Diabetes/Metabolism Research and Reviews This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Issue Information
(Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 2, 2017 Category: Endocrinology Tags: ISSUE INFORMATION Source Type: research

Predicting persistent impaired glucose tolerance in GDM women: the role of hsCRP and adiponectin
ConclusionsMid‐pregnancy hsCRP is a potential predictor of persistent impaired glucose tolerance diagnosed on the postpartum 2hr 75 gram OGTT in GDM women in the immediate postpartum period. Further investigation is needed in a larger population of women prior to using specific cutoffs for diagnostic purposes. hsCRP levels in the immediate postpartum period should be seen as an adjunct, not a replacement, for the standard long term screening of women with a history of a GDM pregnancy. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 1, 2017 Category: Endocrinology Authors: Celeste P. Durnwald, Katheryne Downes, Rita Leite, Michal Elovitz, Samuel Parry Tags: RESEARCH ARTICLE Source Type: research

Dipeptidyl peptidase 4 inhibitors attenuates the decline of skeletal muscle mass in patients with type 2 diabetes
ConclusionsOur data suggest the potential of DPP4i to prevent the progressive loss of muscle mass with aging in patients with type 2 diabetes. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 1, 2017 Category: Endocrinology Authors: Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa Tags: RESEARCH ARTICLE Source Type: research

The role of Diabetes Mellitus and BMI in the surgical treatment of ankle fractures
ConclusionThis study showed that Diabetes Mellitus and higher BMI delay the wound healing and increase the complication rate in young adult patients with surgically treated bimalleolar fractures. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 1, 2017 Category: Endocrinology Authors: Riccardo Maria Lanzetti, Domenico Lupariello, Teresa Venditto, Matteo Guzzini, Antonio Ponzo, Angelo De Carli, Andrea Ferretti Tags: RESEARCH ARTICLE Source Type: research

Type 2 diabetes: does pancreatic fat really matter?
This article reviews the current state of knowledge on the clinical and pathophysiologic relevance of NAFPD in β‐cell function and insulin resistance. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 1, 2017 Category: Endocrinology Authors: V. Guglielmi, P. Sbraccia Tags: REVIEW ARTICLE Source Type: research

TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment
Summary In the past decade, interest in the century‐old tuberculosis vaccine, bacillus Calmette‐Guerin (BCG), has been revived for potential new therapeutic uses in type 1 diabetes and other forms of autoimmunity. Diverse clinical trials are now proving the value of BCG in prevention and treatment of type 1 diabetes, in the treatment of new onset multiple sclerosis and other immune conditions. BCG contains the avirulent tuberculosis strain Mycobacterium bovis, a vaccine originally developed for tuberculosis prevention. BCG induces a host response that is driven in part by tumour necrosis factor (TNF). Induction of TNF ...
Source: Diabetes/Metabolism Research and Reviews - September 29, 2017 Category: Endocrinology Authors: Denise L. Faustman Tags: REVIEW ARTICLE Source Type: research

Use of oral antidiabetic drugs in the treatment of maturity ‐onset diabetes of the young: A mini review
Summary MODY (maturity‐onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes. Most of them have been erroneously diagnosed as patients with either type 1 or type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas. However, some new classes of oral antidiabetic drugs have also been tested and foun...
Source: Diabetes/Metabolism Research and Reviews - September 29, 2017 Category: Endocrinology Authors: Ludmila Brunerova, Dario Raheli ć, Antonio Ceriello, Jan Broz Tags: REVIEW ARTICLE Source Type: research

Ketoacidosis associated with SGLT2 inhibitor treatment: Analysis of FAERS data
ConclusionsOur results support the FDA's warning that SGLT2 inhibitors lead to ketoacidosis, as evidenced by an increased reporting rate for acidosis above that in a comparator population treated with DPP4 inhibitors. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 29, 2017 Category: Endocrinology Authors: Jenny E. Blau, Sri Harsha Tella, Simeon I. Taylor, Kristina I. Rother Tags: RESEARCH ARTICLE Source Type: research

