CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice
Conclusions/interpretationMacrophages and macrophage-derived factors, such as IL-1 β, play an important role in physiological insulin secretion. A better understanding of the tissue-specific effects of CSF1R inhibition on immune cells and glucose homeostasis is crucial for the development of targeted immune-modulatory treatments in metabolic disease.Data availabilityThe RNA-Seq dataset is available in the Gene Expression Omnibus (GEO) under the accession number GSE189434 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE189434).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Racial/ethnic and socioeconomic disparities in achievement of treatment goals within a clinical trial: a secondary analysis of the ACCORD trial
Conclusions/interpretationRacially/ethnically minoritised participants in the ACCORD trial were less likely to achieve high-burden (glycaemic) treatment goals but were generally similarly likely to achieve goals of less intensive interventions. Differences in glycaemic treatment goal achievement were partially mediated by differences in medication use but not mediated by hypoglycaemia, change in BMI or study visit attendance.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Structural changes in Schwann cells and nerve fibres in type 1 diabetes: relationship with diabetic polyneuropathy
Conclusions/interpretationCutaneous SC processes and nerves, but not SC soma, are degenerated and interdependent in individuals with diabetic polyneuropathy. However, an increase in structurally damaged nSCs was seen in individuals with diabetic polyneuropathy. Furthermore, dermal SC processes and nerve fibres correlate weakly with clinical measures of neuropathy and may play a partial role in the pathophysiology of diabetic polyneuropathy in type 1 diabetes.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
The challenges of identifying and studying type 1 diabetes in adults
AbstractDiagnosing type 1 diabetes in adults is difficult since type 2 diabetes is the predominant diabetes type, particularly with an older age of onset (approximately>30 years). Misclassification of type 1 diabetes in adults is therefore common and will impact both individual patient management and the reported features of clinically classified cohorts. In this article, we discuss the challenges associated with correctly identifying adult-onset type 1 diabetes and the implications of these challenges for clinical practice and research. We discuss how many of the reported differences in the characteristics of autoimmun...
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Elevated remnant cholesterol and atherosclerotic cardiovascular disease in diabetes: a population-based prospective cohort study
Conclusions/interpretationElevated remnant cholesterol was associated with increased risk of ASCVD in individuals with diabetes. Remnant cholesterol and low-grade inflammation explained substantial excess risk of ASCVD conferred by diabetes. Whether remnant cholesterol should be used as a treatment target remains to be determined in randomised controlled trials.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Presymptomatic type 1 diabetes and disease severity at onset
(Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Presymptomatic type 1 diabetes and disease severity at onset. Reply to Schneider J, Gemulla G, Kiess W et al [letter]
(Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Up Front
(Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
(Source: Diabetologia)
Source: Diabetologia - November 6, 2023 Category: Endocrinology Source Type: research
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Conclusions/interpretationAPOLs are novel regulators of islet inflammation and may contribute to beta cell damage during the development of diabetes.Data availabilityscRNAseq data generated by our laboratory and used in this study are available in the Gene Expression Omnibus (GEO;www.ncbi.nlm.nih.gov/geo/), accession number GSE218316.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 4, 2023 Category: Endocrinology Source Type: research
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Conclusions/interpretationDespite an albeit modest increase in serum magnesium concentration, oral magnesium supplementation does not improve insulin sensitivity in people with insulin-treated type 2 diabetes and low magnesium levels.Trial registrationEudraCT number 2021-001243-27.FundingThis study was supported by a grant from the Dutch Diabetes Research Foundation (2017 –81–014).Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 3, 2023 Category: Endocrinology Source Type: research
HOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
Conclusions/interpretationProgression to Stages 2 and 3 of type 1 diabetes increases with HOMA-IR and decreases with the Matsuda Index after adjustments for insulin secretion. Indicators of insulin secretion appear helpful for interpreting associations of progression to type 1 diabetes with HOMA-IR or the Matsuda Index in AAb-positive relatives.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - November 2, 2023 Category: Endocrinology Source Type: research
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Conclusions/interpretationThis unique single-centre study confirms that, even in a highly consanguineous population, clinically defined type 1 diabetes is the prevailing paediatric diabetes subtype. Furthermore, a pathogenic cause of monogenic diabetes was identified in 83% of tested participants with neonatal diabetes and 57% of participants with syndromic diabetes, with most variants being homozygous. Causative genes in our consanguineous participants were markedly different from genes reported from non-consanguineous populations and also from those reported in other consanguineous populations. To correctly diagnose synd...
Source: Diabetologia - October 28, 2023 Category: Endocrinology Source Type: research
Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes
Conclusions/interpretationGRI, an integrative index, together with other traditional CGM metrics, helps to identify different glycaemic variability patterns; this might provide specifically tailored monitoring and management strategies for individuals in the various subclusters.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - October 27, 2023 Category: Endocrinology Source Type: research
