The role of fecal calprotectin in diagnosing inflammatory bowel disease and detecting disease activity
Conclusion FC is a sensitive and noninvasive marker that can be used to differentiate IBD from irritable bowel syndrome and to detect IBD activity. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Antivinculin antibodies as a marker of irritable bowel syndrome–diarrhea in Egyptian patients
Conclusion This study recommends the use of antivinculin antibodies as a potential diagnostic biomarker in Egyptian patients with IBS-D with underlying low-grade inflammation as a possible pathogenetic mechanism in IBS. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Adiponectin mediates the hypolipidemic effect of Spirulina against experimentally-induced non-alcoholic fatty liver in rats
Conclusion Spirulina treatment of NAFL rats showed antisteatotic properties; effects that could be attributed at least partially to modulating serum adiponectin and TNF-α levels. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Vitamin D status and CYP27B1-1260 promoter polymorphism in hepatitis C virus-infected children and its effect on response to interferon-α-based treatment
Background Hepatitis C virus (HCV) is a major cause of chronic liver disease with significant morbidity and mortality. Recent evidence suggests that vitamin D through its immunomodulatory, anti-inflammatory, and antifibrotic properties may affect clinical outcomes and treatment response in HCV infection. Aim The aim was to study the vitamin D status in children with chronic HCV infection and the relation of serum levels of 25-hydroxycholecalciferol (25OHD), 1,25-dihydroxycholecalciferol [1,25(OH)2D], and genetic polymorphism of 1α-hydroxylase (CYP27B1-1260 rs10877012) to the response to interferon-α (IFN-&...
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Hepatitis C virus infection in patients with chronic kidney disease and kidney transplantation: an update
Hepatitis C virus (HCV) is independently associated with the development of chronic kidney disease (CKD) and is a significant cause of some forms of glomerulonephritis (GN), especially membranoproliferative GN and mixed cryoglobulinemia syndrome with renal damage. In addition, HCV is a frequent consequence of CKD and increases cardiovascular and liver-related mortality in patients on regular dialysis. HCV also negatively impacts kidney transplant (KT) recipients contributing to post-transplant morbidity and mortality by increasing the risk of new-onset diabetes post-transplant, GN, malignancy, and liver-related complicatio...
Source: Egyptian Liver Journal - October 1, 2018 Category: Gastroenterology Tags: Review article Source Type: research

