An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval
Conclusions Latent signal detection in FAERS validated using the EHR presents an automated and data-driven approach for systematically identifying novel QT-DDIs. The high-confidence hypotheses flagged using this method warrant further investigation. (Source: Drug Safety)
Source: Drug Safety - February 10, 2016 Category: Drugs & Pharmacology Source Type: research

Safety Profile of Atorvastatin 80 mg: A Meta-Analysis of 17 Randomized Controlled Trials in 21,910 Participants
Conclusions Patients treated with atorvastatin 80 mg/day, specifically patients with coronary artery disease (CAD), have a higher risk of transaminase elevation, which is not seen if patient exposure is less than 16 weeks. Atorvastatin 80 mg/day is less well-tolerated compared with controls, especially in patients with CAD, but an overall favorable tolerability profile is found if patient exposure is less than 52 weeks. (Source: Drug Safety)
Source: Drug Safety - February 10, 2016 Category: Drugs & Pharmacology Source Type: research

Side Effects and Efficacy of Neuraxial Opioids in Pregnant Patients at Delivery: A Comprehensive Review
Abstract Neuraxial opioids are an integral part of obstetric anaesthesia and have contributed to greatly improved analgesia for labour and caesarean delivery, both intraoperatively and postoperatively. Despite these advantages, neuraxial opioids may be associated with a number of side effects, some of which (such as respiratory depression), although rare, may be associated with significant morbidity and mortality. The risk of respiratory depression appears to be increased with less lipophilic opioids such as morphine but can be reduced with careful patient selection and monitoring. Other side effects such as pruri...
Source: Drug Safety - January 30, 2016 Category: Drugs & Pharmacology Source Type: research

Vulnerable Patients and Potential Harms: The Contribution of Observational Research
(Source: Drug Safety)
Source: Drug Safety - January 28, 2016 Category: Drugs & Pharmacology Source Type: research

Social Media Listening for Routine Post-Marketing Safety Surveillance
Conclusion Social media listening is an important tool to augment post-marketing safety surveillance. Much work remains to determine best practices for using this rapidly evolving data source. (Source: Drug Safety)
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

Use of Prescription Drug Samples in the USA: A Descriptive Study with Considerations for Pharmacoepidemiology
Conclusions We observed markedly differential exposure to medication samples between branded and generic drugs. This can introduce bias in pharmacoepidemiologic studies, especially when adverse events that occur soon after drug initiation are of interest. (Source: Drug Safety)
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

Safety of Intranasal Quadrivalent Live Attenuated Influenza Vaccine (QLAIV) in Children and Adolescents: A Pilot Prospective Cohort Study in England
Conclusion The pilot study showed no significant change in reactogenicity or other apparent safety signals from the data collected. Continued enhanced surveillance of seasonal influenza vaccines will ensure their ongoing safety for the prevention of serious illness from seasonal influenza outbreaks. (Source: Drug Safety)
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

Sequence Symmetry Analysis as a Signal Detection Tool for Potential Heart Failure Adverse Events in an Administrative Claims Database
Conclusion SSA generated potential new signals of HF for some anti-glaucoma and anti-dyspepsia medicines. For some of the potential signals, the event is biologically plausible and some have pre-marketing and post-marketing case reports to support the finding. Confirmation of these signals using cohort studies is required. (Source: Drug Safety)
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

Maximizing the Post-Approval Safety of Flibanserin: A Role for Regulators, Clinicians, and Patients
Abstract In August 2015, the US Food and Drug Administration (FDA) made the controversial decision to approve flibanserin (Addyi®) for women experiencing hypoactive sexual desire disorder. A number of factors contributed to disagreements regarding the FDA’s decision, including the product’s two prior failed FDA reviews, the unmet need of women with this disorder, extensive advocacy and politicization surrounding the product’s relevance to women and sexual health, the potential for widespread off-label use, and the product’s tenuous risk/benefit profile. Despite that, attention now shift...
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

The 9th International Congress on Cutaneous Adverse Drug Reactions at the 23rd World Congress of Dermatology in Vancouver, 2015
(Source: Drug Safety)
Source: Drug Safety - January 21, 2016 Category: Drugs & Pharmacology Source Type: research

