Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data
The comorbidity of substance use disorders (SUDs) and chronic disease represents double jeopardy in terms of disease burden and healthcare costs (Thorpe et al., 2017). It is imperative to better characterize their comorbid patterns in order to inform behavioral healthcare integration efforts (Laderman, 2015). Specifically, chronic substance misuse and/or SUD could affect a wide range of organs and systems in the body, which may lead to multiple medical problems and an increased risk for contracting infectious diseases (Brick, 2012). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 3, 2018 Category: Addiction Authors: Li-Tzy Wu, He Zhu, Udi E. Ghitza Tags: Full length article Source Type: research
Different socioeconomic backgrounds between hazardous drinking and heavy episodic drinking: prevalence by sociodemographic factors in a Japanese general sample
Lower educational background for both men and women was associated with a higher risk for heavy episodic drinking, while higher household income for men was associated with a higher risk for hazardous drinking in Japan.Figure Legend: OR, odds ratio; HED, heavy episodic drinking; HD, hazardous drinking.Drinkers who had neither HED nor HD were adopted as the reference group in order to calculate the OR. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 3, 2018 Category: Addiction Authors: Aya Kinjo, Yuki Kuwabara, Ruriko Minobe, Hitoshi Maezato, Mitsuru Kimura, Susumu Higuchi, Hiroshi Matsumoto, Takefumi Yuzuriha, Yoshinori Horie, Hideyuki Kanda, Hisashi Yoshimoto, Yoneatsu Osaki Tags: Full length article Source Type: research
Harm perceptions of electronic cigarettes and nicotine: A nationally representative cross-sectional survey of young people in Great Britain
Tobacco smoking is the leading cause of preventable death and disability worldwide (WHO, 2005; WHO, 2015), and while it is primarily the nicotine in cigarettes that is addictive, most of the health harms of smoking are caused by other constituents of tobacco smoke (Benowitz, 2009). Electronic (e-)cigarettes are battery-powered devices that heat a solution usually containing nicotine, flavourings, propylene glycol and/or vegetable glycerin to produce an inhalable aerosol. As e-cigarettes do not contain tobacco and do not involve combustion, current evidence suggests they are less harmful to both users and others relative to...
Source: Drug and Alcohol Dependence - October 3, 2018 Category: Addiction Authors: Katherine East, Leonie S. Brose, Ann McNeill, Hazel Cheeseman, Deborah Arnott, Sara C. Hitchman Tags: Full length article Source Type: research
Predictors of Resistant Alcohol Withdrawal (RAW): A Retrospective Case-Control Study
It has been estimated that 13.8 million Americans (7.4% of the adult population) meet the criteria for alcohol abuse or dependence as specified in the Diagnostic and Statistical Manual of Mental Disorders (Bayard et al., 2004). In medical practice, the prevalence of alcohol abuse or dependence has been estimated at upwards of 20% of hospitalized patients (McKeon et al., 2008). Alcohol withdrawal syndromes (AWS) are common in these hospitalized patients, developing in one-half of those not treated prophylactically (Spies et al., 2003). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 3, 2018 Category: Addiction Authors: Neal J. Benedict, Adrian Wong, Elizabeth Cassidy, Brian R. Lohr, Anthony F. Pizon, Pamela L. Smithburger, Bonnie A. Falcione, Levent Kirisci, Sandra L. Kane-Gill Tags: Full length article Source Type: research
Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviors: A systematic review
Substance use and addictive disorders (SUAD) are characterized by the continued use of a substance, or repeated engagement in addictive behavior, despite known negative consequences (American Psychiatric Association, 2013). Substance use disorders reportedly affect around 0.6% of the global adult population (United Nations Office on Drugs and Crime, 2017), and the use of psychoactive substances (including alcohol and tobacco) accounted for 12.4% of all deaths globally in 2000 (World Health Organization, 2002). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 3, 2018 Category: Addiction Authors: Katherine R. Naish, Lana Vedelago, James MacKillop, Michael Amlung Source Type: research
Corrigendum to “Pharmacotherapy for amphetamine dependence: A systematic review” [Drug Alcohol Depend. 191 (2018) 309–337]
