The Association between Dust Storms and Daily Non-Accidental Mortality in the United States, 1993-2005
Conclusions: Dust storms are associated with increases in lagged non-accidental and cardiovascular mortality. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Crooks JL, Cascio WE, Percy MS, Reyes J, Neas LM, Hilb...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Acute Impact of Hourly Ambient Air Pollution on Preterm Birth
Conclusion: Acute increases in ambient air pollution concentrations above certain levels before onset of labour may stimulate preterm birth. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Li S, Guo Y, Will...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Neurodevelopmental Deceleration by Urban Fine Particles from Different Emission Sources: A Longitudinal Observational Study
Author Affiliations open 1Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain; 2Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; 3CIBER Epidemiología y Salud Pública (CIBERESP), Spain; 4Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Catalonia, Spain; 5Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway; 6MRI Research Unit, CRC Mar, Hospital del Mar, Barcelona, Spain; 7Centro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21, Barcelona, Spain;...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress
Conclusions: Short-term exposure to PM2.5 induces vascular insulin resistance and inflammation triggered by a mechanism involving pulmonary oxidative stress. Suppression of vascular insulin signaling by PM2.5 may accelerate the progression to systemic insulin resistance, especially in the context of diet-induced obesity. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as so...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort
Conclusions: Despite relatively low exposures, our results suggest a monotonic positive relationship between PM2.5 exposure during preconception and pregnancy and IUI. IUI may be a sensitive biomarker for assessing early biological effect of PM2.5 exposure on the developing fetus. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI nu...
Source: EHP Research - April 27, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine Disrupting Substances in the European Union
Conclusions: There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission). This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are complet...
Source: EHP Research - April 25, 2016 Category: Environmental Health Authors: Web Admin Tags: Commentary Source Type: research

A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses’ Health Study and Health Professional Follow-up Study
Conclusions: Estimated intakes of meat mutagens were not significantly associated with CRC risk over 14 years of follow-up in the NHS and HPFS cohorts. Results for PhIP from red, but not from white meat warrant further investigation. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able ...
Source: EHP Research - April 22, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Cooking Coal Use and All-Cause and Cause-Specific Mortality in a Prospective Cohort Study of Women in Shanghai, China
Conclusions: Evidence from this study suggests that past use of coal among women in Shanghai is associated with excess all-cause mortality and from cardiovascular diseases in particular. The decreasing association with cardiovascular mortality as the time since last use of coal increased emphasizes the importance of remediating household coal where use is still widespread. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be r...
Source: EHP Research - April 19, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Next Generation of Risk Assessment Multiyear Study— Highlights of Findings, Applications to Risk Assessment and Future Directions
Conclusions: While considerable uncertainties remain, thoughtful application of new knowledge to risk assessment appears reasonable for augmenting major scope assessments, forming the basis for or augmenting limited scope assessments, and for prioritization and screening of very data limited chemicals. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is a...
Source: EHP Research - April 19, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Effects of Acute Low-Dose Exposure to the Chlorinated Flame Retardant Dechlorane 602 and Th1 and Th2 Immune Responses in Adult Male Mice
Conclusions: To our knowledge, we are the first to report evidence of effects of Dec 602 on immune function in mice, with findings indicating that Dec 602 exposure favored Th2 responses and reduced Th1 function. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this documen...
Source: EHP Research - April 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Critical Review of Health Impacts of Wildfire Smoke Exposure
Conclusions: Consistent evidence from a large number of studies indicates that wildfire smoke exposure is associated with respiratory morbidity with growing evidence supporting an association with all-cause mortality. More research is needed to clarify which causes of mortality may be associated with wildfire smoke, whether cardiovascular outcomes are associated with wildfire smoke, and if certain populations are more susceptible. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable usin...
Source: EHP Research - April 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts
Conclusion: These results support the induction of an adaptive response by BPA co-exposure that alters the microcellular environment and modulates DNA repair. Further work is required to determine whether BPA induces similar DNA lesions in vivo at environmentally relevant doses; however, in the Ku-deficient mouse embryonic fibroblasts, exposure to a high dose of BPA was associated with changes in the cellular microenvironment that may promote survival. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are complet...
Source: EHP Research - April 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey
Conclusions: Under the assumption of the difference-in-differences approach, we identified a causal effect of long-term PM2.5 on mortality which is modified by seasonal temperatures and ecological socio-economic status. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this docum...
Source: EHP Research - April 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Exposure to Greenness and Mortality in a Nationwide Prospective Cohort Study of Women
Conclusions: Higher levels of green vegetation were associated with decreased mortality. Policies to increase vegetation may provide opportunities for physical activity, reduce harmful exposures, increase social engagement, and improve mental health. While planting vegetation may mitigate effects of climate change, evidence of an association between vegetation and lower mortality rates suggests it also might be used to improve health. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable ...
Source: EHP Research - April 14, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003–2010
We examined associations between dietary exposures and urinary chemical concentrations using multivariate linear regression. Results: We observed evidence of a positive, dose-response relationship between fast food intake and exposure to phthalates (p-trend
Source: EHP Research - April 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a Native American Population
Author Affiliations open 1Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York, USA; 2Institute for Health and the Environment, University at Albany, Rensselaer, New York, USA; 3Department of Counseling Psychology, University at Albany, Albany, New York, USA; 4New York State Department of Health, Albany, New York, USA; 5Department of Epidemiology and Biostatistics, School of Public Health, University at Albany. Rensselaer, New York, USA; 6Mohawk Nation at Akwesasne, Hogansburg, New York, USA *Current address: The Chicago School of Profess...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Response to “Comment on ‘Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology’”
1Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 3Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-Universität Bochum, Bochum, Germany; 4Icahn School of Medicine at Mount Sinai, New York, New York, USA; 5Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA; 6Milken Institute School of Public Health, George Washington University, Washin...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence April 2016 Source Type: research

