Abnormal responsiveness to dexamethasone-suppressed crh test in patients with bilateral adrenal incidentalomas.
CONCLUSIONS: A significant proportion of patients with bilateral AI demonstrate positive responses to the DEX-CRH test compared to unilateral AI, providing ground for potential involvement of HPA-axis dysregulation in the pathogenesis, in at least a subgroup, of bilateral AI patients.
PMID: 26147608 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - July 6, 2015 Category: Endocrinology Authors: Vassiliadi DA, Tzanela M, Tsatlidis V, Margelou E, Tampourlou M, Mazarakis N, Piaditis G, Tsagarakis S Tags: J Clin Endocrinol Metab Source Type: research
Feasibility and efficacy of diabetic retinopathy screening among youth with diabetes in a pediatric endocrinology clinic: a cross-sectional study.
CONCLUSIONS: Use of a non-mydriatic fundus camera is feasible and efficacious for DR screening in youth with diabetes. DR screening at routine endocrinology visits may be beneficial in managing youth with diabetes and preventing irreversible vision loss, particularly for those in regions where diabetes rates are high.
PMID: 26136849 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 5, 2015 Category: Endocrinology Authors: Tapley JL, McGwin G, Ashraf AP, MacLennan PA, Callahan K, Searcey K, Witherspoon CD, Saaddine J, Owsley C Tags: Diabetol Metab Syndr Source Type: research
Degludec: the new ultra-long insulin analogue.
Abstract
The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogue degludec (IDeg) has the same amino acid sequence as human insulin except for the removal of threonine in the position 30 of the B chain (Des-B30, "De") and the attachment, via a glutamic acid linker ("glu"), of a 16-carbon fatty diacid (hexadecanoic diacid, "dec") to lysine in the p...
Source: Diabetes Metab - July 5, 2015 Category: Endocrinology Authors: Tambascia MA, Eliaschewitz FG Tags: Diabetol Metab Syndr Source Type: research
Patient perspectives on self-monitoring of blood glucose: perceived recommendations, behaviors and barriers in a clinic sample of adults with type 2 diabetes.
CONCLUSIONS: Findings suggest that many may experience difficulty integrating SMBG into their lives and are unsure of recommendations and appropriate function. Research is needed to promote best practice recommendations for SMBG.
PMID: 26137451 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 5, 2015 Category: Endocrinology Authors: Ward JE, Stetson BA, Mokshagundam SP Tags: J Diabetes Metab Disord Source Type: research
Spontaneous diabetic myonecrosis: report of four cases from a tertiary care institute.
Abstract
UNLABELLED: Spontaneous diabetic muscle infarction (DMI) is a rare and under diagnosed complication of diabetes mellitus. Clinically it presents with acute to subacute onset swelling, pain and tenderness of muscle(s) without systemic manifestations. MRI is helpful in diagnosis, exclusion of other causes and for localization of affected muscle for biopsy in atypical cases. Muscles of the thighs are commonly affected in diabetic myonecrosis (DMN). Here we present the summary of four cases seen in the last 3 years in a tertiary care centre with simultaneous or sequential involvement of multiple group...
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: Mukherjee S, Aggarwal A, Rastogi A, Bhansali A, Prakash M, Vaiphei K, Dutta P Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients.
Abstract
UNLABELLED: To assess continuous subcutaneous hydrocortisone infusion (CSHI) in patients with adrenocortical insufficiency (AI) and difficulties with oral replacement. Three patients with AI and frequent hospital admissions attributed to adrenal crises were treated with CSHI, which was delivered via a continuous subcutaneous infusion. All three patients preferred CSHI and remained on it long term, which permitted prolonged follow-up analysis. All three patients reported symptomatic improvement, and in two cases, reduced hospital admission rates and inpatient stay lengths were observed. The cost of...
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: Khanna A, Khurana R, Kyriacou A, Davies R, Ray DW Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
Pituitary hyperplasia: case series and literature review of an under-recognised and heterogeneous condition.
Abstract
UNLABELLED: Pituitary hyperplasia (PH) occurs in heterogeneous settings and remains under-recognised. Increased awareness of this condition and its natural history should circumvent unnecessary trans-sphenoidal surgery. We performed an observational case series of patients referred to a single endocrinologist over a 3-year period. Four young women were identified with PH manifesting as diffuse, symmetrical pituitary enlargement near or touching the optic apparatus on MRI. The first woman presented with primary hypothyroidism and likely had thyrotroph hyperplasia given prompt resolution with thyrox...
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: De Sousa SM, Earls P, McCormack AI Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
Spontaneous cervical haemorrhage of a parathyroid adenoma.
