Serum leptin in diabetic nephropathy male patients from Gaza Strip
Publication date: Available online 2 February 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Maged M. Yassin, Ayman M. AbuMustafa, Mohamed M. YassinAbstractObjectiveTo assess serum leptin in diabetic nephropathy male patients from Gaza Strip.Materials and methodsThis case-control study comprised 132 type 2 diabetic patients and 44 non-diabetic controls. The diabetic patients were classified into three groups; 44 normoalbuminurics, 44 microalbuminurics and 44 macroalbuminurics. Data were obtained from questionnaire interview, and biochemical analysis of blood and urine samples. Pati...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 2, 2019 Category: Endocrinology Source Type: research

Low magnesium level as an indicator of poor glycemic control in type 2 diabetic patients with complications
ConclusionThe low levels of magnesium in diabetic complications, indicates the poor glycemic control in diabetic patients. Hence, maintaining the sufficient level of magnesium can control glycemia, thereby prevent the development of diabetic complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 2, 2019 Category: Endocrinology Source Type: research

The influence of insulin resistance in the occurence of non-alcoholic fatty liver disease among first degree relatives of type 2 diabetes
ConclusionThe occurrence of NAFLD in FDR of T2DM was influenced by IR (central obesity and obesity). (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - February 1, 2019 Category: Endocrinology Source Type: research

Lessons learned from an unusual case of severe hypoglycemia
Publication date: Available online 31 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): M.R. Improta, F. Strollo, S. Gentile, AMD-OSDI Study Group on Injection TechniqueAbstractWe are hereby reporting on a woman with type 1 diabetes getting insulin, 4 shots a day, and referring to us for an episode of severe hypoglycemia occurred after vigorously rubbing a lipo-hypertrophy (LH). She had always injected insulin into an abdominal LH area but had never suffered from any hypoglycemic event (Hypo) during the last period. Nevertheless her history included frequent Hypos, mostly mild...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 31, 2019 Category: Endocrinology Source Type: research

How the association between obesity and inflammation may lead to insulin resistance and cancer
ConclusionThis review summarizes how cytokine production in adipose tissue of obese subject creates a chronic inflammatory environment that favors tumor cell motility and invasion to enhance the metastatic potential of tumor cells. High levels of cytokine in the circulation of affected individuals have been associated with a significantly worse outcome. This article also reconnoiters the mechanisms that link obesity to numerous disorders such as inflammation, diabetes, cancers and most specifically combine these processes in a single image. Understanding these mechanisms may assist to understand the consequences of obesity...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 30, 2019 Category: Endocrinology Source Type: research

A systematic review of antiglycation medicinal plants
ConclusionThis review can help pharmacologist to findantiglycation natural substance that can be useful in treatment of diabetic complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 30, 2019 Category: Endocrinology Source Type: research

Nutrition and physical activity in Asian Indians with non-alcoholic fatty liver: A case control study
Publication date: Available online 29 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Surya Prakash Bhatt, Anoop Misra, Priyanka NigamAbstractAimWe tested the hypothesis that Asian Indians with non-alcoholic fatty liver disease (NAFLD) would have imbalanced diets and lower intensity of physical activity than those without NAFLD.MethodsWe studied dietary intake, intensity of physical activity and anthropometric and metabolic profiles in subjects with NAFLD and in healthy controls. Complete clinical, biochemical, dietary and physical activity profiles were studied for 169 case...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 30, 2019 Category: Endocrinology Source Type: research

Visceral adiposity index as a predictor for type 2 diabetes mellitus in Asian population: A systematic review
ConclusionsVAI is a practical formula used to estimate the accumulation of visceral fat which can be used as a predictor for T2DM in Asian population. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 30, 2019 Category: Endocrinology Source Type: research

Visceral adiposity index in female with type 2 diabetic mellitus and its association with the glycemic control
Conclusionincreased VAI adversely affects the glycemic control in women with T2DM. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 29, 2019 Category: Endocrinology Source Type: research

Metabolically healthy status and BMI in relation to depression: A systematic review of observational studies
ConclusionsIn conclusion, metabolically health status and BMI are associated with risk of depression. Metabolically unhealthy situation increased risk of depression greater than metabolically healthy status. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 29, 2019 Category: Endocrinology Source Type: research