Adverse Drug Reaction Reporting in Africa and a Comparison of Individual Case Safety Report Characteristics Between Africa and the Rest of the World: Analyses of Spontaneous Reports in VigiBase ®
Conclusions As at the end of September 2015, 35 of 54 African countries were Full Member countries of the PIDM. Although the number of ICSRs from Africa has increased substantially, ICSRs from Africa still make up
Source: Drug Safety - January 11, 2016 Category: Drugs & Pharmacology Source Type: research

Post-Marketing Benefit–Risk Assessment of Rotavirus Vaccination in Japan: A Simulation and Modelling Analysis
Conclusions The benefit–risk balance for Rotarix™ is favorable in Japan. From a public health perspective, the benefits in terms of prevented RVGE hospitalizations and deaths for the vaccinated population far exceed the estimated risks due to intussusception. (Source: Drug Safety)
Source: Drug Safety - January 9, 2016 Category: Drugs & Pharmacology Source Type: research

Performance of Stratified and Subgrouped Disproportionality Analyses in Spontaneous Databases
Conclusions Subgroup analyses perform better than stratified analyses and should be considered over the latter in routine first-pass signal detection. Subgroup analyses are also clearly beneficial over crude analyses for larger databases, but further validation is required for smaller databases. (Source: Drug Safety)
Source: Drug Safety - January 9, 2016 Category: Drugs & Pharmacology Source Type: research

Social Media Mining for Toxicovigilance: Automatic Monitoring of Prescription Medication Abuse from Twitter
Conclusion Our study indicates that social media can be a crucial resource for obtaining abuse-related information for medications, and that automatic approaches involving supervised classification and natural language processing hold promises for essential future monitoring and intervention tasks. (Source: Drug Safety)
Source: Drug Safety - January 9, 2016 Category: Drugs & Pharmacology Source Type: research

Comparative Safety and Tolerability of Prostacyclins in Pulmonary Hypertension
Abstract Prostacyclin (PGI2) is a prostaglandin derived from arachidonic acid in the endothelium and smooth muscle which causes vasodilation, inhibits platelet aggregation, and has anti-inflammatory, anti-thrombotic and anti-proliferative effects. In pulmonary arterial hypertension (PAH), PGI2 levels and PGI2 synthase expression are reduced, contributing to the vasoconstriction and vascular smooth muscle cell proliferation seen in the disease. Based on these findings, PGI2 analogues were developed to target this pathway. Epoprostenol was the first targeted therapy available for treating PAH. Due to the short half-...
Source: Drug Safety - January 9, 2016 Category: Drugs & Pharmacology Source Type: research

Traceability of Biologics in The Netherlands: An Analysis of Information-Recording Systems in Clinical Practice and Spontaneous ADR Reports
Conclusion The limited traceability of brand names and batch numbers in ADR reports may be primarily caused by the shortcomings in the recording of information in clinical practice. We recommend efforts to improve information-recording systems as a first step to improve the traceability of biologics in ADR reporting. (Source: Drug Safety)
Source: Drug Safety - December 30, 2015 Category: Drugs & Pharmacology Source Type: research

Clinicians’ Reports in Electronic Health Records Versus Patients’ Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin
Abstract Introduction Large databases of clinician reported (e.g., allergy repositories) and patient reported (e.g., social media) adverse drug reactions (ADRs) exist; however, whether patients and clinicians report the same concerns is not clear. Objectives Our objective was to compare electronic health record data and social media data to better understand differences and similarities between clinician-reported ADRs and patients’ concerns regarding aspirin and atorvastatin. Methods This pilot study explored...
Source: Drug Safety - December 29, 2015 Category: Drugs & Pharmacology Source Type: research

Safety of Dalbavancin in the Treatment of Skin and Skin Structure Infections: A Pooled Analysis of Randomized, Comparative Studies
Conclusion Dalbavancin exhibits a favorable overall safety profile for treatment of acute bacterial skin and skin structure infections due to Gram-positive bacteria. (Source: Drug Safety)
Source: Drug Safety - December 29, 2015 Category: Drugs & Pharmacology Source Type: research

