Synthesis, characterization and anticancer activity of vincristine loaded folic acid-chitosan conjugated nanoparticles on NCI-H460 non-small cell lung cancer cell line
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Naresh Kumar, Raj Kumar Salar, Minakshi Prasad, Koushlesh RanjanAbstractVincristine is used to treat different type of cancers. But unwanted side effects limit their applications in medicine. To overcome these side effects by targeted drug delivery approach, we synthesized vincristine loaded folic acid-chitosan conjugated nanoparticles by ionic gelation method. The nanoparticles were characterized using Dynamic Light Scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (S...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Phytochemical screening, antioxidant, anti-inflammatory and antiangiogenic activities of Lophira procera A. Chev. (Ochnaceae) medicinal plant from Gabon
The objective of this study was to perform phytochemical screening, to determine the content of phenolic compound, to evaluate antioxidant, anti-inflammatory and antiangiogenic activities of ethanol, water-ethanol and water extracts of Lophira procera. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and phosphomolybdenum assay, anti-inflammatory activity by proteins denaturation inhibition and membranes stabilization test and antiangiogenic activity by chicken chorioallantoic membrane (CAM) method. The results showed that this plant is rich in saponins, polyphenols, tannins, total flavonoids, pr...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed KhalifaAbstractWaterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. The a...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Al Shaima G. Abd El Salam, Mohamed A. Ebrahim, Laila A. Eissa, Mamdouh M. El-Shishtawy (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

A comparative study on larvicidal potential of selected medicinal plants over green synthesized silver nano particles
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Jagadeeswari Sathyan, Mohamed Rafi Mahboob, Kisore P. Venkatesh, Kishore RameshAbstractLarvicidal activity was assessed for alcoholic extracts of Phyllanthus amarus, Annona squamosa, Coccinia grandis and Eclipta prostrata extracted using solvents of various polarity. Third instar stage larvae of Dengue-vector, Aedes aegypti and Japanese encephalitis (JE) causing mosquito Culex tritaeniorhynchus were subjected to larvicidal bioassay at various concentrations (100...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Islam Rady, Hadir Mohamed, Mohamad Rady, Imtiaz A. Siddiqui, Hasan MukhtarAbstract(-)-epigallocatechin-3-gallate (EGCG), the major bioactive catechin in green tea (GT) has been studied for almost past thirty years as an agent initially for its cancer chemoprevention effects and then for its cancer chemotherapeutic ability. This agent has shown considerable anti-cancer effects in a variety of preclinical cell culture and animal model systems. However, its clinical application to human patients is hampered by a var...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Analysis of efficiency of different antennas for microwave ablation using simulation and experimental methods
The objective of this study is to analyze the efficiency of different antennas proposed for microwave ablation therapy using numerical simulation and experimental approach. The simulation was done with COMSOL MULTIPHYSICS® software to design antenna prototypes and evaluate its reflection coefficient, power dissipation distribution, power dissipation density, specific absorption rate and temperature distribution in tissue. Antennas were fabricated from a 50 Ω RG405/U semi-rigid coaxial cable to match the geometric prototypes generated during simulation. Ex vivo bovine livers were ablated with the fabricated antennas usi...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Molecular docking and QSAR analysis of a few Gama amino butyric acid aminotransferase inhibitors
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Usman Abdulfatai, Adamu Uzairu, Sani UbaAbstractMolecular docking and quantitative structure–activity relationship (QSAR) studies were carried out on 37 anticonvulsant compounds to develop a robust model for the prediction of anticonvulsant activities against Gama amino butyric acid aminotransferase (GABAAT) and to determine the dominant structural amino acid residues responsible for the binding affinity of the ligand-GABAAT complex. AutoDock Vina of PyRx virtual screening software was used to perform the molec...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

The vasorelaxant effect of Canarium odontophyllum Miq. (Dabai) extract in rat thoracic aorta
ConclusionThis study suggests that the vasorelaxant effect of aqueous extract from CO leaves was endothelium-independent and was possibly mediated through the blockade of voltage-dependent calcium channel and receptor-operated calcium channel. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Antimicrobial activity of silver nanoparticles biosynthesised by Rhodotorula sp. strain ATL72
In conclusion, the pink yeast Rhodotorula sp., strain ATL72 isolated from Egypt is a promising new biological source for the synthesis of silver nanoparticles having a potent antimicrobial activity against a wide range of pathogenic bacteria and fungi. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

6-(2-Morpholinoethyl)-thiazolo[3,2-a]pyrimidin-5-one: A novel scaffold for the synthesis of potential PI3kα inhibitors
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Ahmed R. Ali, Eman R. El-Bendary, Mariam A. Ghaly, Ihsan A. ShehataAbstractThe present study involves the development of certain thiazolo[3,2-a]pyrimidin-5-ones linked through an ethylene bridge to various amines. The newly synthesized compounds 4–6(a–c) were subjected to in vitro anticancer evaluation using NCI antitumor screening. The target compounds showed observed activity against Renal UO-31 cancer cell line with cell growth promotion 52.72–64.52%. COMPARE analyses revealed compounds 4a and 4b exhibiti...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Asila Ahmed Salim Al Habsi, Mohammad Amzad HossainAbstractTraditionally, Dodonaea viscosa (D. viscosa) is used worldwide for the treatment of different chronic diseases. The current investigation involves the isolation, structure characterization and prediction of antioxidant compounds from the leaves of D. viscosa, which was collected from AL-Hamra, Sultanate of Oman. The leaves samples were used for the extraction of plant constituents with methanol by using hot extraction method. The methanol solvent was evapor...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Microwave-assisted spent black tea leaves as cost-effective and powerful green adsorbent for the efficient removal of Eriochrome black T from aqueous solutions
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Ayub Khan, Xiangke Wang, Kashif Gul, Fazli Khuda, Zaynab Aly, A.M. ElsemanAbstractIn this work, microwave-assisted spent black tea leaves (MASTL) were used as effective low-cost green adsorbents for the removal of Eriochrome Black T (EBT) from aqueous solutions and adequately characterized. The pHpzc of MASTL was found to be 4.6. The experimental conditions, such as pH, contact time, temperature, adsorbent dose and EBT concentration, were optimized to evaluate the interaction of EBT with MASTL. The adsorption isot...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Spectrophotometic determination of Lorazepam in pharmaceutical tablets using batch and reverse flow injection methods
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Maryam Jamal, Hind HadiAbstractA reverse flow injection analysis (RFIA) spectrophotometric method have been developed and compared with batch method for the determination of lorazepam (LOR) at the microgram level in pure and pharmaceutical dosage forms. The methods are based on the reaction of LOR with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ferric chloride in aqueous medium. The water soluble green color product was measured at λmax 659 nm. Under the optimum conditions, l...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Antifungal activity of fabricated mesoporous silica nanoparticles against early blight of tomato
In this study, we described synthesis and evaluation of the direct antifungal activity of mesoporous silica nanoparticles (MSN) compared to metalaxyl (recommended fungicide) against A. solani under laboratory and greenhouse conditions. The structural features of MSN such as high porosity, small particle size and suitable shape contributed to its high antifungal efficacy against Alternaria solani. Laboratory synthesized MSN showed marked increase in tomato growth parameters compared to untreated control. Our study presents promising results of the use of MSN as an effective and safe alternative of fungicides for managing to...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research