Evaluating the Efficacy of Intratympanic Dexamethasone in Protecting Against Irreversible Hearing Loss in Patients on Cisplatin-Based Cancer Treatment: A Randomized Controlled Phase IIIB Clinical Trial
Objective:
To determine the efficacy of long-term high-dose intratympanic dexamethasone in protecting the hearing capacity of cancer patients undergoing cisplatin-based ototoxic treatment.
Design:
A randomized controlled phase IIIB clinical trial to evaluate the efficacy of dexamethasone in protecting against hearing loss in patients undergoing cisplatin treatment. The subjects participating in the clinical trial were patients with a neoplastic disease whose treatment protocol included cisplatin. The average dose of cisplatin was 444.87 mg (SD 235.2 mg). Treatment consisted of intratympanically administering...
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Clinical Trials Source Type: research
Speech Audiometrical Results Before and After Reimplantation of Cochlear Implants
Conclusions:
The present study shows that speech reception performance after reimplantation yields faster and better results than the first implant. It takes a couple of months to get better results than those before the reimplantation. Only in a minority of participants, a small deterioration may be observed. It seems that soft failures in the absence of measurable technical abnormalities call for caution with regard to reimplantation. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
The Longitudinal Relationship Between Speech Recognition in Noise, Need for Recovery After Work, Job Demand, and Job Control Over a Period of 5 Years
Conclusion:
The significant longitudinal association between 5-year worsening in speech recognition in noise and increase in need for recovery over the same time period strengthens the evidence for the importance of early detection of a worsening in speech recognition in noise to identify employees with an increase in need for recovery. The absence of an effect of the uptake of a hearing solution on need for recovery indicates that additional alternative interventions may be needed to foster beneficial use of hearing solutions as well as to mitigate the increased need for recovery in case of worsening speech recognitio...
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Optimizing Parameters for Using the Parallel Auditory Brainstem Response to Quickly Estimate Hearing Thresholds
Conclusions:
The optimal stimulation rate for the pABR is 40 Hz but using multiple rates may prove useful. Perceptual thresholds that subtly change across rate allow for a testing paradigm that easily transitions between rates, which may be useful for quickly estimating thresholds for different configurations of hearing loss. These optimized parameters facilitate expediency and effectiveness of the pABR to estimate hearing thresholds in a clinical setting. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Phantom Stimulation for Cochlear Implant Users With Residual Low-Frequency Hearing
Conclusions:
(1) CI users with low-frequency acoustic residual hearing benefit from low-frequency information conveyed acoustically through combined EAS. (2) Improved speech reception thresholds through low-frequency information conveyed via phantom stimulation were observed for EAS subjects when acoustic stimulation was not used. (3) Speech perception was negatively affected by combining acoustic and phantom stimulation when both stimulation modalities overlapped spectrally in comparison to the familiar EAS. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Changes in Vestibular Function Following Pediatric Cochlear Implantation: a Prospective Study
Conclusions:
The impact of CI on the vestibular function in our dataset was limited. Therefore, the many advantages of simultaneous bilateral implantation may outweigh the risk for vestibular damage postoperatively. However, the impact on the vestibular function may be dependent on various factors (e.g., etiology of the hearing loss), and the clinical outcome is still difficult to predict. Vestibular assessment remains thus an important aspect in the pediatric CI population; first because the vestibular function should be considered in the decision-making process on (simultaneous or sequential bilateral) CI and second ...