Prevalence and association of co-morbidities in diabetic patients along with prescription patterns in Delhi-NCT, India
ConclusionThe number of diabetic population is high in Delhi. It was evident that a significant percentage of diabetic patients suffered from additional diseases that may lead to worsening of the health conditions. Thus, there is an urgent need to educate and spread awareness amongst the masses about the potential benefits of lifestyle modifications like the incorporation of a healthy diet and physical activities. Additionally, continuous and regular tests should be taken to avoid further complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 28, 2019 Category: Endocrinology Source Type: research

Toll-like receptor 2 expression on monocytes and microvascular complications in type 2 diabetic patients
This study aimed to assess the association between the TLR2 and type 2 diabetes mellitus (T2DM) in Egyptian diabetic patients and to investigate its relationship with some diabetic complications.MethodsThis study included a 60 diabetic patients group 1 (diabetic complicated), group 2 (diabetic non-complicated) and 30 age-matched normal healthy blood donors.ResultsToll-like receptors (TLRs) expression was significantly associated with T2DM. In this study, the mean fluorescent intensity (MFI) of TLR2 was 596.9 ± 84.78 in group 1, 326.23 ± 62.98 in group 2 while in group 3 it was 208.47 ± 156....
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 26, 2019 Category: Endocrinology Source Type: research

Management of diabetes mellitus and patients' attitude towards the disease: Data from a nationwide study in Greece
ConclusionsIn a random nationwide sample of the adult population in Greece the majority of subjects with self-reported DM had type 2 DM. Most patients with type 2 were treated with OAD. Almost half of insulin naive subjects were skeptical towards insulin initiation. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 26, 2019 Category: Endocrinology Source Type: research

The importance of measurement of plasma fibrinogen level among patients with type- 2 diabetes mellitus
Publication date: Available online 24 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Manal Khudder Abdul Razak, Ali Adnan SultanAbstractBackground & aimFibrinogen has been implicated as a cause of atherosclerosis and its complications in patients with type 2 DM. We aimed to measure the plasma fibrinogen level in type 2 diabetics and to correlate it with the duration, type of treatment, HbA1c, smoking, lipid profile, diabetic retinopathy, hypertension and ischemic heart disease in comparison to control.MethodsA case control single center study included 50 patients with t...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)
Publication date: Available online 24 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Michael Halim, Alice HalimAbstractDiabetes mellitus is seen to be prevalent among the different epidemics. The prevalence rate of the diabetes mellitus is seen to be increasing in different regions of the world. Type 2 diabetes mellitus is the most common form of the disease that causes the defect in the production of insulin. It is associated with the disruption in the metabolism of fat, proteins and carbohydrates. Different complications that are associated with T2DM includes the retinopa...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Effect of Q10 supplementation on body weight and body mass index: A systematic review and meta-analysis of randomized controlled clinical trials
ConclusionResults of this meta-analysis study failed to show any beneficial effect of coenzyme Q10 supplementation on body weight and BMI of patients in clinical trial studies. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: A case study
Publication date: Available online 24 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Sarah J. Morrill, Kelly J. GibasAbstractIt has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic mutation marker. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) still remains relatively unstudied. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 mutation allele, also known as the Alzheimer's disease gene, are primarily at a greater r...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Patient's lack of understanding producing insulin drug-interactions in Southeast Brazilian primary care clinics
ConclusionsDiabetes patients without practical knowledge about insulin interacting with other pharmaceutical drugs that can produce DDIs with other medicines illustrates a need to develop education programs for diabetics. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Potential role of Peroxisome Proliferator Activated Receptor gamma analogues in regulation of endothelial progenitor cells in diabetes mellitus: An overview
Publication date: Available online 25 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Manik Chhabra, Saurabh SharmaAbstractEndothelial progenitor cells are recognized as the potential targets for the revascularization and angiogenesis because of their ability to get themselves transformed into mature endothelial cells. Underlying pathophysiology in diabetes mellitus leads to decrease in circulatory endothelial progenitor cells, resulting in diabetic macro-vascular and micro-vascular complications. Peroxisome Proliferator Activated Receptor (PPAR) gamma analogues serves as an...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Identification of risk factors affecting impaired glucose metabolism among the adult population of district Srinagar
ConclusionRisk factors for impaired glucose metabolism include increasing age, obesity, and higher consumption of carbonated drinks, hypertension, smoking behavior, high-calorie diet intake and positive family history of diabetes. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 25, 2019 Category: Endocrinology Source Type: research

