Fibroblast growth factor –mediated crosstalk in cancer etiology and treatment
It is becoming increasingly evident that multiple cell types within the tumor work together to drive tumour progression and impact on both the response to therapy and the dissemination of tumour cells throughout the body. Fibroblast growth factor signalling (FGF) is perturbed in a number of tumors, serving to drive tumor cell proliferation and migration, but also has a central role in orchestrating the plethora of cells that comprise the tumor microenvironment. This review focuses on how this family of signalling molecules can influence the interactions between tumor cells and their surrounding environment. Unraveling the ...
Source: Developmental Dynamics - May 18, 2017 Category: Molecular Biology Authors: N. S. Clayton, A. S. Wilson, E. P. Laurent, R. P. Grose, E. P. Carter Tags: Critical Commentaries Source Type: research
Identification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish
Conclusions: Microarray analysis has generated a resource of target genes downstream of Sema6A/PlxnA2 signaling, which can be further investigated to elucidate the downstream effects of this well‐studied neuronal and vascular guidance signaling pathway. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 18, 2017 Category: Molecular Biology Authors: Sarah E. Emerson, Riley M. St. Clair, Ashley L. Waldron, Sierra R. Bruno, Anna Duong, Heather E. Driscoll, Bryan A. Ballif, Sarah McFarlane, Alicia M. Ebert Tags: Patterns & Phenotypes Source Type: research
Issue Information
COVER PHOTOGRAPH: RA signaling is required for normal localization and orientation of neural crest cells in outflow tract cushions. From: Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple cell lineages; Nicolas El Robrini, Heather C. Etchevers, Lucile Ryckebüsch, Emilie Faure, Nathalie Eudes, Karen Niederreither, Stéphane Zaffran and Nicolas Bertrand. Developmental Dynamics Mechanisms of Morphogenesis Special Issue; 245:388–401. Read the full article at DOI:10.1002/dvdy.24357. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 11, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Embryonic development of the annual killifish Austrofundulus limnaeus: An emerging model for ecological and evolutionary developmental biology research and instruction
Conclusions: This study reports for the first time on the detailed development of A. limnaeus and provides a photographic and illustrated atlas of embryos on the two developmental trajectories possible in this species. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 8, 2017 Category: Molecular Biology Authors: Jason E. Podrabsky, Claire L. Riggs, Amie L. Romney, S. Cody Woll, Josiah T. Wagner, Kristin M. Culpepper, Timothy G. Cleaver Tags: Research Article Source Type: research
Tissue growth pressure drives early blood flow in the chicken yolk sac
Conclusions ‐ This study shows that tissue growth pressure can drive early blood flow, and suggests that the mechanical environment, beyond hemodynamics, can contribute to vascular morphogenesis. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 5, 2017 Category: Molecular Biology Authors: Rapha ël Clément, Benjamin Mauroy, Annemiek J.M. Cornelissen Tags: Research Article Source Type: research
Corrigendum: A GAL4 ‐inducible transgenic tool kit for the in vivo modulation of Rho GTPase activity in zebrafish
(Source: Developmental Dynamics)
Source: Developmental Dynamics - May 4, 2017 Category: Molecular Biology Authors: Nicholas J. Hanovice, Emily McMains, Jeffrey M. Gross Tags: Corrigendum Source Type: research
Diverse roles for the Ror ‐family Receptor Tyrosine Kinases in Neurons and Glial Cells during Development and Repair of the Nervous System
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 3, 2017 Category: Molecular Biology Authors: Mitsuharu Endo, Yasuhiro Minami Tags: Review Source Type: research
Developmental ecology of annual killifish Millerichthys robustus (Cyprinodontiformes: Cynolebiidae)
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 1, 2017 Category: Molecular Biology Authors: Omar Dom ínguez‐Castanedo, Stefano Valdesalici, Ana María Rosales‐Torres Tags: Review Source Type: research
The murine lens: A model to investigate in vivo epithelial ‐mesenchymal transition
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 1, 2017 Category: Molecular Biology Authors: Kumi Shirai, Sai ‐ichi Tanaka, Frank J. Lovicu, Shizuya Saika Tags: Reviews Source Type: research
Cadherin interplay during neural crest segregation from the non ‐neural ectoderm and neural tube in the early chick embryo
Conclusions: Our results indicate that partition of the neuroectoderm is mediated by cadherin interplays and ascribe a key role to Cadherin‐6B in the specification and delamination of the NC population. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 1, 2017 Category: Molecular Biology Authors: Alwyn Dady, Jean ‐Loup Duband Tags: Patterns & Phenotypes Source Type: research
Fibroblast Growth Factor mediated cross ‐talk in cancer aetiology and treatment
(Source: Developmental Dynamics)
Source: Developmental Dynamics - May 1, 2017 Category: Molecular Biology Authors: N. S. Clayton, A. S. Wilson, E. P. Laurent, R. P. Grose, E. P. Carter Tags: Critical Commentarie Source Type: research
“Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish”
Conclusions. Microarray analysis has generated a resource of target genes downstream of Sema6A/PlxnA2 signaling, which can be further investigated to elucidate the downstream effects of this well‐studied neuronal and vascular guidance signaling pathway. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 25, 2017 Category: Molecular Biology Authors: Sarah E. Emerson, Riley M. St. Clair, Ashley L. Waldron, Sierra R. Bruno, Anna Duong, Heather E. Driscoll, Bryan A. Ballif, Sarah McFarlane, Alicia M. Ebert Tags: Patterns & Phenotypes Source Type: research
The occhiolino (occ) mutant zebrafish, a model for development of the optical function in the biological lens
CONCLUSION: The occ zebrafish is a novel disease model for visual defects associated with abnormal lens development. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - April 19, 2017 Category: Molecular Biology Authors: Masamoto Aose, Tor H. Linbo, Owen Lawrence, Tadashi Senoo, David W. Raible, John I. Clark Tags: Disease Connections Source Type: research
How many roads lead to cohesinopathies?
(Source: Developmental Dynamics)
Source: Developmental Dynamics - April 19, 2017 Category: Molecular Biology Authors: Rajeswari Banerji, Robert V. Skibbens, M. Kathryn Iovine Tags: Reviews Source Type: research
Regulation of skeletal muscle stem cells by fibroblast growth factors
Fibroblast growth factors (FGFs) are essential for self ‐renewal of skeletal muscle stem cells (satellite cells) and required for maintenance and repair of skeletal muscle. Satellite cells express high levels of FGF receptors 1 and 4, low levels of FGF receptor 3, and little or no detectable FGF receptor 2. Of the multiple FGFs that influence satellite cell function in culture, FGF2 and FGF6 are the only members that regulate satellite cell functionin vivo by activating ERK MAPK, p38 α/β MAPKs, PI3 kinase, PLCγ and STATs. Regulation of FGF signaling is complex in satellite cells, requiring Syndecan‐4, a heparan sulf...
Source: Developmental Dynamics - April 17, 2017 Category: Molecular Biology Authors: Bradley Pawlikowski,
Thomas Orion Vogler,
Katherine Gadek,
Bradley B. Olwin Tags: Review Source Type: research