A Method for the Minimization of Competition Bias in Signal Detection from Spontaneous Reporting Databases
Conclusion The ComIn could greatly minimize the competition bias in SDR detection. Further study using a larger dataset is needed. (Source: Drug Safety)
Source: Drug Safety - December 29, 2015 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity Associated with the Use of Anti-TNF-α Agents
Abstract Medications to inhibit the actions of tumour necrosis factor alpha have revolutionized the treatment of several pro-inflammatory autoimmune conditions. Despite their many benefits, several serious side effects exist and adverse reactions do occur from these medications. While many of the medications’ potential adverse effects were anticipated and recognized in clinical trials prior to drug approval, several more rare adverse reactions were recorded in the literature as the popularity, availability and distribution of these medications grew. Of these potential adverse reactions, liver injury, althoug...
Source: Drug Safety - December 21, 2015 Category: Drugs & Pharmacology Source Type: research

Renal and Bone Adverse Effects of a Tenofovir-Based Regimen in the Treatment of HIV-Infected Children: A Systematic Review
Conclusion This systematic review summarises the reports of renal and bone adverse effects of a TDF-containing regimen in the treatment of HIV-infected children. Our findings suggest that the benefits of using TDF in children need to be balanced against the potential risk of toxicity. (Source: Drug Safety)
Source: Drug Safety - December 21, 2015 Category: Drugs & Pharmacology Source Type: research

Appropriate Polypharmacy and Medicine Safety: When Many is not Too Many
Abstract The use of multiple medicines (polypharmacy) is increasingly common in middle-aged and older populations. Ensuring the correct balance between the prescribing of ‘many’ drugs and ‘too many’ drugs is a significant challenge. Clinicians are tasked with ensuring that patients receive the most appropriate combinations of medications based on the best available evidence, and that medication use is optimised according to patients’ clinical needs (appropriate polypharmacy). Historically, polypharmacy has been viewed negatively because of the associated medication safety risks, such ...
Source: Drug Safety - December 21, 2015 Category: Drugs & Pharmacology Source Type: research

Pharmacovigilance is … Vigilance
Abstract The world changes continuously and pharmacovigilance as a new discipline also must change. There are new fields opening with novel challenges whilst we are still perfecting ways to manage and improve the basic challenges such as inadequate data for decision making and under-reporting. Traditional medicines, vaccines, poisoning and medication error are all aspects of the safety of medicines that we have monitored for decades, though without perhaps paying enough attention to their special aspects. There are many new stakeholders taking serious interest in pharmacovigilance outside the regulatory sphere and...
Source: Drug Safety - December 21, 2015 Category: Drugs & Pharmacology Source Type: research

Risk of Inflammatory Bowel Disease with Oral Contraceptives and Menopausal Hormone Therapy: Current Evidence and Future Directions
Abstract Crohn’s disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel diseases, are archetypical inflammatory disorders of the gastrointestinal tract with rising incidence worldwide. Although the role of genetic factors in disease development has been highlighted by genome-wide association studies, environmental risk factors likely play a pivotal role in development of CD and UC. Prior observational studies have suggested a link between exogenous hormone use and risk of CD and UC. Specifically, studies have shown an association between oral contraceptive use and risk of CD and m...
Source: Drug Safety - December 12, 2015 Category: Drugs & Pharmacology Source Type: research

Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case–Control Analysis Using the Clinical Practice Research Datalink
Conclusion Current use of SSRIs or SNRIs was associated with a twofold increased risk of first-time seizures compared with non-use, while current use of TCAs (mostly low dose) was not associated with seizures. Treatment initiation in SSRI and SNRI users was associated with a higher risk of seizures than longer-term treatment. (Source: Drug Safety)
Source: Drug Safety - December 9, 2015 Category: Drugs & Pharmacology Source Type: research

Tools for Assessing Potential Significance of Pharmacist Interventions: A Systematic Review
Conclusions The majority of tools focused primarily on assessing clinical aspects and failed to detect comprehensive impacts. The heterogeneity of tools and assessment processes hindered our ability to synthesize the results of evaluations. Limited results for their validity and reliability cast doubt on the credibility of this methodology for justification of the value of PIs. Recommendations for development of tools with optimal theoretical, pragmatic, and psychometric properties are proposed. (Source: Drug Safety)
Source: Drug Safety - December 9, 2015 Category: Drugs & Pharmacology Source Type: research