Association of diabetic foot ulcers with chronic vascular diabetic complications in patients with type 2 diabetes
ConclusionChronic vascular diabetic complications are common among type 2 diabetic patients with diabetic foot ulcers. There is statistically significant association between these complications and diabetic peripheral neuropathy (DPN) and peripheral arterial disease (PAD). (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 24, 2019 Category: Endocrinology Source Type: research

Clinical features, radiological characteristics and offloading modalities in stage 0 Acute Charcot's neuroarthropathy - A single centre experience from South India
ConclusionsThis is the first study to highlight the characteristic features of Stage 0 ACN in Indian Type 2 Diabetes patients. Thorough clinical evaluation, infrared thermometry and radiological findigs on MRI foot leads to early disease detection. Complete offloading, preferably with total contact casts can prevent disease progression and chronic deformities. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Biochemical isthmus [nexus] between type 2 diabetes mellitus and thyroid status—an update
Publication date: Available online 22 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Rajendran Jayanthi, Abu Raghavan SrinivasanAbstractBoth Type 1 [T1DM] and Type 2 diabetes mellitus [T2DM] share a nexus with altered thyroid status. In recent times, evidences point to the link between thyroid hormones andT2DM in particular. Several lines of evidences suggest an array of biochemical and molecular events. Gene polymorphism, disturbances in gene expression and regulation, enhanced and bizarre absorption of dietary glucose from intestine, decreased utilization of glucose by ti...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Factors associated with reluctance to initiate or continue oral antihyperglycemic agent (OAHA) treatments in type 2 diabetes mellitus patients in Japan: An observational patient-reported study
ConclusionThe potential barriers addressed in this study should be considered when planning intervention strategies targeted at T2DM patients to promote their treatment in Japan. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Association of demographic and socioeconomic characteristics with body mass index of outpatient diabetic adults attending a tertiary health facility in Enugu, Nigeria
ConclusionThere is a weak negative association of age, sex and occupation with BMI. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Association of fasting glucagon-like peptide-1 with oxidative stress and subclinical atherosclerosis in type 2 diabetes
Publication date: Available online 22 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Hesham Alharby, Talaat Abdelati, Mostafa Rizk, Eman Youssef, Noha Gaber, Khaled Moghazy, Saeed YafieAbstractAimGlucagon-like peptide-1(GLP-1) is a gut hormone that beside its main function in glucose homeostasis may play a role as an anti-oxidant and anti-atherosclerotic factor. The aim of this study was to estimate fasting total GLP-1 level in type 2 diabetes (T2DM) patients and to determine its relation with oxidative stress and atherosclerotic vascular changes.MethodsThe study included 6...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Effects of vitamin D supplementation along with endurance physical activity on lipid profile in metabolic syndrome patients: A randomized controlled trial
This study was conducted to determine the effects of vitamin D supplementation along with endurance physical activity on lipid profile among metabolic syndrome patients.Materials and methodsIn a parallel randomized placebo controlled trial, 70 metabolic syndrome patients, were randomly assigned into three groups. Biochemical tests were assessed as baseline and after 12 weeks of intervention. Statistical analysis was performed using SPSS version 20.ResultsThe mean vitamin D levels was increased significantly in both vitamin D and vitamin D plus physical activity groups (P value 
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Prevalence and risks of hypertension among Indian tribes and its status among the lean and underweight individuals
ConclusionThe increased prevalence and risks ofhypertensionin the background oflean and underweightstatus of Indian tribesindicates their epidemiological transition burdened with alarming cardio-metabolichealthrisks that warrant an early and consistent surveillance. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Psychiatric symptom rate of patients with Diabetes Mellitus: A case control study
ConclusionIn diabetic patient groups, an increase in the rate of psychiatric symptoms was observed. Therefore a careful psychiatric examination is required in DM. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Insight into multidrug-resistant microorganisms from microbial infected diabetic foot ulcers
ConclusionThese findings might effectively help to avert the severe complications of diabetic foot infections (DFIs) besides our endeavors to find new antimicrobial wound dressings. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Leptin level decreases after treatment with the combination of Radiofrequency and Ultrasound cavitation in response to the reduction in adiposity
Publication date: Available online 23 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Mahla Arabpour-Dahoue, Elham Mohammadzadeh, Amir Avan, Pouya Nezafati, Samira Nasrfard, Hamideh Ghazizadeh, Mehrane Mehramiz, Mohammad Safarian, Mohsen Nematy, Lida Jarahi, Gordon A. Ferns, Abdolreza Norouzy, Majid Ghayour-MobarhanAbstractBackgroundObesity and overweight are major public health problem. Different-strategies have been developed for body contouring including Radiofrequency(RF) and Ultrasound(US). The aim of this study was to investigate changes in serum-leptin as a potential-...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 23, 2019 Category: Endocrinology Source Type: research

