Impact of metformin and Dysosmobacter welbionis on diet-induced obesity and diabetes: from clinical observation to preclinical intervention
Conclusions/interpretationD. welbionis abundance is
influenced by metformin treatment and associated with prebiotic response, liver
health and glucose metabolism in humans with obesity and diabetes. This study
suggests thatD. welbionis may play a role in
metabolic health and warrants further investigation.Clinical trialNCT03852069Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
Conclusions/interpretationThe present study provides a model of defective counterregulation in a mouse model of type 2 diabetes. It shows that repeated hypoglycaemic episodes induce multiple defects affecting all hypothalamic cell types and their interactions, indicative of impaired neuronal network signalling and dysegulated hypoglycaemia sensing, and displaying features of neurodegenerative diseases. It also shows that repeated hypoglycaemia leads to specific molecular adaptation in the hypothalamus when compared with the cortex.Data availabilityThe transcriptomic dataset is available via the GEO (http://www.ncbi.nlm.nih...
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial
Conclusions/interpretationThe proposed eTRC diet provides a feasible and effective alternative option for glucose and body weight management in individuals with type 2 diabetes, with no additional metabolic benefits compared with conventional dieting.Trial registrationClinicalTrials.gov NCT05713058FundingThis study was supported by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the Italian Society of Diabetology (SID).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Mineralocorticoid receptor overactivation: targeting systemic impact with non-steroidal mineralocorticoid receptor antagonists
AbstractThe overactivation of the mineralocorticoid receptor (MR) promotes pathophysiological processes related to multiple physiological systems, including the heart, vasculature, adipose tissue and kidneys. The inhibition of the MR with classical MR antagonists (MRA) has successfully improved outcomes most evidently in heart failure. However, real and perceived risk of side effects and limited tolerability associated with classical MRA have represented barriers to implementing MRA in settings where they have been already proven efficacious (heart failure with reduced ejection fraction) and studying their potential role i...
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Hyperglycaemia, diabetes and risk of fragility fractures: observational and Mendelian randomisation studies
Conclusions/interpretationHyperglycaemia and diabetes are risk factors for fragility fracture and one- and two-sample MR analyses supported a causal effect of hyperglycaemia on arm fractures. Diabetes and previous fragility fracture jointly conferred the highest risk of death in the general population.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Effects of maternal type 1 diabetes and confounding factors on neonatal microbiomes
Conclusions/interpretationThese findings indicate that, in addition to maternal type 1 diabetes, glycaemic dysregulation before/in the first trimester of pregnancy, mode of delivery and intrapartum antibiotic prophylaxis may contribute to the inoculation and formation of the neonatal microbiomes.Data availabilityThe BioProject (PRJNA961636) and associated SRA metadata are available athttp://www.ncbi.nlm.nih.gov/bioproject/961636. Processed data on probiotic supplementation and the PICRUSt analysis are available in the Mendeley Data Repository (https://doi.org/10.17632/g68rwnnrfk.1).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Up Front
(Source: Diabetologia)
Source: Diabetologia - January 15, 2024 Category: Endocrinology Source Type: research
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1 α
Conclusions/interpretationOur results demonstrate an essential role for TET3 in the regulation of skeletal muscle insulin sensitivity and suggest that TET3 may be used as a potential therapeutic target for the metabolic syndrome.Data availabilitySequences are available from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) with accession number of GSE224042.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 13, 2024 Category: Endocrinology Source Type: research
Acculturation and glycaemic control in Arab immigrants with type 2 diabetes in Australia
Conclusions/interpretationAmong Arab immigrants in Australia with type 2 diabetes, the degree of acculturation is related to glycaemic control, suggesting possible avenues for new interventions.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 12, 2024 Category: Endocrinology Source Type: research
Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes
Conclusions/interpretationEarly-childhood BMI increased during the COVID-19 pandemic, and was influenced by the level of restrictions during the pandemic. Controlling for the COVID-19 pandemic, elevated BMI during early childhood was associated with increased risk for childhood islet autoimmunity in children with genetic susceptibility to type 1 diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 12, 2024 Category: Endocrinology Source Type: research
Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children
Conclusions/interpretationThis study reveals an sICM profile that is dysregulated during the preclinical stage of type 1 diabetes, and identifies sPD-1 as a pathophysiologically-relevant molecule that is associated with disease progression, offering a potential target for early interventions in autoimmune diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 12, 2024 Category: Endocrinology Source Type: research
Morning exercise as fasted-state activity
(Source: Diabetologia)
Source: Diabetologia - January 12, 2024 Category: Endocrinology Source Type: research
NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function
Conclusions/interpretationOur study highlights NRF2 as an essential transcription factor for maintaining neonatal redox balance, mitochondrial biogenesis and function and beta cell growth, and for preserving functional beta cell mass in adulthood under metabolic stress.Data availabilitySequencing data are available in the NCBI Gene Expression Omnibus, accession number GSE242718 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242718).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 11, 2024 Category: Endocrinology Source Type: research
Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study
Conclusions/interpretationDisease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - January 11, 2024 Category: Endocrinology Source Type: research
Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
(Source: Diabetologia)
Source: Diabetologia - January 11, 2024 Category: Endocrinology Source Type: research