Advances in the Pharmacogenomics of Adverse Drug Reactions
Abstract Rapid developments in pharmacogenomics have been noticeable in recent years, and much of this knowledge has improved understanding of adverse drug reactions. This improved knowledge has largely been the result of improved sequencing technologies and falling costs in this area, as well as improved statistical techniques to analyse the data derived from studies. While the genetic reasons behind adverse drug reactions are becoming better understood, translation of this knowledge, particularly in terms of biomarkers that might be clinically applicable at the bedside, has been more difficult. Understanding of ...
Source: Drug Safety - December 9, 2015 Category: Drugs & Pharmacology Source Type: research

Psychiatric Disorders and Montelukast in Children: A Disproportionality Analysis of the VigiBase ®
Abstract Introduction In 2008, the US FDA issued an alert about an increased risk of psychiatric events associated with montelukast. Recent national pharmacovigilance analyses in Sweden, France and Spain detected a potential increase in reporting risk of the association. Aim Our objective was to analyse spontaneous reports of psychiatric events in children and adolescents worldwide treated with montelukast. Methods We conducted a retrospective analysis of Individual Case Safety Reports (ICSRs) recorded up to 1 Janu...
Source: Drug Safety - November 30, 2015 Category: Drugs & Pharmacology Source Type: research

What Is the Plural of a ‘Yellow’ Anecdote?
(Source: Drug Safety)
Source: Drug Safety - November 23, 2015 Category: Drugs & Pharmacology Source Type: research

Acknowledgement to Referees
(Source: Drug Safety)
Source: Drug Safety - November 19, 2015 Category: Drugs & Pharmacology Source Type: research

Mortality Risk of Hypnotics: Strengths and Limits of Evidence
Abstract Sleeping pills, more formally defined as hypnotics, are sedatives used to induce and maintain sleep. In a review of publications for the past 30 years, descriptive epidemiologic studies were identified that examined the mortality risk of hypnotics and related sedative–anxiolytics. Of the 34 studies estimating risk ratios, odds ratios, or hazard ratios, excess mortality associated with hypnotics was significant (p 
Source: Drug Safety - November 13, 2015 Category: Drugs & Pharmacology Source Type: research

The Association Between Potentially Inappropriate Prescribing and Medication-Related Hospital Admissions in Older Patients: A Nested Case Control Study
Conclusion Our study shows that patients with potentially inappropriate prescribing detected with the STOPP & START 2008 criteria are at risk of preventable medication-related hospital admissions. The STOPP & START 2008 criteria can be used to identify older people at risk of medication-related problems. (Source: Drug Safety)
Source: Drug Safety - November 9, 2015 Category: Drugs & Pharmacology Source Type: research

Consumer Understanding, Preferences, and Responses to Different Versions of Drug Safety Messages in the United States: A Randomized Controlled Trial
We examined how making certain modifications to the way drug risk information is communicated has an impact on comprehension and behavioral intentions, including the user’s likelihood of discontinuing the drug. We also studied how comprehension varied by respondent characteristics, health literacy skills, risk perceptions, and trust in the message. Results Based on a five-item comprehension index, the revised version of the message was associated with significantly greater comprehension of the information relative to the standard version (63 vs 52 % correct, p 
Source: Drug Safety - November 7, 2015 Category: Drugs & Pharmacology Source Type: research

Adverse Drug Reactions Reported to a National HIV & Tuberculosis Health Care Worker Hotline in South Africa: Description and Prospective Follow-Up of Reports
Conclusion Queries about rashes, DILIs and kidney injuries were common. Detection and management of these ADRs should be included in HCW training. In cases with follow-up, concordance with advice was high, and HCWs reported improvement in the majority. (Source: Drug Safety)
Source: Drug Safety - November 7, 2015 Category: Drugs & Pharmacology Source Type: research

