Strategies to Improve Private-Well Water Quality: A North Carolina Perspective
Conclusions: The Summit recommendations, if undertaken, could improve the health of North Carolinians facing elevated risks of exposure to waterborne contaminants because of their reliance on inadequately monitored and maintained private wells. Because many of the challenges in N.C. are common nationwide, these recommendations could serve as models for other states. https://doi.org/10.1289/EHP890 Received: 29 July 2016 Revised: 22 December 2016 Accepted: 15 March 2017 Published: 07 July 2017 Address correspondence to J. M. Gibson, Dept. of Environmental Sciences and Engineering, Gillings School of Global Public Healt...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort
Conclusion: Our findings suggest that several intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communities. https://doi.org/10.1289/EHP353 Received: 01 May 2016 Revised: 19 December 2016 Accepted: 19 January 2017 Published: 07 July 2017 Address correspondence to B. Eskenazi, Center for Environmental Research and Children’s Health. 1995 University Ave., Suite 265. Berkeley, CA 94704, USA. Email: eskenazi@berkeley.edu Supplemental Material is available online (https://doi.org/10.1289/EHP353). The authors declare they have no actual or potential competing financial interests. Note ...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Heat-Related Mortality in Japan after the 2011 Fukushima Disaster: An Analysis of Potential Influence of Reduced Electricity Consumption
Conclusions: In the prefectures with the greatest reductions in electricity consumption, heat-related mortality decreased rather than increased following the Great East Japan Earthquake. Additional research is needed to determine whether this finding holds for other populations and regions, and to clarify its implications for policies to reduce the consequences of climate change on health. https://doi.org/10.1289/EHP493 Received: 11 May 2016 Revised: 07 March 2017 Accepted: 13 March 2017 Published: 06 July 2017 Address correspondence to M. Hashizume, Dept. of Pediatric Infectious Diseases, Institute of Tropical Medic...
Source: EHP Research - July 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Vitamin D and Risk of Breast Cancer within Five Years
Conclusions: In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943 About This Article Received: 09 August 2016 Revised: 23 January 2017 Accepted: 06 February 2017 Published: 06 July 2017 Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Rese...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Estimates of Soil Ingestion in a Population of Chinese Children
Conclusions: Based on the BTM, recommended SIR values for the general population of Chinese children (2.5 to 12 years old) are 52 mg/d for the central tendency and 217 mg/d for the upper percentile. We did not differentiate between outside soil and indoor dust. Considering the lower concentration of tracer elements in indoor dust than outside soil, actual soil and dust ingestion rates could be higher. https://doi.org/10.1289/EHP930 Received: 12 August 2016 Revised: 05 January 2017 Accepted: 23 January 2017 Published: 05 July 2017 Address correspondence to C. Lin, School of Environment, Beijing Normal Universi...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the apoE-/- Mouse Model and the Role of As3mt-Mediated Methylation
Conclusion: Taken together, our findings indicate that As3MT acts to promote cardiovascular toxicity of arsenic and suggest that human AS3MT SNPs that correlate with enzyme function could predict those most at risk to develop atherosclerosis among the millions that are exposed to arsenic. https://doi.org/10.1289/EHP806 Received: 15 July 2016 Revised: 21 December 2016 Accepted: 21 December 2016 Published: 05 July 2017 Correspondence: K.K. Mann, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Rd., Montreal, QC, H3T 1E2 Canada; Telephone: (514) 340-8222 ext. 2760; Email: koren.mann@...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Rice versus Drinking Water: Estimating the Primary Source of Arsenic in the U.S. Diet
This study will facilitate assessing arsenic exposures and more accurately estimating inorganic exposures.” Limitations to the study were primarily associated with the source data. For example, the dietary data, although extensive, captured only what people ate on two days about a week apart, which prevented accurate assessment of exposures at the extreme ends of consumption. “As you go out on the tails of the statistical distribution of rice consumption rates, this two-day survey starts to become unreliable,” says study coauthor Jack Creed, a research chemist at the EPA’s National Exposure Research Laboratory. For...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Web Admin Tags: Science Selections Source Type: research

Erratum: “Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children”
PDF Version (431 KB) About This Article Received: 31 March 2017 Revised: 31 March 2017 Accepted: 06 April 2017 Published: 30 June 2017 Environ Health Perspect 125(4):746–752 (2017), https://doi.org/10.1289/EHP478 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with yo...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Erratum Source Type: research

Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study
Conclusions: This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864 Received: 25 July 2016 Revised: 16 December 2016 Accepted: 22 December 2016 Published: 30 June 2017 Address correspondence to J. Schüz, Section of Environment and Radiation, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France. Telephone: +33 (0)4 72 73 84 41. Email: Schuzj@iarc.fr Supplemental Material is available online (https://doi.org/10.1289/EHP864). The authors declare they have no actual or potential competing financial...
Source: EHP Research - June 30, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children
Conclusions: Hair was found to be a useful exposure biomarker of absorbed As and Se only. Of all measured elements, hair Mn seemed the least reflective of internal dose. https://doi.org/10.1289/EHP1239 Received: 17 October 2016 Revised: 19 January 2017 Accepted: 06 February 2017 Published: 29 June 2017 Address correspondence to M. Vahter, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden. Telephone: 46 8 52487540. Email: marie.vahter@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1239). The authors declare they have no actual or potential co...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Season of Conception, Smoking, and Preeclampsia in Norway
Conclusions: These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963 Received: 14 August 2016 Revised: 24 January 2017 Accepted: 25 January 2017 Published: 29 June 2017 Address correspondence to C.R. Weinberg, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927. Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP963). The authors declare they h...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course
Conclusions The exposome concept was introduced in 2005, yet it remains in a quasi-primordial state. The Emory Exposome Summer Course was established to help advance the development of the exposome. Environmental health sciences is filled with untapped potential for human health discovery, and the exposome captures the excitement, the potential, and the dynamic nature of the field. One important point that arose from the course is the need for academic researchers to include members of the community in exposome research. Participants discussed the need to promote citizen science, and the ethical considerations inherent in ...
Source: EHP Research - June 29, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Brief Communication Source Type: research

Analysis of Temporal Variability in the Short-term Effects of Ambient Air Pollutants on Nonaccidental Mortality in Rome, Italy (1998 –2014)
Conclusions: Mean concentrations of air pollutants have decreased over the last two decades in Rome, but effect estimates for a fixed increment in each exposure were generally consistent. These findings suggest that there has been little or no change in the overall toxicity of the air pollution mixture over time. https://doi.org/10.1289/EHP19 Received: 23 February 2016 Revised: 07 November 2016 Accepted: 07 November 2016 Published: 28 June 2017 Address correspondence to M. Renzi, Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, via Cristoforo Colombo 112, 00147 Rome, Italy. Telephone: 39-06-9972218...
Source: EHP Research - June 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring
Conclusions: Developmental exposure to 0.5 μg/kg BW/d of BPA, which is 8–10 times lower than the current preliminary EFSA (European Food Safety Authority) tolerable daily intake (TDI) of 4 μg/kg BW/d and is within the range of environmentally relevant levels, was associated with sex-specific differences in the expression of genes in adipose tissue plasma triglyceride levels in males and adipocyte cell density in females when F344 rat offspring of dams exposed to BPA at 0.5 μg/kg BW/d were compared with the offspring of unexposed controls. https://doi.org/10.1289/EHP505 Received: 13 May 2016 Revised: 19 Decem...
Source: EHP Research - June 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research