The authors regret, that there is an error in the ‘results’ section of the abstract of this paper. The medication buprenorphine was incorrectly listed instead of bupropion, as being one of four medications demonstrating some limited evidence for reducing amphetamine use. The corrected version of this sentence is as follows: (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 1, 2018 Category: Addiction Authors: Nicole K. Lee, Linda Jenner, Angela Harney, Jacqui Cameron Tags: Corrigendum Source Type: research
Impairments in reversal learning following short access to cocaine self-administration
Cocaine addiction is a chronic relapsing disease that is characterized by drug craving and loss of inhibitory control (Jentsch and Taylor, 1999). A major challenge in the successful treatment of cocaine addiction is reducing the risk of relapse, which remains high after months or even years of abstinence (Dackis and O ’Brien, 2001; Mendelson and Mello, 1996). Concomitant with a high risk of relapse, cocaine addicts also display cognitive deficits in the domain of reversal learning (Ersche et al., 2008). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - October 1, 2018 Category: Addiction Authors: Allison R. Bechard, Amber LaCrosse, Mark D. Namba, Brooke Jackson, Lori A. Knackstedt Tags: Full length article Source Type: research
Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer ’s Disease
The link between cigarette smoking and markedly increased risk for pulmonary, cardiac, and vascular disease as well as for multiple forms of cancer in humans is essentially indisputable (CDC, 2004). A growing body of evidence also indicates that smoking, in otherwise healthy individuals, is associated with neurobiological and neurocognitive abnormalities that are not directly related to the foregoing diseases (Azizian et al., 2009; Durazzo et al., 2014a; Durazzo et al., 2010; Durazzo et al., 2017; Sharma and Brody, 2009). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - September 29, 2018 Category: Addiction Authors: Timothy C. Durazzo, Dieter J. Meyerhoff, Karmen K. Yoder Source Type: research
Corrigendum to “Marijuana use by middle-aged and older adults in the United States, 2015–2016” [Drug Alcohol Depend. 191 (2018) 374–381]
It has come to the attention of the authors that a correction is needed in our paper. One of the citations in the paper incorrectly spelled the first author ’s last name. The correct citation is: Caputi, T.L., Humphreys, K., 2018. Medical marijuana users are more likely to use prescription drugs medically and nonmedically. J. Addict. Med. 12, 295–299. The incorrect spelling of the author’s name occurs in both the reference section and the text of the paper (second paragraph of the discussion). This does not change the findings of the paper. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - September 25, 2018 Category: Addiction Authors: Benjamin H. Han, Joseph J. Palamar Tags: Corrigendum Source Type: research
“Feeling confident and equipped”: Evaluating the acceptability and efficacy of an overdose response and naloxone administration intervention to service industry employees in New York City
Drug overdose mortality rates per year in the United States (US) nearly tripled between 1999 –2014 with opioids involved in almost two-thirds of fatalities (Rudd et al., 2016). In 2016, over 60,000 drug overdose fatalities were reported throughout the US (Centers for Disease Control and Prevention, 2017). New York City (NYC) experienced 1,374 drug overdose deaths in 2016 with 82% involvin g an opioid, with heroin being the most prevalent opioid involved (55%) and 44% involving fentanyl (New York City Department of Health and Mental Hygiene, 2017). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - September 21, 2018 Category: Addiction Authors: Brett Wolfson-Stofko, Marya V. Gwadz, Luther Elliott, Alex S. Bennett, Ric Curtis Tags: Full length article Source Type: research
A preliminary randomized clinical trial of naltrexone reduces striatal resting state functional connectivity in people with methamphetamine use disorder
Behavioral approaches are the main treatments for methamphetamine (MA) use disorder, and although they can be effective, many patients relapse (Vocci and Appel, 2007). Despite a number of clinical trials testing the efficacy of agents including dopamine partial agonists and GABAergic and serotonergic agents, there are no approved pharmacological treatments for MA use disorder (Elkashef et al., 2008; Karila et al., 2010). Early abstinence from MA is accompanied by intense drug craving and high levels of cognitive impairment (Potvin et al., 2018; Zorick et al., 2010), which are important factors in the maintenance of addicti...