Reversal Strategies for NOACs: State of Development, Possible Clinical Applications and Future Perspectives
Abstract The non-vitamin K antagonist oral anticoagulants (NOACs) are used for thromboembolic prophylaxis of patients with atrial fibrillation and in the treatment as well as secondary prophylaxis of patients with venous thromboembolism. Even though NOACs have a better safety profile than vitamin K antagonists (VKAs), there will still be bleeding complications on NOAC treatment. In some cases, stopping the NOAC and non-drug-related management such as manual compression and interventional endoscopy will be sufficient to stop the bleeding. In more serious bleeding events and before acute surgery, coagulation factor ...
Source: Drug Safety - October 30, 2015 Category: Drugs & Pharmacology Source Type: research

An Empirical Approach to Explore the Relationship Between Measures of Disproportionate Reporting and Relative Risks from Analytical Studies
Abstract Introduction Although it seems reasonable to suppose that a drug that increases the risk of an adverse event might tend to show increased disproportionality statistics in spontaneous reporting databases, that relationship is not clear. Therefore, an empirical approach was taken to investigate the relationship between proportional reporting ratios (PRRs) and relative risk (RR) estimates from formal studies in a set of known adverse drug reactions (ADRs). Methods Drug-event pairs that were the subject of pharmacovigilance-driven European regulator...
Source: Drug Safety - October 27, 2015 Category: Drugs & Pharmacology Source Type: research

Authors’ Reply to Sibel Yöntem and Colleagues’ Comment on “Indigenous Medicine Use for Sex Selection During Pregnancy and Risk of Congenital Malformations: A Population-Based Case-Control Study in Haryana, India”
(Source: Drug Safety)
Source: Drug Safety - October 27, 2015 Category: Drugs & Pharmacology Source Type: research

Comment on: “Indigenous Medicine Use for Sex Selection During Pregnancy and Risk of Congenital Malformations: A Population-Based Case–Control Study in Haryana, India”
(Source: Drug Safety)
Source: Drug Safety - October 27, 2015 Category: Drugs & Pharmacology Source Type: research

Testosterone Replacement Therapy and Mortality in Older Men
Abstract While US testosterone prescriptions have tripled in the last decade with lower trends in Europe, debate continues over the risks, benefits and appropriate use of testosterone replacement therapy (TRT). Several authors blame advertising and the availability of more convenient formulations, whilst others have pointed out that the routine testing of men with erectile dysfunction (ED) (a significant marker of cardiovascular risk) and those with diabetes would inevitably increase the diagnosis of hypogonadism and lead to an increase in totally appropriate prescribing. They commented that this was merely an app...
Source: Drug Safety - October 19, 2015 Category: Drugs & Pharmacology Source Type: research

Quantitative Risk–Benefit Analysis of Probiotic Use for Irritable Bowel Syndrome and Inflammatory Bowel Disease
Abstract Probiotics have seen widespread use for a variety of gastrointestinal problems, especially in two common disorders: irritable bowel syndrome and inflammatory bowel disease. Since a wide variety of probiotic preparations has been used, and despite a large number of studies performed, a great deal of heterogeneity exists among them. Straightforward evidence-based recommendations for the use of probiotics in irritable bowel syndrome and inflammatory bowel disease have thus been difficult to formulate. In an effort to improve understanding of the risk–benefit balance of probiotics in these condition...
Source: Drug Safety - October 14, 2015 Category: Drugs & Pharmacology Source Type: research

The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project
Conclusions We found differences across and within national SRSs in the reporting of drug-induced TdP, which finally resulted in five potential new signals of torsadogenicity. These findings warrant targeted pharmacovigilance studies to formally assess the existence of actual drug–event associations. (Source: Drug Safety)
Source: Drug Safety - October 8, 2015 Category: Drugs & Pharmacology Source Type: research

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs
Abstract Use of highly pure antigens to improve vaccine safety has led to reduced vaccine immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine immunogenicity. The ideal adjuvant should maximize vaccine immunogenicity without compromising tolerability or safety. Unfortunately, adjuvant research has lagged behind other vaccine areas such as antigen discovery, with the consequence that only a very limited number of adjuvants based on aluminium salts, monophosphoryl lipid A and oil emulsions are currently approved for human use. Recent strategic initiatives to support adjuvant...
Source: Drug Safety - October 8, 2015 Category: Drugs & Pharmacology Source Type: research