Neutrophil, lymphocyte, and platelet-containing ratios as predictors for hepatocellular carcinoma recurrence in Egyptian patients
Conclusion Low-cost markers such as PLR, NLR, and PNLR could be used to predict recurrence after locoregional intervention in HCC. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Evaluation of macrophage inflammatory protein-1β in diagnosis of spontaneous bacterial peritonitis
Conclusion MIP-1β measured in the ascitic fluid may serve as a diagnostic as well as a prognostic marker for diagnosis and treatment of SBP. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Evaluating noninvasive scoring systems’ accuracy versus liver biopsy in fibrosis staging in patients with nonalcoholic fatty liver disease
Conclusion BARD and FIB-4 scores are better than NAFLD fibrosis score in predicting liver fibrosis in patients with NAFLD and can be reliably used as noninvasive methods for exclusion of advanced fibrosis in patients with NAFLD. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Serum aflatoxin B1M1 and hepatocellular carcinoma in post-hepatitis C virus-infected Egyptian patients
Objectives Hepatitis C virus (HCV) chronically infected patients occur in about 3% of the world population with an increased risk to developing liver cirrhosis and cancer. Aflatoxin B1 (AFB1), a known human carcinogen, has a synergistic effect on HCV-induced hepatocellular carcinoma (HCC). We aimed to evaluate the association between AF B1M1 serum level and HCC in post-HCV-infected Egyptian patients. Patients and methods Group I: 25 HCV-infected patients with HCC; group II: 25 HCV-infected patients without HCC, as well as control group of 25 healthy individuals. Results Serum levels of α fetoprotein (AFP) and...
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Diagnostic and prognostic value of glypican-3 as a biomarker in the diagnosis of hepatocellular carcinoma in Egyptian patients with hepatitis C virus-related cirrhosis before and after interventional treatment
Conclusion GPC-3 has better diagnostic performance than alfa feto protein (AFP) in differentiating HCC from other groups and giving better evaluation in response to treatment in different HCC groups in addition to a combination of GPC-3 and AFP among HCC groups (radiofrequency and transarterial chemoembolization) slightly increases the sensitivity of AFP. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Splenomegaly in patients with nonalcoholic fatty liver disease
Conclusion Splenomegaly is present in 10.38% of the NAFLD patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Platelet count/prothrombin time ratio as a noninvasive predictor for esophageal varices in Egyptian patients with hepatitis C virus-related liver cirrhosis
Conclusion Platelet count/prothrombin time ratio may be used as a new noninvasive predictor for presence of esophageal varices in patients with HCV-related cirrhosis. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Evaluation of serum resistin levels in patients with hepatocellular carcinoma before and after treatment
This study was a randomized, cross-sectional comparative study. Serum resistin levels were measured in 50 patients with hepatitis C virus-related cirrhosis (30 patients with HCC versus 20 patients without HCC). Results Patients with HCC had higher levels of serum resistin. Moreover, the size and number of hepatic focal lesions as well as portal vein invasion had significant correlation with serum resistin. Serum resistin had also significant positive correlations with the following: total bilirubin, international normalized ratio, and model of end-stage liver disease score. A significant reduction of serum resistin leve...
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Assessment of serum hepcidin level and iron profile in obese patients with nonalcoholic fatty liver disease
This study was a case–control comparative study. Serum hepcidin and iron profile were measured in 60 obese patients (30 obese patients with NAFLD vs. 30 obese patients without NAFLD as a control group). Results NAFLD patients had significantly higher levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglycerides, low-density lipoprotein, and serum hepcidin than the control group (P (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Study of serum visfatin level in patients with nonalcoholic fatty liver disease and its role in progression to nonalcoholic steatohepatitis
Conclusion Serum visfatin might be considered as a marker for NAFLD and as an unfavorable prognostic indicator for development of NASH. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Serum adiponectin in Egyptian patients with chronic hepatitis B virus infection
Conclusion Patients with chronic HBV infection have increased levels of serum adiponectin, and this may be directly responsible for the low incidence of IR in those patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Early treatment of recurrent hepatitis C virus infection after liver transplantation in the era of direct-acting antivirals, what we have learned till now?
Conclusion Early treatment with newer combinations of DAAs for recurrent HCV after the first 3 months after LT is recommended to achieve high rates of SVR and adequate safety profile. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Cystic neuroblastoma with liver metastasis
We report the case of a 9-month-old girl having cystic neuroblastoma with liver metastasis that remained asymptomatic for 1 year and 2 months of follow-up and review the literature on the topic. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Case report Source Type: research

