basal expression and carcinogen-induced IL-6 secretion. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used i...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Polybrominated Diphenyl Ether Exposure and Thyroid Function Tests in North American Adults
Conclusion: These results are consistent with those from animal studies showing exposure to PBDEs is associated with a decrease in serum T4. Because the other TH concentrations did not appear to be associated with BDE exposures, our findings do not support effects on the pituitary/thyroid axis. Taken together, our findings suggest that PBDE exposure might decrease the binding of T4 to the serum T4 binding proteins. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This do...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Ambient Particulate Matter Air Pollution Exposure and Mortality in the NIH-AARP Diet and Health Cohort
Conclusions: Long-term exposure to PM2.5 air pollution was associated with an increased risk of total and CVD mortality, providing an independent test of the PM2.5 – mortality relationship in a new large U.S. prospective cohort experiencing lower post-2000 PM2.5 exposure levels. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the cita...
Source: EHP Research - September 15, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort
Conclusions: In utero arsenic exposure was associated with a higher risk of infection during the first year of life in our study population, particularly infections requiring medical treatment, and with diarrhea and respiratory symptoms. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document a...
Source: EHP Research - September 11, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Children's Health Source Type: research

Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX2 Active Site, and Implications for Endocrine Disruption
Conclusions: Chemicals with structural features more varied than previously thought suppress PGD2 synthesis. Our findings signal a need for in-vivo studies to establish the extent of endocrine disrupting effects that might arise from interference with PGD2 signalling and androgen action simultaneously. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI numbe...
Source: EHP Research - September 11, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Alternatives Assessment Frameworks: Research Needs for the Informed Substitution of Hazardous Chemicals
Conclusion: While alternatives assessment is becoming an important science policy field, there is a need for greater cross-disciplinary collaboration to refine methodologies in support of the informed substitution and design of safer chemicals, materials, and products. Case studies can provide concrete lessons to improve alternatives assessment. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as so...
Source: EHP Research - September 4, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research

Occupation and Risk of Non-Hodgkin Lymphoma and Its Subtypes: A Pooled Analysis from the InterLymph Consortium
Conclusions: Our pooled analysis of 10 international studies adds to evidence suggesting that farming, hairdressing, and textile industry-related exposures may contribute to NHL risk. Associations with women’s hairdresser and textile occupations may be specific for certain NHL subtypes. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in ...
Source: EHP Research - September 4, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Review Source Type: research