Feasibility of Prioritizing Drug–Drug-Event Associations Found in Electronic Health Records
Abstract Background and Objective Several studies have demonstrated the ability to detect adverse events potentially related to multiple drug exposure via data mining. However, the number of putative associations produced by such computational approaches is typically large, making experimental validation difficult. We theorized that those potential associations for which there is evidence from multiple complementary sources are more likely to be true, and explored this idea using a published database of drug–drug-adverse event associations derived from electronic health records (EHRs). ...
Source: Drug Safety - October 8, 2015 Category: Drugs & Pharmacology Source Type: research

Statistical Signal Detection as a Routine Pharmacovigilance Practice: Effects of Periodicity and Resignalling Criteria on Quality and Workload
Conclusions In real-life PV practice, signal detection and validation are recurrent periodic activities. Some true signals are only discovered upon resignalling. Our results demonstrate resignalling criteria with high signal detection quality and high efficiency. We found potential earlier detection of true signals using monthly SSD. Additional studies about resignalling should be performed to complement our findings. (Source: Drug Safety)
Source: Drug Safety - September 21, 2015 Category: Drugs & Pharmacology Source Type: research

Association of Attorney Advertising and FDA Action with Prescription Claims: A Time Series Segmented Regression Analysis
Conclusion Regulatory and safety actions likely reduced the number of users and/or prescription rates for some drugs. Attorneys may have strategically chosen to begin advertising adverse drug events prior to major safety actions, but we found little evidence that attorney advertising reduced drug use. Further research is needed to better understand how consumers and physicians respond to attorney advertising. (Source: Drug Safety)
Source: Drug Safety - September 18, 2015 Category: Drugs & Pharmacology Source Type: research

Impact on Drug Safety of Variation in Adherence: The Need for Routinely Reporting Measures of Dose Intensity in Medication Safety Studies Using Electronic Health Data
Abstract Randomized controlled trials always report the dose assessed and usually include a measure of adherence. By comparison, observational studies assessing medication safety often fail to report the dose used and rarely report any measure of adherence to therapy. This limits the ability to control for differences in doses used when undertaking meta-analyses. Non-adherence with therapy is common in the practice setting and varies across countries and settings. Inter-country differences in the registration of medicines may also result in different product strengths being available in different countries. These ...
Source: Drug Safety - September 18, 2015 Category: Drugs & Pharmacology Source Type: research

15th ISoP Annual Meeting “Cubism in Pharmacovigilance” Prague, Czech Republic 27-30 October, 2015
(Source: Drug Safety)
Source: Drug Safety - September 15, 2015 Category: Drugs & Pharmacology Source Type: research

Drug-Induced Hyperglycaemia and Diabetes
Abstract Drug-induced hyperglycaemia and diabetes is a global issue. It may be a serious problem, as it increases the risk of microvascular and macrovascular complications, infections, metabolic coma and even death. Drugs may induce hyperglycaemia through a variety of mechanisms, including alterations in insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells and increases in glucose production. Antihypertensive drugs are not equally implicated in increasing serum glucose levels. Glycaemic adverse events occur more frequently with thiazide diuretics and with certain beta-blocking agents tha...
Source: Drug Safety - September 14, 2015 Category: Drugs & Pharmacology Source Type: research

Useful Interplay Between Spontaneous ADR Reports and Electronic Healthcare Records in Signal Detection
Conclusion An EHR-based system may have additional value for signal detection, alongside already established systems, especially in the presence of adverse events with a high background incidence. While the SRS appeared to be more cost effective overall, for some events the costs associated with signal detection in the EHR might be justifiable. (Source: Drug Safety)
Source: Drug Safety - September 14, 2015 Category: Drugs & Pharmacology Source Type: research

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A National Analysis of Data from 10-Year Post-marketing Surveillance
Conclusion Thanks to the largest national DRESS case series ever reported, we were able to hypothesize, for the first time, that there is an association between use of drugs containing an aromatic ring in their chemical structure and DRESS. This might aid understanding of the aetiology of DRESS and facilitate diagnosis. (Source: Drug Safety)
Source: Drug Safety - September 14, 2015 Category: Drugs & Pharmacology Source Type: research