Significance of tumor-associated macrophage density and CXCR4 expression in renal cell carcinoma
Objective
Renal cancers are considered immunogenic tumors that are frequently infiltrated by immune cells. Tumor-associated macrophages (TAMs) represent a major leukocyte population, infiltrating tumors, and are associated with poor prognosis. Chemokines and their receptors play an important role in the tumorigenesis of many malignancies. The purpose of this investigation was to assess the immunohistochemical expression of TAM-related marker CD68 and chemokine receptor CXCR4 and study their correlation with other clinicopathological factors to detect the usefulness of these markers in the diagnosis and prognosis of renal...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Expression of aquaporin 3 and vascular endothelial growth factor in transitional cell carcinoma-urinary bladder: an immunohistochemical study
Introduction
Dysregulation of aquaporins (AQPs) is thought to be involved in urothelial carcinogenesis and progression. Angiogenesis is necessary for the growth and subsequent metastasis of transitional cell carcinoma. However, whether there is a positive association in transitional cell carcinoma has not yet been established. This research was conducted to analyze the expression of AQP3 and vascular endothelial growth factor (VEGF) in transitional cell carcinoma with a view toward its development and progression and to correlate them with clinicopathological parameters.
Patients and methods
This is a retrospective, s...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Role of fine-needle aspiration cytology in the diagnosis of salivary gland lesions: a 5-year institutional experience
Conclusion
Salivary gland FNAC continues to have a high diagnostic accuracy; consequently, it is helpful for designing appropriate management. Lesions with classic cytomorphology are easily diagnosed; however, pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma, and cysts may impart a diagnostic challenge when inadequately aspirated and therefore we advice repeat aspiration under image guidance. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Comparative analysis of the utility of GATA-binding protein 3 opposed to gross cystic disease fluid protein-15 in the diagnosis of metastatic breast carcinomas and diverse molecular subtypes
Background
Estrogen receptor, gross cystic disease fluid protein-15 (GCDFP-15), and mammaglobin are molecular markers generally used to delineate breast origin. However, these breast-specific markers are frequently lost in triple-negative tumors and some metastatic breast carcinomas. Lately, GATA-binding protein 3 (GATA-3) has emerged as a putative marker in the diagnosis of mammary carcinoma, a relatively specific immunomarker for the breast.
Aim
The aim of this study was to compare the diagnostic performance of GATA-3 and GCDFP-15 in distinguishing metastatic tumor of breast primary and its diverse molecular subtype...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Immuohistochemical expression and prognostic significance of PD-L1 and P53 expression in astrocytoma
Conclusion
The high expression of PD-L1 and P53 was associated with higher grade and poor survival in astrocytoma. A significant association between PD-L1 and P53 might emphasize the interaction between P53 and PD-L1 during astrocytoma progression. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Diagnostic and prognostic significance of immunohistochemistry in pancreatic tumors
Aim
The aim of this study was to reveal better immunohistochemical diagnostic markers for differentiating solid pseudopapillary neoplasm (SPN) from neuroendocrine tumor (NET) and pancreatic ductal adenocarcinoma (PDAC) and examine their prognostic significance in pancreatic tumors.
Patients and methods
We reviewed 55 pancreatic surgical specimens of SPN (10 cases), NET (15 cases), and PDAC (30 cases). We carried out comprehensive immunohistochemical profiling using three markers: CD99, E-cadherin, and claudin-5.
Results
In SPN, 90% (9/10) of the cases displayed paranuclear dot-like immunoreactivity for CD99; in con...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Evaluation of K-Ras mutation and Fas tissue expression in common neoplastic and nonneoplastic colonic lesions
This study enrolled 85 cases: control 10, ulcerative colitis (UC) with and without dysplasia 3 and 7, respectively, Crohn’s disease (CD) 10, bilharzial colitis 15, and CRC 40. Immunohistochemical staining for K-Ras and Fas monoclonal antibodies was done.
Results
K-Ras was negative in control. UC with and without dysplasia, CD and bilharzial colitis showed positivity for K-Ras relative to CRC (P (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
The potential role of Beclin 1 and Bcl-2 expression in renal cell carcinoma: an immunohistochemical study
Conclusion
It seems reasonable to assume that Beclin 1 may play a role in RCC tumorigenesis. High Beclin 1 level is an unfavorable prognostic factor of RCC being linked with aggressive histopathologic parameters. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Osteopontin tissue expression and vitamin D levels in normal versus preeclamptic pregnancies
Objective
Over the last few years, vitamin D deficiency (VDD) was inconsistently reported to be linked to the development of preeclampsia. Osteopontin is an adhesion molecule necessary for trophoblastic invasion, a process which is defective in preeclampsia. As vitamin D was shown to affect osteopontin expression in different tissues, this study investigated this relation in preeclampsia.
Patients and methods
Gestational age-matching (32–40 weeks) controls (n=51) and preeclamptic pregnancies (n=51) were enrolled in this case–control study. Preeclampsia was subdivided into mild, early-onset, and late-onset severe p...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Clinicopathological significance and prognostic effect of CD133 expression in invasive ductal breast carcinoma
Conclusion
CD133 was overexpressed in breast cancers with aggressive features. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Significance of combined analysis of PARP1 and EZH2 expression as potentially targetable biomarkers in breast cancer
Conclusion
Our findings prove that the combined high PARP1 and EZH2 expression was statistically associated with poor prognosis and survival outcome in early-stage BC, in particular BRCA1-negative and TNBC. Therefore, these results suggest that patients with high PARP1 and EZH2 expression may benefit from combining PARPi and EZH2 inhibitor therapy in BRCA1-negative BCs. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Childhood ganglioneuroma: experience of the Children’s Cancer Hospital Egypt
Conclusion
GN has very good outcome with or without surgical removal of the mass. GNBi also presents nearly the same clinicopathologic features, with same favorable outcome even in cases showing incomplete resection. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Snail-1, ALDH1, and claudin-1 tissue protein expression in patients with colorectal cancer: clinicopathological and prognostic implications
In this study, we aimed to determine whether EMT markers, the expression of stem cell markers, and levels of the tight junction proteins are associated with the clinical and pathological features and clinical prognosis of patients with CRC by evaluating tissue protein expression of Snail-1, ALDH1, and claudin-1.
Patients and methods
Expressions of Snail-1, ALDH1, and claudin-1 were evaluated in sections from 50 paraffin blocks that were retrieved from 50 patients having CRC. We have followed up the patients for 3 years. We correlated expression of markers with clinical, pathological, and follow-up parameters.
Results
...
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Diagnostic utility of claudin-1 and cytokeratin 17 expression in different follicular thyroid lesions
Conclusion
The use of claudin-1 and CK17 can be valuable in differentiating thyroid carcinoma from other mimicking benign thyroid follicular lesions, but they cannot help in segregating types of thyroid cancer. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
Hepatocellular expression of epithelial–mesenchymal transition markers in a sample of hepatitis C virus-infected Egyptian patients
In conclusion, we assume that hepatocytes show a phenotypic transition to fibroblasts. The increased positivity of the fibroblastic markers in cirrhosis and HCC signifies that EMT of hepatocytes participates in the progression of fibrosis and development of HCC. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2018 Category: Pathology Tags: ORIGINAL ARTICLES Source Type: research