Comment on “Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology”
1Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA; 2College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA; 3Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA; 4Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA About This Article open Citation: Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, vom Saal FS. 2016. Comment on “Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology.” Environ Health Perspect 124:A66; http://dx...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence April 2016 Source Type: research

Response to “Comment on ‘Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts’”
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy; 2Department of Cellular Biology, University of Geneva, Geneva, Switzerland About This Article open Citation: Lappano R, Pupo M, Maggiolini M. 2016. Response to “Comment on ‘Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.’” Environ Health Perspect 124:A65; http://dx.doi.org/10.1289/ehp.1611288 Address correspondence to M. Maggiolini, Department of Pharmacy, Health ...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence April 2016 Source Type: research

Comment on “Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts”
1Institut National de la Santé et de la Recherche Médicale (INSERM), Nice, France; 2Université de Nice–Sophia Antipolis, Nice, France; 3Centre Hospitalier Universitaire de Nice, Nice, France About This Article open Citation: Chevalier N, Paul-Bellon R, Fénichel P. 2016. Comment on “Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.” Environ Health Perspect 124:A64; http://dx.doi.org/10.1289/ehp.1510927 Address correspondence to P. Fé...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence April 2016 Source Type: research

Informing 21st-Century Risk Assessments with 21st-Century Science
Conclusions Understanding the environmental determinants of disease and protecting susceptible and vulnerable populations are daunting scientific challenges. Addressing these challenges will require an inclusive multidisciplinary research approach and an improved recognition of the methods and informational needs of risk assessors. Progress will also require coordination across multiple federal programs and agencies—especially in resource-constrained times. The 2015 workshop started with the recognition that there is a chasm between current risk assessment practices and evolving data from mechanistic and environmenta...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication April 2016 Source Type: research

Marking a New Understanding of Climate and Health
National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, USA About This Article open Citation: Birnbaum LS, Balbus JM, Tart KT. 2016. Marking a new understanding of climate and health. Environ Health Perspect 124:A59; http://dx.doi.org/10.1289/ehp.1611410 E-mail: thigpenk@niehs.nih.gov Final Publication: 1 April 2016 PDF Version (171 KB) The month of April brings two observances of significance for many readers of EHP: National Public Health Week and Earth Day. The first recognizes the importanc...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Editorial April 2016 Source Type: research

