Serum adiponectin in Egyptian patients with chronic hepatitis B virus infection
Conclusion
Patients with chronic HBV infection have increased levels of serum adiponectin, and this may be directly responsible for the low incidence of IR in those patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Early treatment of recurrent hepatitis C virus infection after liver transplantation in the era of direct-acting antivirals, what we have learned till now?
Conclusion
Early treatment with newer combinations of DAAs for recurrent HCV after the first 3 months after LT is recommended to achieve high rates of SVR and adequate safety profile. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Cystic neuroblastoma with liver metastasis
We report the case of a 9-month-old girl having cystic neuroblastoma with liver metastasis that remained asymptomatic for 1 year and 2 months of follow-up and review the literature on the topic. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Case report Source Type: research
Metabolic outcomes of laparoscopic sleeve gastrectomy
Conclusion
LSG is a feasible and safe restrictive bariatric procedure, with good short-term results. It offers the advantages of a simple and reproducible technique with good outcome and low morbidity and mortality. LSG is accepted as a standalone definitive therapy, as it has a high percentage of postoperative excess weight loss as well as reduction of obesity-related comorbidities. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Effect of Helicobacter pylori on insulin resistance in nonobese, nondiabetic, and normolipidemic Egyptian patients
Conclusion
H. pylori infection has a positive effect on the NAFLD score and the HOMA-IR with older age, even after removing confounders of hyperlipidemia, hyperglycemia, and obesity from the equation, but this needs further confirmation by a wide-scale studies. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Golgi protein 73 versus serum α-fetoprotein as tumor markers for hepatocellular carcinoma in patients with hepatitis C cirrhosis
Conclusion
Serum GP-73 level at cut-off value of 16.25 ng/ml can be used as a diagnostic marker for HCC in patients with chronic HCV. However, it is not superior to AFP as both of them had the same sensitivity, but AFP showed higher specificity. Combination of both increases the sensitivity. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Predictive value of hepcidin in patients with chronic hepatitis C infection among Egyptians
This study included 80 (54 patients and 26 controls) individual who were matched in age and sex. Serum hepcidin levels and serum iron status were determined. Their levels were correlated with each other and with other laboratory parameters.
Results
Mean serum hepcidin levels were significantly lower in patients with CHC than in controls (P=0.001). Patients with CHC had significantly higher mean values of serum iron and ferritin than controls (P=0.001 and 0.017, respectively). There was a significant negative correlation between hepcidin levels and alanine aminotransferase, (r=−0.454, P (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Sofosbuvir/simeprevir versus sofosbuvir/ribavirin regimen in Egyptian patients with hepatitis C virus
Conclusion
A 12-week course of sofosbuvir/simeprevir showed a higher response rate than 24 weeks of sofosbuvir/ribavirin among patients with HCV-related Child A cirrhosis. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Drug development challenges in liver disease clinical trials
Drug development process faces many challenges, including those encountered in clinical trials for liver diseases. Drug development is a lengthy and highly costly process. Only 10% of compounds entering first study in humans (phase 1) make it to the market after an average of 14 years with a cost of ~$3 billion. Interestingly, according to the Centers for Medicare and Medicaid services, prescription drugs constituted only 10% of each healthcare dollar spent in the USA in 2015. Examples of challenges encountered in liver clinical trials include lack of validated patient-reported outcome tools, blinding issues, and the use o...
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Review article Source Type: research
Cardiac echoparameters (geometry and dimensions), interleukin 6, and anthropometric measurements in Egyptian adolescents with hepatitis C and hepatocellular carcinoma
Conclusion
IL-6 is a useful marker to compare between HCV and HCC in adolescent patients instead of depending on the evaluation of cardiac and growth complications that showed no differences. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research
Assessment of health-related quality of life after hepatocellular carcinoma management (radiofrequency ablation or transarterial chemoembolization): a pilot Egyptian study
This study aimed to assess the effect of HCC and different locoregional HCC therapy [radiofrequency ablation (RFA) or transarterial chemoembolization (TACE)] on the HRQoL.
Patients and methods
Eighty HCC patients with CLD, 58 (72.5%) men and 22 (27.5%) women, mean age 51.8±6.2 years, were categorized into two groups. Group I included 40 HCC patients treated with RFA and group II included 40 HCC patients treated with TACE. The control Group included 40 CLD patients without HCC. HCC was managed according to the Barcelona Clinic Liver Cancer algorithm. The Short Form-36 questionnaires were filled in before and 1 month aft...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research
Peritransplant predictors of small-for-size syndrome and surveillance of graft functions in an Egyptian Adult Living Donor Liver Transplantation Center
This study was conducted on 45 Egyptian adult recipients and their graft donors in one of Egyptian ALDLT Center. The recipients were divided as follows: group I: included eight recipients diagnosed as SFSS. This group was subdivided into two subgroups according to mortality incidence. Subgroup 1A: included five recipients who are still alive. Subgroup 1B: included three recipients, two of them died after 21 days, and the third one died after 1 month. Group II: included 37 recipients without SFSS. Perioperative predictors of SFSS in both recipients and donors were assessed and compared between the two groups.
Results
Gra...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research
Dieulafoy’s lesion the uncommon cause of upper gastrointestinal bleeding
Upper gastrointestinal bleeding is a challenging condition for the gastroenetrologists. The most common causes in a descending manner are peptic ulcer, erosive disease, variceal bleeding, esophagitis, Mallory–Weiss tears, malignancy, vascular lesions, and no identified causes. Dieulafoy's lesion is a congenital arterial malformation that is associated with brisk bleeding, shock, lower hemoglobin concentration and increased demand for blood transfusion. It is associated with 20% rebleeding rate. It is difficult to diagnose especially in acute severe bleeding cases. Usually it is identified endoscopically as 2–5 mm pigme...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Case report Source Type: research
Natural history of chronic hepatitis C development and progression as a consequence of iron and HFE or TfR1 mutations
Conclusion
Hepatic iron and HFE and TfR1 mutations were comorbid factors that increased progression of chronic hepatitis C and decreased the response to interferon therapy. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original article Source Type: research
Sex hormone profile in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation
Background and aim
Gonadal function is affected significantly in male patients with cirrhosis. The aim of this study was to assess the level of sex hormones in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation.
Patients and methods
This cross-sectional study was carried out on 40 consecutive male patients with hepatitis C virus-related cirrhosis of Child–Pugh class C in addition to 20 age-matched healthy male participants (control group). All were subjected to an assay of serum hormonal levels: total and free testosterone, estradiol (E2), sex hormone-binding glo...
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research
