Egyptian Journal of Basic and Applied Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Diphyllin: An effective anticandidal agent isolated from Cleistanthus collinus leaf extract
In this study, diphyllin [9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one] was isolated from Cleistanthus collinus leaf extract. The isolated compound and leaf extract were evaluated for their in vitro anticandidal activity against Candida strains such as Candida albicans, C. tropicalis, and C. glabrata. Diphyllin was found to possess higher anticandidal activity against various Candida species with the Minimal Fungicidal Concentration (MFC) of 85–145 μg and inhibition zone of 9.5 ± 0.5–13.5 ± 0.5 mm at 200 μg concentration against the yeast pathogens studied. Thus, diphy...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Fatty acids and survival of bacteria in Hammam Pharaon springs, Egypt
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Yehia A. Osman, Mahmud Mokhtar Gbr, Ahmed Abdelrazak, Amr M. MowafyAbstractA great lack of knowledge of Hammam Pharaon's microbial community; the most famous hot spring in Sinai, Egypt, derived this work. Three different hyperthermophilic bacterial were isolated from vents in the area, where the temperature was above 80 °C. Response Surface Methodology algorithm such as Central Composite Design determined the optimum cultivation conditions for these isolates. Accordingly, the best growth conditions were at 70â€...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Therapeutic challenges in ocular delivery of lipid based emulsion
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Rahul Tiwari, Vikas Pandey, Saket Asati, Vandana Soni, Dharmendra JainAbstractIn the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil globule...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
The aqueous extract of Ocimum gratissimum leaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats
In conclusion, Ocimum gratissimum leaves possesses ameliorative effects against acetic acid-induced colitis as a consequence of its anti-inflammatory and anti-oxidative properties. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Screening and identification of novel inhibitors against human 4-aminobutyrate-aminotransferase: A computational approach
Publication date: Available online 6 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): S. Vijayakumar, G. Kasthuri, S. Prabhu, P. Manogar, N. ParameswariAbstract4-Aminobutyrate aminotransferase (GABA) receptors are the key mediators of quick inhibitory synaptic transmission in the midpoint of the nervous system in mammalian. Dysfunction of GABA receptors contributes the genetic disorders and chronic neurological disorders include childhood absence epilepsy, juvenile myoclonic epilepsy, adolescent myoclonic epilepsy, and seizures. They get affected by mutations of GABA subunit genes from the brain. T...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Malignant pleural mesothelioma: Presentation of a case report
Publication date: Available online 7 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Munir Ahmad, Muhammad Omer Aamir, Khurram Minhas, Khwaja Ajmal, Iftikhar AhmadAbstractMalignant pleural mesothelioma (MPM) is a rare and highly aggressive intrathoracic neoplasm that typically offer poor prognosis. In general, development of MPM is linked with a history of asbestos exposure. Herein we report a 56-year-old female patient with MPM, who presented with complains of chest pain, cough, shortness of breath and weight loss. The patient’s radiological work-up demonstrated right sided plural effusion with...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Characterization and applications of exopolysaccharide produced by marine Bacillus altitudinis MSH2014 from Ras Mohamed, Sinai, Egypt
Publication date: Available online 8 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Sahar S. Mohamed, Shaimaa K. Amer, Manal S. Selim, Hala M. RifaatAbstractThe present study aims to survey exopolysaccharides (EPSs) production in 29 bacterial strains isolated from the sediments around the mangrove trees in Ras Mohamed area, Red Sea Coast, Sinai Peninsula, Egypt. Two of the strains were able to produce EPSs. A higher yield of EPS was obtained from isolate No. 12. Strain identification resulted in a close similarity with Bacillus altitudinis. The produced EPS was characterised as a heteropolysaccha...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Column chromatography and HPLC analysis of phenolic compounds in the fractions of Salvinia molesta mitchell