Metabolic outcomes of laparoscopic sleeve gastrectomy
Conclusion LSG is a feasible and safe restrictive bariatric procedure, with good short-term results. It offers the advantages of a simple and reproducible technique with good outcome and low morbidity and mortality. LSG is accepted as a standalone definitive therapy, as it has a high percentage of postoperative excess weight loss as well as reduction of obesity-related comorbidities. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Effect of Helicobacter pylori on insulin resistance in nonobese, nondiabetic, and normolipidemic Egyptian patients
Conclusion H. pylori infection has a positive effect on the NAFLD score and the HOMA-IR with older age, even after removing confounders of hyperlipidemia, hyperglycemia, and obesity from the equation, but this needs further confirmation by a wide-scale studies. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Golgi protein 73 versus serum α-fetoprotein as tumor markers for hepatocellular carcinoma in patients with hepatitis C cirrhosis
Conclusion Serum GP-73 level at cut-off value of 16.25 ng/ml can be used as a diagnostic marker for HCC in patients with chronic HCV. However, it is not superior to AFP as both of them had the same sensitivity, but AFP showed higher specificity. Combination of both increases the sensitivity. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Predictive value of hepcidin in patients with chronic hepatitis C infection among Egyptians
This study included 80 (54 patients and 26 controls) individual who were matched in age and sex. Serum hepcidin levels and serum iron status were determined. Their levels were correlated with each other and with other laboratory parameters. Results Mean serum hepcidin levels were significantly lower in patients with CHC than in controls (P=0.001). Patients with CHC had significantly higher mean values of serum iron and ferritin than controls (P=0.001 and 0.017, respectively). There was a significant negative correlation between hepcidin levels and alanine aminotransferase, (r=−0.454, P (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Sofosbuvir/simeprevir versus sofosbuvir/ribavirin regimen in Egyptian patients with hepatitis C virus
Conclusion A 12-week course of sofosbuvir/simeprevir showed a higher response rate than 24 weeks of sofosbuvir/ribavirin among patients with HCV-related Child A cirrhosis. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Original articles Source Type: research

Drug development challenges in liver disease clinical trials
Drug development process faces many challenges, including those encountered in clinical trials for liver diseases. Drug development is a lengthy and highly costly process. Only 10% of compounds entering first study in humans (phase 1) make it to the market after an average of 14 years with a cost of ~$3 billion. Interestingly, according to the Centers for Medicare and Medicaid services, prescription drugs constituted only 10% of each healthcare dollar spent in the USA in 2015. Examples of challenges encountered in liver clinical trials include lack of validated patient-reported outcome tools, blinding issues, and the use o...
Source: Egyptian Liver Journal - January 1, 2018 Category: Gastroenterology Tags: Review article Source Type: research

Cardiac echoparameters (geometry and dimensions), interleukin 6, and anthropometric measurements in Egyptian adolescents with hepatitis C and hepatocellular carcinoma
Conclusion IL-6 is a useful marker to compare between HCV and HCC in adolescent patients instead of depending on the evaluation of cardiac and growth complications that showed no differences. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Assessment of health-related quality of life after hepatocellular carcinoma management (radiofrequency ablation or transarterial chemoembolization): a pilot Egyptian study
This study aimed to assess the effect of HCC and different locoregional HCC therapy [radiofrequency ablation (RFA) or transarterial chemoembolization (TACE)] on the HRQoL. Patients and methods Eighty HCC patients with CLD, 58 (72.5%) men and 22 (27.5%) women, mean age 51.8±6.2 years, were categorized into two groups. Group I included 40 HCC patients treated with RFA and group II included 40 HCC patients treated with TACE. The control Group included 40 CLD patients without HCC. HCC was managed according to the Barcelona Clinic Liver Cancer algorithm. The Short Form-36 questionnaires were filled in before and 1 mon...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Peritransplant predictors of small-for-size syndrome and surveillance of graft functions in an Egyptian Adult Living Donor Liver Transplantation Center
This study was conducted on 45 Egyptian adult recipients and their graft donors in one of Egyptian ALDLT Center. The recipients were divided as follows: group I: included eight recipients diagnosed as SFSS. This group was subdivided into two subgroups according to mortality incidence. Subgroup 1A: included five recipients who are still alive. Subgroup 1B: included three recipients, two of them died after 21 days, and the third one died after 1 month. Group II: included 37 recipients without SFSS. Perioperative predictors of SFSS in both recipients and donors were assessed and compared between the two groups. Results Gra...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Dieulafoy’s lesion the uncommon cause of upper gastrointestinal bleeding
Upper gastrointestinal bleeding is a challenging condition for the gastroenetrologists. The most common causes in a descending manner are peptic ulcer, erosive disease, variceal bleeding, esophagitis, Mallory–Weiss tears, malignancy, vascular lesions, and no identified causes. Dieulafoy's lesion is a congenital arterial malformation that is associated with brisk bleeding, shock, lower hemoglobin concentration and increased demand for blood transfusion. It is associated with 20% rebleeding rate. It is difficult to diagnose especially in acute severe bleeding cases. Usually it is identified endoscopically as 2–5 ...
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Case report Source Type: research

