Cellular glycosylation senses metabolic changes and modulates cell plasticity during epithelial to mesenchymal transition
Epithelial to mesenchymal transition (EMT) is a developmental program reactivated by tumor cells that leads to the switch from epithelial to mesenchymal phenotype. During EMT, cells are transcriptionally regulated to decrease E‐cadherin expression while expressing mesenchymal markers such as vimentin, fibronectin, and N‐cadherin. Growing body of evidences suggest that cells engaged in EMT undergo a metabolic reprograming process, redirecting glucose flux toward hexosamine biosynthesis pathway (HBP), which fuels aberrant glycosylation patterns that are extensively observed in cancer cells. HBP depends on nutrient availa...
Source: Developmental Dynamics - August 18, 2017 Category: Molecular Biology Authors: Patricia Carvalho ‐cruz, Frederico Alisson‐Silva, Adriane R. Todeschini, Wagner B. Dias Tags: Reviews Source Type: research
Putative binding sites for mir ‐125 family miRNAs in the mouse Lfng 3′UTR affect transcript expression in the segmentation clock, but mir‐125a‐5p is dispensable for normal somitogenesis
Conclusions: These results suggest that mir‐125a sites in the Lfng 3′ untranslated region influence transcript turnover in both mouse and chicken embryos, and support the existence of position‐dependent regulatory mechanisms in the PSM. They further suggest the existence of compensatory mechanisms that can rescue the loss of mir‐125a‐5p in mice. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 18, 2017 Category: Molecular Biology Authors: Kanu Wahi, Sophia Friesen, Vincenzo Coppola, Susan E. Cole Tags: Research Article Source Type: research
Zebrafish models of orofacial clefts
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 10, 2017 Category: Molecular Biology Authors: Kaylia Duncan, Kusumika Mukherjee, Robert A. Cornell, Eric C. Liao Tags: Reviews Source Type: research
Epithelial ‐to‐mesenchymal transition in cutaneous wound healing: Where we are and where we are heading
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 10, 2017 Category: Molecular Biology Authors: Daniel Haensel, Xing Dai Tags: Reviews Source Type: research
An ex vivo model to quantitatively analyze cell migration in tissue
Conclusion: The technique described here is a viable ex vivo model to quantitatively analyse cell migration and differentiation. We demonstrate the ability to detect changes in cell migration within distinct tissue region across tissue samples using the technique described here. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 9, 2017 Category: Molecular Biology Authors: Conor J. O' Leary, Mikail Weston, Kieran W. McDermott Tags: Techniques Source Type: research
The gene network underlying the glial regenerative response to central nervous system injury
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 9, 2017 Category: Molecular Biology Authors: Kentaro Kato, Maria Losada ‐Perez, Alicia Hidalgo Tags: Reviews Source Type: research
Mutations in the Katnb1 gene cause left ‐right asymmetry and heart defects
Conclusion: Katanin function is a critical regulator of heart development in mice. These findings are potentially relevant to human cardiac development. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 9, 2017 Category: Molecular Biology Authors: M.B. Furtado, D.J. Merriner, S. Berger, D. Rhodes, D. Jamsai, M.K O'Bryan Tags: Patterns & Phenotypes Source Type: research
Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development and craniofacial morphogenesis
Conclusions:
Our results show that Hdac1 and Hdac2 function redundantly within the neural crest to regulate proliferation and the development of the pharyngeal arches via repression of cyclin‐dependent kinase inhibitors. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 9, 2017 Category: Molecular Biology Authors: Zachary J. Milstone, Grace Lawson, Chinmay M. Trivedi Tags: Patterns & Phenotypes Source Type: research
Issue Information
COVER PHOTOGRAPH: Immunostaining for KRT14 intermediate filament protein in esophageal epithelium at E17.5. Despite rescuing lethality in the immediate perinatal period with IRF6 expression in basal epithelium, Irf6 knockout embryos have persistent esophageal adhesions that appear to shape the esophageal lumen into an “S”. From: IFR6 expression in basal epithelium partially rescues Irf6 knockout mice; Youssef A. Kousa, Dina Moussa and Brian C. Schutte; Developmental Dynamics 246:670–681. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 8, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Rebooting the Collagen Gel: Artificial Hydrogels for the Study of Epithelial Mesenchymal Transformation
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Source: Developmental Dynamics - August 1, 2017 Category: Molecular Biology Authors: Robert W. Dettman, Hans ‐Georg Simon Tags: Critical Commentaries Source Type: research
HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells
Conclusions: HMGB2 expression is strongly associated with transition from the quiescent to the proliferative state of NSCs, supporting the possibility that HMGB2 is involved in the regulation of adult neurogenesis and can be used as a novel marker to identify NSCs primed for activation in the adult hippocampus. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 1, 2017 Category: Molecular Biology Authors: Ayaka Kimura, Taito Matsuda, Atsuhiko Sakai, Naoya Murao, Kinichi Nakashima Tags: Patterns & Phenotypes Source Type: research
Neural stem cell therapy aiming at better functional recovery after spinal cord injury
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 1, 2017 Category: Molecular Biology Authors: Yicheng Zhu, Naohiro Uezono, Tetsuro Yasui, Kinichi Nakashima Tags: Reviews Source Type: research
The role of the extracellular matrix in cancer ‐associated epithelial to mesenchymal transition phenomenon
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 31, 2017 Category: Molecular Biology Authors: George Tzanakakis, Rafaela ‐Maria Kavasi, Kallirroi Voudouri, Aikaterini Berdiaki, Ioanna Spyridaki, Aristidis Tsatsakis, Dragana Nikitovic Tags: Reviews Source Type: research
Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon
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Source: Developmental Dynamics - July 26, 2017 Category: Molecular Biology Authors: Vikram Kohli, Diana Nardini, Lisa A. Ehrman, Ronald R. Waclaw Tags: Patterns & Phenotypes Source Type: research
Diverse Roles for Glycosaminoglycans in Neural Patterning
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 24, 2017 Category: Molecular Biology Authors: Kristian Saied ‐Santiago, Hannes E. Bülow Tags: Reviews Source Type: research