In this study the active fractions of the fern extract were separated using column chromatography and phenolic compounds present in the active fractions were determined by RP-HPLC. Ethyl acetate extract was found to possess significant pharmacological activity when compared to other extracts under study and therefore an attempt was made to fractionate ethyl acetate extract. The analysis was performed through two different mobile phases involving solvent A (acetonitrile) and solvent B (0.1% phosphoric acid in water) and solvent A (methanol) and Solvent B (4% acetic acid). HPLC analysis indicated the presence of phenolic com...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Molecular structure investigation towards pharmacodynamic activity and QSAR analysis on hypoxanthine using experimental and computational tools
Publication date: Available online 14 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): G. Susithra, S. Ramalingam, S. Periandy, R. AarthiAbstractThe structural properties of Hypoxanthine compound related to molecular dynamic activity have been ornately interpreted in this methodical research work. The FT-IR, FT-Raman, NMR and UV–Visible spectral analysis has been carried out and the obtained results were validated using theoretical tools. The tautomerism of the compound has been monitored while analyzing the molecular structure regarding to describe unknown properties and applications. The displa...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Protective effect of Spirulina against cyclophosphamide-induced urotoxicity in mice
In conclusion, pre-treatment with Sp protected mice from CP-induced urotoxicity, probably via its anti-oxidant and anti-apoptotic properties. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research
Therapeutic challenges in ocular delivery of lipid based emulsion
Publication date: Available online 12 April 2018 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Rahul Tiwari, Vikas Pandey, Saket Asati, Vandana Soni, Dharmendra Jain In the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil glob...
Source: Egyptian Journal of Basic and Applied Sciences - April 12, 2018 Category: Science Source Type: research
Microwave-assisted spent black tea leaves as cost-effective and powerful green adsorbent for the efficient removal of Eriochrome black T from aqueous solutions
Publication date: Available online 10 April 2018 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Ayub Khan, Xiangke Wang, Kashif Gul, Fazli Khuda, Zaynab Aly, A.M. Elseman In this work, microwave-assisted spent black tea leaves (MASTL) were used as effective low-cost green adsorbents for the removal of Eriochrome Black T (EBT) from aqueous solutions and adequately characterized. The pHpzc of MASTL was found to be 4.6. The experimental conditions, such as pH, contact time, temperature, adsorbent dose and EBT concentration, were optimized to evaluate the interaction of EBT with MASTL. The adsorption ...
Source: Egyptian Journal of Basic and Applied Sciences - April 10, 2018 Category: Science Source Type: research
Fatty acids and survival of bacteria in Hammam Pharaon springs, Egypt
Publication date: Available online 10 April 2018 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Yehia A.O. Ellazeik, Mahmud Mokhtar Gbr, Ahmed Abdelrazak, Amr M. Mowafy A great lack of knowledge of Hammam Pharaon's microbial community; the most famous hot spring in Sinai, Egypt, derived this work. Three different hyperthermophilic bacterial were isolated from vents in the area, where temperature was above 80 °C. Response Surface Methodology algorithm such as Central Composite Design, determined the optimum cultivation conditions for these isolates. Accordingly, the best growth conditions were at ...
Source: Egyptian Journal of Basic and Applied Sciences - April 10, 2018 Category: Science Source Type: research
Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke
Publication date: Available online 19 February 2018 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed Khalifa Waterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. T...
Source: Egyptian Journal of Basic and Applied Sciences - February 20, 2018 Category: Science Source Type: research
6-(2-Morpholinoethyl)-thiazolo[3,2-a]pyrimidin-5-one: A novel scaffold for the synthesis of potential PI3k α inhibitors
Publication date: Available online 16 February 2018 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Ahmed R. Ali, Eman R. El-Bendary, Mariam A. Ghaly, Ihsan A. Shehata The present study involves the development of certain thiazolo[3,2-a]pyrimidin-5-ones linked through an ethylene bridge to various amines. The newly synthesized compounds 4–6(a–c) were subjected to in vitro anticancer evaluation using NCI antitumor screening. The target compounds showed observed activity against Renal UO-31 cancer cell line with cell growth promotion 52.72–64.52%. COMPARE analyses revealed compounds 4a and 4b exh...
Source: Egyptian Journal of Basic and Applied Sciences - February 17, 2018 Category: Science Source Type: research