Natural history of chronic hepatitis C development and progression as a consequence of iron and HFE or TfR1 mutations
Conclusion Hepatic iron and HFE and TfR1 mutations were comorbid factors that increased progression of chronic hepatitis C and decreased the response to interferon therapy. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2017 Category: Gastroenterology Tags: Original article Source Type: research

Sex hormone profile in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation
Background and aim Gonadal function is affected significantly in male patients with cirrhosis. The aim of this study was to assess the level of sex hormones in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation. Patients and methods This cross-sectional study was carried out on 40 consecutive male patients with hepatitis C virus-related cirrhosis of Child–Pugh class C in addition to 20 age-matched healthy male participants (control group). All were subjected to an assay of serum hormonal levels: total and free testosterone, estradiol (E2), sex hormone-binding...
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

The relation between nonalcoholic fatty liver disease and carotid intima-media thickness in Egyptian patients
This study was designed to assess the correlation between NAFLD as a cardiovascular risk factor and carotid atherosclerosis. Patients and methods A hospital-based case–control analytical study was conducted on 60 participants who were divided into three groups as follows. Group I included 20 diabetic patients with NAFLD. Group II included 20 nondiabetic patients with NAFLD. Group III included 20 healthy participants who served as a control group. The right and left carotid intima-media thickness (CIMTs) and their maximum reading (CIMTmax) was measured by a skilled sonographer blind to the groups. Pelviabdominal ul...
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Use of sofosbuvir in combination with ribavirin with or without pegylated interferon for the treatment of patients with hepatitis C infection genotype 4
Conclusion Use of PEG-IFN-α with ribavirin and SOF increases the SVR more than the use of both drugs alone. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Feasibility of single-port laparoscopic appendectomy
Conclusion SPLA demonstrates its feasibility and supports the promise of minimizing the access of laparoscopic surgery. The clear advantage is its cosmetic benefit. SPLA is a safe technique and shows excellent cosmetic results. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Evaluating tumor necrosis factor-α and interleukin-6 in spontaneous bacterial peritonitis
Conclusion Serum and ascitic fluid samples should be included in the routine investigations carried out on hospitalized patients with cirrhosis and ascites. Examination of these samples for levels of TNF-α and IL-6 help in early detection of SBP to avoid complication. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Microbiological study of spontaneous bacterial peritonitis in Tanta University Hospitals: empirical antibiotic therapy
Conclusion E. coli is the most common organism causing SBP; however, Gram positive bacteria are progressively increasing. Meropenem and amikacin are the drugs of choice for empirical treatment with increasing resistance to third-generation cephalosporins. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Can hepatitis C virus core antigen be used as a reliable marker of viral load for hepatitis C virus infection in genotype 4?
In this study, HCV core antigen sensitivity, specificity, positive predictive value, and negative predictive value were 96.15, 100, 100, and 80%, respectively, in relation to HCV RNA PCR results. There was a positive correlation between HCV RNA and HCV core Ag (r=0.916, P (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - January 1, 2017 Category: Gastroenterology Tags: Original articles Source Type: research

