Issue Information
COVER PHOTOGRAPH: Photograph of an adult specimen of Euperipatoides rowelli (Onychophora: Peripatopsidae), stained with the DNA‐selective fluorescent dye DAPI. From: Conserved versus derived patterns of controlled cell death during the embryonic development of two species of Onychophora (velvet worms); Sandra Treffkorn and Georg Mayer; Developmental Dynamics: 246:403–416.
Read the full article at DOI: 10.1002/dvdy.24492 (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 17, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Epithelial ‐Mesenchymal Plasticity and Circulating Tumor Cells: Travel Companions to Metastases
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 13, 2017 Category: Molecular Biology Authors: Marie ‐Emilie Francart, Justine Lambert, Aline M. Vanwynsberghe, Erik W. Thompson, Morgane Bourcy, Myriam Polette, Christine Gilles Tags: Reviews Source Type: research
Heart function and hemodynamic analysis for zebrafish embryos
The Zebrafish has emerged to become a powerful vertebrate animal model for cardiovascular research in recent years. Its advantages include easy genetic manipulation, transparency, small size, low cost, and the ability to survive without active circulation at early stages of development. Sequencing the whole genome and identifying ortholog genes with human genome made it possible to induce clinically relevant cardiovascular defects via genetic approaches. Heart function and disturbed hemodynamics need to be assessed in a reliable manner for these disease models in order to reveal the mechanobiology of induced defects. This ...
Source: Developmental Dynamics - April 11, 2017 Category: Molecular Biology Authors: Huseyin C. Yalcin, Armin Amindari, Jonathan T. Butcher, Asma Althani, Magdi Yacoub Tags: Review Source Type: research
Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos
Conclusion: We conclude that Pten is required for proamniotic cavity formation by establishing polarity for epiblast cells to form a rosette that expands into the proamniotic lumen, rather than facilitating apoptosis to create the cavity. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 7, 2017 Category: Molecular Biology Authors: Yue Meng, Kathy Q. Cai, Robert Moore, Wensi Tao, Jeffrey D. Tse, Elizabeth R. Smith, Xiang ‐Xi Xu Tags: Research Article Source Type: research
Ex vivo analysis of the contribution of FGF10+ cells to airway smooth muscle cell formation during early lung development
Conclusions: Our data demonstrate, in real time, that FGF9 is an important regulator of amplification, migration and subsequent differentiation of ASMC progenitors during early lung development. The attained results agree with previous findings regarding ASMC formation, and highlight the complexity of growth factor signaling networks in controlling mesenchymal cell‐fate decisions in the developing mouse lung. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 7, 2017 Category: Molecular Biology Authors: Elie El Agha, Vahid Kheirollahi, Alena Moiseenko, Werner Seeger, Saverio Bellusci Tags: Patterns & Phenotypes Source Type: research
Bud detachment in Hydra requires activation of FGFR and a Rho ‐ ROCK ‐ myosin II signaling pathway to ensure formation of a basal constriction
Conclusion: Our data suggest an essential role of FGFR and a Rho‐ROCK‐myosin II pathway in the control of cell shape changes required for bud detachment. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 1, 2017 Category: Molecular Biology Authors: Oliver Holz, David Apel, Patrick Steinmetz, Ellen Lange, Simon Hopfenm üller, Kerstin Ohler, Stefanie Sudhop, Monika Hassel Tags: Research Article Source Type: research
Hit Pause: Developmental arrest in annual killifishes and their close relatives
(Source: Developmental Dynamics)
Source: Developmental Dynamics - April 1, 2017 Category: Molecular Biology Authors: Karen Martin, Jason E. Podrabsky Tags: perspective Source Type: research
The role of small GTPases of the Rho/Rac family in TGF ‐β‐induced EMT and cell motility in cancer
Conclusions: Given the tumor‐promoting role of TGF‐β in late‐stage carcinomas and the intimate crosstalk of Rho/Rac1/Rac1b and TGF‐β signaling in various tumor cell responses, targeting specific Rho GTPases may allow for selective interference with prooncogenic TGF‐β responses to aid in anti‐cancer treatments. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 1, 2017 Category: Molecular Biology Authors: Hendrik Ungefroren, David Witte, Hendrik Lehnert Tags: Reviews Source Type: research
