An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study
Conclusions/interpretationUsing machine learning approaches, we show that insulin requirement risk can be modestly well predicted by predominantly clinical variables. Inclusion of molecular markers improves the prognostic performance beyond that of clinical variables by up to 5%. Such prognostic models could be useful for identifying people with diabetes at high risk of progressing quickly to treatment intensification.Data availabilitySummary statistics of lipidomic, proteomic and metabolomic data are available from a Shiny dashboard athttps://rhapdata-app.vital-it.ch.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 19, 2024 Category: Endocrinology Source Type: research
Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits
Conclusions/interpretationOur findings provide new insights into the genetic basis of GDM and glycaemic traits during pregnancy in an East Asian population and highlight the potential role of inflammatory pathways in the aetiology of GDM and variations in glycaemic levels.Data availabilitySummary statistics for GDM; fasting plasma glucose; 0 h, 1 h and 2h OGTT; and the 55 biomarkers are available in the GWAS Atlas (study accession no.: GVP000001,https://ngdc.cncb.ac.cn/gwas/browse/GVP000001).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 19, 2024 Category: Endocrinology Source Type: research
Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial
Conclusions/interpretationThe results indicate that the tested multivalent CVB vaccine is well tolerated and immunogenic, supporting its further clinical development.Trial registrationClinicalTrials.gov NCT04690426.FundingThis trial was funded by Provention Bio, a Sanofi company.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 19, 2024 Category: Endocrinology Source Type: research
Metabolomic and genetic architecture of gestational diabetes subtypes
Conclusions/interpretationThis study demonstrates that physiological GDM subtypes differ in their metabolome and genetic architecture. These findings require replication in additional cohorts, but suggest that these differences may contribute to subtype-related adverse pregnancy outcomes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 17, 2024 Category: Endocrinology Source Type: research
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
Conclusions/interpretationOur data support the increasing evidence that individuals with mild loss-of-function KATP channel mutations may develop insulin deficiency in early adulthood and even frank diabetes in middle age. In this case, the patient may have had hyperinsulinism that escaped detection in early life. Our results support the importance of functional analysis of KATP channel mutations in cases of atypical diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 17, 2024 Category: Endocrinology Source Type: research
Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis
Conclusions/interpretationCGM use compared with SMBG is associated with improvements in glycaemic control in adults with type 2 diabetes. However, all studies were open label. In addition, outcome data on incident severe hypoglycaemia and incident microvascular and macrovascular complications were scarce.RegistrationThis systematic review was registered on PROSPERO (ID CRD42023418005).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 16, 2024 Category: Endocrinology Source Type: research
The insulin resistant brain: impact on whole-body metabolism and body fat distribution
AbstractInsulin exerts its actions not only on peripheral organs but is also transported into the brain where it performs distinct functions in various brain regions. This review highlights recent advancements in our understanding of insulin ’s actions within the brain, with a specific emphasis on investigations in humans. It summarises current knowledge on the transport of insulin into the brain. Subsequently, it showcases robust evidence demonstrating the existence and physiological consequences of brain insulin action, while also i ntroducing the presence of brain insulin resistance in humans. This pathophysiological ...
Source: Diabetologia - February 16, 2024 Category: Endocrinology Source Type: research
Up Front
(Source: Diabetologia)
Source: Diabetologia - February 16, 2024 Category: Endocrinology Source Type: research
Feasibility of prevention of type 2 diabetes in low- and middle-income countries
AbstractType 2 diabetes is a leading cause of global mortality and morbidity. Nearly 80% of individuals with diabetes live in low- and middle-income countries (LMICs), where nearly half of those with the condition remain undiagnosed. The majority of known cases have sub-optimal clinical outcomes. Moreover, large populations with impaired glucose tolerance and/or impaired fasting glucose contribute to the rapid increase in type 2 diabetes. Globally, priority should be given to limit the population with diabetes, especially in LMICs, alongside actions to optimise the care of people diagnosed with diabetes. Primary prevention...
Source: Diabetologia - February 15, 2024 Category: Endocrinology Source Type: research
Keeping pace: the primary cilium as the conducting baton of the islet
AbstractPrimary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting evidence supports important roles of these structures in the regulation of beta cell function and insulin secretion. The sensory abilities of the cilium arise from local receptor activation that is coupled to intrinsic signal transduction, and ciliary signals can propagate into the cell and influence cell function. Here, we review recent advances and studies that provide insights into intra-islet cues that trigger primary cilia signalling; how second messenger signals ...
Source: Diabetologia - February 14, 2024 Category: Endocrinology Source Type: research
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
AbstractThe type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effectiveness and acceptance at population level. Artificial intelligence (AI) has the potential to contribute to solving these issues, starting with the identification and stratification of at-risk individuals. ASSET (AI for ...
Source: Diabetologia - February 14, 2024 Category: Endocrinology Source Type: research
Keeping pace: the primary cilium as the conducting baton of the islet
AbstractPrimary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting evidence supports important roles of these structures in the regulation of beta cell function and insulin secretion. The sensory abilities of the cilium arise from local receptor activation that is coupled to intrinsic signal transduction, and ciliary signals can propagate into the cell and influence cell function. Here, we review recent advances and studies that provide insights into intra-islet cues that trigger primary cilia signalling; how second messenger signals ...
Source: Diabetologia - February 14, 2024 Category: Endocrinology Source Type: research
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
AbstractThe type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effectiveness and acceptance at population level. Artificial intelligence (AI) has the potential to contribute to solving these issues, starting with the identification and stratification of at-risk individuals. ASSET (AI for ...
Source: Diabetologia - February 14, 2024 Category: Endocrinology Source Type: research
Correction to: Dose –response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
(Source: Diabetologia)
Source: Diabetologia - February 13, 2024 Category: Endocrinology Source Type: research
