The role of fecal calprotectin in diagnosing inflammatory bowel disease and detecting disease activity
Conclusion
FC is a sensitive and noninvasive marker that can be used to differentiate IBD from irritable bowel syndrome and to detect IBD activity. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Antivinculin antibodies as a marker of irritable bowel syndrome–diarrhea in Egyptian patients
Conclusion
This study recommends the use of antivinculin antibodies as a potential diagnostic biomarker in Egyptian patients with IBS-D with underlying low-grade inflammation as a possible pathogenetic mechanism in IBS. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Adiponectin mediates the hypolipidemic effect of Spirulina against experimentally-induced non-alcoholic fatty liver in rats
Conclusion
Spirulina treatment of NAFL rats showed antisteatotic properties; effects that could be attributed at least partially to modulating serum adiponectin and TNF-α levels. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Vitamin D status and CYP27B1-1260 promoter polymorphism in hepatitis C virus-infected children and its effect on response to interferon-α-based treatment
Background
Hepatitis C virus (HCV) is a major cause of chronic liver disease with significant morbidity and mortality. Recent evidence suggests that vitamin D through its immunomodulatory, anti-inflammatory, and antifibrotic properties may affect clinical outcomes and treatment response in HCV infection.
Aim
The aim was to study the vitamin D status in children with chronic HCV infection and the relation of serum levels of 25-hydroxycholecalciferol (25OHD), 1,25-dihydroxycholecalciferol [1,25(OH)2D], and genetic polymorphism of 1α-hydroxylase (CYP27B1-1260 rs10877012) to the response to interferon-α (IFN-α)-based t...
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Hepatitis C virus infection in patients with chronic kidney disease and kidney transplantation: an update
Hepatitis C virus (HCV) is independently associated with the development of chronic kidney disease (CKD) and is a significant cause of some forms of glomerulonephritis (GN), especially membranoproliferative GN and mixed cryoglobulinemia syndrome with renal damage. In addition, HCV is a frequent consequence of CKD and increases cardiovascular and liver-related mortality in patients on regular dialysis. HCV also negatively impacts kidney transplant (KT) recipients contributing to post-transplant morbidity and mortality by increasing the risk of new-onset diabetes post-transplant, GN, malignancy, and liver-related complicatio...
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Review article Source Type: research
Neutrophil, lymphocyte, and platelet-containing ratios as predictors for hepatocellular carcinoma recurrence in Egyptian patients
Conclusion
Low-cost markers such as PLR, NLR, and PNLR could be used to predict recurrence after locoregional intervention in HCC. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Evaluation of macrophage inflammatory protein-1β in diagnosis of spontaneous bacterial peritonitis
Conclusion
MIP-1β measured in the ascitic fluid may serve as a diagnostic as well as a prognostic marker for diagnosis and treatment of SBP. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Evaluating noninvasive scoring systems’ accuracy versus liver biopsy in fibrosis staging in patients with nonalcoholic fatty liver disease
Conclusion
BARD and FIB-4 scores are better than NAFLD fibrosis score in predicting liver fibrosis in patients with NAFLD and can be reliably used as noninvasive methods for exclusion of advanced fibrosis in patients with NAFLD. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Serum aflatoxin B1M1 and hepatocellular carcinoma in post-hepatitis C virus-infected Egyptian patients
Objectives
Hepatitis C virus (HCV) chronically infected patients occur in about 3% of the world population with an increased risk to developing liver cirrhosis and cancer. Aflatoxin B1 (AFB1), a known human carcinogen, has a synergistic effect on HCV-induced hepatocellular carcinoma (HCC). We aimed to evaluate the association between AF B1M1 serum level and HCC in post-HCV-infected Egyptian patients.
Patients and methods
Group I: 25 HCV-infected patients with HCC; group II: 25 HCV-infected patients without HCC, as well as control group of 25 healthy individuals.
Results
Serum levels of α fetoprotein (AFP) and AFM1...
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Diagnostic and prognostic value of glypican-3 as a biomarker in the diagnosis of hepatocellular carcinoma in Egyptian patients with hepatitis C virus-related cirrhosis before and after interventional treatment
Conclusion
GPC-3 has better diagnostic performance than alfa feto protein (AFP) in differentiating HCC from other groups and giving better evaluation in response to treatment in different HCC groups in addition to a combination of GPC-3 and AFP among HCC groups (radiofrequency and transarterial chemoembolization) slightly increases the sensitivity of AFP. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Splenomegaly in patients with nonalcoholic fatty liver disease
Conclusion
Splenomegaly is present in 10.38% of the NAFLD patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Platelet count/prothrombin time ratio as a noninvasive predictor for esophageal varices in Egyptian patients with hepatitis C virus-related liver cirrhosis
Conclusion
Platelet count/prothrombin time ratio may be used as a new noninvasive predictor for presence of esophageal varices in patients with HCV-related cirrhosis. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Evaluation of serum resistin levels in patients with hepatocellular carcinoma before and after treatment
This study was a randomized, cross-sectional comparative study. Serum resistin levels were measured in 50 patients with hepatitis C virus-related cirrhosis (30 patients with HCC versus 20 patients without HCC).
Results
Patients with HCC had higher levels of serum resistin. Moreover, the size and number of hepatic focal lesions as well as portal vein invasion had significant correlation with serum resistin. Serum resistin had also significant positive correlations with the following: total bilirubin, international normalized ratio, and model of end-stage liver disease score. A significant reduction of serum resistin leve...
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Assessment of serum hepcidin level and iron profile in obese patients with nonalcoholic fatty liver disease
This study was a case–control comparative study. Serum hepcidin and iron profile were measured in 60 obese patients (30 obese patients with NAFLD vs. 30 obese patients without NAFLD as a control group).
Results
NAFLD patients had significantly higher levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, low-density lipoprotein, and serum hepcidin than the control group (P (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
Study of serum visfatin level in patients with nonalcoholic fatty liver disease and its role in progression to nonalcoholic steatohepatitis
Conclusion
Serum visfatin might be considered as a marker for NAFLD and as an unfavorable prognostic indicator for development of NASH. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research
