Morning exercise as fasted-state activity
(Source: Diabetologia)
Source: Diabetologia - March 4, 2024 Category: Endocrinology Source Type: research
Cost –utility analysis of Dexcom G6 real-time continuous glucose monitoring versus FreeStyle Libre 1 intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in Belgium
Conclusions/interpretationWhen priced similarly, Dexcom G6 rtCGM with alert functionality has both economic and clinical benefits compared with FreeStyle Libre 1 isCGM without alerts in adults with type 1 diabetes in Belgium, and appears to be a cost-effective glucose monitoring modality.Trial registration ClinicalTrials.gov NCT03772600Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 29, 2024 Category: Endocrinology Source Type: research
A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes
Conclusions/interpretationOur study identified a novel group of SIGLEC-1+ monocytes that may serve as an important indicator for early diagnosis, activity assessment and monitoring of therapeutic efficacy in type 1 diabetes, and may also be a novel target for preventing and treating type 1 diabetes.Data availabilityRNA-seq data have been deposited in the GSA human database (https://ngdc.cncb.ac.cn/gsa-human/) under accession number HRA003649.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 29, 2024 Category: Endocrinology Source Type: research
Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank
Conclusions/interpretationAltered metabolomic signatures in DKD are associated with incident CVD and improve CVD risk stratification.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 27, 2024 Category: Endocrinology Source Type: research
Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment
Conclusions/interpretationITGA1 serves as a biomarker for monitoring cardiac structural and functional damage, can be used to accurately diagnose the presence of HFpEF, and can be used to predict potential deterioration in cardiac structure and function as well as re-hospitalisation for individuals with type 2 diabetes. Its measurement holds promise for facilitating risk stratification and early intervention to mitigate the adverse cardiovascular effects associated with diabetes.Data availabilityThe proteomic data of left ventricular myocardial tissue from individuals with type 2 diabetes, encompassing both those with and ...
Source: Diabetologia - February 27, 2024 Category: Endocrinology Source Type: research
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
Conclusions/interpretationipRCG dysfunction in diabetic retinopathy is associated with disruptions of the 24 h melatonin rhythm, suggesting circadian dysregulation in diabetic retinopathy.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 27, 2024 Category: Endocrinology Source Type: research
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
Conclusions/interpretationWe found disparities in cholesterol target achievement and statin prescribing by SMI status. This reinforces the importance of clinical review of statin prescribing for secondary prevention of CVD, particularly among people with SMI.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 26, 2024 Category: Endocrinology Source Type: research
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
Conclusions/interpretationFor the first time, a 10-year incidence trend of type 2 diabetes is reported for Germany, showing a strong decline from 2012 to 2017, followed by a less pronounced decline from 2018 to 2021. The incidence trend of type 2 diabetes appears not to have been affected by the first 2 years of the COVID-19 pandemic. Despite an overall increasing prevalence, the incidence is decreasing, potentially resulting from robust screening by family physicians, reducing the median age at diagnosis by 3 to 5 years. However, further investigation is needed to fully identify the reasons for the declining incidence tre...
Source: Diabetologia - February 26, 2024 Category: Endocrinology Source Type: research
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Conclusions/interpretationThese data suggest that IFN- α and IFN-γ are key cytokines at the islet level in human type 1 diabetes, contributing to the triggering and amplification of autoimmunity.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 26, 2024 Category: Endocrinology Source Type: research
Should children with type 1 diabetes really receive statin treatment using the same criteria as for children with familial hypercholesterolaemia?
(Source: Diabetologia)
Source: Diabetologia - February 26, 2024 Category: Endocrinology Source Type: research
Correction to: Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research
(Source: Diabetologia)
Source: Diabetologia - February 23, 2024 Category: Endocrinology Source Type: research
Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes
Conclusions/interpretationPrecision medicine approaches can facilitate effective individualised treatment choice between SGLT2i and GLP1-RA therapies, and the use of routinely collected clinical features for treatment selection could support low-cost deployment in many countries.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 22, 2024 Category: Endocrinology Source Type: research
Low birthweight and overweight during childhood and young adulthood and the risk of type 2 diabetes in men: a population-based cohort study
Conclusions/interpretationLow birthweight and overweight in young adulthood are the major developmental determinants of adult type 2 diabetes risk in men. They contribute in an additive manner to the risk of type 2 diabetes. To reduce the risk of type 2 diabetes, young adult overweight should be avoided, especially in boys with a low birthweight.Data availabilityThe SPSS analysis code, the R analysis code and a data dictionary have been made available in an online repository (https://osf.io/bx2as/).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 22, 2024 Category: Endocrinology Source Type: research
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
AbstractDyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting circulating lipoparticle metabolism (LDL, VLDL, chylomicrons, HDL) have recently been approved by the European and US medical agencies, including anti- proprotein convertase subtilisin/kexin 9 (PCSK9) antibodies; an siRNA targeting PCSK9; bempedoic acid, which targets ATP citrate lyase; an antisense oligonucleotide targeting apolipoprotein C-III; an anti-angiopoietin-like 3 antibody; and a purified omega-3 fatty acid, icosapent ethyl. Other therapies are in different phases of ...
Source: Diabetologia - February 20, 2024 Category: Endocrinology Source Type: research
Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment
AbstractAn association between diabetes and infection has been recognised for many years, with infection being an important cause of death and morbidity in people with diabetes. The COVID-19 pandemic has re-kindled an interest in the complex relationship between diabetes and infection. Some infections occur almost exclusively in people with diabetes, often with high mortality rates without early diagnosis and treatment. However, more commonly, diabetes is a complicating factor in many infections. A reciprocal relationship occurs whereby certain infections and their treatments may also increase the risk of diabetes. People ...
Source: Diabetologia - February 20, 2024 Category: Endocrinology Source Type: research
