Glycemic variability in normal glucose tolerance women with the previous gestational diabetes mellitus.
CONCLUSIONS: Normal glucose tolerance women with pGDM were presented with elevated glycemic variability, which may be associated with impaired islet β cell function. PMID: 26405461 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 26, 2015 Category: Endocrinology Authors: Wang YM, Zhao LH, Su JB, Qiao HF, Wang XH, Xu F, Chen T, Chen JF, Wu G, Wang XQ Tags: Diabetol Metab Syndr Source Type: research

Energy balance and metabolic changes with SGLT2 inhibition.
Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors are the latest addition to the class of oral glucose-lowering drugs. They have been rapidly adopted into clinical practice due to therapeutic advantages including weight loss and reduction in blood pressure in addition to glycaemic benefits and a low intrinsic risk of hypoglycaemia. Although there are extensive data on the clinical effects of SGLT2 inhibition, the metabolic effects of inhibiting renal glucose re-absorption have not been fully described. Recent studies have identified compensatory metabolic effects such as an increase in endogenous...
Source: Diabetes Metab - September 25, 2015 Category: Endocrinology Authors: Rajeev SP, Cuthbertson DJ, Wilding JP Tags: Diabetes Obes Metab Source Type: research

Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus.
CONCLUSIONS: We identified combinations of metabolites in early pregnancy that are associated with subsequent risk of GDM. Replication of findings may improve understanding of GDM pathogenesis and may have implications for the design of GDM prevention and early diagnosis protocols. PMID: 26406294 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 25, 2015 Category: Endocrinology Authors: Enquobahrie DA, Denis M, Tadesse MG, Gelaye B, Ressom HW, Williams MA Tags: J Clin Endocrinol Metab Source Type: research

Altered circulating miRNA expression profile in pregestational and gestational obesity.
CONCLUSIONS: This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and post-natal growth. PMID: 26406295 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 25, 2015 Category: Endocrinology Authors: Carreras-Badosa G, Bonmatí A, Ortega FJ, Mercader JM, Guindo-Martínez M, Torrents D, Prats-Puig A, Martinez-Calcerrada JM, Platero E, De Zegher F, Ibáñez L, Fernandez-Real JM, Lopez-Bermejo A, Bassols J Tags: J Clin Endocrinol Metab Source Type: research

Adiponectin levels differentiate metabolically healthy versus unhealthy among obese and non-obese white individuals.
CONCLUSIONS: Higher ADPN and lower waist-to-hip ratios (higher peripheral adiposity) are associated with better metabolic health in both non-obese and obese white individuals. These results suggest that ADPN and peripheral adiposity play a key role in determining the metabolic health independent of BMI. PMID: 26401592 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 24, 2015 Category: Endocrinology Authors: Ahl S, Guenther M, Zhao S, James R, Marks J, Szabo A, Kidambi S Tags: J Clin Endocrinol Metab Source Type: research

Chromium, zinc and magnesium status in type 1 diabetes.
Abstract PURPOSE OF REVIEW: Chromium, zinc, and magnesium are involved in insulin signal transduction, glucose metabolism, and cellular antioxidative defense. This review details the statuses of chromium, zinc, and magnesium in type 1 diabetes patients. RECENT FINDINGS: Blood levels of trace elements (especially magnesium and zinc) were lower in type 1 diabetes patients than in controls and were even lower in type 1 diabetes patients with poor glycemic control. Studies with mouse models have shown that chromium and magnesium supplementation alleviated diabetes-induced complications and improved gly...
Source: Diabetes Metab - September 24, 2015 Category: Endocrinology Authors: Lin CC, Huang YL Tags: Curr Opin Clin Nutr Metab Care Source Type: research

The effectiveness of German disease management programs (DMPs) in patients with type 2 diabetes mellitus and coronary heart disease: results from an observational longitudinal study.
CONCLUSIONS: The results of this study concerning the effectiveness of DMPs in patients with DM and CHD are mixed, but are weakly in favor of DMPs. However, we found a clear positive impact of guideline care on quality adjusted survival in this patient group. The development of the association between DMP enrollment and guideline care over the follow-up time indicates some external effects, which should be the subject of further investigations. PMID: 26388948 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 23, 2015 Category: Endocrinology Authors: Laxy M, Stark R, Meisinger C, Kirchberger I, Heier M, von Scheidt W, Holle R Tags: Diabetol Metab Syndr Source Type: research

Five-year change of clinical and complications profile of diabetic patients under primary care: a population-based longitudinal study on 127,977 diabetic patients.
CONCLUSIONS: Standard of public primary care for diabetic patients enhanced from 2009 to 2013, as reflected by the improvement in outcomes of care. It could be related to the implementation of the territory-wide quality enhancement programmes in all public primary care clinics since 2009, with coverage increasing from 3.1 % (2009) to 81.9 % (2013). Clinical trial number and registry: NCT02034695, ClinicalTrials.gov. PMID: 26388950 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 23, 2015 Category: Endocrinology Authors: Fung CS, Wan EY, Jiao F, Lam CL Tags: Diabetol Metab Syndr Source Type: research

Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study).
Abstract To evaluate the efficacy of azelnidipine and amlodipine on diabetic nephropathy and atherosclerosis, we designed a prospective and randomized controlled clinical study in type 2 diabetic patients with stable glycemic control with fixed dose of anti-diabetic medication. Although there was no difference in blood pressure between both groups, urinary albumin excretion and maximum carotid intima-media thickness were reduced in azelnidipine group, but not in amlodipine group. In addition, inflammatory cytokine levels were decreased only in azelnidipine group which possibly explains such beneficial effe...
Source: Diabetes Metab - September 23, 2015 Category: Endocrinology Authors: Tawaramoto K, Kaneto H, Hashiramoto M, Kawasaki F, Tatsumi F, Shimoda M, Kamei S, Matsuki M, Mune T, Kaku K Tags: Diabetol Metab Syndr Source Type: research

Hormonal, radiological, NP-59 scintigraphy and pathological correlations in patients with Cushing's syndrome due to Primary Pigmented Nodular Adrenocortical Disease (PPNAD).
CONCLUSION: Standard adrenal CT scan most often reveals micronodules but there is no specific CT-imaging. NP-59 scintigraphy always shows a bilateral adrenal uptake confirming the bilateral nature of the disease, but asymmetrical scintigraphic uptake can be observed in patients with macronodules. PMID: 26390100 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 21, 2015 Category: Endocrinology Authors: Vezzosi D, Tenenbaum F, Cazabat L, Tissier F, Bienvenu M, Carrasco CA, Laloi-Michelin M, Barrande G, Lefebvre H, Hiéronimus S, Tabarin A, Bertagna X, Legmann P, Christine Vantyghem M, Bertherat J Tags: J Clin Endocrinol Metab Source Type: research

Effect of sensor-augmented pump treatment vs. multiple daily injections on albuminuria: a 1 year randomized study.
CONCLUSION: SAP treatment reduced UACR in a randomized controlled trial in type 1 diabetes patients with a history of albuminuria on stable RAS-inhibition. Significance was reached after adjustment. SAP treatment reduced HbA1c and glucose variability (calculated as SD). PMID: 26390102 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 21, 2015 Category: Endocrinology Authors: Rosenlund S, Willum Hansen T, Rossing P, Andersen S Tags: J Clin Endocrinol Metab Source Type: research

C-reactive protein is associated with low-density lipoprotein cholesterol and obesity in type 2 diabetic Sudanese.
CONCLUSION: The high prevalence of obesity among diabetics, together with elevated levels of triglycerides and CRP, suggest coexistence of dyslipidemia and inflammation in diabetes. Our findings emphasize that diabetics were 5.6 times more likely to have high CRP levels than nondiabetics; as CRP is a predictor of cardiovascular disease risk, it can be recognized that diabetics are at more risk of cardiovascular disease than nondiabetics. Considering evaluation of CRP together with the lipid profile in prediction of cardiovascular disease risk in Sudanese diabetics should be further tested in large-scale studies. PM...
Source: Diabetes Metab - September 19, 2015 Category: Endocrinology Authors: Dongway AC, Faggad AS, Zaki HY, Abdalla BE Tags: Diabetes Metab Syndr Obes Source Type: research

Fluconazole and acetazolamide in the treatment of ectopic Cushing's syndrome with severe metabolic alkalosis.
We present the case of an 80-year-old woman affected by CS due to an unknown cause. The patient had severe metabolic alkalosis with refractory hypokalemia. To treat the underlying CS, fluconazole was initiated due to unavailability of ketoconazole. In spite of markedly decreasing cortisol levels, metabolic alkalosis persisted. Treatment of metabolic alkalosis with acetazolamide was thus initiated and pH levels successfully lowered. This case report shows that hypercortisolism can be effectively treated with fluconazole in cases where ketoconazole is unavailable or not tolerated and that persistent severe metabolic alkalosi...
Source: Diabetes Metab - September 19, 2015 Category: Endocrinology Authors: Schwetz V, Aberer F, Stiegler C, R Pieber T, Obermayer-Pietsch B, Pilz S Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Direct association of visit-to-visit HbA1c variation with annual decline in estimated glomerular filtration rate in patients with type 2 diabetes.
CONCLUSIONS: Consistency of glycemic control is important to preserve kidney function in type 2 diabetic patients, in particular, in those with nephropathy. PMID: 26380227 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 19, 2015 Category: Endocrinology Authors: Takenouchi A, Tsuboi A, Terazawa-Watanabe M, Kurata M, Fukuo K, Kazumi T Tags: J Diabetes Metab Disord Source Type: research

Association between serum uric acid level and metabolic syndrome components.
CONCLUSION: This study showed that those individuals with MetS have higher uric acid levels; the association of uric acid and MetS components supports that it might be an additional components of MetS. PMID: 26380228 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 19, 2015 Category: Endocrinology Authors: Nejatinamini S, Ataie-Jafari A, Qorbani M, Nikoohemat S, Kelishadi R, Asayesh H, Hosseini S Tags: J Diabetes Metab Disord Source Type: research