Single and combined effects of inflammatory markers on 10  year diabetes incidence: The mediating role of adiposity—Results from the ATTICA cohort study
ConclusionsThe reported results underline the significant role of individual IL‐6 or combinations of CRP‐IL‐6 and CRP‐fibrinogen in diabetes prediction. Adiposity seems to be primarily responsible for an increase in inflammatory markers, leading through this mechanism to insulin resistance and increasing diabetes risk. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 25, 2017 Category: Endocrinology Authors: Efi Koloverou, Demosthenes B. Panagiotakos, Ekavi N. Georgousopoulou, Christina Chrysohoou, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos, Tags: RESEARCH ARTICLE Source Type: research

HDL ‐C / apoA‐I ] : a multi‐vessel cardiometabolic risk marker in women with T2DM
Conclusion[HDL‐C/apoA‐I] can stratify T2DM women according to metabolic phenotype, macrovascular and coronary damage, β‐cell function, microangiopathic risk, and retinopathy. This ratio is a versatile and readily available marker of cardiometabolic status and vascular complications in T2DM women. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 15, 2017 Category: Endocrinology Authors: Michel P. Hermans, Paul Valensi, Sylvie A. Ahn, Michel F. Rousseau Tags: RESEARCH ARTICLE Source Type: research

Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes
ConclusionThrough both empirical and biological validation, we have established a prediction model for estimating lifetime T1D risk, using class II HLA. This prediction model should prove useful for future investigations to identify high‐risk subjects for prevention research in high‐risk populations. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 15, 2017 Category: Endocrinology Authors: Lue Ping Zhao, Annelie Carlsson, Helena Elding Larsson, Gun Forsander, Sten A. Ivarsson, Ingrid Kockum, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Eva Örtqvist, Chul‐Woo Pyo, Hamid Bolouri, Michael Zhao, Wyatt C. Nelson, Daniel Tags: RESEARCH ARTICLE Source Type: research

Glycaemia control and the risk of hospitalisation for infection in patients with type 2 diabetes: Hong Kong Diabetes Registry
ConclusionsIn patients with type 2 diabetes, burden of serious infection is high. In the diabetic population, a U‐shape relationship between glycaemia and infection‐related hospitalisation was detected. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 7, 2017 Category: Endocrinology Authors: Andrea O.Y. Luk, Eric S.H. Lau, Kitty K.T. Cheung, Alice P.S. Kong, Ronald C.W. Ma, Risa Ozaki, Francis C.C. Chow, Wing ‐Yee So, Juliana C.N. Chan Tags: RESEARCH ARTICLE Source Type: research

Liraglutide mitigates TNF ‐α induced pro‐atherogenic changes and microvesicle release in HUVEC from diabetic women
ConclusionsTNF‐α induced pro‐atherogenic alterations are amplified in endothelial cells chronically exposed to hyperglycemia in vivo. Liraglutide mitigates TNF‐α effects and reduces cell stress/damage indicators, such as endothelial microvesicle (EMV) release. These results foster the notion that Liraglutide could exert a protective effect against hyperglycemia and inflammation triggered endothelial dysfunction. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 6, 2017 Category: Endocrinology Authors: Pamela Di Tomo, Paola Lanuti, Natalia Di Pietro, Maria Pompea Antonia Baldassarre, Marco Marchisio, Assunta Pandolfi, Agostino Consoli, Gloria Formoso Tags: RESEARCH ARTICLE Source Type: research

Progression of skin autofluorescence of AGEs over 4  years in patients with type 1 diabetes
ConclusionsThe skin autofluorescence of advanced glycation end‐products progresses in patients with type 1 diabetes, more if they have diabetic nephropathy, less if they are treated by continuous subcutaneous insulin infusion. This progression is associated with the development of nephropathy. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 5, 2017 Category: Endocrinology Authors: Kalina Rajaobelina, Catherine Helmer, Fritz ‐Line Vélayoudom‐Céphise, Sovanndany Nov, Blandine Farges, Emilie Pupier, Laurence Blanco, Marie Hugo, Henri Gin, Vincent Rigalleau Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - September 4, 2017 Category: Endocrinology Tags: ISSUE INFORMATION Source Type: research