A fatal adverse effect of cefazolin administration
Tribuddharat S, Sathitkarnmanee T, Kitkhuandee A, Theerapongpakdee S, Ngamsaengsirisup K, Chanthawong S (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - February 8, 2016 Category: Drugs & Pharmacology Source Type: research

Benefit & ndash;risk assessment of golimumab in the treatment of refractory ulcerative colitis
(Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - February 2, 2016 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Benefit–risk assessment of golimumab in the treatment of refractory ulcerative colitis
Daniela Pugliese, Carla Felice, Rosario Landi, Alfredo Papa, Luisa Guidi, Alessandro Armuzzi Inflammatory Bowel Disease Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy Abstract: Significant advances in the management of patients with ulcerative colitis (UC) have been made since the introduction of anti-tumor necrosis factor (TNF)-alpha agents, especially for those who fail or do not tolerate conventional therapies. Two drugs, infliximab first, then adalimumab afterward, showed effectiveness in inducing and maintaining long-term remission both in pivotal trials as well as in clinical practice. However, ...
Source: Drug, Healthcare and Patient Safety - February 2, 2016 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Risk assessment of golimumab in the treatment of UC
Pugliese D, Felice C, Landi R, Papa A, Guidi L, Armuzzi A (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - February 2, 2016 Category: Drugs & Pharmacology Source Type: research

Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension
Andrew L Dodgen,1 Kevin D Hill1,2 1Department of Pediatrics, Duke University Medical Center, 2Duke Clinical Research Institute, Durham, NC, USA Abstract: Sildenafil is a phosphodiesterase type-5 inhibitor approved for treatment of pulmonary arterial hypertension (PAH) in adults. Data from pediatric trials demonstrate a similar acute safety profile to the adult population but have raised concerns regarding the safety of long-term use in children. Interpretation of these trials remains controversial with major regulatory agencies differing in their recommendations – the US Food and Drug Administration recommends agains...
Source: Drug, Healthcare and Patient Safety - December 15, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Safety profile of dalfampridine extended release in multiple sclerosis: 5-year postmarketing experience in the United States
Conclusion: The 5-year US postmarketing safety data of dalfampridine-ER is consistent with the safety profile observed in clinical trials. Incidence of reported seizures remained stable over time. Since commercial availability in March 2010, a warning regarding the risk of anaphylaxis and severe allergic reactions was added to the US prescribing information. Keywords: dalfampridine, fampridine, multiple sclerosis, adverse events, postmarketing safety (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 15, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Dalfampridine-ER: 5-year postmarketing safety
Jara M, Aquilina T, Aupperle P, Rabinowicz AL (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 14, 2015 Category: Drugs & Pharmacology Source Type: research

Sildenafil safety in children
Dodgen AL, Hill KD (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 14, 2015 Category: Drugs & Pharmacology Source Type: research

Clinical efficacy, safety, and tolerability of fingolimod for the treatment of relapsing-remitting multiple sclerosis
Alberto Gajofatto,1,2 Marco Turatti,2 Salvatore Monaco,1,2 Maria Donata Benedetti2 1Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy; 2Division of Neurology B, Verona University Hospital, Verona, Italy Abstract: Fingolimod is a selective immunosuppressive agent approved worldwide for the treatment of relapsing-remitting multiple sclerosis (MS), a chronic and potentially disabling neurological condition. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rate and ameliorates a number of brain MRI measures, including cere...
Source: Drug, Healthcare and Patient Safety - December 10, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Safety and efficacy of fingolimod for multiple sclerosis
Gajofatto A, Turatti M, Monaco S, Benedetti MD (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 10, 2015 Category: Drugs & Pharmacology Source Type: research