Source: Drug and Alcohol Dependence - September 21, 2018 Category: Addiction Authors: Milky Kohno, Laura E. Dennis, Holly McCready, Daniel L. Schwartz, William F. Hoffman, P. Todd Korthuis Tags: Full length article Source Type: research
The neural representation of the association between comorbid drug use disorders and childhood maltreatment
Drug use disorders (DUDs) are highly prevalent with over 20 million individuals throughout the US having a DUD in 2016 (Ahrnsbrak, 2016). DUDs co-occurring with other psychiatric illnesses (e.g., depression, post-traumatic stress disorder (PTSD), general anxiety disorder) are a clinically prevalent subpopulation, with 27-73% of DUD patients diagnosed with DUD comorbidity (Ahrnsbrak, 2016). Persons with DUD comorbidity have poorer mental health outcomes than persons with DUD alone - including more complex and costly treatment plans (Hoff and Rosenheck, 1999), poorer treatment responses (Grella et al., 2001), and greater ris...
Source: Drug and Alcohol Dependence - September 21, 2018 Category: Addiction Authors: Bradford S. Martins, Ricardo C áceda, Josh M. Cisler, Clinton D. Kilts, G. Andrew James Tags: Full length article Source Type: research
Developmental trajectories of externalizing behavior from ages 4 to 12: Prenatal cocaine exposure and adolescent correlates
Externalizing behavior refers to overt behavior problems that are characterized by impulsivity and lack of self-regulation (Tucker et al., 2015). It typically involves conflicts with other people (Achenbach and Rescorla, 2001), such as aggression, rule-breaking, and disruptive behavior. Externalizing behavior in childhood is associated with school failure, peer problems, and juvenile delinquency; it is also a well-established precursor to substance use (King et al., 2004; Iacono et al., 2008) and sexual risk behaviors (Min et al., 2015, 2016). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - September 21, 2018 Category: Addiction Authors: Meeyoung O. Min, Sonia Minnes, Hyungyong Park, Ty Ridenour, June-Yung Kim, Miyoung Yoon, Lynn T. Singer Source Type: research
Feeling confident and equipped: Evaluating the acceptability and efficacy of an overdose response and naloxone administration intervention to service industry employees in New York City
Drug overdose mortality rates per year in the United States (US) nearly tripled between 1999-2014 with opioids involved in almost two-thirds of fatalities (Rudd et al., 2016). In 2016, over 60,000 drug overdose fatalities were reported throughout the US (Centers for Disease Control and Prevention, 2017). New York City (NYC) experienced 1,374 drug overdose deaths in 2016 with 82% involving an opioid, with heroin being the most prevalent opioid involved (55%) and 44% involving fentanyl (New York City Department of Health and Mental Hygiene, 2017). (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - September 21, 2018 Category: Addiction Authors: Brett Wolfson-Stofko, Marya V. Gwadz, Luther Elliott, Alex S. Bennett, Ric Curtis Tags: Full length article Source Type: research
The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats
Opioid agonists (e.g., oxycodone and morphine) are highly efficacious for the treatment of pain. However, their therapeutic effects are coupled with adverse side effects that include tolerance, dependence, respiratory depression, and abuse liability (Chan et al., 2017). Opioid agonists mediate their physiological actions through the G protein-coupled receptor (GPCR) family of opioid receptors, specifically the mu-opioid receptor (Kieffer, 1999; Matthes et al., 1996; Mello and Negus 1996). It is well established that GPCRs modify cell activity through various intracellular pathways including G-protein and b-arrestin signali...
Source: Drug and Alcohol Dependence - September 18, 2018 Category: Addiction Authors: C. Austin Zamarripa, Shelley R. Edwards, Hina N. Qureshi, John N. Yi, Bruce E. Blough, Kevin B. Freeman Tags: Full length article Source Type: research
