Updating the NIEHS Strategic Plan
Author Affiliations open 1Director, National Institute of Environmental Health Sciences, and 2Director, National Toxicology Program, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Email: birnbaumls@niehs.nih.gov PDF Version (56 KB) About This Article About This Article Published: 26 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Editorial Source Type: research

Location Is Everything: The Pollutants in Yellowfin Tuna Depend on Where It ’s Caught
PDF Version (312 KB) About This Article Published: 25 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Geographic Differences in Persistent Organic Pollutant Leve...
Source: EHP Research - July 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States
Conclusions: We found evidence of racial/ethnic and socioeconomic differences in model-based estimates of noise exposure throughout the United States. Additional research is needed to determine if differences in noise exposure may contribute to health disparities in the United States. https://doi.org/10.1289/EHP898 Received: 01 August 2016 Revised: 06 February 2017 Accepted: 06 February 2017 Published: 25 July 2017 Address correspondence to J.A. Casey, University of California, Berkeley, 13B University Hall, Berkeley, CA 94610 USA. Telephone: 541-760-8477; Email: joanacasey@berkeley.edu Supplemental Material is avail...
Source: EHP Research - July 25, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maiden Voyage of the Collaborative Cross Mouse: Exploring Variability in Animals ’ Response to Perchloroethylene
PDF Version (742 KB) About This Article Published: 24 July 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Characterization of Variability in Toxicokinetics and Tox...
Source: EHP Research - July 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Northern Trek: The Spread of Ixodes scapularis into Canada
This study is an extension of previous work published in 20141 showing the predicted expansion of the distribution of the Lyme disease tick vector into Canada,” says Maria Diuk-Wasser, a professor at Columbia University who focuses on the emergence of vector-borne diseases. “Although the results are not qualitatively different, it represents an improvement on the previous study by incorporating the full range of and most up-to-date climate models and emission scenarios.” Importantly, she says, the new study accounts for the inherent uncertainty in such models and scenarios but also indicates that an increased risk ca...
Source: EHP Research - July 24, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Weekly Personal Ozone Exposure and Respiratory Health in a Panel of Greek Schoolchildren
Conclusions: The study provides evidence that airway inflammation and the frequency of respiratory symptoms increase, whereas lung function decreases with increased ozone exposure in schoolchildren. https://doi.org/10.1289/EHP635 Received: 09 June 2016 Revised: 08 March 2017 Accepted: 13 March 2017 Published: 21 July 2017 Please address correspondence to A. Karakatsani, 2nd Pulmonary Department, ATTIKON University Hospital, School of Medicine, National and Kapodistrian University of Athens, 1, Rimini St., 124 62 Haidari, Greece. Telephone: 30-210-5831184. Email: annakara@otenet.gr, akarakats@med.uoa.gr The authors de...
Source: EHP Research - July 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Prevalence of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant Escherichia Coli in Poultry Chickens and Variation According to Farming Practices in Punjab, India
Conclusions: Our findings suggest that unregulated use of clinically relevant antimicrobials in Indian broiler and layer farms may contribute to the emergence of resistance and support the need to curb the nontherapeutic use of medically important antimicrobials in food animal production. https://doi.org/10.1289/EHP292 Received: 31 March 2016 Revised: 16 December 2016 Accepted: 17 December 2016 Published: 20 July 2017 Address correspondence to R. Laxminarayan and C. Brower, Center for Disease Dynamics, Economics & Policy, 1400 Eye St. NW, #500, Washington, DC 20005 USA. Telephone: 202-939-3300. Email:...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

The Saliva Exposome for Monitoring of Individuals ’ Health Trajectories
Conclusions: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. https://doi.org/10.1289/EHP1011 Received: 23 August 2016 Revised: 08 November 2016 Accepted: 18 November 2016 Published: 20 July 2017 Address correspondence to V. Bessonneau, Silent Spring Institute, 320 Nevada St., Suite 302, Newton, Massachusetts 02460 USA. Telephone: (617) 332-4288. Email: vincent.bessonneau@gmail.com The authors declare they have no actual or po...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study
Conclusions: Exposures to specific pesticides may be modifiable risk factors for AMD. https://doi.org/10.1289/EHP793 Received: 12 July 2016 Revised: 17 March 2017 Accepted: 18 March 2017 Published: 19 July 2017 Address correspondence to F. Kamel, Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Dr., Bldg. 101, Room 327, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709 USA. Telephone: 919-541-1581; Email: kamel@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP793). The authors declare they have no actual or potential competing financi...
Source: EHP Research - July 19, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors
Conclusions: These results demonstrate the possibility to predict large-scale mixture effects for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput ranking and risk assessment. The size of the effects predicted is consistent with an increased risk of infertility in women from everyday exposures to our chemical environment. https://doi.org/10.1289/EHP742 Received: 30 June 2016 Revised: 07 December 2016 Accepted: 24 February 2017 Published: 19 July 2017 Address correspondence to F.Y. Bois, INERIS, DRC/VIVA, Parc ALATA, BP 2, 60550 Verneuil en Halatte, France. Telephone: 33-...
Source: EHP Research - July 19, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a Prospective Cohort Study
Conclusions: In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827 Received: 18 July 2016 Revised: 16 November 2016 Accepted: 09 December 2016 Published: 18 July 2017 Address correspondence to A.J. White, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233 USA. Telephone: (919) 316-4867. Email: alexandra.white@nih.gov Supp...
Source: EHP Research - July 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study
Conclusions: Our results provide novel evidence of associations between exposure to some pesticides and RA in male farmers. https://doi.org/10.1289/EHP1013 Received: 24 August 2016 Revised: 19 January 2017 Accepted: 13 February 2017 Published: 14 July 2017 Address correspondence to C.G. Parks, Epidemiology Branch, A3-05, National Institite of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27599 USA; Telephone: (919) 541-2577; Email: Parks1@mail.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1013). The authors declare that they have...
Source: EHP Research - July 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

A Longitudinal Analysis of the Influence of the Neighborhood Environment on Recreational Walking within the Neighborhood: Results from RESIDE
Conclusions: Our findings provide urban planners and policy makers with stronger causal evidence of the positive impact of well-connected neighborhoods and access to local parks of varying sizes on local residents’ recreational walking and health. https://doi.org/10.1289/EHP823 Received: 19 July 2016 Revised: 29 January 2017 Accepted: 10 February 2017 Published: 12 July 2017 Address correspondence to H. Christian, School of Population Health (M707), The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia. Telephone: 61-8-6488 8501. Email: hayley.christian@uwa.edu.au Supplemental Materia...
Source: EHP Research - July 12, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Conclusion: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875 Received: 27 July 2016 Revised: 18 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to E. S. Barrett, Dept. of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, 170 Frelinghuysen Road, Piscataway, NJ 08854...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose –Response Analysis
Conclusions: Developmental BPA exposures heighten prostate cancer susceptibility in a complex dose- and lobe-specific manner. Importantly, elevated carcinogenic risk is found at doses that yield undetectable serum free BPA. Dose-specific epigenetic modifications of selected genes provide a mechanistic framework that may connect early-life BPA to later-life predisposition to prostate carcinogenesis. https://doi.org/10.1289/EHP1050 Received: 1 September 2016 Revised: 13 January 2017 Accepted: 19 January 2017 Published: 11 July 2017 Address correspondence to G.S. Prins, Dept. of Urology, University of Illinois at Chicago...
Source: EHP Research - July 11, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research