Challenges facing effective implementation of co-trimoxazole prophylaxis in children born to HIV-infected mothers in the public health facilities
Conclusion: Most children who were initiated with co-trimoxazole prophylaxis did not experience significant opportunistic infections, and the drug was well tolerated. The major barrier for co-trimoxazole prophylaxis was due to frequent out-of-stocks of pediatric co-trimoxazole formulations in the health facilities. Dose determination was based on the age rather than the weight of children, thus creating potential for under- or over-dosing of children.Keywords: health facilities, opportunistic infections, CD4, parents, guardians (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - October 29, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Cotrimoxazole prophylaxis in children
Kamuhabwa AAR, Manyanga V (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - October 28, 2015 Category: Drugs & Pharmacology Source Type: research

The effectiveness and limitations of regulatory warnings for the safe prescribing of citalopram
Kevin J Friesen, Shawn C BugdenFaculty of Health Sciences, College of Pharmacy, University of Manitoba, Winnipeg, MB, CanadaBackground: Citalopram is the most commonly prescribed antidepressant in Canada. Concerns have been raised about its cardiac safety, and a dose-dependent prolongation of the QT interval has been documented. Drug interactions involving concomitant use of other medications that prolong the QT interval or increase citalopram levels by interfering with its metabolism increase the cardiac risk. Regulatory bodies (Health Canada and the US Food and Drug Administration) issued warnings and required labeling c...
Source: Drug, Healthcare and Patient Safety - August 19, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Citalopram prescribing changes post regulatory warnings
Friesen KJ, Bugden SC (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - August 19, 2015 Category: Drugs & Pharmacology Source Type: research

Drug utilization in selected health facilities of South West Shoa Zone, Oromia Region, Ethiopia
Conclusion: In general, drug utilization at the study sites was found to be good, although there are major deviations from the concept of rational drug use. Keywords: drug utilizations, rational drug use, health facilities (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - July 23, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Cardiovascular effects of hormone therapy for prostate cancer
Jason F Lester,1 Malcolm D Mason1,2 1Velindre Hospital, Whitchurch, 2School of Medicine, Cardiff University, Heath Park, Cardiff, UK Abstract: Androgen deprivation therapy (ADT) has been the mainstay of treatment for advanced prostate cancer for decades, and has been shown to control disease and improve symptoms. In addition, for men with high-risk localized or locally advanced prostate cancer, short-course ADT in combination with radiotherapy improves survival. There is evidence that ADT increases cardiovascular risk, particularly in men with preexisting cardiovascular disease. This increased risk may apply even with shor...
Source: Drug, Healthcare and Patient Safety - July 23, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Drug utilization in selected health facilities
Kebede M, Kebebe Borga D, Mulisa Bobasa E (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - July 23, 2015 Category: Drugs & Pharmacology Source Type: research

Complications of hormone therapy for prostate cancer
Lester JF, Mason MD (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - July 22, 2015 Category: Drugs & Pharmacology Source Type: research

Cardiovascular effects of basal insulins
Edoardo Mannucci,1 Stefano Giannini,2 Ilaria Dicembrini1 1Diabetes Agency, Careggi Teaching Hospital, Florence, 2Section of Endocrinology, Department of Biomedical Clinical and Experimental Sciences, University of Florence and Careggi University Hospital, Florence, Italy Abstract: Basal insulin is an important component of treatment for both type 1 and type 2 diabetes. One of the principal aims of treatment in patients with diabetes is the prevention of diabetic complications, including cardiovascular disease. There is some evidence, although controversial, that attainment of good glycemic control reduces long-term cardiov...
Source: Drug, Healthcare and Patient Safety - July 10, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Basal insulins and the cardiovascular system
Mannucci E, Giannini S, Dicembrini I (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - July 10, 2015 Category: Drugs & Pharmacology Source Type: research

Prevalence and predictors of antibiotic prescription errors in an emergency department, Central Saudi Arabia
Menyfah Q Alanazi,1 Majed I Al-Jeraisy,2,3 Mahmoud Salam2 1Drug Policy and Economic Center, 2King Abdullah International Medical Research Center (KAIMRC), 3King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia Background: Inappropriate antibiotic (ATB) prescriptions are a threat to patients, leading to adverse drug reactions, bacterial resistance, and subsequently, elevated hospital costs. Our aim was to evaluate ATB prescriptions in an emergency department of a tertiary care facility. Methods: A cross-sectional study was conducted by reviewing charts of patients complaining of infections. ...
Source: Drug, Healthcare and Patient Safety - June 4, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Prevalence and predictors of antibiotic prescription errors
Alanazi MQ, Al-Jeraisy MI, Salam M (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - June 3, 2015 Category: Drugs & Pharmacology Source Type: research