This report describes a previously fit and well 54-year-old woman who presented with acute neck swelling and pain with an overlying ecchymosis. Admission laboratory tests revealed a raised parathyroid hormone and hypercalcaemia. A computed tomography (CT) scan showed widespread anterior cervical haemorrhage and a lesion at the inferior pole of the left thyroid gland. A working diagnosis of spontaneous haemorrhage from a parathyroid adenoma was made. As she was haemodynamically stable, she was treated conservatively with a period of observation in hospital to monitor for signs of neck organ compression. Follow-up imaging wi...
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: Ulrich L, Knee G, Todd C Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
Consequences of AphanizomenonFlos-aquae(AFA) extract (Stemtech (TM) ) on metabolic profile of patients with type 2 diabetes.
CONCLUSION: StemtechTM intervention brought in positive consequence on blood glucose levels in Iranian patients with type 2 diabetes, consequently suggests the Stemtech (TM) as a functional food for the management of diabetes.
PMID: 26131436 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: Sanaei M, Ebrahimi M, Banazadeh Z, Shafiee G, Khatami F, Ahadi Z, Heshmat R Tags: J Diabetes Metab Disord Source Type: research
Prevalence of vitamin D deficiency across the spectrum of glucose intolerance.
CONCLUSION: Our data showed that VDD is prevalent in the majority of the population, irrespective of the underlying glucose intolerance. Further studies are required to determine the association between the vitamin D and diabetes.
PMID: 26131437 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 3, 2015 Category: Endocrinology Authors: Modi KD, Ahmed MI, Chandwani R, Kumar KV Tags: J Diabetes Metab Disord Source Type: research
Erratum.
Authors:
PMID: 26094570 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - June 28, 2015 Category: Endocrinology Tags: Diabetes Obes Metab Source Type: research
You are what you eat: O-linked N-acetylglucosamine in disease, development and epigenetics.
Abstract
PURPOSE OF REVIEW: The O-linked N-acetylglucosamine (O-GlcNAc) modification is both responsive to nutrient availability and capable of altering intracellular cellular signalling. We summarize data defining a role for O-GlcNAcylation in metabolic homeostasis and epigenetic regulation of development in the intrauterine environment.
RECENT FINDINGS: O-GlcNAc transferase (OGT) catalyzes nutrient-driven O-GlcNAc addition and is subject to random X-inactivation. OGT plays key roles in growth factor signalling, stem cell biology, epigenetics and possibly imprinting. The O-GlcNAcase, which removes...
Source: Diabetes Metab - June 10, 2015 Category: Endocrinology Authors: Olivier-Van Stichelen S, Hanover JA Tags: Curr Opin Clin Nutr Metab Care Source Type: research
Developmental programming of type 2 diabetes: early nutrition and epigenetic mechanisms.
Abstract
PURPOSE OF REVIEW: The environment experienced during critical windows of development can 'programme' long-term health and risk of metabolic diseases such as type 2 diabetes in the offspring. The purpose of this review is to discuss potential epigenetic mechanisms involved in the developmental programming of type 2 diabetes by early nutrition.
RECENT FINDINGS: Maternal and more recently paternal nutrition have been shown to play key roles in metabolic programming of the offspring. Although the exact mechanisms are still not clear, epigenetic processes have emerged as playing a plausible ro...
Source: Diabetes Metab - June 10, 2015 Category: Endocrinology Authors: Ong TP, Ozanne SE Tags: Curr Opin Clin Nutr Metab Care Source Type: research
Heat shock proteins and heat therapy for type 2 diabetes: pros and cons.
Abstract
PURPOSE OF REVIEW: Heat therapy, such as sauna and hot tub, has become an increasingly regular therapeutical practice around the world since several studies have shown benefits of heat therapy in metabolic and cardiovascular diseases. The use of heat therapy in people with type 2 diabetes mellitus revealed a striking reduction of 1% unit in the glycated hemoglobin, suggesting this therapy for the treatment of diabetes. Herein, we shall discuss the use of heat therapy and the mechanisms involved, and suggest a provisional guide for the use of heat therapy in obesity and diabetes.
RECENT FIN...
Source: Diabetes Metab - June 10, 2015 Category: Endocrinology Authors: Krause M, Ludwig MS, Heck TG, Takahashi HK Tags: Curr Opin Clin Nutr Metab Care Source Type: research
Genetics of insulin resistance in polycystic ovary syndrome.
Abstract
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is a very common endocrine disease in women all over the world. A variety of symptoms such as hirsutism and hyperandrogenism, irregular menstrual cycles and anovulatory infertility together with metabolic dysfunction, insulin resistance, and type 2 diabetes mellitus in lean and obese individuals and the development of consecutive diseases are key problems in this heterogeneous syndrome.
RECENT FINDINGS: Disease-modifying and potentially disease-causing candidate genes are described. A number of genetic associations have been investigated,...
Source: Diabetes Metab - June 10, 2015 Category: Endocrinology Authors: Obermayer-Pietsch B, Trummer C, Schwetz V, Schweighofer N, Pieber T Tags: Curr Opin Clin Nutr Metab Care Source Type: research
