Egyptian Journal of Medical Human Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Modified T-cells (using TCR and CTAs), chimeric antigen receptor (CAR) and other molecular tools in recent gene therapy
Publication date: July 2018Source: Egyptian Journal of Medical Human Genetics, Volume 19, Issue 3Author(s): A.S. Odiba, V.E. Ottah, O.K. IrohaAbstractT-cell-based cancer immunotherapy by the transfer of cloned TCRs that are isolated from tumor penetrating T-cells becomes a possibility through NY-ESOc259; a human-derived affinity-enhanced TCR that provides a level of sufficiency in long-term safety and efficacy. NY-ESOc259 recognizes a peptide common to CTAs (LAGE-1 and NY-ESO-1) in melanoma. Risks associated with insertion related transformation in gene therapy have been alleviated through strategies that include the engin...
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Autism and KIR genes of the human genome: A brief meta-analysis
ConclusionsAutism spectrum disorders are accompanied by KIR3DS1 which is an activating gene of KIR. It seems that hyper-activity of NK cells results in inflammation in neuroimmune system that in turn can be associated with autism. The legend of 3DS1 receptor is unknown, and suggested to be investigated. This meta-analysis should be updated in future. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Oncolytic virotherapy – A novel strategy for cancer therapy
Publication date: July 2018Source: Egyptian Journal of Medical Human Genetics, Volume 19, Issue 3Author(s): Mohanan Geetha Gopisankar, A. SurendiranAbstractOncolytic virotherapy is a new modality of cancer treatment which uses competent replicating viruses to destroy cancer cells. This field progressed from earlier observations of accidental viral infections causing remission in many malignancies to virus drugs targeting and killing cancer cells. More competent and specific viruses which attack tumor cells but not healthy cells could be made with advancements in the field of genetic engineering. Studying virus as a drug ha...
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese
ConclusionOur study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer
ConclusionThe interaction of the cell death pathway genes Fas and FasL polymorphisms could be associated with the risk of lung cancer, in the same respect Fas AA genotype could also potentiate this risk. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Evaluation of the association of single nucleotide polymorphisms in DDP4 and CDK5RAP2 genes with rheumatoid arthritis susceptibility in Iranian population
ConclusionsIt appears that gene polymorphisms of DPP4 and CDK5RAP2 are not involved in the pathogenesis of RA in Iranian population. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of variable number tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in children
Conclusionwe concluded that the P2 allele is an allelic variant predisposing to ESRD in children with CKD and it could be considered a risk factor for the development of ESRD. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Expression study of CYP19A1 gene in a cohort of Iranian leiomyoma patients
ConclusionsOur results were in accordance with previous studies and imply that up-regulation of CYP19A1 is correlated with the pathogenesis of leiomyoma tumors. We also observed that expression level of CYP19A1 was not linked to the tumor size or localization. It can be concluded that; up-regulation of aromatase is a key factor in the initiation of tumor development as well as tumor growth. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population
ConclusionThese findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population. Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Copy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration
ConclusionObservations of an association between CNVs of VEGF gene and wet AMD have revealed that the CNVs of VEGF gene appears to be a possible contributor to wet AMD subjects in Malaysia. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Genotyping of PPAR-γ gene polymorphism in Egyptian neonates affected with sepsis disease and its severity
ConclusionPPAR-γ gene has been suggested to be a candidate gene for neonatal sepsis. Therefore, Pro12Ala polymorphism might be useful in predicting the risk factor of neonatal sepsis and its severity. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

A modified protocol for highly efficient EBV-mediated immortalization of human B lymphocytes from small volumes of peripheral blood serum
ConclusionThe method is applicable for immortalization of B lymphocytes from small blood samples and is essential for studies involving children or patients when large blood volume sampling is impossible. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Risk factors of neural tube defects: A reality of Batna region in Algeria
ConclusionNTD represents a real public health problem in Batna, Algeria. Various genetic and/or nutritional factors are implicated, although the mechanism is not clear. We suggest that further research should continue planning for preventive measures and effective treatment to reduce the incidence of NTDs in Algeria. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran
ConclusionIn Lur population of Iran, 1513A/C polymorphism of P2X7 is associated with susceptibility to pulmonary TB. It is suggested that bio-information banks should be established and developed in countries. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research

Association of interleukin-6 and its -174G/C promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients
ConclusionSerum IL-6 levels and -174G/C promoter polymorphism were higher in RA patients than in healthy controls. The positive correlation of IL-6 level with the DAS28 and duration of morning stiffness may confirm its’ increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan. The negative correlation of IL-6 level with the hemoglobin level may confirm IL-6 play a significant role in anemia of RA. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 5, 2018 Category: Genetics & Stem Cells Source Type: research