Antiviral and immunomodulatory effects of oral bovine lactoferrin therapy among patients with chronic hepatitis C
Conclusion Oral BLF is a promising immunomodulatory drug; it is safe and has no side effects and can be used in combination with other antiviral drugs for the treatment of patients with CHC. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Impact of schistosomal periportal fibrosis on the results of transient elastography (FibroScan) in pure bilharzial patients
Conclusion Patients with hepatic schistosomiasis and significant periportal fibrosis had a higher stiffness on examination with TE, which could influence treatment judgment. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Thyroid dysfunction in chronic viral hepatitis [B and C]; An Egyptian pilot study
Conclusion Chronic HCV infection can be associated with the appearance of TD. Antithyroid Abs (anti-TG and anti-TPO Abs) provide valuable information as regards the TD that may occur in patients with both HCV and HBV. Chronic HCV-infected patients should be informed of the risk for TD, and hence the importance of their screening for autoantibodies and serum TSH hormone to assess their medical status. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Relation between hepatitis B viral load and liver fibrosis assessed using transient elastography in patients with chronic hepatitis B virus infection
Conclusion HB viral load was nonsignificantly higher in patients with higher grades of liver fibrosis and cirrhosis with weak diagnostic performance in differentiation between different fibrosis stages. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Antiviral and immunomodulatory effects of oral bovine lactoferrin therapy among patients with chronic hepatitis C
Conclusion: Oral BLF is a promising immunomodulatory drug; it is safe and has no side effects and can be used in combination with other antiviral drugs for the treatment of patients with CHC. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Impact of schistosomal periportal fibrosis on the results of transient elastography (FibroScan) in pure bilharzial patients
Conclusion: Patients with hepatic schistosomiasis and significant periportal fibrosis had a higher stiffness on examination with TE, which could influence treatment judgment. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Thyroid dysfunction in chronic viral hepatitis [B and C]; An Egyptian pilot study
Conclusion: Chronic HCV infection can be associated with the appearance of TD. Antithyroid Abs (anti-TG and anti-TPO Abs) provide valuable information as regards the TD that may occur in patients with both HCV and HBV. Chronic HCV-infected patients should be informed of the risk for TD, and hence the importance of their screening for autoantibodies and serum TSH hormone to assess their medical status. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Relation between hepatitis B viral load and liver fibrosis assessed using transient elastography in patients with chronic hepatitis B virus infection
Conclusion: HB viral load was nonsignificantly higher in patients with higher grades of liver fibrosis and cirrhosis with weak diagnostic performance in differentiation between different fibrosis stages. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - October 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Chronic hepatitis following short-term colchicine use in a child: case report and review of the literature
We report on a child developing chronic hepatitis after short-term colchicine use in therapeutic doses and review the literature on the topic. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2016 Category: Gastroenterology Tags: Case report Source Type: research

Value of serum CA 19-9 in obstructive jaundice
Conclusion: A nonsignificant decrease in CA 19-9 following biliary drainage in cases of obstructive jaundice suggests malignancy. Malignant obstructive jaundice could be predicted at CA 19-9 cutoff value above 40.5 IU/ml. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Assessment of interleukin-28B (interferon λ3) rs12979860 C/T gene polymorphism and the risk for hepatocellular carcinoma in chronic hepatitis C cirrhotic patients
Conclusion: Our study concluded that IL-28 C/T gene polymorphism may contribute to risk for developing hepatoma in CHC cirrhotic patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Transient elastography (Fibroscan) in prediction of esophageal varices in hepatitis C virus-related chronic liver disease: an Egyptian experience
Conclusion: Transient elastography (Fibroscan) can predict the presence of EVs and large varices and may help to select patients for endoscopic screening. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - July 1, 2016 Category: Gastroenterology Tags: Original articles Source Type: research

Assessment of glucokinase regulatory protein rs1260326 gene variant polymorphism in the development of nonalcoholic fatty liver disease among Egyptian obese children
Conclusion: The most prevalent polymorphic genotype of rs 1260326 within the GCKR among Egyptian obese children with NAFLD was CC, and the most prevalent allele among them was the C allele. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2016 Category: Gastroenterology Tags: Original Articles Source Type: research

TRAIL-R1 polymorphisms predict the risk of development of hepatocellular carcinoma in Egyptian patients with chronic hepatitis C: a case control study
Conclusion: DR4 polymorphisms are associated with the risk of developing HCC in HCV patients and can allow better risk stratification of those patients and can help in the early detection, management, and better outcome of HCC/HCV patients. (Source: Egyptian Liver Journal)
Source: Egyptian Liver Journal - April 1, 2016 Category: Gastroenterology Tags: Original Articles Source Type: research