Population attributable risk of risk factors for type 2 diabetes; Bayesian methods
ConclusionsIn this study, age was the strongest determinant of diabetes. And then type 2 diabetes is mainly attributable to WHR, significantly more so in women than men. Therefore, central obesity probably should be considered as a major strategy for reducing incidence of type 2 diabetes. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 22, 2019 Category: Endocrinology Source Type: research

Body-mass index and the risk of albuminuria in hypertensive patients with a poor estimated glomerular filtration rate and the potential role of diabetes mellitus
ConclusionObesity defined by a high BMI was not found to be a significant risk factor for micro/macroalbuminuria in hypertensive patients with a poor estimated glomerular filtration rate, when diabetes mellitus and the low eGFR value act as confounders. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 22, 2019 Category: Endocrinology Source Type: research

Association between selected trace elements and body mass index and waist circumference: A cross sectional study
ConclusionInverse correlation present between plasma zinc, calcium and magnesium level and BMI and waist circumference, but positive correlation seen between phosphate level and waist circumference. Further studies are needed to evaluate the effect of dietary or supplemental interventions on obesity and central obesity. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 22, 2019 Category: Endocrinology Source Type: research

Metabolically healthy status and BMI in relation to depression: A systematic review of observational studies
ConclusionsIn conclusion, metabolically health status and BMI are associated with risk of depression. Metabolically unhealthy situation increased risk of depression greater than metabolically healthy status. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 22, 2019 Category: Endocrinology Source Type: research

The association between metabolic syndrome and polycystic ovary syndrome: A systematic review and meta-analysis study
Publication date: Available online 21 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Masoumeh Otaghi, Milad Azami, Ali Khorshidi, Milad Borji, Zainab TardehAbstractBackgroundOne of the most common endocrinopathy in women of reproductive age is polycystic ovary syndrome (PCOS). Recent studies have reported different prevalence of metabolic syndrome (MetS) in women with PCOS. The aim of this study was to determine whether women with PCOS are at an increased risk of MetS.MethodThe present systematic review and meta-analysis study was conducted using preferred reporting items f...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 21, 2019 Category: Endocrinology Source Type: research

Lipid profile in type 2 diabetic patients with new dapagliflozin treatment; actual clinical experience data of six months retrospective lipid profile from single center
ConclusionThere are conflicting results about the effect of SGLT2 inhibitors on the lipid profile in the literature. According to our data, dapagliflozin has positive effects on lipid profile as weight and glycemic control and it is well tolerated. Therefore, dapagliflozin therapy is beneficial because of the positive change in lipid profile and weight loss in diabetic patients with overweight and hyperlipidemia. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Prognostication of clinical outcomes in diabetes mellitus: Emerging role of cardiac biomarkers
Publication date: Available online 18 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Alexander E. BerezinAbstractType 2 diabetes mellitus (T2DM) remains substantial health problem and one of the most prevalent metabolic diseases worldwide. The impact of T2DM on CV mortality and morbidity is embedded through a nature evolution of the disease and is modulated by numerous risk factors, such as hypertension, obesity, dyslipidemia. There is large body of evidence regarding use of the cardiac biomarkers to risk stratification at higher CV risk individuals who belongs to general p...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Optimal waist circumference cutoff values for predicting metabolic syndrome among older adults in Ecuador
ConclusionsThe optimal waist circumference cutoff values for predicting metabolic syndrome among older Ecuadorians adults were 90.7 cm for women and 91.2 cm for men. Moreover, current standard definitions of abdominal obesity may overestimate the prevalence of MetS, particularly in Latin American women. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy – A pilot study
ConclusionIn this study, we found that LLLT improved the QL and hence may be a useful therapeutic option in treating peripheral neuropathic pain in type 2 diabetic patients. The progress in the serum Magnesium and Vit. D levels were proportional to the QL and may be a good indicator of the prognosis of DPN after LLLT. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Serum AGEs and sRAGE levels are not related to vascular complications in patients with prediabetes
Conclusions: sRAGE and pentosidine levels are similar in patients with obesity with and without prediabetes and do not correlate to the markers of micro- and macrovascular complications. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