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Multiple Cases of Auditory Neuropathy Illuminate the Importance of Subcortical Neural Synchrony for Speech-in-noise Recognition and the Frequency-following Response
Conclusion:
Subcortical synchrony is subject to multiple forms of disruption but results in a consistent phenotype of an absent FFR and substantial difficulties recognizing SIN. These results support the hypothesis that subcortical synchrony is necessary for the FFR. Thus, in healthy listeners, the FFR may reflect subcortical neural processes important for SIN recognition. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Home Auditory Environments of Children With Cochlear Implants and Children With Normal Hearing
Conclusions:
These findings suggest that there are similarities and differences in the home auditory environment experienced by children with CIs and children with NH. These findings have implications for early intervention programs to promote spoken language development for children with CIs. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
A Retrospective Study of Hearing Loss in Patients Diagnosed with Peroxisome Biogenesis Disorders in the Zellweger Spectrum
Conclusion:
The results of this retrospective study provide insight into the hearing loss associated with PBD-ZSD, but also emphasize the need for more complete assessments of hearing loss type and middle ear function in these patients. The addition of more comprehensive datasets to the ongoing natural history study will enhance our understanding of the pathophysiology underlying PBD-ZSD and guide the development of targeted evaluation and management recommendations for patients with PBD-ZSD. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Assessing Loss to Follow-up After Newborn Hearing Screening in the Neonatal Intensive Care Unit: Sociodemographic Factors That Affect Completion of Initial Audiological Evaluation
Conclusions:
Maternal age, gravidity, and smoking status are risk factors for loss to follow-up for NHS in newborns with extended NICU stay, a group at high risk for hearing loss. Our findings demonstrate that socioeconomic and demographic factors for loss to follow-up in the extended-stay NICU population are distinct from the well-baby population. Further investigation of these patients will allow prioritization of limited resources to subgroups within the extended-stay NICU population at risk for loss to follow-up for newborn hearing screening. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Preserving Wideband Tympanometry Information With Artifact Mitigation
Conclusions:
Unlike smoothing algorithms used in the past, our artifact mitigation specifically removes artifacts caused by noise. It does not change frequency response characteristics, such as narrow-band peaks and notches in absorbance at different frequencies that can be important for diagnosis. Also, by reducing intermeasurement variability, the artifact mitigation can improve the test–retest reliability of these measurements. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
The Recognition of Whispered Speech in Real-Time
Conclusion:
When listeners are confronted with whispered speech, they engage in a “wait-and-see” approach. Listeners delay lexical access, and by the time they begin to consider what word they are hearing, the beginning of the word has largely come and gone, and activation for cohorts is reduced. However, delays in lexical access actually increase consideration of rhyme competitors; the delay pushes lexical activation to a point later in processing, and the recognition system puts more weight on the word-final overlap between the target and the rhyme. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Changes in Orientation Behavior due to Extended High-Frequency (5 to 10 kHz) Spatial Cues
Conclusions:
These earlier, swifter orientations demonstrate spatial benefits beyond static localization accuracy in plausible conditions; extended bandwidth without pinna cues provided more salient cues in a realistic mixture of talkers. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Acoustic Change Complex and Visually Reinforced Infant Speech Discrimination Measures of Vowel Contrast Detection
Conclusions:
The ACC for vowel contrasts presented at a rate of 2/s is a robust index of vowel-contrast detection when obtained in typically developing infants under the age of 1 year. The ACC is present in over 90% of infants tested at this rate when an amplitude ratio criterion of ≥1.5 is used to define a response. The amplitude ratio appears to be a sensitive metric for the difference between a control and contrast condition. The ACC can be obtained in infants who do not yet exhibit valid behavioral responses for vowel change contrasts and may be useful for estimating neural capacity for discriminating these sound...
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
Effects of Device Limitations on Acquisition of the /t/-/k/ Contrast in Children With Cochlear Implants
Conclusions:
Children with CIs not only produced /t/ and /k/ less accurately than peers with NH, they also demonstrated idiosyncratic patterns of acquisition, likely resulting from receiving degraded and distorted spectral information critical for differentiating /t/ and /k/. Speech-language pathologists should consider perceptual confusability of consonants (and their allophonic variations) during their assessment and treatment of this unique population of children. (Source: Ear and Hearing)
Source: Ear and Hearing - February 28, 2022 Category: Audiology Tags: Research Article Source Type: research