α5β1 Integrin Mediates Pulmonary Epithelial Cyst Formation
Conclusion: We conclude that lung epithelial cyst formation in development is mediated in part by α5β1 integrin dependent fibrillogenesis. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - March 31, 2017 Category: Molecular Biology Authors: Susan K. Legan, Daniel D. Lee, Margaret A. Schwarz Tags: Research Article Source Type: research
From Snapshots to Movies: Understanding Early Tooth Development in Four Dimensions
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - March 21, 2017 Category: Molecular Biology Authors: Rebecca Kim, Jeremy B.A. Green, Ophir D. Klein Tags: Critical Commentarie Source Type: research
Neuregulin1 fine ‐tunes pre‐, post‐, and perisynaptic neuromuscular junction development
Conclusion: These findings suggest that, while NRG1 may not be critical for overall development, it appears to be important in fine‐tuning pre‐, post‐, and perisynaptic development of the NMJ. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - March 19, 2017 Category: Molecular Biology Authors: Jiajing Wang, Fei Song, Jeffrey A. Loeb Tags: Research Article Source Type: research
Hatching Date Variability In Wild Populations of Four Coexisting Species Of African Annual Fishes
Conclusions: We suggest that hatching of annual killifish in the wild is a result of the interplay between environmental conditions and individual predisposition to respond to threshold environmental cues, ensuring effective bet‐hedging against unpredictable inundation. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - March 18, 2017 Category: Molecular Biology Authors: Martin Reichard, Radim Bla žek, Matej Polačik, Milan Vrtílek Tags: Research Article Source Type: research
Signaling pathways in mammalian preimplantation development: Linking cellular phenotypes to lineage decisions
The first stages of mammalian development, before implantation of the embryo in the maternal uterus, result in the establishment of three cell populations in the blastocyst: trophectoderm, epiblast, and primitive endoderm. These events involve only a small number of cells, and are initiated by morphological differences among them related to cell adhesion and polarity. Much attention has been paid to the master transcription factors that are critical for establishing and maintaining early lineage choices. Nevertheless, a large body of work also reveals that additional molecular mechanisms are involved. Here, we provide an u...
Source: Developmental Dynamics - March 15, 2017 Category: Molecular Biology Authors: Sergio Menchero,
Teresa Rayon,
Maria Jose Andreu,
Miguel Manzanares Tags: Reviews Source Type: research
Vascular endothelial growth factor control mechanisms in skeletal growth and repair
Vascular endothelial growth factor A (VEGF) is a critical regulator of vascular development and postnatal angiogenesis and homeostasis, and it is essential for bone development and repair. Blood vessels serve both as structural templates for bone formation and they provide essential cells, growth factors and minerals needed for synthesis and mineralization, as well as turnover, of the extracellular matrix in bone. Through its regulation of angiogenesis, VEGF contributes to coupling of osteogenesis to angiogenesis, and it directly controls the differentiation and function of osteoblasts and osteoclasts. In this review, we s...
Source: Developmental Dynamics - March 15, 2017 Category: Molecular Biology Authors: Kai Hu,
Bjorn R. Olsen Tags: Review Source Type: research
MicroRNA ‐142 is a multifaceted regulator in organogenesis, homeostasis, and disease
Over the past decade,microRNA ‐142 (miR ‐142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However,miR ‐142 is expressed in many other tissues, and recent evidence suggests that it may play a more pleiotropic role during embryonic development. In addition,miR ‐142 has been shown to play important functions in disease.miR ‐142 displays a functional role in cancer, virus infection, inflammation, and immune tolerance. Both a guide strand (miR ‐142‐3p) and passenger strand (miR ‐142‐5p) are generated from themiR ‐142 hairpin.miR ‐142‐3p and‐5p display overlapping...
Source: Developmental Dynamics - March 15, 2017 Category: Molecular Biology Authors: Amit Shrestha,
Regina T. Mukhametshina,
Sara Taghizadeh,
Esmeralda V ásquez‐Pacheco,
Hector Cabrera‐Fuentes,
Albert Rizvanov,
Bernard Mari,
Gianni Carraro,
Saverio Bellusci Tags: Review Source Type: research