Antifungal agent utilization evaluation in hospitalized neutropenic cancer patients at a large teaching hospital
Afsaneh Vazin,1 Mohammad Ali Davarpanah,2 Setareh Ghalesoltani3 1Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2HIV Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 3International Branch of Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Abstract: To evaluate pattern of using of three antifungal drugs: fluconazole, amphotericin B and voriconazole, at the hematology–oncology and bone marrow transplant wards of one large teaching hospital. In a prospective cross-sectional study, we evaluated the appropriateness of...
Source: Drug, Healthcare and Patient Safety - June 1, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Antifungal agent utilization evaluation
Vazin A, Davarpanah MA, Ghalehsoltani S (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - June 1, 2015 Category: Drugs & Pharmacology Source Type: research

Environmental and host-related determinants of tuberculosis in Metema district, north-west Ethiopia
Cheru Tesema,1 Takele Tadesse,2 Mulat Gebrehiwot,2 Azanaw Tsegaw,3 Fitsum Weldegebreal4 1College of Medical and health science, Debremarkos Universitty, Debremarkos, 2Institute of Public Health, College of Medical and Health Sciences, University of Gondar, 3College of Health and Medical Sciences, University of Gondar, Gondar, 4Haramaya University, College of Health and Medical Sciences, Department of Medical laboratory Science, Harar, Ethiopia Background: Each year, one third of the world's population is estimated to be infected with tuberculosis (TB). Globally in 2011, there were an estimated 8.7 million TB cases that...
Source: Drug, Healthcare and Patient Safety - May 27, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Environmental and host-related determinants of TB in Ethiopia
Tesema C, Tadesse T, Gebrehiwot M, Tsegaw A, Weldegebreal F (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - May 26, 2015 Category: Drugs & Pharmacology Source Type: research

Determinant factors of tobacco use among ever-married men in Bangladesh
Conclusion: Tobacco use was found to be remarkably common among males in Bangladesh. The high prevalence of tobacco use suggests that there is an urgent need for developing intervention plans to address this major public health problem in Bangladesh. Keywords: tobacco use, smoking tobacco, chewing tobacco, prevalence rate, logistic regression model (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - May 13, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Determinant factors of tobacco use
Rahman MS, Mondal MNI, Islam MR, Rahman MM, Hoque MN, Alam MS (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - May 12, 2015 Category: Drugs & Pharmacology Source Type: research

Multicenter, noninterventional, post-marketing surveillance study to evaluate dosing of recombinant human follicle-stimulating hormone using the redesigned follitropin alfa pen in women undergoing ovulation induction
Frank Nawroth,1 Andreas Tandler-Schneider,2 Wilma Bilger3 1Centre for Reproductive and Prenatal Medicine, Endocrinology and Osteology, Hamburg, Germany; 2Center for Reproductive Medicine, Fertility Center Berlin, Berlin, Germany; 3Medical Affairs, Fertility, Endocrinology and General Medicine, Merck Serono GmbH, Darmstadt, Germany (an affiliate of Merck KGaA, Darmstadt, Germany) Abstract: This prospective, noninterventional, post-marketing surveillance study evaluated doses of recombinant human follicle-stimulating hormone (r-hFSH) using the redesigned follitropin alfa pen in women who were anovulatory or oligomenorrheic a...
Source: Drug, Healthcare and Patient Safety - April 15, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Individualized recombinant human follicle-stimulating hormone dosing using the CONSORT calculator in assisted reproductive technology: a large, multicenter, observational study of routine clinical practice
Olaf GJ Naether,1 Andreas Tandler-Schneider,2 Wilma Bilger3 1Reproductive Endocrinology, MVZ Fertility Center Hamburg, Hamburg, 2Center for Reproductive Medicine, Fertility Center Berlin, Berlin, 3Medical Affairs, Fertility, Endocrinology and General Medicine, Merck Serono GmbH, a subsidiary of Merck KGaA, Darmstadt, Germany Purpose: This postmarketing surveillance survey was conducted to investigate the utility of the CONsistency in r-FSH Starting dOses for individualized tReatmenT (CONSORT) calculator for individualizing recombinant human follicle-stimulating hormone (r-hFSH) starting doses for controlled ovarian stimula...
Source: Drug, Healthcare and Patient Safety - April 15, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Follitropin alfa in ovulation induction
Nawroth F, Tandler-Schneider A, Bilger W (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - April 14, 2015 Category: Drugs & Pharmacology Source Type: research