Pollen Overload: Seasonal Allergies in a Changing Climate
Several intertwined factors influence how a plant grows and how much pollen it produces. Projected rises in two of these—regional temperatures and atmospheric carbon dioxide levels—could mean an increase in the number of people affected by seasonal allergies.© Joe Petersburger/Getty   Pollen (gold spheres) is produced by the stamens (gray), which are the male reproductive organ of flowering plants. Pollen grains are covered in proteins that assist in reproduction but also trigger allergic reactions in sensitized people.© Martin Oeggerli/Science Source Seaso...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News April 2016 Source Type: research

Unexamined Endocrine Disruption? Pesticides Inhibit Prostaglandin Activity
This study is thought to be the first to test pesticides for these effects. OPP is applied to citrus fruits and other crops after harvest to prevent spoilage. The general population is thought to consume levels of OPP well below recommended limits, although workers likely receive greater exposures.12 It is unknown whether OPP causes human health effects. © David Thurber/Corbis Prostaglandins serve many purposes—from the promotion and resolution of the immune system’s inflammatory response7 to male sexual development in utero.5 Previous studies have suggested that synthesis of prostaglandin-D2 (PGD2) may ...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection April 2016 Source Type: research

Studies Need More than a Spot Sample: Variability of Urinary Metal Levels over Time
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. About This Article open Citation: Barrett JR. 2016. Studies need more than a spot sample: variability of urinary metal levels over time. Environ Health Perspect 124:A77; http://dx.doi.org/10.1289/ehp.124-A77 Published: 1 April 2016 PDF Version (218 KB) Related EHP Article Variability of Metal Levels in Spot, First Morning, and 24-Hour Urine Samples over a 3-Month Period in Healthy Adult Chinese Men Yi-Xin Wang, Wei Feng, Qiang Zen...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection April 2016 Source Type: research

Phthalates and Childhood Body Fat: Study Finds No Evidence of Obesogenicity
Wendee Nicole was awarded the inaugural Mongabay Prize for Environmental Reporting in 2013. She writes for Discover, Scientific American, National Wildlife, and other magazines. About This Article open Citation: Nicole W. 2016. Phthalates and childhood body fat: study finds no evidence of obesogenicity. Environ Health Perspect 124:A78; http://dx.doi.org/10.1289/ehp.124-A78 Published: 1 April 2016 PDF Version (243 KB) Related EHP Article Prenatal Phthalate Exposures and Childhood Fat Mass in a New York City Cohort Jessie P. Buckley, Stephanie M. Engel, Michelle A. Mendez, David B. Richardson, Julie L. Daniels, A...
Source: EHP Research - April 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection April 2016 Source Type: research

Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults
Conclusions: These data join a growing body of evidence suggesting that TRAP exposures may accelerate aging-related declines in health. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Weuve J, Kaufman JD, Szpiro ...
Source: EHP Research - March 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Particulate Matter Exposure and Preterm Birth: Estimates of U.S. Attributable Burden and Economic Costs
Conclusions: PM2.5 may contribute substantially to burden and costs of PTB in the US, and considerable health and economic benefits could be achieved through environmental regulatory interventions that reduce PM2.5 exposure in pregnancy. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be a...
Source: EHP Research - March 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Arsenic Species in Chicken Breast: Temporal Variations of Metabolites, Elimination Kinetics, and Residual Concentrations
Conclusion: Feeding of Rox to chickens increased the concentrations of five arsenic species in breast meat. Although most arsenic species were excreted rapidly when the feeding of Rox stopped, arsenic species remaining in the Rox-fed chickens were higher than the background levels. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the...
Source: EHP Research - March 18, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community
Author Affiliations open 1School of Community Health Sciences, University of Nevada, Reno, Reno, Nevada, USA; 2Department of Epidemiology, Emory University, Atlanta, Georgia, USA; 3Department of Environmental Health, Emory University, Atlanta, Georgia, USA; 4Department of Public Health Sciences, University of California, Davis, Davis, California, USA; 5School of Social Ecology, University of California, Irvine, Irvine, California, USA; 6Department of Statistics and Department of Epidemiology, University of California, Irvine, Irvine, California, USA PDF Version (525 KB) Abstract About This A...
Source: EHP Research - March 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast High Throughput Data
Conclusions: Certainly, more research is required to put these screening level analyses into context, but the information presented in this review should facilitate development of new hypotheses. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage ...
Source: EHP Research - March 15, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Incense Burning during Pregnancy and Birth Weight and Head Circumference among Term Births: The Taiwan Birth Cohort Study
Conclusions: Prenatal incense burning was associated with lower birth weight for boys and smaller head circumference for boys and girls from OLS regressions. The associations were more pronounced among the lower quantiles of birth outcomes. Further research is necessary to confirm whether incense burning has differential effects by gender. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited an...
Source: EHP Research - March 11, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men: The Normative Aging Study
Conclusions: These results suggest that air pollution distorts the distribution of cardiovascular risk factors, and that, for several outcomes, effects may be greatest among individuals who are already at high risk. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this doc...
Source: EHP Research - March 11, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and Women
The objectives were to determine: 1) if arsenic exposure is associated with global (%) levels of PTHMs: H3K36me2, H3K36me3, and H3K79me2 in a sex-dependent manner and 2) if %PTHMs are stable when arsenic exposure is reduced. Methods: We examined associations between arsenic, measured in blood and urine, and %PTHMs in peripheral blood mononuclear cells from 317 participants enrolled in the Bangladesh Folic Acid and Creatine Trial (FACT). We also examined the stability of %PTHMs after the use of arsenic-removal water filters (n = 60). Results: Associations between natural log-transformed (ln) urin...
Source: EHP Research - March 11, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The VA Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings support the hypothesis that long-term PM2.5 exposure negatively affects renal function and renal function decline. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication ...
Source: EHP Research - March 8, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice
Conclusion: These findings suggest that sex-specific differences in SPP1 expression contribute to the differential sensitivity of male and female mice to the development of silica-induced fibrosis. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stag...
Source: EHP Research - March 8, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated and Potential Endocrine Disruptors
Conclusions: The informatics approach increased the number of products considered in a traditional analysis by two orders of magnitude, but missing/incomplete product labels can limit the effectiveness of this approach. Such an approach must resolve synonymy to ensure that chemicals of interest are not missed. Commonly occurring chemical combinations can be used to prioritize cumulative toxicology risk assessments. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number...
Source: EHP Research - March 8, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire
Author Affiliations open 1Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; 2Children’s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, New Hampshire, USA; 3Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; 4Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; 5Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, New Hampshire, U...
Source: EHP Research - March 8, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study
This study demonstrates that techniques available to consumers, such as choosing personal care products that are labelled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine disrupting chemicals. Involving youth in the design and implementation of the study was key to recruitment, retention, compliance, and acceptability of the intervention. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the ar...
Source: EHP Research - March 7, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Ingested Nitrate and Breast Cancer in the Spanish Multicase-Control Study on Cancer (MCC-Spain)
Author Affiliations open 1Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; 2Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra. Barcelona, Spain; 3CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 4Cancer and Environmental Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain; 5Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta De Hierro, Madrid, Spain; 6Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian,...
Source: EHP Research - March 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice
Conclusions: This study supports Pprc1 as key regulator for renal Hg excretion. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Alkaissi H, Ekstrand J, Jawad A, Nielsen JB, Havarinasab S, Soderkvist P, Hultman P....
Source: EHP Research - March 4, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Response to “Comment on ‘Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice’”
Discussion section of our paper, some of the results under our exposure scheme do not recapitulate those observed in other studies. The main difference that could contribute to these discrepancies is that the offspring in our study were fostered to dams that were not exposed to As during gestation. Dams exposed gestationally to As are known to produce lower-quality milk, which can result in weight deficits in their pups (Kozul-Horvath et al. 2012). In contrast, the studies mentioned by Williams and DeSesso left offspring with their As-exposed mothers. It is therefore possible that the impacts of gestational As exposure on ...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence March 2016 Source Type: research

Comment on “Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice”
Exponent, Inc., Alexandria, Virginia, USA About This Article open Citation: Williams AL, DeSesso JM. 2016. Comment on “Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice.” Environ Health Perspect 124:A46; http://dx.doi.org/10.1289/ehp.1511031 Address correspondence to A.L. Williams, Exponent, Inc., 1800 Diagonal Rd., Ste. 500, Alexandria, VA 22314 USA. E-mail: awilliams@exponent.com Financial support for this analysis was provided in part by the Arsenic Science Task Force. The analysis and conclusions presen...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence March 2016 Source Type: research

Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication March 2016 Source Type: research

The Value of Alternatives Assessment
National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, USA About This Article open Citation: Weis CP. 2016. The value of alternatives assessment. Environ Health Perspect 124:A40; http://dx.doi.org/10.1289/ehp.1611248 E-mail: christopher.weis@nih.gov The author declares he has no actual or potential competing financial interests. Final Publication: 1 March 2016 PDF Version (99 KB) The pages of EHP are replete with studies documenting the potential human health and ecosystem impacts of toxic chemicals. Such research is...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Editorial March 2016 Source Type: research

Erratum: “Exposure to Household Air Pollution from Wood Combustion and Association with Respiratory Symptoms and Lung Function in Nonsmoking Women: Results from the RESPIRE Trial, Guatemala”
About This Article open Citation: Pope D, Diaz E, Smith-Sivertsen T, Lie RT, Bakke P, Balmes JR, Smith KR, Bruce NG. 2016. Erratum: “Exposure to Household Air Pollution from Wood Combustion and Association with Respiratory Symptoms and Lung Function in Nonsmoking Women: Results from the RESPIRE Trial, Guatemala.” Environ Health Perspect 124:A48; http://dx.doi.org/10.1289/ehp.124-A48 Final Publication: 1 March 2016 PDF Version (49 KB) Environ Health Perspect 123(4):285–292 (2015), http://dx.doi.org/10.1289/ehp.1408200 The author list of the original paper was incomplete. Anaité Dí...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Erratum March 2016 Source Type: research

Inflammatory Bowel Disease in Asia: A Second Chance at Uncovering Environmental Factors
Inflammatory bowel disease (IBD) has become common in the Western world, but its causes remain unclear. With the dramatic increase of cases in Asia in recent years—echoing the disease’s drastic rise in the West decades earlier—investigators have another shot at studying environmental contributors to IBD as it emerges in new populations.© SPL/Science Source Although rates of IBD in Asia are rising, they are still relatively low compared with industrialized areas including North America, several European countries, Australia, and New Zealand.Source: Kaplan (2015)1 ...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News March 2016 Source Type: research

Eating for Two: Does an Organic Diet Make a Difference?
Carol Potera, based in Montana, also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing. About This Article open Citation: Potera C. 2016. Eating for two: does an organic diet make a difference? Environ Health Perspect 124:A55; http://dx.doi.org/10.1289/ehp.124-A55 Published: 1 March 2016 PDF Version (212 KB) Related EHP Article Organic Food Consumption During Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa) Anne Lise Brantsæter, Hanne Torjusen, Helle Margrete Meltzer, Eleni Papadopoulou, Jane A. Hoppin, Jan Alexander, Geir ...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection March 2016 Source Type: research

A Satellite View of Pollution on the Ground: Long-Term Changes in Global Nitrogen Dioxide
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications. About This Article open Citation: Seltenrich N. 2016. A satellite view of pollution on the ground: long-term changes in global nitrogen dioxide. Environ Health Perspect 124:A56; http://dx.doi.org/10.1289/ehp.124-A56 Published: 1 March 2016 PDF Version (233 KB) Related EHP Article Long-Term Trends Worldwide in Ambient NO2 Concentrations Inferred from Satellite Observations Jeffrey A. Geddes, Randall V. Martin,...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection March 2016 Source Type: research

Noise and Body Fat: Uncovering New Connections
Wendee Nicole was awarded the inaugural Mongabay Prize for Environmental Reporting in 2013. She writes for Discover, Scientific American, National Wildlife, and other magazines. About This Article open Citation: Nicole W. 2016. Noise and body fat: uncovering new connections. Environ Health Perspect 124:A57; http://dx.doi.org/10.1289/ehp.124-A57 Published: 1 March 2016 PDF Version (368 KB) Related EHP Article Road Traffic and Railway Noise Exposures and Adiposity in Adults: A Cross-Sectional Analysis of the Danish Diet, Cancer, and Health Cohort Jeppe Schultz Christensen, Ole Raaschou-Nielsen, Anne Tjønneland, ...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection March 2016 Source Type: research