New insights into bioelectronic medicines: A new approach to tackle diabetic peripheral neuropathy pain in clinics
Publication date: Available online 18 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Alok Raghav, Prerna Singh, Jamal AhmadAbstractBioelectronic medicines are a newer way to treat and diagnose the diseases associated with biological systems. All vital organs of the body are innervated, commanding brain to regulate the homeostasis functions. Bioelectronic medicines rely on implications of electrical stimulations or signals associated with the nervous system for real-time treatment. Diabetic peripheral neuropathy (DPN) is a most prevalent micro-vascular complication associate...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Paraoxonase-1 Q192R polymorphism and its association with hs-CRP and fasting blood glucose levels and risk of coronary artery disease
Conclusionwe demonstrate that PON1-Q192R-polymorphism was associated with CRP and FBS levels; R-allele of PON1-Q192R may be an independent risk factor for CAD. Further studies are warranted to determine the value of this marker as a surrogate marker in CAD patients. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

The association between psoriasis and diabetes mellitus: A systematic review and meta-analysis
Publication date: Available online 19 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Mina Mamizadeh, Zainab Tardeh, Milad AzamiAbstractBackgroundPsoriasis is a chronic inflammatory immune mediated skin disease with unknown etiology. Current findings demonstrated that psoriatic patients are at increased risk of other systemic disorders such as diabetes mellitus. The present study was conducted to evaluate the association between psoriasis and diabetes mellitus.MethodThe current study was conducted based on preferred reporting items for systematic reviews and meta-analysis (P...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Chronic unpredictable environmental stress impair biochemical and physiological homeostasis: Role in diabetes mellitus
This study investigates the role of CUES on impaired homeostasis.Material and methodsStressed group mice (n = 20) were exposed to CUES for 16 weeks. Weekly body weight, feed consumption, feed efficiency ratio, fasting blood glucose were monitored. Plasma HbA1c, plasma cortisol, plasma epinephrine and plasma insulin, serum lipids, antioxidants and carbohydrate metabolizing enzymes activity were assessed along with DNA damage and histopathological examination of liver, kidney, pancreas, spleen and skeletal muscles.Results and conclusions: Fasting blood glucose levels & HbA1c in the stressed were significantly higher ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Identification of risk factors affecting impaired glucose metabolism among adult population of district Srinagar
ConclusionRisk factors for impaired glucose metabolism include increasing age, obesity, and higher consumption of carbonated drinks, hypertension, smoking behavior, high-calorie diet intake and positive family history of diabetes. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 20, 2019 Category: Endocrinology Source Type: research

Pattern recognition receptors as potential therapeutic targets in metabolic syndrome: From bench to bedside
Publication date: Available online 18 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Amanda Almeida de Oliveira, Destiny Davis, Kenia Pedrosa NunesAbstractPattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) play crucial roles in the underlying mechanisms of metabolic syndrome (MetS). Mainly, these receptors have been suggested to participate in the pathophysiological processes involved in the complications associated with this condition. Therefore, to evolve therapeutic strategies targeting PRRs might be an imperative approa...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 18, 2019 Category: Endocrinology Source Type: research

Assessment of autonomic functions and its association with telomerase level, oxidative stress and inflammation in complete glycemic spectrum– an exploratory study
ConclusionOxidative damage, inflammation and autonomic dysregulation may be involved in Telomere/Telomerase dysregulation in diabetes and telomerase levels can be used as a cardio-metabolic marker of diabetes. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 17, 2019 Category: Endocrinology Source Type: research

The effects of glycemic control on morbidity and survival among diabetic patients
ConclusionsMore than one-half of the investigated persons had UCG. Controlled HbA1c was associated with lower co-morbidities and higher ES-10Y. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 17, 2019 Category: Endocrinology Source Type: research

Screening for basal metabolic rate and visceral fat among postmenopausal osteoporosis with type 2 diabetes mellitus
ConclusionThere is a decrease in BMR in women with T2DM with postmenopausal osteoporosis. BMR was significantly correlated with level of physical activity and visceral fat. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - January 17, 2019 Category: Endocrinology Source Type: research