Individualized r-hFSH dosing using the CONSORT calculator
Naether OGJ, Tandler-Schneider A, Bilger W (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - April 14, 2015 Category: Drugs & Pharmacology Source Type: research

Patient-reported outcomes after discontinuation of long-term topical corticosteroid treatment for atopic dermatitis: a targeted cross-sectional survey
Naoko Takahashi-Ando,1 Mark A Jones,2 Shigeki Fujisawa,3 Rokuro Hama4 1Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University, Saitama, Japan; 2School of Population Health, The University of Queensland, Herston, Queensland, Australia; 3Fujisawa Dermatology Clinic, Tokyo, Japan; 4Japan Institute of Pharmacovigilance, Osaka, Japan Background: Topical corticosteroid (TCS) treatment is widely prescribed for atopic dermatitis (AD). However, TCS treatment is associated with tachyphylaxis, and discontinuation after long-term use may cause exacerbation of symptoms. Some AD patients are reluctant to us...
Source: Drug, Healthcare and Patient Safety - April 7, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Outcomes after topical corticosteroid withdrawal
Takahashi-Ando N, Jones MA, Fujisawa S, Hama R (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - April 6, 2015 Category: Drugs & Pharmacology Source Type: research

Survey on appropriateness of use of nimesulide in nine European countries
Conclusion: The results of this survey demonstrate that nimesulide is generally prescribed in compliance with the information reported in the summary of product characteristics (SmPC) with regard to daily dose and treatment duration, and suggest that it is mainly used for the management of episodes of acute pain in patients with a chronic disorder. These findings indicate the appropriateness of use of nimesulide in the European countries considered in this survey. Keywords: non-steroidal anti-inflammatory drug, NSAID, appropriateness of use, European Medicine Agency, computer-aided telephone interviews (Source: Drug, Healt...
Source: Drug, Healthcare and Patient Safety - March 15, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Appropriateness of use of nimesulide in EU
Franchi S, Heiman F, Visentin E, Sacerdote P (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - March 15, 2015 Category: Drugs & Pharmacology Source Type: research

Persistent nonmalignant pain management using nonsteroidal anti-inflammatory drugs in older patients and use of inappropriate adjuvant medications
Conclusion: The high percentage of NSAIDs prescription in older patients is alarming. We recommend investigating the appropriateness of the high prevalence of NSAIDs use among older patients reported in our study. Keywords: pain management, NSAIDs, inappropriate adjuvant, AGS guideline, NAMCS (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - January 29, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Persistent pain management and medication use
Rianon N, Knell ME, Agbor-Bawa W, Thelen J, Burkhardt C, Rasu RS (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - January 28, 2015 Category: Drugs & Pharmacology Source Type: research

Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies
Jay L Goldstein,1 Byron Cryer21Department of Medicine, NorthShore University HealthSystem, Evanston, IL, USA; 2Division of Gastroenterology, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, TX, USAAbstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective anti-inflammatory and analgesic agents and are among the most commonly used classes of medications worldwide. However, their use has been associated with potentially serious dose-dependent gastrointestinal (GI) complications such as upper GI bleeding. GI complications resulting from NSAID use are among the most common drug s...
Source: Drug, Healthcare and Patient Safety - January 22, 2015 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Case study and review of NSAID-associated GI injury
Goldstein JL, Cryer B (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - January 21, 2015 Category: Drugs & Pharmacology Source Type: research

Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges
Richard A Epstein,1 Katherine M Moore,2 William V Bobo2 1Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, 2Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA Abstract: Treating pregnant women with bipolar disorder is among the most challenging clinical endeavors. Patients and clinicians are faced with difficult choices at every turn, and no approach is without risk. Stopping effective pharmacotherapy during pregnancy exposes the patient and her baby to potential harms related to bipolar relapses and residual mood symptom-related dysfunction. Continuing effective pharm...
Source: Drug, Healthcare and Patient Safety - December 23, 2014 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Treatment of bipolar disorder during pregnancy
Epstein RA, Moore K, Bobo WV (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 23, 2014 Category: Drugs & Pharmacology Source Type: research

Ability of Saudi mothers to appropriately and accurately use dosing devices to administer oral liquid medications to their children
Conclusion: Among mothers using measuring devices, the most accurate doses were found to be measured with the use of the oral syringe, whereas the most errors were made with the use of the dropper. Moreover, education status had a significant effect on dosing errors. The use of a pictographic diagram could improve the mothers' dosing abilities and, thus, reduce dosing errors. Keywords: paracetamol, syringe, cup, dropper, accurate, education, counselling (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 22, 2014 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Accuracy of medication administration to children by Saudi mothers
Almazrou S, Alsahli H, Alwattar H, Alturki L, Alamri M (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 21, 2014 Category: Drugs & Pharmacology Source Type: research

Frequency of medication errors in an emergency department of a large teaching hospital in southern Iran
This study was conducted with the purpose of determining the frequency of medication errors (MEs) occurring in tertiary care emergency department (ED) of a large academic hospital in Iran. The incidence of MEs was determined through the disguised direct observation method conducted by a trained observer. A total of 1,031 medication doses administered to 202 patients admitted to the tertiary care ED were observed over a course of 54 6-hour shifts. Following collection of the data and analysis of the errors with the assistance of a clinical pharmacist, frequency of errors in the different stages was reported and analyzed in ...
Source: Drug, Healthcare and Patient Safety - December 11, 2014 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Medication errors in an emergency department
Vazin A, Zamani Z, Hatam N (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - December 10, 2014 Category: Drugs & Pharmacology Source Type: research

Transient visual loss and delayed resolution of vitreomacular traction after intravitreal ocriplasmin
This report highlights that it is important for patients to be made fully aware of the risks of intravitreal ocriplasmin and the prognosis for visual improvement. Keywords: ocriplasmin, macular hole, visual loss, vitreoretinal (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - November 25, 2014 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Vitreomacular traction after intravitreal ocriplasmin
DaCosta J, Younis S (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - November 24, 2014 Category: Drugs & Pharmacology Source Type: research

Observational study of upper gastrointestinal tract bleeding events in patients taking duloxetine and nonsteroidal anti-inflammatory drugs: a case-control analysis
Conclusion: There was no evidence of an increased risk for UGI bleeding when duloxetine was taken with prescription NSAIDs or aspirin. In addition, there was no evidence of an interaction between duloxetine and prescription NSAIDs or aspirin for an increased risk of these events.Keywords: duloxetine, upper gastrointestinal bleeding, NSAIDs, aspirin (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - October 29, 2014 Category: Drugs & Pharmacology Tags: Drug, Healthcare and Patient Safety Source Type: research

Upper GI bleeding associated with duloxetine and concomitant NSAID use
Li H, Cheng Y, Ahl J, Skljarevski V (Source: Drug, Healthcare and Patient Safety)
Source: Drug, Healthcare and Patient Safety - October 28, 2014 Category: Drugs & Pharmacology Source Type: research